This study investigated the interplay between personality traits and mobile phone use while driving (MPUWD) among 392 drivers in Zahedan. The study revealed that individuals with higher levels of agreeableness and conscientiousness were less likely to MPUWD. For each unit increase in agreeableness or conscientiousness, there was an 8 % decrease in the odds of MPUWD, along with decreases in various phone-related activities. Conversely, individuals with higher levels of neuroticism were more likely to engage in MPUWD, with increased odds for various activities. Open-minded individuals tended to avoid MPUWD, showing decreases in odds for certain activities with each unit increase. Additionally, higher extraversion scores were associated with decreased odds of taking pictures while driving. Notably, the study highlighted the positive association between agreeableness and hands-free MPUWD. Additionally, the study demonstrated that personality traits molded TBP constructs and moral norms. The multiple regression model revealed that agreeableness exhibited significant relationships with behavior intention, while conscientiousness was linked to attitude, perceived behavior control, and subjective norms. Furthermore, moral norms demonstrated significant associations with both agreeableness and conscientiousness. However, the study's reliance on self-reported measures may introduce biases, highlighting the importance of incorporating objective measures and observational data in future research to enhance validity.