A mass mortality of the sea scallop Placopecten magellanicus occurred between 2004 and 2005 in the Nantucket Lightship Closed Area (NLCA), a Marine Protected Area (MPA) in the Great South Channel, USA. On a broad scale (3951 km 2 ), scallop density (ind. m -2 ) in the MPA declined by 35%. On a fine scale (504 km 2 ), in the northeast corner of the MPA where most scallops occur, density declined by 50%. The scallops that perished were large and probably old; 80% had shell heights >130 mm (H ∞ = 155 mm). Only 6% of the decline in the northeast corner was explained by fishing mortality. The mass mortality equaled approximately 6484 metric tons of harvestable scal- lop meat (equivalent to US $100 million ex-vessel). Closing the NLCA to fishing in 1994 removed fish- ing mortality, increasing scallop survival rates. Scallops that recruited in 1994 reached 10 yr of age in 2004. Individuals of this age may suffer the effects of senescence, including parasitism by shell bor- ers and prokaryotic infection, which likely caused the mass mortality. If MPAs are used to manage fisheries, surveys with the accuracy and precision to resolve population dynamics on the spatial scale of the MPA are required or the benefits may be offset by increases in natural mortality.