Increase In Average Life Expectancy Research Articles

The Future of Nursing Education: Necessary Elements and Implementation Strategies for Learning Artificial Intelligence

As populations age, average life expectancy increases and the complexity of diseases rises, leading to nursing care and healthcare systems facing severe challenges related to inadequate resources. Artificial intelligence (AI), including elements such as investigation, integration, learning, prediction, and decision-making, holds significant potential for application in clinical care not only to enhance care quality but also to help guide the future direction of healthcare. AI applications are already being increasingly utilized to improve the quality of clinical care and to streamline workflows. However, because nursing education has lagged behind in terms of adopting AI, greater attention must be given to training up nursing students with AI-related knowledge and application skills. AI technologies should be integrated into nursing curricula and clinical internships to adapt to the rapidly changing high-tech healthcare environment, enabling the more-effective use of AI technology in providing high-quality and safe nursing care.

International Immigration: A Potentially Feasible Solution to China’s Population Ageing

For a long time, China has been seen as a youthful country, and there are lots of studies have illustrated that the demographic dividend was a crucial factor in China’s super-rapid economic growth over the past few decades. However, as a result of strict family planning policies which lasted nearly half a century as well as a significant increase in average life expectancy, the population ageing problem is beginning to emerge in today’s China. Although policymakers have been aware of this trend, current domestic remedies are not sufficient to address potential risks effectively. The core viewpoint of this paper is that China is ought to put international measures on the agenda to prevent future demographic crises. In addition, based on China’s actual national conditions and the experience of the developed world in dealing with the ageing problem, this paper also makes some suggestions to support the improvement of China’s international immigration policies.

Cellular Senescence, Mitochondrial Dysfunction, and Their Link to Cardiovascular Disease.

Cardiovascular diseases (CVDs), a group of disorders affecting the heart or blood vessels, are the primary cause of death worldwide, with an immense impact on patient quality of life and disability. According to the World Health Organization, CVD takes an estimated 17.9 million lives each year, where more than four out of five CVD deaths are due to heart attacks and strokes. In the decades to come, an increased prevalence of age-related CVD, such as atherosclerosis, coronary artery stenosis, myocardial infarction (MI), valvular heart disease, and heart failure (HF) will contribute to an even greater health and economic burden as the global average life expectancy increases and consequently the world's population continues to age. Considering this, it is important to focus our research efforts on understanding the fundamental mechanisms underlying CVD. In this review, we focus on cellular senescence and mitochondrial dysfunction, which have long been established to contribute to CVD. We also assess the recent advances in targeting mitochondrial dysfunction including energy starvation and oxidative stress, mitochondria dynamics imbalance, cell apoptosis, mitophagy, and senescence with a focus on therapies that influence both and therefore perhaps represent strategies with the most clinical potential, range, and utility.

(009) Sexual Function & Sexual Satisfaction Differences Between Cisgender Women of Different Age Groups

Abstract Introduction As the average life expectancy increases, so does the need to improve older adults’ quality of life. Sexual function and satisfaction have been intimately tied to well-being, and older age has been associated with a decline in sexual activity, sexual function, and desire. However, there is limited research that focuses on the association between age and specific measurements of sexual function, such as orgasm parameters, frequency of sexual activity, and sexual satisfaction. Objective To describe and compare measures of sexual activity, orgasm quality, and satisfaction between women of different ages. Methods Respondents were recruited via Qualtrics and administered an anonymous online survey. Respondents were separated into groups based on age ranges: younger adults (<40 years old), middle-aged adults (40 to 59 years old), and older adults (≥60 years old). Additional demographic characteristics and sexuality measures were documented, including sexual orientation, partnership status at the time of survey, ability to orgasm, frequency of masturbation and sexual activity, and sexual satisfaction (as measured by the validated New Sexual Satisfaction Scale (NSSS)). An orgasm quality inventory queried the following six variables, under the control condition of masturbation: (1) time to orgasm; (2) duration of orgasm; (3) refractory period between orgasms; (4) experience of orgasm as a single or multi-peak event; (5) bodily location of orgasm experience; and (6) satisfaction with orgasm quality. Results A total of 423 sexually active cisgender women (average age ± standard deviation: 48.9 ± 15.6 years old) completed our survey. Older women were significantly more likely to identify as heterosexual and deny dating or being in a current relationship (both p<0.001). Additionally, older women were significantly more likely to deny masturbation and sexual activity with a partner (p<0.001). There was no statistically significant difference in ability to achieve orgasm between age groups (p=0.5). With respect to orgasm parameters (Table 1), younger women reported a significantly lower refractory period between orgasms, as compared to middle-aged and older women. Compared to other age groups, significantly more older women reported their orgasm as a multi-peak event (p<0.04) and were more likely to report the location of orgasm sensation as occurring in their genitals, as opposed to extragenital areas (e.g., arms, thighs, face, back) or whole body (p<0.01). There were no statistically significant differences between age and lead time to orgasm, duration of orgasm, or satisfaction with orgasm. Differences in sexual satisfaction (as measured by the NSSS, with higher scores indicating greater sexual satisfaction) were found to be statistically insignificant as well. Conclusions While older women reported a significant decrease in frequency of masturbation and sexual activity, they only differed in three out of six measures in our orgasm inventory. While these measures indicate a difference in older women’s experience of orgasm, it is important to note that there were no significant differences across multiple measures of sexual satisfaction between women of different ages. Disclosure No.

Eternal Youth: A Comprehensive Exploration of Gene, Cellular, and Pharmacological Anti-Aging Strategies.

The improvement of human living conditions has led to an increase in average life expectancy, creating a new social and medical problem-aging, which diminishes the overall quality of human life. The aging process of the body begins with the activation of effector signaling pathways of aging in cells, resulting in the loss of their normal functions and deleterious effects on the microenvironment. This, in turn, leads to chronic inflammation and similar transformations in neighboring cells. The cumulative retention of these senescent cells over a prolonged period results in the deterioration of tissues and organs, ultimately leading to a reduced quality of life and an elevated risk of mortality. Among the most promising methods for addressing aging and age-related illnesses are pharmacological, genetic, and cellular therapies. Elevating the activity of aging-suppressing genes, employing specific groups of native and genetically modified cells, and utilizing senolytic medications may offer the potential to delay aging and age-related ailments over the long term. This review explores strategies and advancements in the field of anti-aging therapies currently under investigation, with a particular emphasis on gene therapy involving adeno-associated vectors and cell-based therapeutic approaches.

Clinical Significance of Carotid Endarterectomy and Carotid Artery Stenting in Older Patients Over 80.

As the average life expectancy increases, neurosurgeons are likely to encounter patients aged 80 years and above with carotid stenosis; however, whether old age affects clinical post-treatment outcomes of carotid endarterectomy (CEA) or carotid artery stenting (CAS) remains inconclusive. Thus, this study aimed to evaluate the outcomes following CEA or CAS in patients aged 80 years and above. This study included older over 80 years (n = 34) and younger patients (<80 years; n = 222) who underwent CEA or CAS between 2012 and 2022. All of them were followed up for a mean of 55 months. All-cause mortality, the incidence of vascular events, ability to perform daily activities, and nursing home admission rates were assessed. During follow-up periods, 34 patients (13.3%) died due to coronary artery disease, malignancy, and pneumonia, and the incidence was significantly higher in the elderly group than in the younger group (P = 0.03; HR, 3.01; 95% CI, 1.53-5.56). The incidence of vascular events did not differ between the older group (29.5%) and the younger group (26.9%, P = 0.58); however, the incidence was significantly higher in patients with high-intensity plaques than in those without that (P = 0.008; HR, 2.83, 95%CI, 1.27-4.87). The decline in the ability to perform daily activities and increased nursing home admission rates were high in elderly patients (P < 0.01). Although the mortality rate was higher in the elderly group, subsequent vascular events were comparable to that in the younger group. The results suggest that CEA and CAS are safe and useful treatments for carotid stenosis in older patients, especially to prevent ipsilateral ischemic stroke.

Cytotoxicity and antitumor activity of sesquiterpene lactones. Structure, activity

The article discusses the results of 19 samples screening of sesquiterpene γ-lactones argolide, grosheimin, estafiatin, and their derivatives for cytotoxicity and antitumor activity. The research results indicate significant cytotoxicity and selectivity of the action of sesquiterpene γ-lactones and their derivatives against most tumor cell lines. Aim. The purpose of this study is to study the cytotoxicity and antitumor activity of the sesquiterpene γ-lactones argolide, grosheimin, estafiatin and their chemically modified derivatives, as practically renewable materials. Methods. The cytotoxicity of the compounds was determined using vero cells, THP-1, Pliss lymphosarcoma cell lines, Walker carcinosarcoma, sarcoma 45, sarcoma-180, alveolar liver cancer PC-1, P-388 leukemia, L-1210 leukemia, and resistant to 5-fluorouracil sarcoma 45. The antitumor activity of the samples was studied in in vivo experiments on white outbred rats with transplanted tumor strains and was assessed by inhibition of tumor growth and the magnitude of the increase in average life expectancy. Statistical processing of the results was carried out using the program “GraphPad Prism v. 6.0" (GraphPad Software Inc., USA). Conclusion. When determining cytotoxicity in in vitro samples of the sesquiterpene γ-lactones argolide, grosheimin, and estafiatin showed selectivity of their action on cells of 8 tumor lines, on cells of human acute monocytic leukemia THP-1 and in relation to the larvae of sea crustaceans Artemia salina (Leach). Samples of argolide, 8-acetylgrosheimin, 13-morpholinogrosheimin, 3-keto-4-methylene-cis-guaianolide, 3α-acetoxyisozaluzanin C, and 10α(14)-epoxy-1,5,7α,4,6β(H)-guai-11(13)-en-4(3),6(12)-diolide in experiments in vivo possessed high antitumor activity against transplantable tumor strains of Pliss lymphosarcoma, Walker carcinosarcoma, sarcoma 45, sarcoma 37, sarcoma 180, alveolar liver cancer PC-1, leukemia P-388 and L-1210, resistant to 5-fluorouracil sarcoma 45

Демографическая бездна или закономерность? К проблеме управления численностью населения (на примере регионов РФ и мира)

A different correlation has been established for different regions of the South of the Russian Federation of the following demographic factors: life expectancy, the ratio of births to deaths, the average life expectancy of men and women, their difference in age, as well as per capita gross regional product. For a world population of about 5 billion people and 51 states of the world, a single natural relationship has been established between an increase in average life expectancy and a decrease in the ratio of the number of births and deaths, regardless of the level of socio-economic development of the regions. The problem of population management in regions and states of different socio-economic levels is associated with the need to solve exclusively socio-economic problems, including in the direction of reducing the difference in the average life expectancy of men and women. Harmonization of the steady state of demographic dynamics is established at the points of the ratio of births and deaths near the golden numbers: 0.618, 1.618, 2.618.

The impact of demographic changes in Poland on the development of the aesthetic medicine market

The phenomenon of an "aging Polish society" is a multi‑faceted problem which includes, among others, an increase in average life expectancy, an increased proportion of older people in the population, as well as migration to large cities. These changes, which have been taking place for many years, have impacted the development of the aesthetic medicine market. Through analyzing the general population demographics against the demographics of the aesthetic medicine market, we believe that in the coming years there will be an increased demand for aesthetic treatments in people over 50 years of age, especially in offices located in large urban centers.

Demographic indicators, models, and testing

The use of simple demographic indicators to describe mortality dynamics can obscure important features of the survival curve, particularly during periods of rapid change, such as those caused by internal or external factors, and especially at the oldest or youngest ages. Therefore, instead of the generally accepted Gompertz method, other methods based on demographic indicators are often used. In human populations, chronic phenoptosis, in contrast to age-independent acute phenoptosis, is characterized by rectangularization of the survival curve and an accompanying increase in average life expectancy at birth, which can be attributed to advances in society and technology. Despite the simple geometric interpretation of the phenomenon of rectangularization of the survival curve, it is difficult to notice one, detecting changes in the optimal coefficients in the Gompertz-Makeham law due to high computational complexity and increased calculation errors. This is avoided by calculating demographic indicators such as the Keyfitz entropy, the Gini coefficient, and the coefficient of variation in lifespan. Our analysis of both theoretical models and real demographic data shows that with the same value of the Gini coefficient in the compared cohorts, a larger value of the Keyfitz entropy indicates a greater proportion of centenarians relative to average life expectancy. On the contrary, at the same value of the Keyfitz entropy, a larger value of the Gini coefficient corresponds to a relatively large mortality at a young age. We hypothesize that decreases in the Keyfitz entropy may be attributable to declines in background mortality, reflected in the Makeham term, or to reductions in mortality at lower ages, corresponding to modifications in another coefficient of the Gompertz law. By incorporating dynamic shifts in age into survival analyses, we can deepen our comprehension of mortality patterns and aging mechanisms, ultimately contributing to the development of more reliable methods for evaluating the efficacy of anti-aging and geroprotective interventions used in gerontology.

OCCUPATIONAL THERAPY INTERVENTIONS TO IMPROVE OCCUPATIONAL PARTICIPATION AND REDUCE THE RISK OF FALLS IN ELDERLY PEOPLE WITH OSTEOARTHRITIS

Global trends show an increase in life expectancy. A similar trend in life expectancy growth is typical for Ukraine. However, even a positive trend towards an increase in average life expectancy cannot stop the inevitable process of aging, which leads to a decrease in the functional and physiological capabilities of all body systems.&#x0D; Osteoarthritis is the most common disease of elderly. Osteoarthritis of the joints of the lower extremities is a risk factor for falls syndrome. Falls lead to a decrease in physical functioning, independence and occupational participation, increase the fear of the next fall, and bring serious injuries, even depth. The role of an occupational therapist in falls prevention is undeniable. It helps maximize the ability to participate in the occupational activity that is meaningful to the client, and modifies the client's lifestyle and living environment for safe occupational performance.&#x0D; The aim of the research. To scientifically justify and develop a comprehensive program of occupational therapy interventions to reduce the risk of falls for elderly women with osteoarthritis of the lower extremities by means of occupational therapy.&#x0D; Materials and methods. In order to fully solve the tasks and study the activity of elderly women with osteoarthritis of the joints of the lower extremities, the following research methods were chosen: analysis of special and scientific and methodical literature; content analysis of medical records, interviews, observations; WOMAC Osteoarthritis Index and assessment of fear of falling according to Falls Efficacy Scale International.&#x0D; 48 women aged 62 to 89 took part in the ascertainment experiment. Women were divided into 2 groups - main (MG) and control (CG), 24 people in each. The main group included women with osteoarthritis of the lower extremities. In the control group people were without damage to the joints. The program lasted for 6 (six) months. The people of CG received recommendations about general physical activity with reference to WHO guideline. The people of MG received therapeutic exercises on strength, balance, coordination, endurance, improvement of walking skills and occupational therapy interventions with: training to perform occupations safely; creation of a new stereotype of behavior to avoid falling; modification of the environment; review of medications which can provoke a fall; learning to use assistive equipment; techniques to get up safely and effectively after a fall.&#x0D; Research results. Based on the obtained data, it is evident that both groups experienced an increase of independence level in functioning, less of pain, stiffness and fear of falling.&#x0D; Conclusions. Both falling and the fear of falling significantly reduce the ability to lead a full and independent life, bring undesirable consequences, including serious injuries, and interfere with the ability to do what is most important for a person. In the foreign literature, there is a lot of evidence about the contribution of occupational therapy to the prevention of falls. The results of the conducted research give grounds for asserting that the application developed by us a multi-component program of occupational therapy interventions developed for elderly people with osteoarthritis of the joints of the lower extremities is an effective means of reducing the risk of falls in this category of people. The advantages of the developed program are confirmed by the results of own research.

Effects of Physical Activity on Cognitive Functioning: The Role of Cognitive Reserve and Active Aging.

The increase in average life expectancy necessitates the identification of possible mechanisms capable of promoting "active aging" to ensure adequate levels of global functioning. Numerous studies show that regular physical activity promotes, even in the elderly, a state of functional psychophysical well-being capable of slowing down age-related cognitive decline. This study aimed to clarify whether, and how, the intensity of physical activity can modulate cognitive and executive skills by influencing specific psychological variables. Our sample consisted of 151 senior subjects divided into hikers (HIK), gentle gymnastics (GYM), and sedentary (SED), who practice intense, moderate, and reduced physical activity, respectively. A battery of psychological questionnaires was administrated to evaluate attentional skills, decision-making, the ability to implement targeted behaviors, perceived self-efficacy, and psychophysical well-being. We included: the Mini-Mental State Examination, Cognitive Reserve Index Questionnaire, General Self-Efficacy Scale, Letter Cancellation Test, Everyday Competence Questionnaire, and Geriatric Depression Scale (GDS). Comparisons between the scores reported by the three groups showed that the HIK group differs from the others with respect to most of the measurements, presenting better mood and cognitive performance, and a specific psychological profile. On the contrary, the GYM group appeared to have a greater affinity with the SED group than with the HIK group, both cognitively and psychologically. Types of physical activity, as well as the intensity and frequency with which they are practiced, are factors that promote an active aging process, protecting the psychophysical well-being and overall cognitive functioning of the elderly.

Излечение здравоохранения: исторический опыт старых демократий и уроки для России

Contrary to widespread belief government-run Healthcare was not the first mass affordable solution for medical problems. Governmental healthcare has not caused main breakthroughs in the mortality decrease and significant increase in average life expectancy. Safeguards for private property and ironclad protection of personal rights and liberties caused modern economic growth phenomena, a rise in wealth, and unleashed scientific and technical progress. The rise in wealth and scientific progress were the principal reasons behind progress in medicine. Nowadays huge government spending and poor efficiency make unclear the overall impact of government-run healthcare on public health. The government's Famous attempts to protect drug consumers caused huge costs possibly outweighing their benefits. The foremost public concern ought to be the numerous ethical challenges of the governmental rule in Healthcare, the power usurped by healthcare officials to decide for and instead the patient his fate.

Incidence and prevalence of neurological disorders in the United Arab Emirates: a systematic review

Background/ObjectivesThe United Arab Emirates (UAE) is a rapidly developing country. With the increase in average life-expectancy, high rates of consanguinity, and the adoption of a Western lifestyle, the burden of neurological disorders is expected to increase over the next few decades. Despite the importance of neurological disorders, there has not been a systematic review of published studies on the epidemiology of neurological disorders in the UAE.MethodsWe searched for studies of incidence and/or prevalence of neurological disorders in the UAE published in English in MEDLINE, Google Scholar, Embase, and Scopus databases with no date restrictions up until 01 October 2023. Two authors independently assessed abstracts and full texts of possibly relevant papers, followed by data extraction from studies satisfying the eligibility criteria.ResultsEight articles (N = 2067 patients) were included, half reported incidence and prevalence of multiple sclerosis, with an average crude prevalence 56/100,000 and related demyelinating disorders. Others were related to headache, meningitis, cerebral venous thrombosis, and brain tumours.ConclusionThere is a distinct lack of data on the epidemiology of different neurological diseases in the UAE. Large population-based studies, ideally longitudinal, are required to provide accurate and reliable estimates of the incidence and prevalence of neurological disorders to help inform healthcare capacity planning.

Case study of intergenerational learning courses implemented in a preschool: perceptions of young children and senior citizens

ABSTRACT Public awareness of health-related topics is increasing, and an increase in average life expectancy has increased the senior citizen population in Taiwan. Furthermore, because of the high cost of raising young children, people’s willingness to give birth has decreased. Taiwan’s aging population and declining birth rate are key challenges for its population development, and the promotion of interactions between young children and senior citizens is also a crucial topic for scholars. Therefore, intergenerational learning has been proposed, and several Taiwanese preschools have attempted to develop intergenerational learning courses. This study explored the perceptions of young children and senior citizens during the implementation of intergenerational learning courses in a preschool. The results revealed that the implementation of such courses allowed young children and senior citizens to influence each other’s life experiences and develop positive feelings. The interactions also promoted their psychological well-being. Through this study, we clarified the effectiveness of intergenerational learning courses. Finally, we proposed that intergenerational learning courses with the themes of ‘caring’ and ‘love’ should be developed and integrated into intergenerational learning courses.

Brown adipose tissue-derived exosomes delay fertility decline in aging mice.

Ovarian aging has steadily grown to be a significant health issue for women as a result of the increase in average life expectancy and the postponement of reproductive age. One of the important pathological foundations of ovarian aging is formed by mitochondrial dysfunction, which causes decreases in follicle quantity and oocyte quality. In recent years, brown adipose tissue (BAT) transplantation has been proven as an effective treatment for aging-related diseases, such as ovarian aging. However, BAT transplantation is an invasive operation with long-term risks. Therefore, we need to find an alternative strategy. We injected BAT-derived exosomes into eight-month-old C57BL/6 female mice. The fertility was detected by the estrous cycle and mating test. The changes of ovary and oocyte were measured by ovarian volume, organ coefficient, follicle counting, and oocyte maturation rate. ROS level, mitochondrial membrane potential and ATP level were measured to analyze the mitochondrial function of oocytes. The changes in metabolism were explored by cold stimulation test, body weight and blood sugar. The possible molecular mechanism was further investigated by RNA sequencing. In terms of fertility, the estrous cycle of aging mice after BAT-derived exosome intervention was more regular, and the number of progenies and litters was increased. At the tissue level, the ovaries in the BAT-exosome group were larger, and the number of primordial follicles, secondary follicles, antral follicles and total follicles increased. At the cellular level, BAT-derived exosomes improved the maturation of oocytes in vivo and in vitro, increased the mitochondrial membrane potential and ATP levels of oocytes, and decreased ROS levels. Besides, BAT-derived exosomes ameliorated the metabolism and viability of aging mice. Furthermore, mRNA sequencing showed that BAT exosomes altered the expression levels of genes related to metabolism and the quality of oocytes. BAT-derived exosomes enhanced mitochondrial function, promoted follicle survival, improved fertility, and extended ovarian lifespan in aging mice.

Analysis of risk factors for severe COVID-19

Global aging has accompanied the worldwide increase in average life expectancy over the past century. The coronavirus disease (COVID-19) pandemic has increased morbidity among all groups of the population, but it poses a particular threat to people of older age groups. Multiple concomitant pathologies form an unfavorable background for the course of COVID-19. It was found that the level of in-hospital mortality in the care of older age groups was high, including in countries with high-income levels and expenditures on health care. We have identified predictors of the severe course of COVID-19. In our opinion, such predictors should be considered when identifying risk groups and applying anticipatory strategies to them, in particular, timely hospitalization, the administration of antiviral therapy, and treatment of concomitant pathology (chronic kidney disease, hypertension, diabetes mellitus, etc.). The question of testing elderly patients for the presence of SARS-CoV-2 is especially relevant when weakness increases, the state of consciousness worsens, and/or dyspnea appears or worsens. Postponement of hospitalization can negatively affect the results of treatment. Thus, interleukin-6, C-reactive protein, the absolute level of lymphocytes, albumin, and ferritin can be used when evaluating the criteria for hospitalization in this group of patients. Interleukin-6 and C-reactive protein are positively associated with body mass index. The excess of adipose tissue is considered an independent predictor of severe COVID-19 and, unlike age, can be modified. We suggested that a hospital mortality risk calculator based on the personalized lethality risk index on admission should be used in practice. Adequate therapy of concomitant pathology is also important in the prevention of COVID-19 complications. Protection of susceptible groups at high risk of severe COVID-19 has strategic importance in preventing high mortality rates in population regardless of age.

Flexible and Wearable Capacitive Pressure Sensor for Monitoring Heart Parameters

The increase in global average life expectancy over the past century has been largely attributed to medical science developments. In this study, we demonstrate a polymer-based capacitive pressure sensor for measuring heart rate and pulse pressure signal. The fabricated sensor has been characterized to evaluate its performance and to verify its repeatability and precision. It is observed that the sensor works in the range of 0 – 8 kPa pressure range and is suitable for measuring the pulse pressure. This sensor has a high sensitivity of 7.11 kPa <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">-1</sup> in the low-pressure range of 0 to 8 kPa. Further, the sensor demonstrated a considerable amount of repeatability with an error less than 6% in consecutive measurements. Moreover, the sensor demonstrated the use of a wearable, flexible piezo-capacitive pressure sensor for pulse pressure monitoring. The wrist pulse was used as the stimulus for the experimental characterization of the sensor, and health markers related to the measured response were also discussed.

Cytotoxicity and Antitumor Activity of Arglabin and its Derivatives.

At present, more than 8000 sesquiterpene lactones have been isolated and described from natural sources, a significant part of which has cytotoxicity and antitumor activity. One of the practically available sesquiterpene lactones is arglabin, which, as a renewable material, is used for the synthesis of new compounds. The article presents data on the study of cytotoxicity and antitumor activity of the arglabin and its derivatives using molecular modeling methods and, in the experiment in vitro and in vivo. The aim of this work is to study the cytotoxicity and antitumor activity of new compounds based on the sesquiterpene lactone arglabin using molecular modeling and experimental pharmacology. ChemDraw programs and a set of AutoDock programs were used for computer simulation. Molecular docking was carried out using the Maestro graphical interface of the Schrödinger Suite software package (Schrödinger, LLC, New York, NY, 2017). Docking modes standard precision and XP (extra precision) were used. In in vitro experiments, the antitumor activity of compound samples was studied in models of 60 human tumor cell lines, and clonogenic C6 rat glioma cells. The antitumor activity of the samples was studied in experiments in vivo on white outbred rats with transplanted tumors and was evaluated by the inhibition of tumor growth and the magnitude of the increase in average life expectancy. When studying the antitumor activity on 60 cell lines of tumor cells (NCI60), clonogenic cells of C6 rat glioma, a high antitumor activity of some arglabin derivatives was established. The connection between the structure of arglabin derivatives and their inhibitory effect on farnesyl protein transferase, topoisomerases -I and -II was studied.

A Study on Chinese Residents' Willingness to Delay Retirement Based on Machine Learning Algorithm

At present, the problem of population aging caused by the increase of average life expectancy continues to worsen, and thus leads to a series of problems. The implementation of a delayed retirement policy in China will affect everyone. In this paper, the data of China Health and Pension tracking survey in 2018 are used. Firstly, the optimal parameter combination of deep neural network, RF, GBDT and XGBoost are obtained by grid search algorithm to conduct single model modeling. On the basis of the above four single models, linear effects are introduced by logistic regression. By using the idea of model fusion, a new prediction model is obtained by weighted fusion learning of the above five models. The important factors affecting the public's retirement intention are found and the high precision prediction of retirement intention classification is carried out.