High-performance titanium alloy fasteners play an important role in the aerospace industry as important general basic parts. This work developed a high-elastic-modulus Ti-6.2Al-4.26Mo-1.33Mn alloy with good balance of strength and plasticity through regulating its primary equiaxed α (αp) phase with solution aging treatment. The influence of αp on the tensile properties and low-cycle fatigue (LCF) behavior of the alloy was investigated systematically, and the crack propagation mechanism of fatigue fracture of titanium alloy was revealed. The results show that with increasing solution temperature, the content of αp phase decreases from 43.6 % to 15.1 % in the range of 825 °C–925 °C, and the LCF life is increased by almost 2 times. However, the size of αp phase is almost unchanged with a diameter of about 2.3 μm. With the increase in solution temperature, the tensile strength of the alloy is improved, while the plasticity decreases gradually. At the solution temperature of 875 °C, the ultimate tensile strength (UTS) of the alloy is 1350 MPa, which is 18.6 % higher than the as-forged alloy, with an elongation (El) of >7 %. Moreover, the fatigue performance is also significantly improved, which is associated with the reduced αp phase that was characterized to act as crack initiations and crack propagation path.