This study investigated the solubility of UO2 in LiCl-2 wt% Li2O at 650 °C with O2 partial pressures up to 114 torr. Experiments were run in which UO2 powder was contacted with the molten salt for up to 120 h. Salt samples were taken and analyzed for U and corrosion product concentration using inductively coupled plasma mass spectrometry and for Li2O concentration using titration. The highest measured U concentration in the salt was 0.06 wt%, and O2 partial pressure was observed to have little to no effect on the solubility. Increasing O2 partial pressure did increase the concentration of corrosion products in the salt. The concentration of Li2O in the molten salt progressively decreased with time in contact with UO2. This can be explained by the formation of Li2UO4 via reaction of UO2 with Li2O.