Increase In Quality Of Life Research Articles

Tatalaksana Radioterapi pada Kekambuhan Lokal Kanker Ovarium Clear Cell

Clear Cell Carcinoma is a rare subtype of ovarian cancer. At early stage ovarian cancer were not exhibit symptoms, most of case were found at advanced stage. Treatments for advanced stage ovarian cancer are cytoreduction surgery and carboplatin and paclitaxel adjuvant chemotherapy. Cancer stem cells resilient and chemoresistants phenotype of clear cell carcinoma were responsible for local relapse. Radiotherapy with palliative intents can alleviate symptoms and increase quality of life, radiotherapy can also be given curatively for local relapse. Brachytherapy as dose escalation is recommended for limited and locally tumor residue.

Effect of Adapted Game-Aided Physical Education Program on the Motor Skills of Children with Autism Spectrum Disorders: Longitudinal Case Study

The aim of this study is to reveal the effect of long term adapted game aided physical education intervention programconducted on an individual with ASD and to conserve the achieved skills. The participant was fourteen years oldduring study and was fifteen years old when research was completed. The study took 15 months in total including 12months of implementation process and 3 months of interval before retention test conducted on the participant. TheShort Form of 2nd version of Bruininks-Oseretsky Motor Proficiency Test (BOT-2 SF) was used as a measuring set.Obtained data were evaluated graphically. According to the obtained data, we determined a development but BOT-2SF started in different periods in 8 sub-dimensions under the title of fine and gross motor skills. When permanencytest was obtained after an interval of 3 months for examined intervention program, it was clear that all skills exceptpower sub-dimension were conserved. There was a decrease in a certain amount only in power sub-dimension. In thelight of all these consequences, we can say that even though it is late, adapted intervention programs conducted onthe individuals with ASD affect motor skill levels positively and it can be said that this development will be effectivein increasing life quality of the individuals with ASD.

Retinal Prostheses and Artificial Vision

In outer retinal degenerative diseases such as retinitis pigmentosa, choroideremia, and geographic atrophy, 30% of the ganglion cell layer in the macula remains intact. With subretinal and epiretinal prostheses, these inner retinal cells are stimulated with controlled electrical current by either a microphotodiode placed in the subretinal area or a microelectrode array tacked to the epiretinal region. As the patient learns to interpret the resulting phosphene patterns created in the brain through special rehabilitation exercises, their orientation, mobility, and quality of life increase. Implants that stimulate the lateral geniculate nucleus or visual cortex are currently being studied for diseases in which the ganglion cells and optic nerve are completely destroyed.

THE IMPLEMENTATION OF GERMAS (HEALTHY LIFE MOVEMENT) IN SENIOR CITIZENS WITH DEGENARATIVE DISEASES

Healthy Life Movement or Germas is a government program to increase life quality. It is a systematic planned action simultaneously done by all components of this state with their own awareness and willingness as well as ability to live healthily to increase life quality. The objective of this study is to explore the implementation of healthy life movement in senior citizens with degenerative diseases descriptively. The population of this study is 191 people and the samples are taken using purposive sampling. There are 108 samples in this study; those are the senior citizens who participated in the implementation of healthy life movement and those with degenerative diseases. The result of this study shows that implementation of implementation of healthy life. The movement in Luwoo Village of Telaga Jaya Sub-district in Gorontalo Regency is through encouraging the senior citizens are urged to do exercises. It shows that 81.5% of the senior citizens conduct physical activities, and 97.2% of them consumed fruit and vegetables, and 96.3% conduct routine medical check up. In addition, large proportion of these senior citizens also suffers from hypertension (54,6%). The conclusion of this observational study is that Implementation of healthy life movement in Luwoo Village of Telaga Jaya sub-district has been properly implemented. Article visualizations:

Abstract 5307: Androgen Receptor promotes localization of E-cadherin to cell-cell junctions through Abi1 signaling

Abstract According to American Cancer Society, prostate cancer is a slow progressing disease that affects nearly 50 percent of males over the age of 60. Every year, 165,000 new cases are diagnosed and 30,000 deaths are reported. Current therapies such as Androgen Depravation Therapy (ADT) and Anti-Androgen treatments such as Enzalutamide increase quality of life and extend survival but do not provide a definitive treatment and are ineffective in highly metastatic prostate cancer. Castrate Resistant Prostate Cancer (CRPC) is an untreatable highly metastatic form of prostate cancer and once diagnosed the survival rate is 1-2 years. Hence, the understanding of molecular mechanisms of CRPC is of critical importance. We previously linked prostate cancer to Abi1 gene. Abl interactor 1 (Abi1) is a scaffolding protein and an integral member of the WAVE Regulatory Complex (WRC). WRC is actin nucleation promoting factor that acts upstream of Arp2/3 to enhance the speed of actin polymerization and is critical for various cellular functions including cell-cell junction formation. Our previous research using a prostate cancer mouse models shows that loss of Abi1 expression leads to down-regulation of cellular adhesion proteins such as E-cadherin. Studies using our CRISPR KO RWPE cell line indicate that loss of Abi1 disrupts cell-cell junction formation via decreased levels of E-cadherin. Analysis of patient data demonstrated loss of Abi1 in a subset of CRPC patients. Castrate resistant tumor growth is androgen independent therefore anti-androgen therapy is ineffective. In search of a link between the androgen signaling and the role of Abi1 in prostate cancer we found that Abi1 gene contains androgen receptor (AR) binding sites. Consistent with the idea that Abi1 is an AR responsive gene, expression levels of Abi1 are increased following AR stimulation with the synthetic androgen, R1881, of the hormone sensitive cell line LNCaP. We also observed increased levels of E-cadherin at the cell-cell junctions. In contrast, cells lacking Abi1 do not form proper cell junctions neither respond to AR stimulation in the same way as wild type cells. We propose that Abi1 is a critical part of androgen signaling by promoting cell-cell junctions and tissue integrity. Supported by NCI R01 CA161018 (LK). Citation Format: Baylee Porter, Disharee Nath, Susan A. Krum, Gennady Bratslavsky, Vladimir A. Kuznetsov, Leszek Kotula. Androgen Receptor promotes localization of E-cadherin to cell-cell junctions through Abi1 signaling [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 5307.

Management of anticoagulation in patients with metastatic castration–resistant prostate cancer receiving abiraterone + prednisone

Abiraterone has been proven to be an effective agent used in the management of metastatic castration-resistant prostate cancer, significantly improving overall and progression-free survival. Due to the pharmacodynamic and pharmacokinetic properties of abiraterone, concurrent use with anticoagulation may pose a challenge for clinicians. Thrombosis within the cancer setting continues to increase patient mortality; therefore, appropriate anticoagulation through the use of a management algorithm can reduce adverse events and increase quality of life. A review of the literature was preformed by a medical oncologist, haematologist and pharmacists to identify relevant randomized controlled trials, meta-analyses and retrospective studies. Major society guidelines were reviewed to further aid in developing the anticoagulation protocol for non-valvular atrial fibrillation and venous thromboembolism within this patient population. After reviewing the literature, a clinical framework was designed to aid clinicians in the management of those patients receiving abiraterone concurrently with an anticoagulant. In this review, we describe the potential interactions between abiraterone and various anticoagulants and provide management strategies based on the most recent literature for atrial fibrillation, venous thromboembolism and mechanical heart valves to avoid potential drug-drug interactions. Abiraterone therapy has become a mainstay of the management of advanced prostate cancer and is often used over prolonged years. In this review, we have summarized a framework of how to use abiraterone in men with prostate cancer on anticoagulants. Evidence available to date suggests that patients with an indication for anticoagulation such as atrial fibrillation, venous thromboembolism and mechanical heart valves can be treated safely with abiraterone in the appropriate setting, with appropriate monitoring.

Psychosocial and Demographic Characteristics of Children and Adolescents With Headache Presenting for Treatment in a Headache Infusion Center.

Approximately 10% of pediatric patients have recurrent headaches, with migraine being the most common headache type. If untreated, migraine may progress to status migrainosus, a debilitating condition of prolonged duration, high pain severity, and significant disability. There is high variability in the treatment of status migrainosus including medications used and treatment setting, which may occur in the emergency room, as an inpatient admission, or, less often, in an outpatient infusion center. The paucity of research on the treatment of status migrainosus is a limitation to treatment effectiveness. The objective of the study was twofold. First, we sought to examine the demographic characteristics of children and adolescents accessing our outpatient infusion center for prolonged headache. Second, we sought to determine whether any demographic or psychosocial differences exist between patients who access infusion therapy compared to patients who do not access infusion therapy for their headaches. We conducted a retrospective chart review of all patients between the ages of 6 and 19years who were treated in our outpatient headache infusion center. A subset of these patients completed a behavioral health evaluation (treatment group) and they were compared to a control group of similar age (birthdate within 6months) and gender to patients not seeking infusion treatment. Variables of interest included patient demographics, headache type and characteristics, and scores on the Pediatric Quality of Life Inventory (PedsQL), Functional Disability Inventory (FDI), Pediatric Pain Coping Inventory (PPCI), and the Behavior Assessment System for Children - Second Edition (BASC-2). A total of 284 patients were included in the study (n=227 receiving infusion treatment and n=57 controls). Patients were primarily female (224/286; 78.9%), Caucasian (254/286; 90.1%), and had a mean age of 15years. Findings suggest a promising difference in the PPCI Distraction subscale, χ2 (1)=3.7, P=.054, with a mean rank score of 61.90 for the treatment group and 50.21 for the control group. Additionally, a statistically significant difference was noted on the Social Support subscale, χ2 (1)=10.6, P=.001, with a mean rank score of 65.92 for the treatment group and 46.26 for the control group. Results also indicated a statistically significant difference in disability scores, χ2 (1)=10.0, P=.002, with a mean rank FDI score of 66.83 for the treatment group and 47.34 for the control group. Patients in the infusion group also reported lower quality of life on the PedsQL Total score (F[1, 109]=5.0, P=.028; partial η2 =0.044), and on the Physical (F[1, 109]=7.9, P=.006; partial η2 =0.069) and School (F[1, 109]=4.6, P=.035; partial η2 =0.041) subscales. No significant differences were found on the BASC-2. Parent reported data also revealed a significantly higher level of disability among patients seeking infusion treatment compared to the non-infusion group χ2 (1)=11.7, P=.001. However, there were no significant differences on the PedsQL, PPCI, or BASC-2. Our findings support the disabling nature of migraine among children and adolescents, with higher levels of disability and lower quality of life reported in the group of patients utilizing infusion treatment. Developing concrete treatment plans and goals combined with bio-behavioral therapy are necessary to reduce functional disability and increase quality of life among these patients. Awareness of this patient group's pain-related coping strategies may help healthcare providers tailor treatment recommendations and develop or refine cognitive-behavioral headache treatment techniques.

Transarterial Chemoembolization (TACE) with Lipiodol� in HCC PatientsTechnical, clinical and imagistic aspects

Hepatocellurar carcinoma (HCC) is the most frequent primary hepatic tumor, the vast majority of patients have less than a 12 month survival rate. The aim of this study was to evaluate the efficacy of TACE in patients with HCC, based on a case series and literature review. The study included 12 consecutive patients with HCC who underwent surgical treatment (resection, liver transplantation � resection) at the Department of Transplantation and Surgery, Semmelweis University, Budapest, during 2009-2015. All the patients received at least one TACE session. Patients with BCLC B-stage who benefit from TACE and another alternative therapy (eg, RFA) may be associated with or exhibit tumor stagnation, or tumor necrosis in most cases. In C BCLC stages, desperate cases - the two patients to whom TACE was the last therapeutic attitude, despite the predicted prognosis, TACE assured the prolongation of life and increased life quality. In the majority of patients in this study, stage A BCLC, chemoembolization was a therapeutic attitude that allowed subsequent liver transplantation (when it was not feasible initially due to tumor size) or liver resection in apparently inoperable cases. The arterial chemotherapy is the unanimously accepted indication in patients with stage B, BCLC. The data presented encourages us to opt for TACE with the intention of destaging BCLC and giving an operability character to the hepatic tumors (resection � hepatic transplantation). In stage C BCLC, TACE can be a last attempt to improve the quality of life and to control tumor progression.

Life Quality and Compliance After Transplant: The Case of Turkey

ObjectiveChronic renal failure is one of the most significant health problems in Turkey, as it is all over the world, and negatively affects quality of life. The aim of this study is to find factors affecting compliance levels and quality of life of patients undergoing kidney transplant. Materials and methodsThe population of the study consisted of 244 patients who underwent kidney transplant. Although the study aimed to cover the entire target population in the sampling selection, it was conducted among 206 patients. The data were collected by face-to-face interview. ResultsOf the patients, 92.7% were between 46 and 59 years of age, 54.4% had a living donor transplant, 54.9% had adverse effects, and 2.9% had rejection due to incompatibility. There was a significant relationship between compliance and quality of life; increasing frequency of adverse effects would decrease in direct proportion to compliance, which would, therefore, increase quality of life. All the subscale scores of the 36-Item Short Form Health Survey were found to have an average of 60 and above. The mean of the compliance scale was 48.33 (SD, 3.21), and, with the maximum score at 55, the mean of the group was high. In our country, patients view transplant as a final and definite treatment method. This might be related to fact that the longer the time after transplant, the lower the level of compliance.

Effectiveness of Road Chicanes in Access Zones to a Village at 70 km/h Speed Limit

The development of motoring has increased life quality and pace. As a result, not only cities but also smaller towns and villages with roads face transportation challenges. The fundamental problem in smaller towns and villages is to ensure road safety at pedestrian crossings on through roads. The guidelines of road building recommend to introduce traffic calming devices at places where traffic enters a built-up area, to reduce speeds at the entry of a city or village. Chicanes curve the trajectory of traffic and consequently cause speed reduction. The authors conducted a series of speed measurements in free and continuous traffic flow conditions on major local roads with different types of road chicanes. For each case, additional data regarding road characteristics in the vicinity of a chicane were gathered, including the contour of the town visible while approaching the chicane, the distance from the chicane to the nearest buildings in the village, how visible the road continuity behind the chicane was, developments of the greenery and the type of traffic arrangement used. The paper analyses road sections with 70 km/h speed limit before the chicane, as on B-33 road sign. For comparison purposes, speed measurements were also conducted at the entry to the village, where although no chicanes were built, there was B-33 road sign with the speed limit of 70 km/h. The comparative tests aimed at determining whether drivers reduce speed when they see the road sign, because of the chicane or following another determinant. Comparative analysis showed that given B-33 sign (which introduces 70 km/h speed limit) at the entry zone to the town, drivers’ speeds significantly exceed 70 km/h in free traffic flow. Even in continuous traffic flow, speeds usually oscillate around 70 km/h. The speeds are significantly lower behind the chicane. The maximum reduction of speed at the entry to the village was achieved for other determinants recorded in the study, including a clearly visible silhouette of the village, closely located houses, a horizontal curve behind the chicane with limited visibility of the further section of the road. >90% of motorists behind the chicane drive with speeds <70 km/h. At the entry zone which was an open space, with a well visible silhouette of the village, with the chicane approximately 200 m away from the nearest houses or at the entry zone covered with forest and poor visibility of the built-up area, 70-77% of motorists behind the chicane drive with speeds <70 km/h. If the access to the town is preceded by a long stretch of straight road section, with poor visibility of the silhouette of the village, only approximately 50% of drivers enter the village with speeds <70 km/h. Depending on the determinants recorded in the study, motorists in most cases exceed 70 km/h and enter the village with much greater speeds if there is no chicane.

145. Urgent Need For Physical Activity Policies And Promotion Among Adolescents In Saudi Arabia: Lessons From “Jeeluna”

Physical activity is recognized as an important tool to increase life quality and decrease disease burden. Data on physical activity trends, barriers and facilitators among adolescents in Saudi Arabia is scarce. While most of the research on physical activity has been conducted on age groups such as 14-19 and 15-19 years, there is lack of research on the adolescent group (10-19 years). “Jeeluna” (Arabic for “Our Generation”) is a national school-based study aiming to identify health risk behaviors and health status of adolescents in Saudi Arabia. Here we share findings from Jeeluna that will help identify socio-demographic characteristics of adolescents who participate in physical activity, as well as their associated health and lifestyle behaviors, which will support program development addressing adolescents' local needs. A cross sectional, national study was conducted in intermediate and secondary schools in all 13 regions of Saudi Arabia. Sampling was done through multistage, cluster, random sampling technique. Boys and girls from public and private schools (N=12,463) aged 10-19 years were invited to complete the survey instrument which included demographics, health risk behaviors and health status, anthropometric measurements and blood sampling for laboratory investigations. Physical activity was assessed by asking participants how many days in the past week they had engaged in exercise for at least 30 minutes each day. Adolescents who performed exercise 1-7 days were considered as ‘engage in exercise’. Sedentary lifestyle included how much time they spent on TV, internet, video games, and cell phone each day. Those who spent more than 2 hours a day was considered as ‘sedentary lifestyle’. Mean age of the participants was 15.8±0.8 years, and 51.3% were male. Most of the participants (97.9%) lived in urban area. Little over half (53.4%) reported engaging in exercise regularly and over one-third (35.4%) engaged in physical activity at school. Out of the 13 regions, Jizan had the highest mean number of days per week spent doing >30 minutes of exercise, in total as well as in males, but had the lowest mean among females. Additionally, Jizan also had the highest proportion of total and male students engaging in physical activity in school, but the lowest proportion of females for the same measurement. Significant difference in age, gender, areas of residence, and grade were found in terms of engagement in exercise, being higher among younger adolescents (10-14 years), male, urban area, and intermediate school (p<0.01). Mental health was found to be better (low frequency of feelings of sadness, frustration and anxiety) among adolescents who engaged in exercise regularly (<0.01). Adolescents who engaged in exercise were more likely to eat healthy food (<0.01) and less likely to live a sedentary lifestyle (<0.01). It is imperative that socio-cultural and demographic factors be taken into consideration during program and policy development. This study highlights the urgent need for promotion of physical activity among adolescents in Saudi Arabia and addressing perceived barriers, while also offering a treasure of information to policy and decision makers involved in the progression of adolescent health.

OPRM1 Gene Interaction with Sleep in Chronic Pain Patients Treated with Opioids

Background: The experience of chronic non-cancer pain (CNCP) is one of the most common reasons individuals seek medical attention. Patients with CNCP frequently experience concomitant sleep-related problems. Objectives: The aim was to evaluate sleep problems in opioid naïve CNCP patients, before and after opioid titration, analyzing the influence of OPRM1 gene variants. Study Design: A prospective, cohort, observational study. Setting: This study was performed at the Pain Unit of the Alicante University General Hospital. Methods: Pain and Medical Outcomes Study Sleep questionnaire (MOS-Sleep) were assessed at baseline and 3 months after opioid titration in 231 opioid naïve CNCP patients. Sleep data was compared with a matched-control group (n = 64). Morphine equivalent daily doses, adverse events, and drugs prescribed for pain were also registered. OPRM1 polymorphism rs1799971 was analyzed by RT-PCR. Ethics Committee approved the study and results were analyzed by R software. Results: After 3 months of opioid titration, patients with CNCP (63 ± 14 years, 64% female, VAS 74 ± 17 mm) significantly decreased pain intensity, anxiety and depression, and increased quality of life. Sleep problems were significantly more frequent in females (P = 0.002). Age, quality of life, anxiety, and depression all influenced sleep disturbances and problems indices, which were significantly different from the control group. Furthermore, the OPRM1 118- GG genotype was also associated with significantly lower sleep adequacy, and more sleep problems. Limitations: Total number of subjects studied was relatively small and most patients were on other non-opioid centrally-acting medications. Conclusions: Opioids decreased CNCP severity, improving patients’ psychological areas, and quality of life. However, patients with OPRM1 118-GG genotype indicated an increase in sleep problems and worsening sleep pattern while taking opioids. Key words: OPRM1, pharmacogenetics, MOS-Sleep, opioids, chronic noncancer pain, sleep related problems, sleep problem index SLP-6 and SLP-9

Hypertension in adult polycystic kidney disease: a narrative review

Autosomal dominant polycystic kidney disease (ADPKD) is an inherited renal disorder that impacts approximately 12 million worldwide. It is characterized by bilateral kidney enlargement and cystic growth. Hypertension (HTN) is a focal point in the management of ADPKD and is linked to a faster progression to end stage renal disease. Current novel therapies have proven to reduce the progression of renal damage. The ideal goal is to minimize risk through preventative studies and pharmacology to further increase life expectancy and quality. The purpose of this article is to highlight the importance of blood pressure management in ADPKD and review current literature to determine the most effective preventative pharmacotherapy.

The Effect of a Yoga Program on "Health-Related Quality of Life" of Children in Residential Care Centers

Abstract Introduction: Children living in residential care centers are a vulnerable population and have a lower Health-Related Quality of Life (HRQOL). This study explored a yoga exercise program on HRQOL in children living in residential care centers. Methods: In this quasi-experimental, one group before-after study with time series design, all children aged 8 to 13 years, who qualified for inclusion criteria and were living in governmental residential care centers of Isfarayen were selected, using census method. The participants took part in yoga classes for 8 weeks. The HRQOL was assessed using Kids Screen Health-related Quality of Life Questionnaire (KS-HRQOLQ). The gleaned data were analyzed with SPSS21 using repeated measurements analysis. Results: Changes in total score of HRQOL obtained in five measurements were not statistically significant (P = 0.270). Variations in score of HRQOL in dimensions of mental well-being, the relations with parents and self-autonomy, social support and peers, and school environment were not significant before to one month after completion of interventions (P = 0.29, P = 0.67, P = 0.16, P = 0.50, respectively). For physical well-being dimension, changes were significant frombefore to immediately after completion of interventions (P = 0.013). Changes were not significant in presence of personal and demographic variables (P = 0.45, P > 0.05). Conclusions: This study indicated that yoga increases life quality only in physical well-being dimension. Given that life quality reflects wishes, expectations, and hopes of children and teenagers in relation to their present and future life and this feeling is time-related, culture-dependent, and context-oriented, it appears that life conditions of children in current study and chronic continuous tension present in residential care centers probably made effects of yoga different.

External conditions of bankruptcy institute functioning in the economy of Ukraine

Introduction. In modern conditions of Ukrainian economy development, it is interesting to justify certain measures to support enterprises in the conditions of national economy dependence on fluctuations in the world market and the inflation growth, in order to ensure the stability of business entity functioning in all spheres of the economy. Under such circumstances, effective bankruptcy institute functioning becomes of particular importance, since the possibility of industrial production growth, employment level increase and people life quality improvement depends on the financial recovery of enterprises of real sector economy.&#x0D; Aim and tasks. The aim of the article is to study external conditions of bankruptcy Institute functioning in the economy of Ukraine and their modern transformation. The obtained results determine what exactly should be done in the direction of further improvement of the regulatory instruments of state policy in this area. To achieve the goal, it has been used a complex of scientific research complementary methods of economic processes and phenomena, with an application of statistical and analytical materials, as well as the results of authors scientific research.&#x0D; Results. As a result of a study of external conditions of bankruptcy Institute functioning in the economy of Ukraine, it is determined that existing macroeconomic environment has a significant impact on its character of functioning, defining the goals and objectives of further transformation processes regulation. It is determined that the external factors of the macroeconomic environment are the most threatening because there is almost no opportunity to influence them at the enterprise level. In the research, the peculiarities of the external conditions of bankruptcy Institute functioning in the economy of Ukraine are identified based on the use of indicators that directly or indirectly help determine the effectiveness of bankruptcy institute, the laws of its development, and interaction of social, political, economic and other processes at the macro level.&#x0D; Conclusions. On the basis of the obtained results, it can be determined that most indicators testify difficult external conditions of bankruptcy institute functioning, with a certain improvement of the situation in recent years. Thereby, there is a need for further bankruptcy institute transformation, in order to maintain the balance between the interests of the state, economic entities, competitive market environment, and entrepreneurial activity risk minimization.

YAŞANABİLİR KENT: AYVALIK’ TA BİR ÖĞRENCİ PROJESI TASARIMI

Gunumuzde tarihi kentler kentsel yasam kalitesini azaltan degisimlerle basa cikmakta zorlanmaktadir. Sokaklar tasitlar ile asiri yuklenmekte ve islevinden uzaklasarak yayalar icin korkutucu olacak sekilde arac park alanlarina donusmektedir. Genellikle, kentsel acik alanlar bir sehri yasanabilir hale getiren en onemli olcutler olan surdurulebilirlik, ulasilabilirlik ve yaya dostu olma ozelliklerinden uzaklasmaktadir. Buna karsilik kentin yasanabilirlik olcutleri, deneyimlenebilen ve guclendirilebilen toplu iyi olma hali icin onemli bir etmen olmaktadir. Modern bir kent yasayanlarin yasam kalitesini artirabilir ozelliklere sahip olmalidir. Bu makale yasanabilir bir kentin teorik olarak yasam kalitesini artiran olcutleri onermektedir. Iki kentsel kalite olan surdurulebilirlik ve ulasilabilirlik kavramlari, yaya yollari, acik alanlar, hizmet alanlari ve yesil alanlar ag katmanlari uzerinden yaya dostu olma temasi ile ortaya konmustur. Olcutler ortaya konduktan sonra Ayvalik kenti vakasi uzerinden degerlendirilmistir. Kentin tarihsel ve kentsel analizi yapildiktan sonra, yasanabilirlik katmanlari uzerine oneriler sunulmustur. Kararlar ve donusum ilkeleri kent merkezinde secilen bir alan uzerinde detayli sekilde aciklanmistir. Bu ilkeler Istanbul Teknik Universitesi’ de yuksek lisans bolumu ogrenci deneysel projesi olarak bir kultur merkezi mimari projesi uzerinden uygulanmistir.

Aging male’s strength reduction: population based study

We conducted a population-based cross-sectional study to identify the prevalence of aging male’s strength reduction (AMSR) and factors associated to this condition. The study included 421 men aged 40 years or older, living in the urban area of Pelotas, Southern Brazil. The questionnaire covered sociodemographic, behavioral and health variables and, to assess the aging male’s strength reduction, one question of the Aging Male’s Symptoms Scale was used. The prevalence of AMSR was 19.0% (CI95% 15.2 - 22.8). After controlling for confounders, the AMSR was significantly associated with aging, smoking, physical activity score and self-perceived health status. Our findings reinforce the need to keep healthy behaviors such as not smoking and regular physical activity as a healthier lifestyle could reduce the AMSR acceleration and increase life quality and expectancy.

Integrating fMRI data into 3D conventional radiotherapy treatmentplanning of brain tumors

Introduction: This study was aimed to investigate the beneficial effects of functional magnetic resonance imaging (fMRI) data in treatment planning for patients with CNS tumors in order to decrease the injury of functional regions of the brain followed by increase in life quality and survival of patients. This study pursues a novel approach in planning for the treatment of brain tumors in which using fMR imaging as a repeatable procedure, safe, and shorter scanning time functional regions of the brain are imaged and considered as organs at risk in radiation treatment planning. The present survey has been proposed for the first time in Iran and we hope that the obtained results will lead to increased quality of life. Materials and Methods: In this study, 11 patients with brain tumor were enrolled. Prior to processing and analyzing of radiation treatment planning, computed tomography (CT), conventional MR, and fMR images were acquired from the patients. fMRI data were obtained using 1.5 T Siemens scanner. Initially, structural scans were acquired an axial T1- weighted MP-RAGE sequence for the localization of activation. fMRI scans were acquired using an echo planar imaging (EPI) sequence in the same position as the structural images. Employed tasks for each patient were determined considering the tumor location and extension in conventional MR images together with our knowledge in neuroanatomy. Owing to the higher risk of radiation damage in regions near to tumor, tumor-vicinity tasks were selected. fMRI data were processed via SPM software and functional active volumes were recognized. fMRI data and conventional MR images of T1W acquired in a same position were fused with one another and sent to the planning system. In order to investigate the potential benefits of integrating fMRI information in planning system, 3D conventional plans with and without fMRI data were compared using DVH analysis. All the active volumes were contoured as functional organs at risk (FOARs) in radiation treatment planning. Results: Comparing the two plans it is expected to observe a significant dose decrease in functional regions while maintaining a similar coverage to the planning target volume and keeping structural organs at risk within accepted dose tolerance. Conclusion: Precise combination of fMRI data in radiation treatment planning is expected not only to reduce radiation injury, but also to increase the cure rate for tumors by allowing delivery of a sufficient dose without fear of adverse reactions. Therefore, not only we have missed anything, but rather have prevented the critical regions from radiation damage which can lead to increased quality of life and life expectancy of patients.

PMU99 - PERCEPTIONS OF THE GREEK POPULATION CONCERNING MEDICINES – A DESCRIPTIVE ANALYSIS

To assess the opinions of the Greek population concerning medicines in general and innovative ones, with regard to their safety and effectiveness, their contribution to health improvements and their role as a commodity. Primary data were extracted from the “Health and Welfare” health interview survey conducted by the Hellenic National School of Public Health and refer to year 2015. The study sample was representative of the Greek population and consisted of 2,003 adults. Participants were asked to state their level of agreement on statements over medicines in general and innovative ones in particular, on a scale of 1-10 (1=completely negative/disagree and 10=completely positive/agree). Mean agreement scores were estimated for each variable. Concerning medicines in general, mean score of agreement on their usefulness and importance was 8.31 (SD=2.106) and on their safety and effectiveness was 7.15 (SD=2.174). Regarding innovative medicines, mean score of agreement on their increased safety and effectiveness compared to older ones was 6.89 (SD=2.357). Mean agreement scores on whether innovative medicines are primarily developed to (a) improve the population health was 7.24 (SD=2.485), (b) address new life-threatening diseases was 7.67 (SD=2.295), (c) address chronic diseases was 7.78 (SD=2.129), (d) increase life expectancy was 7.33 (SD=2.477) and (e) increase quality of life was 7.55 (SD=2.336). Mean agreement score on whether medicines are mainly developed to create profits for the pharmaceutical industry was 8.92 (SD=1.770). Based on the results, perceptions concerning medicines are quite positive among the Greek population, since it is largely believed that they are useful, safe and effective, while their objective towards improving health indicators is recognized. However, the belief that innovative medicines are profit-oriented gathers the highest score among all the suggested objectives. Further investigation would be useful to understand the reasoning behind the population’s perceptions concerning medicines and the factors associated to it.

Hubungan Spiritualitas dengan Kesepian pada Lansia di UPT Pelayanan Sosial Tresna Werdha (PSTW)

Elderly is a condition where someone experience a lot of changes, for instance psychological change.Loneliness is a elderly psychological disorder elderly that can be overcome with spirituality. This studyaimed to analyze the correlation between spirituality and loneliness in elderly in the Pelayanan SosialTresna Werdha (PSTW) Jember. This research applied an observasional analytic design with crosssectional approach. 91 respondents are gained by employing simple random sampling using SpiritualWell-Being Scale (SWBS)(r=0,895) and UCLA Loneliness Scale (r=0,94). Data were analyzed byusing Spearmen correlation test with significance level of 0.05. The result of the spirituality variablereserach shows 71,00 median and ± 45-86, meanwhile on loneliness variable 38,00 median and ± 20-69. There was a significant negative correlation between spirituality ang loneliness (p value: 0.000 ; r:-0,718). Spirituality become one of coping strategy to overcome elderly’s loneliness. Spiritualitybecome power to elderly in facing problem and increasing life quality so can decrease their loneliness.The study shows that the importance of increasing the spirituality to decrease loneliness level onelderly who live at Panti Werdha.Keywords: elderly, spirituality, loneliness