Increase In Hemoglobin Levels Research Articles

Iron Sucrose versus Ferric Carboxymaltose: Effectiveness in Treatment of Postpartum Anaemia following Caesarian Section

Background: Postpartum anemia is a leading cause of maternal mortality and morbidity throughout the world, particularly in developing countries.The most common causes of postpartum anemia are antepartum iron deficiency anemia and blood loss during childbirth. Treatment of anemia with ferric carboxymaltose during labor can considerably reduce maternal and newborn morbidity. The aim of the study is to compare the effectiveness of iron sucrose and ferric carboxymaltose in the treatment of postpartum anaemia following caesarian section. Materials and methods: A comparative cross-sectional study was carried out among the 234 outdoor patients of the Department of Obstetrics and Gynecology at Sheikh Hasina Medical College Hospital, Tangail during the period from July 2017 to June 2020. Results: The pre-transfusion mean of hemoglobin level was 8.9±0.5 gm/dl and the post-transfusion mean of hemoglobin level was 10.4±0.4 gm/dl in group A. The pre-transfusion mean of hemoglobin level was 8.7±0.7 gm/dl and the post-transfusion mean of hemoglobin level was 11.0±0.4 gm/dl in group B. The mean of increased hemoglobin level was 1.5±0.4 gm/dl and 2.3±0.5 gm/dl respectively in both groups. The pre-transfusion mean of ferritin level was 46.3±16.1 ng/mL and the post-transfusion mean of ferritin level was 171.5±25.8 ng/mLin group A. The pre-transfusion level was 46.5±16.2 ng/mL and the post-transfusion mean ferritin level was ±24.9 ng/mLin group B. The mean of increased ferritin level was 125.2±22.2 ng/mL and 149.0± 20.5 ng/mL respectively in both groups. These differences were statistically significant within the study groups (p<0.05). Conclusions: The study revealed that serum ferritin levels increased significantly in the FCC group than ISC group. Ferric carboxymaltose are more effective and safe for the treatment of iron deficiency anemia in postpartum patients. IAHS Medical Journal Vol 7(1), June 2024; 8-12

High Protein Milk Affected the Increase of the Hb Levels of Third-trimester of Pregnancy with Anemia

Anemia is a risk factor that contributes to 50% of all maternal deaths. The main factors causing anemia are low iron intake and infection. Protein intake, especially animal protein intake, helps increase iron absorption. This study aims to determine the effect of providing high protein milk intake on increasing hemoglobin levels in pregnant women in the third trimester with iron deficiency. This type of research is Pre-Experimental with One Group Pretest-Posttest Design. The population in this study was all third-trimester of pregnant women with pale faces in the of the Gondanglegi Public Health Center Kabupaten Malang. The sample was 33 people taken by using the total sampling technique. The measuring test was the Wilcoxon Marked Rank Test. The examination results showed that the average hemoglobin level before treatment was 10.1 gr/dl, and after treatment was 11.1 gr/dl. The results showed that there was an effect of giving high-protein milk on increasing hemoglobin levels in third-trimester pregnant women with pale skin in Gondanglegi Health Center (p-value = 0.000). This study concludes that milk protein consumption basically affects the increase in hemoglobin levels in pregnant women. It is recommended for pregnant women who get anemia to focus on their food intake, especially protein consumption.

High Protein Milk Affected the Increase of the Hb Levels of Third-trimester of Pregnancy with Anemia

Anemia is a risk factor that contributes to 50% of all maternal deaths. The main factors causing anemia are low iron intake and infection. Protein intake, especially animal protein intake, helps increase iron absorption. This study aims to determine the effect of providing high protein milk intake on increasing hemoglobin levels in pregnant women in the third trimester with iron deficiency. This type of research is Pre-Experimental with One Group Pretest-Posttest Design. The population in this study was all third-trimester of pregnant women with pale faces in the of the Gondanglegi Public Health Center Kabupaten Malang. The sample was 33 people taken by using the total sampling technique. The measuring test was the Wilcoxon Marked Rank Test. The examination results showed that the average hemoglobin level before treatment was 10.1 gr/dl, and after treatment was 11.1 gr/dl. The results showed that there was an effect of giving high-protein milk on increasing hemoglobin levels in third-trimester pregnant women with pale skin in Gondanglegi Health Center (p-value = 0.000). This study concludes that milk protein consumption basically affects the increase in hemoglobin levels in pregnant women. It is recommended for pregnant women who get anemia to focus on their food intake, especially protein consumption.

Comparative analysis of ferric carboxymaltose and iron sucrose in treating iron deficiency anemia in perimenopausal women with heavy menstrual bleeding: a randomized controlled trial.

To evaluate the impact of intravenous ferric carboxymaltose (FCM) compared to iron sucrose (ISC) in perimenopausal women with heavy menstrual bleeding (HMB) and anemia. This prospective, open-label, randomized controlled trial enrolled perimenopausal women (40-50 years) with HMB and hemoglobin levels between 6-10 g/dL, intolerant or non-compliant to oral iron therapy. The study compared FCM and ISC by assessing hematological parameters, including hemoglobin, ferritin, and iron levels, over a 12-week period. The patients were followed up at 3, 6, and 12 weeks after initiation. The adverse effects were also evaluated. The study included 60 perimenopausal women, with 30 in each group. The baseline patient characteristics were comparable. FCM demonstrated a statistically significant higher mean increase in hemoglobin (4.97 g/dL) than ISC (4.63 g/dL) over 12 weeks. The proportion of patients achieving correction of anemia (Hb ≥12%) was higher in the FCM group (75.9% vs. 65.5%). Serum ferritin levels were significantly higher in the FCM group after 3 weeks. Adverse effects were minimal and comparable between the groups. Although the direct cost of FCM is high, its ability to be administered in larger doses may result in lower total costs. In perimenopausal women with heavy menstrual bleeding and iron deficiency anemia, FCM and ISC show comparable efficacy in increasing hemoglobin levels with similar side effect profiles. This study highlights the potential benefits of FCM and calls for further exploration of these therapies in diverse patient populations.

Enhancing Hemoglobin Levels and Macro-Micronutrient Intake Through the Well-Being Workshop of First 8000 Days of Life

Introduction: Chronic malnutrition is a major source of concern in the malnutrition community. Addressing nutritional needs that are inappropriate for pre-conception adolescents in the first 8000 days of life is a trigger for anemia and stunting in children later in life. The authors developed The Well-Being Workshop of First 8000 Days of Life. This study compared the hemoglobin levels and macro-micro nutrient intake of female adolescents before and after the well-being workshop of first 8000 days of life and their assistance. Methods: An experimental design, within group method, with an equivalent time series design, and 3 times interventions were carried out. A hundred female adolescents aged 14-19 years Yogyakarta city were assigned to this study. All respondents underwent a pretest and posttest before and after being given interventions of well-being workshop. On completion of the three times workshop, blood sampling of haemoglobin level and food record were collected analyzed. In total, the data was collected 3 times after each workshop was held. The data generated was processed using a paired t test. Results: The average hemoglobin level in female adolescents has increased from the first to the fourth examination, with a standard limit value (> 12.0 gr/dL), but the average of macro and micronutrients intake, as assessed using the Nutrisurvey, is below the standard threshold value. A paired T-test revealed a significant difference within the increase in Hb levels on all examinations. The analysis of macronutrients showed that only fiber had a significant difference before and after a series of well-being workshops of first 8000 days of life interventions, i.e. the first and second examinations. Meanwhile the micronutrient analysis, only iron and zinc there were significant differences before and after being given a series of workshops. Conclusions: "The well-being workshops of first 8000 days of life" can be considered in changing the eating behavior of female adolescents to increase hemoglobin levels.

Impact of Haemodialysis: Analysis of Haemoglobin Levels and Blood Pressure Control in Patients with End-Stage Renal Disease

Aims: To analyze the effect of hemodialysis on hemoglobin levels and blood pressure in patients with End Stage Renal Disease (ESRD). Method: The study used a one-group pretest-posttest design with 17 respondents. Data were collected using EDTA tubes, sphygmomanometers, and stethoscopes. A paired t-test and Wilcoxon signed-rank test were applied to analyze the significance of changes between pretest and posttest results Results: The mean hemoglobin level before hemodialysis was 7.92 g/dL and increased to 8.50 g/dL after hemodialysis (p = 0.001). The mean systolic blood pressure decreased from 136.6 mmHg before to 124.0 mmHg after hemodialysis (p = 0.003). However, there was no significant difference in diastolic blood pressure, with an average of 80.6 mmHg before and 78.6 mmHg after hemodialysis (p = 0.180). Conclusion: It can be concluded that hemodialysis significantly increases hemoglobin levels and reduces systolic blood pressure in ESRD patients, while diastolic blood pressure remains unchanged. Regular monitoring of hemoglobin and systolic blood pressure is crucial for managing patient health. Hemodialysis effectively raises hemoglobin levels and reduces systolic blood pressure in ESRD patients. Regular monitoring of both parameters is essential for effective patient management. While the findings highlight the benefits of hemodialysis, the limited sample size may restrict the generalizability of the results. Further studies with larger sample sizes are needed to confirm these findings and explore the long-term implications.

Intervention on Anemia prevention among adolescent girls: A quasi-experimental study on providing meatballs chips modified to increase hemoglobin levels

Adolescent girls are at higher risk of anemia due to menstrual cycle, with iron deficiency from daily food intake being the most common cause. Therefore, this study aimed to determine the effect of fried meatballs modified with a combination of local ingredients, such as chicken liver flour, moringa oleifera leaves, soybean tempeh flour, and mackerel fish, abbreviated as Tioek chips, on changes in haemoglobin levels on adolescent girls in Kupang City and Kupang Regency. The results show that foods modified with nutritious local ingredients such as Tioek chips can be classified as an affordable and delicious alternative to healthy snacks to prevent anemia.

THE EFFECT OF SPINACH CONSUMPTION ON INCREASING HAEMOGLOBIN IN PREGNANT WOMEN

Background: Anemia is a symptom of a lack of red blood cells due to low hemoglobin levels. Based on the performance assessment report of the Tuban Regency Senori Community Health Center East Java Indonesia in 2022, it was found that 36.65% of pregnant women experienced anemia. This shows that there are still many pregnant women who experience anemia and need treatment. The aim of this research is to determine the effect of spinach consumption on increasing hemoglobin levels in pregnant women. Method: quasi experiment with One Group Pretest-Posttest design. The sample in this study was 16 pregnant women with anemia in the Senori Community Health Center Tuban Regency East Java Indonesia, who met the inclusion criteria. The research instrument used an observation sheet to determine hemoglobin levels in the blood before and after consuming green spinach, an easy touch Hb level check tool. Data were analyzed using paired T-test. Result : The average Hb level of pregnant women before the intervention was 10.20 gr% and after the intervention was 11.18 gr%, the results of the paired t-test showed a significance value = 0.000, so the significance value (2-tailed) < α (0 .05) which shows that there is an effect of spinach consumption on increasing hemoglobin levels in pregnant women. Conclusion : There is an effect of spinach consumption on increasing Hb levels in pregnant women. Integrated ANC activities are expected to be carried out routinely so that pregnant women who experience anemia can be detected early and health workers can provide explanations to pregnant women about the dangers of anemia during pregnancy and the consumption of spinach and its benefits.

Effectiveness of Consumption of Moringa Leaves, Fe Tablets with Dates and Fe Tablets Against Increasing Hemoglobin in Pregnant Women with Anemia

Anemia is a significant health issue with serious consequences, including increased maternal and infant mortality and reduced performance in various activities. In pregnant women, nutritional anemia not only jeopardizes the mother's health but also affects fetal development and pregnancy outcomes. This study aimed to assess the effectiveness of consuming Moringa leaves and dates in increasing hemoglobin levels in pregnant women with anemia. A quasi-experimental design with a pre-test and post-test was used, involving 210 pregnant women divided into two groups. Group 1 received Moringa leaves and Fe tablets, while Group 2 received dates and Fe tablets, with interventions lasting 30 days. Initial tests showed moderate anemia in both groups. After the intervention, significant improvements in hemoglobin levels were observed in both groups. However, the combination of dates and Fe tablets proved more effective than Moringa leaves and Fe in raising hemoglobin levels. The findings suggest that both Moringa leaves and dates are effective in combating anemia in pregnant women, with dates showing slightly better results.

Pengaruh Pemberian Jus Buah Naga terhadap Perubahan Kadar Hemoglobin Ibu Hamil di Wilayah Kerja Puskesmas Kota Baru Kabupaten Indragiri Hilir

The prevalence of iron deficiency anemia in pregnancy is around 95% due to iron deficiency (iron deficiency anemia). Anemia is the second main cause of maternal death, accounting for around 12.8% of maternal deaths due to postpartum hemorrhage. One way to overcome anemia in pregnancy is to consume dragon fruit regularly, in addition to consuming Fe tablets that have been given by midwives or health workers. Giving dragon fruit juice is effective in increasing Hb levels in pregnant women. The research design used in this study was a pre-test and post-test with control group design in the Kota Baru Health Center Working Area, Indragiri Hilir Regency. A population of 230 pregnant women with a sampling technique using simple random sampling obtained 32 respondents (16 intervention groups and 16 control groups). Data analysis used the independent t-test. The results of this study indicate that there is an effect of giving dragon fruit juice on changes in hemoglobin levels of pregnant women in the Kota Baru Health Center Working Area, Indragiri Hilir Regency. Dragon fruit can be used as a supplement to increase hemoglobin levels in pregnant women to treat anemia.

Correlation Crossmatching Test with Effectiveness of Transfusion in Hemolytic Anemia Patients

Hemolytic anemia is anemia caused by the premature destruction of red blood cells. Transfusion with hemolytic anemia is a dilemmatic indication and is still based on clinical decisions. Several studies assessed the effectiveness of transfusions in hemolytic anemia patients with incompatible crossmatching showed effectiveness. This study aimed to analyze crossmatching with transfusion effectiveness in hemolytic anemia patients. Retrospective cohort observational study with medical record data from January 2019 to May 2022 of hemolytic anemia patients who got transfusion therapy. The variables included age, gender, hemoglobin levels before and after transfusion, crossmatching test, and transfusion effectiveness based on increased hemoglobin after transfusion 1 g/dL of 1 Pack Red Cell (PRC) unit. One hundred three (103) patients with hemolytic anemia 45 received PRC, 12 males (26.7%) and 33 females (73.3%). Ages 19 - < 45 years subjects had the most transfusions. Hemoglobin levels before and after transfusion showed significant differences (p-value =0.000) in the patients with a diagnosis of hereditary, unspecified, and autoimmune hemolytic anemias. The correlation between the effectiveness of transfusions with gender and age was not found (p=0.521, p=0.240). The correlation between crossmatching with the effectiveness of transfusion was not found (p=0.089). Hemolytic anemia patients with transfusion showed an increase in hemoglobin levels between before and after transfusion even with incompatible crossmatching. The correlation between the results of crossmatching with transfusion effectiveness in patients with hemolytic anemia was not found. Good premedication treatment can provide effective transfusion.

Effect of storage duration on outcome of patients receiving red blood cell in emergency department.

The effect of the duration of red blood cell (RBC) storage on the outcomes of transfused patients remains controversial, and studies on patients in the emergency department (ED) are limited. This study aimed to determine the association between RBC storage duration and outcomes of patients receiving transfusions in the ED. For RBCs issued to patients in the ED between 2017 and 2022, the storage period of the RBC and data on the transfused patient were obtained. Patients were divided into fresh (≤ 7 days) and old (> 7 days) RBC groups, and the associations between storage duration, outcomes, and laboratory changes were evaluated. There was no significant difference in outcomes between the two groups in the 28-day mortality (adjusted odds ratio [OR] 0.91, 95% confidence interval [CI] 0.75-1.10, P = 0.320) and the length of stay (fresh 13.5 ± 18.1 vs. old 13.3 ± 19.8, P = 0.814). Regarding changes in laboratory test results, the increase in hemoglobin and hematocrit levels was not affected by the storage durations. The study revealed that transfusion of older RBCs is not associated with inferior outcomes or adverse clinical consequences when compared to that of fresh RBCs in patients in the ED.

Effects of 60 degrees of flexion and perioperative use of tranexamic acid on recovery after knee replacement

Abstract OBJECTIVE To explore the effect of 60 knee flexion combined with multiple tranexamic acid application on postoperative recovery of knee replacement patients. METHODS Knee replacement patients admitted to our hospital from October 2020 to September 2022 were selected as the study subjects, and randomly divided into two groups. Postoperative D-dimer, prothrombin time and partial thrombin time were recorded in the two groups, and the differences between the two groups were compared. Erythrocyte, hemoglobin and erythrocyte volume were recorded before, 1 day and 3 days after surgery and the affected limb circumference were also assessed. RESULTS On the 1st and 3rd day after surgery, the red blood cells, hemoglobin, and hematocrit levels in the experimental group were higher than those in the control group, and the differences were statistically significant(P<0.05). The difference in VAS score and circumference between the two groups on the 1st day and 3rd day after surgery was compared, and the difference was statistically significant. The difference in VAS score and circumference was lower in the control group(P<0.05). After surgical treatment, knee joint function recovered, knee joint mobility and HSS score improved, and the difference between the experimental groups was statistically significant (P<0.05). CONCLUSION Perioperative 60-degree flexion combined with multiple tranexamic acids can significantly reduce blood loss in patients undergoing knee replacement surgery, increase red blood cells, hemoglobin levels and red blood cell volume on postoperative days 1 and 3, and reduce postoperative swelling of the affected limb.

Pil-Pintar Intervention Reduce Anemia among Young Teen Girls: A Pilot Study

Background: Iron deficiency anemia and low adherence to take iron tablets are prevalent issues among teenage school girls in Indonesia. To address this concern and encourage regular iron supplementation, the public health office of Sukoharjo Central Java Indonesia introduced a pil-pintar program, colloquially known as the “smart pill.” Aims: This study aimed to measure the increase in hemoglobin (Hb) levels and its correlation with nutrient intake related to Hb synthesis following the pil-pintar intervention. Methods: A quasi-experimental design with a one-group pre-posttest approach was performed involving 49 school teenage girls aged 12-15 years in a public school in Sukoharjo, Indonesia. Each student was given an iron sugar coat tablet containing 182 mg of ferrous-fumarate (equivalent to 60 mg elemental iron) and 0.400 mg of folic acid per tablet, called pil-pintar, once a week for 12 weeks. Results: A decrease in anemia prevalence by 24.4% and a notable increase in Hb levels by 1.0 mg/dL (p = 0.001) were observed in the 12 weeks of intervention. However, the study found no association between the nutrient intakes related to Hb production and the resulting Hb levels. Conclusion: The pil-pintar program effectively improved the hemoglobin levels of anemic teenage girls in the Sukoharjo district, Indonesia.

Efektifitas Komsumsi Tablet Fe dengan Air Jeruk Nipis terhadap Peningkatan Kadar HB Ibu Hamil Anemia Ringan Trimester III

Background: Anemia is a body condition where the hemoglobin level in red blood cells is lower than the normal standard. Pregnant women are said to be anemic if their Hb content is <11gr/dL. According to WHO, the prevalence of pregnant women throughout the world who experience anemia is 41.8%. The percentage of anemia in pregnant women in Indonesia is 37.1%. For the Special Region of Yogyakarta, the prevalence in pregnant women is 19.01%, and the highest incidence of anemia is in Bantul Regency (27.67%). Data from the Bantul District Health Service, from 27 Community Health Centers, there are 5 Community Health Centers with the highest number of anemia, namely at Sewon II Community Health Center. From this data, Sewon II Community Health Center is in second place. Objective: To determine the effectiveness of consuming fe tablets with lime juice on increasing Hb levels in mildly anemic pregnant women at the Sewon II Bantul Community Health Center, Yogyakarta. Method: This quasi-experiment research uses a one group pretest-posttest design. The sample in the study consisted of 30 pregnant women. The sampling technique uses total sampling. The research instrument gave lime to pregnant women with mild anemia for 2 weeks. Then the hemoglobin level was checked before and after drinking lime using a hemoglobin meter checking device in collaboration with the Puskesmas lab section. Results: The results of this research are based on univariate analysis of the characteristics of respondents aged 20-35 years as many as 26 (86.3%) respondents, the majority have a high school education as many as 26 (86.7%) respondents, the occupation of respondents is housewives 28 (93.3%) ) respondents. The results of the bivariate analysis showed that there was a significant effect on the average value of increasing hemoglobin levels before (10.21) and after drinking lime (11.23) with an average of (1.02). Conclusion: Based on the research results, it can be concluded that there is an effect of giving lime juice on hemoglobin levels in pregnant women in the second trimester at the Sewon II Bantul Community Health Center.

PENGARUH PEMBERIAN EKSTRAK MORINGA LEAVES TERHADAP KENAIKAN KADAR HEMOGLOBIN PADA IBU HAMIL DI WILAYAH KERJA PUSKESMAS BLUTO

Iron deficiency always occurs in pregnant women. Moringa leaves can increase hemoglobin levels because they contain iron, folic acid, vitamin A and vitamin C. The research aims to analyze the impact of giving Moringa leaf extract on increasing hemoglobin levels in pregnant women. This research is a quantitative study with a quasi eksperimen design using the one group method. pre-test post-test. The population was 72 pregnant women. The sample was selected using a random sampling technique, obtaining 19 respondents for the control group and 19 respondents for the treatment group. The results of the study showed that hemoglobin levels in pregnant women before administering Moringa leaf extract had an average of 10.4 gr%, while after administration it had an average of 11.5 gr%. The statistical test results show a p-value of 0.000 (p<?), which indicates that there is a significant effect of administering Moringa leaf extract on increasing hemoglobin levels in pregnant women. Therefore, it is recommended for pregnant women to consume vegetables that are rich in iron such as Moringa leaves.

Effectiveness of Giving Dragon Fruit on Increasing Hemoglobin Levels in Pregnant Women with Mild Anemia at Jakarta Harbor Hospital in 2024

Research conducted at Jakarta Harbor Hospital in 2024 aimed to evaluate the effectiveness of dragon fruit in increasing hemoglobin levels in pregnant women with mild anemia. Anemia is a common condition at the hospital, affecting around 30% of pregnant women in 2022. The study involved 36 third-trimester pregnant women with anemia. Hemoglobin levels were measured using a digital Hb meter (Quick Check), blood lancet, and strip. Data were analyzed using univariate and bivariate methods. The paired sample t-test was applied if the data followed a normal distribution, while the Wilcoxon test was used for non-normal distributions. After 14 days of administering dragon fruit, the study found an average increase in hemoglobin levels of 0.538 g/dL. This indicates that dragon fruit is effective in raising hemoglobin levels in pregnant women with mild anemia.

Activating pyruvate kinase improves red blood cell integrity by reducing band 3 tyrosine phosphorylation

AbstractIn a phase 1 study (NCT04000165), we established proof of concept for activating pyruvate kinase (PK) in sickle cell disease (SCD) as a viable antisickling therapy. AG-348 (mitapivat), a PK activator, increased adenosine triphosphate (ATP) and decreased 2,3-diphosphoglycerate levels while patients were on treatment, in line with the mechanism of the drug. We noted that the increased hemoglobin (Hb) persisted for 4 weeks after stopping AG-348 until the end of study (EOS). Here, we investigated the pathways modulated by activating PK that may contribute to the improved red blood cell (RBC) survival after AG-348 cessation. We evaluated frozen whole blood samples taken at multiple time points from patients in the phase 1 study, from which RBC ghosts were isolated and analyzed by western blotting for tyrosine phosphorylation of band 3 (Tyr-p-bd3), ankyrin-1, and intact (active) protein tyrosine phosphatase 1B (PTP1B) levels. We observed a significant dose-dependent decrease in mean Tyr-p-bd3 from baseline in the patients, accompanied by an increase in the levels of membrane-associated ankyrin-1 and intact PTP1B, all of which returned to near baseline by EOS. Because PTP1B is cleaved (inactivated) by intracellular Ca2+-dependent calpain, we next measured the effect of AG-348 on ATP production and calpain activity and the plasma membrane Ca2+ ATPase pump–mediated efflux kinetics in HbAA and HbSS erythrocytes. AG-348 treatment increased ATP levels, decreased calpain activity, and increased Ca2+ efflux. Altogether, our data indicate that ATP increase is a key mechanism underlying the increase in hemoglobin levels upon PK activation in SCD. This trial was registered at www.clinicaltrials.gov as #NCT04000165.

Improving Exercise Tolerance: Blood Transfusions and Physical Well-being in HIV Patients

Individuals living with HIV often experience reduced exercise tolerance due to anemia, fatigue, and muscle deconditioning, significantly impacting their quality of life. Blood transfusions emerge as a critical intervention to improve physical well-being by increasing hemoglobin levels and enhancing oxygen delivery to tissues. This review article explores the mechanisms by which blood transfusions positively influence exercise tolerance in HIV patients, highlighting the physiological benefits of improved oxygenation and energy levels, which facilitate greater participation in physical activities. In addition to the physiological benefits, enhanced exercise tolerance can lead to psychological improvements, reducing symptoms of anxiety and depression commonly faced by individuals with HIV. Engaging in physical activities fosters a sense of accomplishment and boosts self-esteem, creating a positive feedback loop that encourages a more active lifestyle. This multifaceted approach underscores the importance of integrating blood transfusion therapy into comprehensive HIV care to support both physical and mental health. Keywords: anemia, blood transfusions, exercise tolerance, HIV, physical well-being

Postoperative Intravenous Iron Infusion in Anemic Colorectal Cancer Patients: An Observational Study.

Anemia is the most common extraintestinal symptom of colorectal cancer, with a prevalence of 30-75%. While the preoperative anemia in this patient population has been well studied and its correction 4-6 weeks prior to surgery is recommended when feasible, there is a paucity of data regarding the management of postoperative anemia, which has a prevalence of up to 87% in these patients. To address this issue, we conducted an observational cohort study of surgically treated postoperative anemic patients with colorectal cancer. The objective of this study was to evaluate the effect of intravenous ferric carboxymaltose on the correction of postoperative anemia by postoperative day 30 (POD30). The primary outcome was the change in hemoglobin on POD30, while the secondary outcomes were the change in iron and other laboratory parameters, postoperative complications and transfusions. The results demonstrated that patients treated with intravenous iron exhibited a significant increase in hemoglobin levels by POD30, along with a concomitant increase in hematocrit, ferritin, and transferrin saturation levels, compared to the control group. The findings imply that patients undergoing colorectal cancer surgery with anemia that was not corrected in the preoperative setting may benefit from early postoperative intravenous iron infusion.