A gain guided and index alternate-guided fiber (GGIA-GF) is proposed and numerically demonstrated. The conditions of single mode oscillation are analyzed based on the fiber laser parameters. The output laser power and slope efficiency of the GGIA-GF laser are derived from the improved rate equations. The results show that the output characteristics of the laser based on GGIA-GF can be greatly improved than that of the gain guided and index anti-guided fiber laser through the optimal design of the fiber laser parameters. GGIA-GF would be better applied in the field of large mode area and single mode fiber lasers.