Increase In Latency Research Articles

Effect and mechanism of Donepezil hydrochloride on Alzheimer’s disease

Objective: To explore the effect and mechanism of donepezil hydrochloride on Alzheimer’s disease (AD).Methods: Thirty-six 3-month-old SD rats were selected as the research subjects and randomly divided into a normal control (NC) group and a model group. The model group was given continuous intraperitoneal injection of D-galactose solution (120 mg/kg/d) combined with aluminum trichloride (10 mg/kg/d) by gavage for 60 days. Morris water maze test was conducted to test the learning and memory abilities of the rats, and AD rats were selected. After modeling, AD rats were divided into a normal saline (NS) group and a drug treatment (DT) group. The DT group was given donepezil hydrochloride (1.0 mg/kg) by gavage intervention, and the NC group and the NS group were given equal volumes of physiological saline by gavage. After 4 weeks of intervention, Morris water maze test was conducted to detect the escape latency, the number of platform crossings and residence time in the target quadrant, the rats were euthanized, with serum and hippocampal tissues collected, and hippocampal tissue homogenate (10%) was prepared by using NS. Enzyme linked immunosorbent assay (ELISA) was used to detect the inflammatory and oxidative stress indicators in rat hippocampal tissues and serum, and hematoxylin eosin (HE) staining was used to observe pathological damage in rat hippocampal tissues.Results: Compared with the NC group, the NS group showed a significant increase in escape latency (p < .05), a significant decrease in the number of platform crossings and residence time in the target quadrant (p < .05), and a significant decrease in the activities of superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) in serum and hippocampal tissues (p < .05). The content of malondialdehyde (MDA) was significantly increased (p < .05), and the levels of interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) were significantly increased (p < .05). Compared with the NS group, the DT group can significantly reduce the escape latency (p < .05), increase the number of platform crossings and residence time in the target quadrant (p < .05), significantly increase the activities of SOD and GSH-Px in serum and hippocampal tissues and reduce the content of MDA (p < .05) and the levels of IL-6 and TNF-α (p < .05). After intervention with donepezil hydrochloride, the number of neurons in the hippocampus were significantly increased.Conclusions: Donepezil hydrochloride can improve the learning and memory abilities of rats, reduce the levels of oxidative stress and inflammation in the brain and serum, and improve pathological damage in the hippocampus.

Wakefulness Induced by TAAR1 Partial Agonism in Mice Is Mediated Through Dopaminergic Neurotransmission.

Trace amine-associated receptor 1 (TAAR1) is a negative regulator of dopamine (DA) release. The partial TAAR1 agonist RO5263397 promotes wakefulness and suppresses NREM and REM sleep in rodents and non-human primates. We tested the hypothesis that the TAAR1-mediated effects on sleep/wake regulation were due, in part, to DA release. Male C57BL6/J mice (n = 8) were intraperitoneally administered the D1R antagonist SCH23390, the D2R antagonist eticlopride, a combination of D1R + D2R antagonists, or saline at ZT5.5, followed 30 min later by RO5263397 or vehicle per os. EEG, EMG, subcutaneous temperature, and activity were recorded across the 8 treatments and sleep architecture was analyzed for 6 h post-dosing. As described previously, RO5263397 increased wakefulness and delayed NREM and REM sleep onset. D1, D2, and D1 + D2 pretreatment reduced RO5263397-induced wakefulness for 1-2 h after dosing but only the D1 antagonist significantly reduced the TAAR1-mediated increase in NREM latency. Neither the D1 nor the D2 antagonist affected the TAAR1-mediated suppression of REM sleep. These results suggest that, whereas the TAAR1 effects on wakefulness are mediated, in part, through the D2R, D1R activation plays a role in reversing the TAAR1-mediated increase in NREM sleep latency. In contrast, the TAAR1-mediated suppression of REM sleep appears not to involve D1R or D2R mechanisms.

Unveiling the Multi-Targeted Mode of Action: Investigating the Antiepileptic Activity of Murraya koengii Extract in PTZ-induced Seizures.

Recurrent seizures are the hallmark of the neurological condition known as epilepsy. Murraya koenigii (curry leaves) has been traditionally used in medicine for various ailments. This study aimed at the anticonvulsant activity of HAEMK using a petylenetetrazole (PTZ) induced seizure model. Behavioral and biochemical parameters were assessed to determine the effectiveness of the extract in mitigating seizures. Albino mice were orally administered with different doses of the extract prior to PTZ administration. The behavioral parameters, including seizure latency, duration and severity, were monitored and recorded. Additionally, acetylcholine esterase, GSH, and malondialdehyde (MDA), three indicators of oxidative stress, were assessed in brain tissue homogenates. HAEMK-treated groups demonstrated a substantial increase in seizure latency and a decrease in seizure length and intensity compared to the control group. A dose-dependent MDA and acetylcholine esterase decreased concurrent GSH rise were seen in the HA-treated groups. These findings suggest that the hydroalcoholic extract of M. koenigii possesses antiepileptic activity, possibly mediated through its antioxidative mechanisms.

Pulsed electromagnetic fields attenuate human musculocutaneous nerve damage induced by biceps eccentric contractions.

Pulsed electromagnetic field (PEMF) therapy, a noninvasive treatment, has shown promise in mitigating nerve damage. However, unaccustomed exercises, such as eccentric contractions (ECCs), can damage both muscle and nerve tissue. This study investigated whether magnetic stimulation (MS) with PEMF could aid in nerve recovery after ECCs in the elbow flexors. Twenty participants were randomly assigned to either a control (CNT) or an MS group. Following ECCs, we measured the latency of the M-wave in the musculocutaneous nerve as an indicator of nerve function. Additionally, isometric torque, range of motion, and muscle pain were assessed for muscle function. Interestingly, only the CNT group exhibited a significant increase in latency on Day 2 (p < 0.05). The MS group, on the other hand, displayed an earlier recovery trend in isometric torque, range of motion, and muscle soreness. Notably, muscle soreness significantly decreased immediately after MS treatment compared to pretreatment levels. These findings suggest that MS treatment can effectively attenuate nerve damage induced by ECCs exercise.

ERP biomarkers for go/no-go tasks to detect potential cognitive impairment in community-dwelling older adults

With an aging population, detecting cognitive dysfunction at an early stage is important. However, no current neurophysiological assessments examine brain activity status in community-dwelling older adults. Therefore, this study aimed to characterize event-related potential (ERP) during go/no-go tasks in older adults with potential cognitive impairment living in the community. The participants were 34 young adults and 46 older adults. They underwent a go/no-go task to measure ERP. The older adults were divided into two groups for analysis based on the results of the Japanese version of the Montreal Cognitive Assessment (MoCA-J): cognitively normal and cognitively impaired. N2 latency was significantly delayed in the cognitively impaired group compared to the cognitively normal and younger groups. Furthermore, the younger group exhibited a significant increase in P3 amplitude and shorter latency compared to both older adult groups. The results of the correlation analysis between ERP and neuropsychological test scores showed that N2 latency correlated with neuropsychological test scores. The results also suggested that receiver operating characteristic curve analysis can measure cognitive function. These results indicated that N2 latency reflected potential cognitive dysfunction in community-dwelling older adults. Furthermore, P3 amplitude may be useful in detecting age-related inhibitory function decline.

Slow negative potentials in the pre-stimulus period in norm and patients with the first episode of schizophrenia

Behavioral data (correct response latency and errors number increase) indicate a significant decrease in the task performance efficiency in patients with the first episode of schizophrenia, compared to the norm. At the same time the SNP 1, 2, 3 amplitudes were found to enhance in the patients group, compared to the norm, which may reflect a compensatory activation of predictive attention and inhibition cortical networks for increase the response efficiency. Intergroup differences in the topography of the SNP1 and SNP2 peaks amplitude suggest “disorganization” of the left hemisphere cognitive control cortical networks at the early stage of schizophrenia. It is assumed that the SNP 1, 2, 3 components can be considered as potentially significant clinically markers of cognitive control disorders in schizophrenia.

Wakefulness Induced by TAAR1 Partial Agonism is Mediated Through Dopaminergic Neurotransmission.

Trace amine-associated receptor 1 (TAAR1) is known to negatively regulate dopamine (DA) release. The partial TAAR1 agonist RO5263397 promotes wakefulness and suppresses NREM and REM sleep in mice, rats, and non-human primates. We tested the hypothesis that the TAAR1-mediated effects on sleep/wake were due, at least in part, to DA release. Male C57BL6/J mice (n=8) were intraperitoneally administered the D1R antagonist SCH23390, the D2R antagonist eticlopride, a combination of D1R+D2R antagonists or saline at ZT5.5, followed 30 min later by RO5263397 or vehicle (10% DMSO in DI water) at ZT6 per os. EEG, EMG, subcutaneous temperature, and activity were recorded in each mouse across the 8 treatment conditions and sleep architecture was analyzed for 6 hours post-dosing. Consistent with our previous reports, RO5263397 increased wakefulness as well as the latency to NREM and REM sleep. D1, D2, and D1+D2 pretreatment reduced RO5263397-induced wakefulness during the first 1-2 hours after dosing, but only the D1+D2 combination attenuated the wake-promoting effect of RO5263397 from ZT6-8, mostly by increasing NREM sleep. Although D1+D2 antagonism blocked the wake-promoting effect of RO5263397, only the D1 antagonist significantly reduced the TAAR1-mediated increase in NREM latency. Neither the D1 nor the D2 antagonist affected TAAR1-mediated suppression of REM sleep. These results suggest that, whereas TAAR1 effects on wakefulness are mediated in part through the D2R, D1R activation plays a role in reversing the TAAR1-mediated increase in NREM sleep latency. By contrast, TAAR1-mediated suppression of REM sleep appears not to involve D1R or D2R mechanisms.

Fronto-Central Changes in Multiple Frequency Bands in Active Tactile Width Discrimination Task.

The neural basis of tactile processing in humans has been extensively studied; however, the neurophysiological basis of human width discrimination remains relatively unexplored. In particular, the changes that occur in neural networks underlying active tactile width discrimination learning have yet to be described. Here, it is hypothesized that subjects learning to perform the active version of the width discrimination task would present changes in behavioral data and in the neurophysiological activity, specifically in networks of electrodes relevant for tactile and motor processing. The specific hypotheses tested here were that the performance and response latency of subjects would change between the first and the second blocks; the power of the different frequency bands would change between the first and the second blocks; electrode F4 would encode task performance and response latency through changes in the power of the delta, theta, alpha, beta, and low-gamma frequency bands; the relative power in the alpha and beta frequency bands in electrodes C3 and C4 (Interhemispheric Spectral Difference-ISD) would change because of learning between the first and the second blocks. To test this hypothesis, we recorded and analyzed electroencephalographic (EEG) activity while subjects performed a session where they were tested twice (i.e., two different blocks) in an active tactile width discrimination task using their right index finger. Subjects (n = 18) presented high performances (high discrimination accuracy) already in their first block, and therefore no significant improvements were found in the second block. Meanwhile, a reduction in response latency was observed between the two blocks. EEG recordings revealed an increase in power for the low-gamma frequency band (30-45 Hz) for electrodes F3 and C3 from the first to the second block. This change was correlated with neither performance nor latency. Analysis of the neural activity in electrode F4 revealed that the beta frequency band encoded the subjects' performance. Meanwhile, the delta frequency band in the same electrode revealed a complex pattern where blocks appeared clustered in two different patterns: an Upper Pattern (UP), where power and latency were highly correlated (Rho = 0.950), and a sparser and more uncorrelated Lower Pattern (LP). Blocks belonging to the UP or LP patterns did not differ in performance and were not specific to the first or the second block. However, blocks belonging to the LP presented an increase in response latency, increased variability in performance, and an increased ISD in alpha and beta frequency bands for the pair of electrodes C3-C4, suggesting that the LP may reflect a state related to increased cognitive load or task difficulty. These results suggest that changes in performance and latency in an active tactile width discrimination task are encoded in the delta, alpha, beta, and low-gamma frequency bands in a fronto-central network. The main contribution of this study is therefore related to the description of neural dynamics in frontal and central networks involved in the learning process of active tactile width discrimination.

Temperature control during pars plana vitrectomy.

To evaluate the impact of temperature-controlled pars plana vitrectomy (PPV) on structural and functional outcomes in a rabbit eye model in vivo. Ten healthy New Zealand White rabbits underwent temperature-controlled PPV in the right eye (group A), using a device specifically designed to heat the infusion fluid/air and integrated into the vitrectomy machine, and conventional PPV in the left eye (group B). Both eyes received ophthalmic examination and electroretinography (ERG) before and 1week postoperatively. After 1-week ERG, rabbits were enucleated and then sacrificed. Histological and immunohistochemical examinations were performed on enucleated eyes and expression of glial fibrillary acidic protein (GFAP) and vimentin investigated. Postoperatively, only group B showed significantly decreased amplitude and increased latency of a-wave at 3cd·s/m2 (p = 0.001 and 0.005, respectively). Significant increase of b-wave latency at 0.01cd·s/m2 was detected in both groups (p = 0.019 and 0.023, respectively). Postoperatively, amplitude of oscillatory potentials (OPs) increased significantly in group A (p = 0.023) and decreased in group B. In both groups, OPs latency significantly increased at 1-week test (P < 0.05). A greater number of eyes without structural retinal alterations was detected in group A compared to group B (6 vs 5, respectively). GFAP expression was higher in group B than group A, even if the difference was not statistically significant. Temperature-controlled PPV resulted in more favorable functional and structural outcomes in rabbit eyes compared with conventional PPV, supporting the potential beneficial role of the intraoperative management of intraocular temperature in vitreoretinal surgery.

Prolonged latency of the gustatory evoked potentials for sucrose solution in subjects living with obesity compared with normal-weight subjects.

A difference in cortical treatment of taste information could alter food intake promoting the development of obesity. The main purpose was to compare, in subjects living with obesity (OB) and normal-weight subjects (NW), the characteristics of gustatory evoked potentials (GEP) for sucrose solution (10 g.100 mL-1) before and after a standard lunch. The secondary objective was to evaluate the correlations between GEP and the plasmatic levels of acylated ghrelin, leptin, insulin and serotonin. Each subject had 2 randomized sessions spaced by an interval of 2 days. During one session, subjects were fasting and during the other, subjects took a lunch low in sugar. In each session, subjects had a blood test before a first GEP recording followed by a second GEP recording either after a lunch (feeding session) or no lunch (fasting session). Twenty-eight OB (BMI: 38.6 ± 9.0 kg.m-2) were matched to 22 NW (BMI: 22.3 ± 2.2 kg.m-2). GEP latencies were prolonged in OB regardless the sessions and the time before and after lunch, compared with NW (in Cz at the morning: 170 ± 33 ms vs 138 ± 25 ms respectively; p < 0.001). The increase in latency observed in NW after lunch was not observed in OB. Negative or positive correlations were noted in all participants between GEP latencies and ghrelin, leptin, insulin plasmatic levels (P1Cz, r = -0.38, r = 0.33, r = 0.37 respectively, p < 0.0001). This study highlights a slower activation in the taste cortex in OB compared with NW.

Influence of network latency and bandwidth on robot-assisted laparoscopic telesurgery: A pre-clinical experiment.

Telesurgery has the potential to overcome spatial limitations for surgeons, which depends on surgical robot and the quality of network communication. However, the influence of network latency and bandwidth on telesurgery is not well understood. A telesurgery system capable of dynamically adjusting image compression ratios in response to bandwidth changes was established between Beijing and Sanya (Hainan province), covering a distance of 3000km. In total, 108 animal operations, including 12 surgical procedures, were performed. Total latency ranging from 170ms to 320ms and bandwidth from 15-20Mbps to less than 1 Mbps were explored using designed surgical tasks and hemostasis models for renal vein and internal iliac artery rupture bleeding. Network latency, jitter, frame loss, and bit rate code were systemically measured during these operations. National Aeronautics and Space Administration Task Load Index (NASA-TLX) and a self-designed scale measured the workload and subjective perception of surgeons. All 108 animal telesurgeries, conducted from January 2023 to June 2023, were performed effectively over a total duration of 3866min. The operations were completed with latency up to 320ms and bandwidths as low as 1-5Mbps. Hemostasis for vein and artery rupture bleeding models was effectively achieved under these low bandwidth conditions. The NASA-TLX results indicated that latency significantly impacted surgical performance more than bandwidth and image clarity reductions. This telesurgery system demonstrated safety and reliability. A total of 320ms latency is acceptable for telesurgery operations. Reducing image clarity can effectively mitigate the potential latency increase caused by decreased bandwidth, offering a new method to reduce the impact of latency on telesurgery.

Does an improvement in cord-level intraoperative neuromonitoring data lead to a reduced risk for postoperative neurologic deficit in spine deformity surgery?

To determine if an improvement in cord-level intraoperative neuromonitoring (IONM) data following data loss results in a reduced risk for new postoperative motor deficit in pediatric and adult spinal deformity surgery. A consecutive series of 1106 patients underwent spine surgery from 2015 to 2023 by a single surgeon. Cord alerts were defined by Somatosensory-Evoked Potentials (SSEP; warning criteria: 10% increase in latency or > 50% loss in amplitude) and Motor-Evoked Potentials (MEP; warning criteria: 75% loss in amplitude without return to acceptable limits after stimulation up 100V above baseline level). Timing of IONM loss and recovery, interventions, and baseline/postoperative day 1 (POD1) lower extremity motor scores were analyzed. IONM Cord loss was noted in 4.8% (53/11,06) of patients and 34% (18/53) with cord alerts had a POD1 deficit compared to preoperative motor exam. MEP and SSEP loss attributed to 98.1% (52/53) and 39.6% (21/53) of cord alerts, respectively. Abnormal descending neurogenic-evoked potential (DNEP) was seen in 85.7% (12/14) and detected 91.7% (11/12) with POD1 deficit. Abnormal wake-up test (WUT) was seen in 38.5% (5/13) and detected 100% (5/5) with POD1 deficit. Most cord alerts occurred during a three-column osteotomy (N = 23/53, 43%); decompression (N = 12), compression (N = 7), exposure (N = 4), and rod placement (N = 14). Interventions were performed in all 53 patients with cord loss and included removing rods/less correction (N = 11), increasing mean arterial pressure alone (N = 10), and further decompression with three-column osteotomy (N = 9). After intervention, IONM data improved in 45(84.9%) patients (Full improvement: N = 28; Partial improvement: 17). For those with full and partial IONM improvement, the POD1 deficit was 10.7% (3/28) and 41.2% (7/17), respectively. For those without any IONM improvement (15.1%, 8/53), 100% (8/8) had a POD1 deficit, P < 0.001. A full or partial improvement in IONM data loss after intraoperative intervention was significantly associated with a lower risk for POD1 deficit with an absolute risk reduction of 89.3% and 58.8%, respectively. All patients without IONM improvement had a POD1 neurologic deficit.

ELEKTROFIZJOLOGICZNE POMIARY UPOŚLEDZENIA SŁUCHU U NARAŻONYCH NA HAŁAS ŻOŁNIERZY ZE SŁUCHEM W NORMIE

IntroductionSome electrophysiological changes can occur in the auditory system in response to noise exposure with or without any permanent auditory threshold shift. The purpose of this study was to identify and measure cochlear function after noise exposure in individuals with normal hearing according to standard audiometric thresholds.Material and methodsPure tone audiometry (PTA) over the standard 0.250–8 kHz range and at 12 kHz, as well as distortion product otoacoustic emission (DPOAE) and auditory brainstem response (ABR) testing, were performed on 42 soldiers who had participated in combat. A control group of 40 participants underwent the same tests.ResultsIn the noise-exposed group, significantly poorer PTA thresholds were recorded at 12 kHz. DPOAE levels were significantly low only at 4 kHz. On ABR testing, both wave I and wave V demonstrated a significant decrease in amplitude and a significant increase in latency for the noise-exposed group.ConclusionsOur findings reveal that high levels of noise can not only damage outer hair cells but also cause changes at the level of the synapses (synaptopathy) which are not evident using standard PTA tests. However, electrophysiological methods can detect some changes in cochlear function.

OffloaD: Detection Failure-based Scheduler for Offloading Object Detection

The current times ask for resource-constrained devices such as drones, light mobile robots, XR glasses, or mobile phones to perform object detection efficiently and in real time. However, when executed on the device, object detection fails to achieve the accuracy requirements. In addition, depending on a powerful edge to offload computation is time-consuming as it requires the transmission of a large amount of data and limits the usage in degraded network conditions. In this paper, we propose OffloaD, a novel offloading scheduler based on the detection of failures for object detection. The method addresses the problem of offloading between a resource-constrained device and an edge by leveraging the accuracy of the object detection model at the device and the network conditions. Accuracy is considered through a detection failure metric that consists of introspective, golden and latency scores. Our main contribution is the offloading scheduler based on the detection of failures of the object detector, which reduces unnecessary data transmission without accuracy degradation. Our method demonstrates that offloading to expensive detectors will not always increase performance and enables detection results and failure estimations even if the network is degraded or unavailable. We implement OffloaD in a physical testbed and perform extensive comparisons against several baselines. The experiments suggest that our approach improves the overall precision-latency performance by reducing the end-to-end latency between 18% and 37% in ideal network conditions and a low latency increase in degraded network conditions while obtaining an accuracy with minimum degradation compared to the baselines. In addition, comparisons to related work methods demonstrate the state-of-the-art performance of OffloaD.

The effects of time-restricted eating on sleep in adults: a systematic review of randomized controlled trials.

Time-restricted eating (TRE), a dietary pattern reducing the duration of daily food consumption, has recently gained popularity. Existing studies show the potential benefits of TRE for cardiometabolic health. Uncertainty remains about whether these benefits are solely from altered meal timing or influences on other health behaviors, including sleep. Despite growing scientific interest in the effects of TRE on sleep parameters, the topic has not been systematically explored. This review examined the effects of TRE interventions (daily fasting duration ≥14 h) lasting at least 8 weeks on objective and subjective sleep parameters. Six randomized control trials were identified through Pubmed, Embase, Google Scholar, and Scopus through September 2023. Of the included studies, three employed objective sleep measures using wearables and five studies assessed sleep subjectively through self-report questionnaires. Only one study reported significant improvements in subjective sleep quality following a TRE intervention. Additionally, one study found significant decreases in sleep duration, two studies found significant decreases in sleep efficiency, and one found significant increases in sleep onset latency. Current evidence indicates that short to mid-term TRE does not typically worsen sleep parameters. However, some populations may experience reduced sleep disturbances, while others may experience reductions in sleep efficiency. Longer duration studies with objective sleep assessments are needed to better understand the effects of TRE on sleep parameters.

Oculomotor and Vestibular Deficits in Friedreich Ataxia - Systematic Review and Meta-Analysis of Quantitative Measurements

Disease-specific oculomotor assessments play a crucial role in the early diagnosis of hereditary cerebellar ataxias. Whereas several studies have reported on quantitative oculomotor and vestibular measurements in Friedreich’s Ataxia (FRDA), the value of specific oculomotor paradigms remains unclear. We aimed to address this knowledge gap through a systematic literature review and providing disease-specific recommendations for a tailored set of eye-movement recordings in FRDA. MEDLINE and Embase were searched for studies reporting on quantitative oculomotor and/or vestibular measurements in FRDA-patients. Data on oculomotor and vestibular parameters were extracted and correlations with a range of clinical parameters were sought. Included studies (n = 17) reported on 185 patients. Abnormalities observed included the presence of saccadic intrusions (143/161) such as square-wave jerks (SWJ, 90/109) and ocular flutter (21/43), impaired eccentric gaze-holding (40/104), abnormal pursuit (81/93) and angular vestibulo-ocular reflex (aVOR) deficits (39/48). For visually-guided saccades (VGS), we frequently observed increases in saccade latency (27/38) and dysmetric saccades (71/93), whereas saccade velocity was more often preserved (37/43). Augmented anti-saccade (AS) latency, downbeat nystagmus and frequent macro-SWJ correlated with disease duration. Increased AS-latency and VGS-latency, frequent macro-SWJ, reduced aVOR-gain and augmented aVOR peak-latency correlated with disease severity. A broad range of oculomotor and vestibular deficits are documented in the literature. Impairments in pursuit, saccades and aVOR-responses are most commonly reported, and as such, should be prioritized as disease markers. Quantitative oculomotor testing in FRDA may facilitate early diagnosis and prove valuable in monitoring disease progression and treatment response.

CAL: Core-Aware Lock for the big.LITTLE Multicore Architecture

The concept of “all cores are created equal” has been popular for several decades due to its simplicity and effectiveness in CPU (Central Processing Unit) design. The more cores the CPU has, the higher performance the host owns and the higher the power consumption. However, power-saving is also one of the key goals for servers in data centers and embedded devices (e.g., mobile phones). The big.LITTLE multicore architecture, which contains high-performance cores (namely big core) and power-saved cores (namely little core), has been developed by ARM (Advanced RISC Machine) and Intel to trade off performance and power efficiency. Facing the new heterogeneous computing architecture, the traditional lock algorithms, which are designed to run on homogeneous computing architecture, cannot work optimally as usual and drop into the performance issue for the difference between big core and little core. In our preliminary experiment, we observed that, in the big.LITTLE multicore architecture, all these lock algorithms exhibit sub-optimal performance. The FIFO-based (First In First Out) locks experience throughput degradation, while the performance of competition-based locks can be divided into two categories. One of them is big-core-friendly, so their tail latency increases significantly; the other is little-core-friendly. Not only does the tail latency increase, but the throughput is also degraded. Motivated by this observation, we propose a Core-Aware Lock for the big.LITTLE multicore architecture named CAL, which keeps each core having an equal opportunity to access the critical section in the program. The core idea of the CAL is to take the slowdown ratio as the matric to reorder lock requests of these big and little cores. By evaluating benchmarks and a real-world application named LevelDB, CAL is confirmed to achieve fairness goals in heterogeneous computing architecture without sacrificing the performance of the big core. Compared to several traditional lock algorithms, the CAL’s fairness has increased by up to 67%; and Its throughput is 26% higher than FIFO-based locks and 53% higher than competition-based locks, respectively. In addition, the tail latency of CAL is always kept at a low level.

Assessment of Moroccan Cannabis Sativa Seed Oil: Chemical Analysis and Evaluation of Antioxidant, Toxicological, and Antinociceptive Effects.

Assessment of Moroccan Cannabis sativa Seed Oil: Chemical Analysis and Evaluation of Antioxidant, Toxicological, and Antinociceptive Effects. by K. Raoui et al., Cadi Ayyad University, Marrakech, Morocco. Cannabis sativa L., locally known as "El kif", belongs to the Cannabaceae family. This study aims to conduct a chemical analysis of Cannabis sativa seed oil (CSSO) and assess its acute toxicity, antioxidant properties, and analgesic effects. The chemical analysis was performed using gas chromatography and mass spectrometry (GC/MS) to identify fatty acids (FAs) contents. Antioxidant activity was evaluated in vitro using the (2,2-diphenyl-1-picrylhydrazyl) DPPH radical scavenging method and the (ferric reducing antioxidant power) FRAP method. Concurrently, acute toxicity, along with antinociceptive activity, was studied through three distinct animal models: writhing test, formalin test, and hot plate test. The results revealed that linoleic acid, oleic acid, α-linolenic acid, and palmitic acid were the main components of CSSO. The LD50 of CSSO was greater than 5 g/kg, indicating low toxicity. Additionally, CSSO exhibited a significant content of flavonoids and total polyphenols, along with notable antioxidant activity with important values. The results indicated a significant increase in thermal stimulus latency, a reduction in the number of writhes induced by acetic acid, and a decrease in licking time in both phases of the formalin test. In conclusion, this study suggests promising results for CSSO, emphasizing its potential as a therapeutic agent.

QoS-Oriented uplink OFDMA random access for the next-gen WLAN

Abstract OFDMA, introduced by the IEEE 802.11ax standard, divides the channel into multiple resource units (RUs), enabling parallel access for multiple users. On this basis, we propose a QoS-oriented double arbitration random access (Q-DARA) scheme. This scheme ensures high-priority priority access through priority arbitration in the first phase and random code arbitration in the second phase. It can also greatly reduce collisions and effectively guarantee the QoS of high-priority traffic. Simulation shows that our proposed scheme has better performance on throughput and latency. Compared to the traditional EDCA, the throughput and latency increase by more than 70%. Compared to the PATB scheme, the throughput increases by about 20%, and the latency increases by about 23%. Moreover, our proposed scheme has almost no changes to the protocol and is suitable for 802.11ax and beyond.

Evaluating the Performance of ETSI-ITS Multi-Stack Protocols for V2V Communication in VANETs: A Simulation Study

The research evaluates various multi-stack protocols for Vehicular Ad-hoc Networks (VANETs), focusing on Vehicle-to-Vehicle (V2V) communication scenarios with Emergency Vehicle (EV) simulations. The study uses the ns-3 network and SUMO (Simulation of Urban MObility) traffic simulators to test these protocols in diverse scenarios, including fluctuating data rates and dense network conditions. By implementing the IEEE 802.11p protocol alongside vehicular message dissemination stacks compliant with ETSI (European Telecommunications Standards Institute) ITS (Intelligent Transport Systems) standards, the study performs simulation experiments with varying vehicle counts, ranging from 20 to 35. It employs two distinct data rate configurations while maintaining a constant transmission power of 23 dBm. The results indicate a decline in the average Packet Reception Ratio (PRR) as vehicle density increases, indicating heightened contention and interference. At the same time, there is an observed increase in average latency, contributing to increased message transmission and reception delays. The quantitative analysis demonstrates an inverse relationship between the average PRR and the total vehicle count when the SEND_CAM message is enabled. On the other hand, disabling SEND_CAM maintains a relatively consistent average PRR across scenarios. Additionally, a positive correlation between vehicle count and average latency underlines the impact of network congestion and interference on communication efficacy within VANETs. Despite suboptimal PRR values falling between 41% and 47%, latency performance remains satisfactory, with average latency durations ranging from 0.154 s to 0.187 s. Notably, the SEND_CAM parameter status shows negligible impact on protocol performance, suggesting that network density plays a more pivotal role. Finally, this study offers valuable insights into the trade-offs and challenges of multi-stack protocols in V2V communication within VANETs. Further optimization efforts are recommended to improve packet reception ratios, especially in high-vehicle-density environments, while maintaining acceptable latency levels. These findings contribute to the ongoing efforts to enhance the reliability and efficiency of communication protocols in VANETs, thus advancing the development of intelligent transportation systems. The study's quantitative protocol performance analysis under varying network conditions provides valuable guidance for optimizing V2V communication deployments in VANETs.