Incorporated Iron Oxide Research Articles

Incorporating iron oxide nanoparticles in polyvinyl alcohol/starch hydrogel membrane with biochar for enhanced slow-release properties of compound fertilizers

Biochar-based fertilizers show promise in enhancing nutrient utilization and soil health, but their slow-release performance remains a challenge. Herein, hydrogel membranes incorporating iron oxide nanoparticles within a polyvinyl alcohol and starch matrix (Fe/PVA/ST) were synthesized. These membranes were utilized to coat compound fertilizer particles, with biochar powder applied to the outer layer to form what is known as Fe/PVA/ST-BSRFs. The results revealed that Fe/PVA/ST-BSRFs exhibit markedly improved slow-release performance compared to both PVA/ST-BSRFs lacking iron nanoparticles and commercial compound fertilizers. Within a 30-day period, the cumulative leaching ratios of N, P, and K from Fe/PVA/ST-BSRFs with 0.75 % iron content were significantly lower compared to other tested fertilizers, with values of 22.87 %, 34.93 %, and 84.08 %, respectively. Furthermore, the incorporation of iron oxide nanoparticles into the PVA/ST membrane enhanced its swelling and water-retention properties without compromising its biodegradability. Mechanistic investigations revealed that the exceptional slow-release properties of Fe/PVA/ST-BSRFs stem from a combination of nutrient diffusion control outside the membrane and the loose control mechanism of the membrane. Pot tests demonstrated that Fe/PVA/ST-BSRFs effectively promoted the growth of chili plants while ensuring high utilization of N-P-K and improving the nutritional indices of chili fruits. Economic analysis further underscored the promising application prospects of Fe/PVA/ST-BSRFs.

Magnetic Nanoparticles in Biopolymer Fibers: Fabrication Techniques and Characterization Methods.

Hybrid nanocomposites combining biopolymer fibers incorporated with nanoparticles (NPs) have received increasing attention due to their remarkable characteristics. Inorganic NPs are typically chosen for their properties, such as magnetism and thermal or electrical conductivity, for example. Meanwhile, the biopolymer fiber component is a backbone, and could act as a support structure for the NPs. This shift towards biopolymers over traditional synthetic polymers is motivated by their sustainability, compatibility with biological systems, non-toxic nature, and natural decomposition. This study employed the solution blow spinning (SBS) method to obtain a nanocomposite comprising poly(vinyl pyrrolidone), PVA, and gelatin biodegradable polymer fibers incorporated with magnetic iron oxide nanoparticles coated with poly(acrylic acid), PAA2k, coded as γ-Fe2O3-NPs-PAA2k. The fiber production process entailed a preliminary investigation to determine suitable solvents, polymer concentrations, and spinning parameters. γ-Fe2O3-NPs were synthesized via chemical co-precipitation as maghemite and coated with PAA2k through the precipitation-redispersion protocol in order to prepare γ-Fe2O3-NPs-PAA2k. Biopolymeric fibers containing coated NPs with sub-micrometer diameters were obtained, with NP concentrations ranging from 1.0 to 1.7% wt. The synthesized NPs underwent characterization via dynamic light scattering, zeta potential analysis, and infrared spectroscopy, while the biopolymer fibers were characterized through scanning electron microscopy, infrared spectroscopy, and thermogravimetric analysis. Overall, this study demonstrates the successful implementation of SBS for producing biopolymeric fibers incorporating iron oxide NPs, where the amalgamation of materials demonstrated superior thermal behavior to the plain polymers. The thorough characterization of the NPs and fibers provided valuable insights into their properties, paving the way for their potential applications in various fields such as biomedical engineering, environmental remediation, and functional materials.

Temporal Characterization of Prion Shedding in Secreta of White-Tailed Deer in Longitudinal Study of Chronic Wasting Disease, United States.

Chronic wasting disease (CWD) affects cervids in North America, Asia, and Scandinavia. CWD is unique in its efficient spread, partially because of contact with infectious prions shed in secreta. To assess temporal profiles of CWD prion shedding, we collected saliva, urine, and feces from white-tailed deer for 66 months after exposure to low oral doses of CWD-positive brain tissue or saliva. We analyzed prion seeding activity by using modified amyloid amplification assays incorporating iron oxide bead extraction, which improved CWD detection and reduced false positives. CWD prions were detected in feces, urine, and saliva as early as 6 months postinfection. More frequent and consistent shedding was observed in deer homozygous for glycine at prion protein gene codon 96 than in deer expressing alternate genotypes. Our findings demonstrate that improved amplification methods can be used to identify early antemortem CWD prion shedding, which might aid in disease surveillance of cervids.

4D printing thermo-magneto-responsive PETG-Fe3O4 nanocomposites with enhanced shape memory effects

In this groundbreaking study, Polyethylene Terephthalate Glycol (PETG)-Fe3O4 nanocomposites were developed for 4D printing, incorporating iron oxide (Fe3O4) nanoparticles into PETG matrix. The research contribution lies in its innovative approach to enhancing the shape memory effect (SME) through thermo-magnetic responsiveness, positioning PETG-Fe3O4 as a revolutionary material in smart additive manufacturing. The composites were synthesized using a melt mixing method, followed by 3D printing into specimens for comprehensive evaluation through dynamic mechanical thermal analysis (DMTA), scanning electron microscopy (SEM), and uniaxial tensile tests. The findings revealed that the incorporation of Fe3O4 nanoparticles significantly boosts the composites’ storage modulus and glass transition temperature, indicative of improved stiffness and thermal properties. Notably, the 15 % Fe3O4 composite emerged as the optimal blend, exhibiting the highest tensile strength and a favourable balance between mechanical integrity and flexibility. A key result was the enhanced SME under both thermal and magnetic stimuli, with recovery efficiency and speed escalating with nanoparticle concentration. This advancement underscores the potential of PETG-Fe3O4 nanocomposites in fabricating smart structures capable of environmental adaptability, paving the way for impacts in biomedical, aerospace, and robotic devices. Through this work, a new paradigm in material functionality for 4D printing has been established, demonstrating the viability of magnetic nanoparticle integration for added smart capabilities.

Efficient adsorptive removal of 2,4-dichlorophenoxyacetic acid (2,4-D) using biomass derived magnetic activated carbon nanocomposite in synthetic and simulated agricultural runoff water

This study focused on evaluating the efficacy of a magnetic activated carbon material (CPAC@Fe3O4) derived from pods of copper pod tree in adsorbing the toxic herbicide, 2,4- (2,4-D) from aqueous solutions. The synthesized CPAC@Fe3O4 adsorbent, underwent various characterization techniques. FESEM images indicated a rough surface, incorporating iron oxide nanoparticles, while EDS analysis confirmed the presence of elements like Fe, O, and C. Notably, the CPAC@Fe3O4 exhibited high surface area (749.10 m2/g) and pore volume (0.5351 cm³/g), confirming its mesoporous nature. XRD investigations identified distinct signals associated with graphitic carbon and magnetite nanoparticles, while VSM analysis verified its magnetic properties with a high magnetic saturation value (2.72 emu/g). The adsorption process was exothermic, with a decrease in adsorption capacity at higher temperatures. Freundlich isotherm provided the best fit for the adsorption, and the pseudo-second-order equation effectively described the kinetics. Remarkably, the maximum adsorption capacity ranged from 246.43 to 261.03 mg/g, surpassing previously reported values. The ΔH° value (−8.67 kJ/mol) suggested a physisorption mechanism, and the negative ΔG° values established the spontaneous nature. Furthermore, the synthesized adsorbent demonstrated exceptional reusability, allowing for up to five cycles of adsorption-desorption operations. When applied to simulated agricultural runoff, CPAC@Fe3O4 showcased a significant adsorption capacity of 160.71 mg/g for 50 mg/L 2,4-D, using a 0.2 g/L dosage at pH 2. This study showcased the transformation of copper pod biomass into a valuable magnetic nanoadsorbent capable of efficiently eliminating the noxious 2,4-D pollutant from aqueous environments.

Atrazine degradation through a heterogeneous dual-effect process using Fe–TiO2-allophane catalysts under sunlight

This study investigated the novel application of Fe–TiO2-allophane catalysts with 6.0 % w/w of iron oxide and two TiO2 proportions (10 % and 30 % w/w) for degrading atrazine (ATZ) using the heterogeneous dual-effect (HDE) process under sunlight. Comparative analyses with Fe-allophane and TiO2-allophane catalysts were conducted in both photocatalysis (PC) and HDE processes. FTIR spectra reveal the unique hydrous feldspathoids structure of allophane, showing evidence of new bond formation between Si–O groups of allophane clays and iron hydroxyl species, as well as Si–O–Ti bonds that intensified with higher TiO2 content. The catalysts exhibited an anatase structure. In Fe–TiO2-allophane catalysts, iron oxide was incorporated through the substitution of Ti4+ by Fe3+ in the anatase crystal lattice and precipitation on the surface of allophane clays, forming small iron oxide particles. Allophane clays reduced the agglomeration and particle size of TiO2, resulting in an enhanced specific surface area and pore volume for all catalysts. Iron oxide incorporation decreased the band gap, broadening the photoresponse to visible light. In the PC process, TiO2-allophane achieves 90 % ATZ degradation, attributed to radical species from the UV component of sunlight. In the HDE process, Fe–TiO2-allophane catalysts exhibit synergistic effects, particularly with 30 % w/w TiO2, achieving 100 % ATZ degradation and 85 % COD removal, with shorter reaction time as TiO2 percentage increased. The HDE process was performed under less acidic conditions, achieving complete ATZ degradation after 6 h without iron leaching. Consequently, Fe–TiO2-allophane catalysts are proposed as a promising alternative for degrading emerging pollutants under environmentally friendly conditions.

Iron Oxide-Activated Carbon Composites for Enhanced Microwave-Assisted Pyrolysis of Hardwood

A commercial activated carbon (AC) was modified through iron oxide incorporation to obtain microwave absorbers (MWAs) for microwave-assisted pyrolysis. The influence of iron oxide content (5 and 20 wt% Fe3O4) and the modification methods were tested as follows: (1) in situ co-precipitation + washing step with Milli-Q; (2) in situ co-precipitation + washing step with Milli-Q/ethanol; and (3) physical iron oxide blending. The resulting MWAs were evaluated on the microwave-assisted pyrolysis of hardwood in a Milestone Flexiwave microwave reactor. The biochar yield varied from 24 wt% to 89 wt% and was influenced by the modification method rather than the iron oxide addition. The MWAs with physically blended iron oxide resulted in biochar yields comparable to conventional biochar (450 °C). Furthermore, the addition of iron oxide-activated carbon composites during the microwave-assisted pyrolysis caused a significant decrease in the biochar’s 16 EPA polycyclic aromatic hydrocarbons, mainly by reducing the amount of pyrene in the biochar.

Enhancing osteogenic bioactivities of coaxial electrospinning nano-scaffolds through incorporating iron oxide nanoparticles and icaritin for bone regeneration

Enhancing osteogenic bioactivities of coaxial electrospinning nano-scaffolds through incorporating iron oxide nanoparticles and icaritin for bone regeneration

Structural, thermal and optoelectrical study of PVA/iron oxide nanocomposite films

AbstractThe work reported here deals with fabricating iron oxide nanoparticles incorporated polyvinyl alcohol nanocomposite films via the solution‐casting green route, characterized using various characterization techniques. X‐ray diffraction analysis shows interaction of nanoparticles with the polyvinyl alcohol matrix, scanning electron microscopy shows surface morphology of crack‐free films, energy dispersive spectroscopy indicates elemental purity, tensiometer analysis shows changing behavior of hydrophilic to hydrophobic, thermogravimetric analysis shows improved thermal stability, ultraviolet‐visible spectroscopy shows tunable optical properties, and frequency response analysis shows improved electrical properties. A small incorporation (1 wt. %) of iron oxide nanoparticles has induced significant alternations in structural, wetting, thermal, optical, and electrical properties of the polyvinyl alcohol‐based nanocomposite films. Results showed notable changes in the structural phases, water contact angle (39.5° to 97.7°), optical absorption edge (5.12 eV to 4.84 eV), indirect band gap (4.99 eV to 4.68 eV), direct bandgap (5.41 eV to 5.21 eV), and band tail (0.57 eV to 0.89 eV) from native polyvinyl alcohol to polyvinyl alcohol/iron oxide nanocomposite films. Enhancements were observed in refractive indices, optical conductivity, optical dielectric loss, thermal stability, dielectric constant, and dielectric loss on incorporating iron oxide nanoparticles into the polyvinyl alcohol matrix. The fabricated nanocomposite films might be a potential material for optoelectronic and microelectronics applications.

Enhancing energy efficiency and heat transfer performance of engine oil flow through hybrid nanoparticles in convergent/divergent channel

Engine oil (EO) is employed as a lubricant in various machinery engines. Efficient heat transfers are a fundamental requirement for all processes. To improve heat transfer rates and reduce the energy loss caused by high temperatures, this study focuses on incorporating Iron Oxide (Fe3O4) and Cupper Oxide (CuO) into the engine oil as suspended particles. However, the focus of this research paper is to analyze entropy generation in a convergent/divergent channel that contains a hybrid nanofluid. Mathematical modeling is utilized to present the continuity, momentum, and energy equations. Using the resemblance transformation variables, the governing dimensional partial differential equations (PDEs) are transformed into a system of non-dimensional ordinary differential equations (ODEs), which are then resolved in ascending order through the BVP4c scheme. The graphical results illustrate the effects of various parameters on fluid velocity, temperature, entropy generation, and Bejan number. The study explores changes in velocity profiles under different Hartmann numbers, revealing opposing variations in divergent and convergent channels. Velocity profiles exhibit similar patterns when varying the porosity parameter. In the convergent passage, a higher porosity parameter results in a higher temperature field. Entropy rises against Eckert and Hartmann numbers in both Convergent and Divergent cases. These insights aid in designing and optimizing machinery engines.

Investigating the mechanical properties of al7075 metal matrix composite with improved performance through the incorporation of fe3o4 and RHS

Heavily employed in engineering, Metal Matrix Composites are the primary focus of this research. Metal Matrix Composites have much improved mechanical properties and find extensive use across several sectors, including automotive and aerospace. The experiment entails using aluminium (Al7075) as the base material and incorporating iron oxide and RHS in weight ratios of 3%, 6%, and 9% to fabricate a strengthened Metal Matrix Composite. The stir-casting technique is used for the fabrication of these composites. The stir casting technology is selected because to its advantages, including its straightforward manufacturing process, cost efficiency, and reliable distribution of reinforced particles. The Fe3O4 reinforcing particle and RHS have a significant impact on the engineering material properties. The examination revealed enhancements in mechanical properties, including tensile, compression, and hardness strengths. The tensile strength of the 9% wt. reinforced Fe3O4 and RHS is found to be the highest at 362 MPa, while the yield strength is measured at 262 MPa, when compared to the original Al- 7075 alloy. Furthermore, the recently manufactured Al7075/Fe3O4 and RHS Metal Matrix Composite were subjected to microstructural examinations using SEM and EDS methodologies. The investigations demonstrated a uniform and homogeneous dispersion of Fe3O4and RHS reinforced particles inside the composite material.

Exploration of the mechanical characteristics of al7075 metal matrix composite enhanced with fe3o4 and pksa

This research primarily focuses on Aluminum hybrid compounds that have extensive applications throughout every realm of manufacturing. Hybrid metal Matrix Composites possess greatly improved physical properties and find extensive utilization across several sectors, including vehicle components and even aviation. The investigation entails using aluminum (Al-7075) as the foundational component and then incorporating iron oxide and PKSA in weight ratios of 3%, 6%, and 9% to fabricate a strengthened Hybrid Metal Matrix Composite. A manufacturing stir-casting technique is being utilized for the fabrication of such compounds. Stirred molding technology is selected because of its advantages, including a very straightforward manufacturing process, cost efficiency, and reliable distribution of reinforcement particles. The inclusion of overall reinforcement grain Fe3O4/PKSA is essential to defining technical composite qualities. The current examination indicated enhancements in physical properties, including elasticity, compression, as well as toughness strength. A longitudinal value at a 9% wt. strengthened Fe3O4/PKSA is found to be the highest at 342 MPa, while the yield strength is measured at 248 MPa, as equated to a standard Al-7075 alloy. Furthermore, the recently manufactured Al-7075/ Fe3O4/PKSA HMMC were subjected to microstructural examinations using SEM and EDS methodologies. The investigations demonstrated a uniform and homogeneous dispersion of Fe3O4/PKSA reinforcement particulates inside the mixture matrix.

Removal of Rhodamine B from Wastewater by Adsorption using Iron Oxide-Polymer Composite Material

The discharge of dye-containing wastewater from textile, paper and plastic industries poses serious environmental pollution hazards. This study investigates the potential application of an ion exchange material-iron oxide composite to remove rhodamine B dye from aqueous solutions. The composite was synthesized by incorporating iron oxide nanoparticles into a cationic ion exchange matrix containing amine groups with high affinity for rhodamine B dye. Batch adsorption experiments were conducted under controlled pH, temperature and initial rhodamine B dye concentrations. The results demonstrate that the composite material can effectively remove rhodamine B dye, with adsorption capacities reaching 23570.4 mg/g and removal efficiencies over 90% under the optimal conditions at pH 7 and 30 ºC. The adsorption followed pseudo-second order kinetics indicating chemisorption as the main mechanism. The findings suggested that this composite material can serve as an efficient and low-cost adsorbent for removing cationic dyes like rhodamine B dye from textile and other industrial wastewaters due to its high capacity, rapid adsorption rate and magnetic properties that enable easy separation.

Cold atmospheric plasma-enabled platelet vesicle incorporated iron oxide nano-propellers for thrombolysis

A new approach to treating vascular blockages has been developed to overcome the limitations of current thrombolytic therapies. This approach involves biosafety and multimodal plasma-derived theranostic platelet vesicle incorporating iron oxide constructed nano-propellers platformed technology that possesses fluorescent and magnetic features and manifold thrombus targeting modes. The platform is capable of being guided and visualized remotely to specifically target thrombi, and it can be activated using near-infrared phototherapy along with an actuated magnet for magnetotherapy. In a murine model of thrombus lesion, this proposed multimodal approach showed an approximately 80 % reduction in thrombus residues. Moreover, the new strategy not only improves thrombolysis but also boosts the rate of lysis, making it a promising candidate for time-sensitive thrombolytic therapy.

Novel polycarbonate/Fe3O4 nanocomposite membranes: Fabrication and performance evaluation in water treatment

AbstractIn this work, a novel polycarbonate (PC) nanocomposite membrane was prepared by incorporation of iron oxide (Fe3O4) nanoparticles using the nonsolvent induced phase separation method. The prepared membranes was applied in a submerged membrane system for bovine serum albumin (BSA) filtration through two cycles of 60 min. The properties and performance of fabricated membranes was characterized using water content, porosity, water contact angle, mechanical and thermal properties, membrane morphology including FESEM and AFM, antifouling performance, and BSA rejection. Results showed that by incorporation of Fe3O4 up to 0.5 wt.% in membrane, the hydrophilicity and porosity was increased and then decreased again by more nanoparticles concentration. DSC analysis indicated that Tg of membrane increased from 135.2 to 140.1°C when 0.5 wt.% of Fe3O4 was used. Also, the results of FESEM images revealed that addition of Fe3O4 nanoparticles significantly increased the number and pore size of membrane surface. According to AFM analysis, the membrane containing 0.5 wt.% showed smoother surface as compared to other membranes. Additionally, the PC/Fe3O4–0.5 membrane had better antifouling properties in term of high flux recovery ratio of 82.3% and 85% in the first and second cycles, respectively, while the neat PC membrane showed lower FRR of 70.4% and 74%.

Formulation, Characterization, and Cytotoxic Effect of PVA Incorporated Iron Oxide Nanoparticles of Gramine Using HCT-116 Cell Line in vitro

Formulation, Characterization, and Cytotoxic Effect of PVA Incorporated Iron Oxide Nanoparticles of Gramine Using HCT-116 Cell Line in vitro

Molecular Modelling and Characterization of Metal Incorporated Biochar from Industrial Wastes

Globally, manufacturing industries are generating a large volume of solid waste during their processes. These wastes, when spread through soil/water affect public health. This work focuses on the use of solid industrial waste from herbal medicine and TiO2 manufacturing industries to produce iron oxide incorporated biochar, which can be served as adsorbent and low cost catalyst for many reactions. Biochar was produced by the slow pyrolysis of waste collected from herbal manufacturing units using tubular furnace at 550°C at a heating rate of 5°C/min. The iron oxide waste collected from Kerala Minerals and Metals Limited, Kerala, India (KMML), was incorporated into the produced biochar by using planetary ball mill apparatus. Structural and elemental analysis of produced biochar and Fe2O3 incorporated biochar was conducted using XRD, SEM and SEM-EDS, BET surface area analysis, ICP-OES, and CHNS analysis. The H/C ratio of prepared biochar shows it has a rectangular layered structure of 50*50 aromatic cluster size. The changes in bonds and groups before and after metal incorporation were studied using FTIR spectroscopic analysis and temperature stability of prepared samples were analyzed using TGA. The molecular structure of produced biochar and changes in their bond length was studied and optimized employing Avogadro and Chemcraft software. The BET analysis shows the surface area of biochar become increased after the metallic incorporation. The same results were concluded from the molecular modelling data obtained from Chemcraft software. These results proved that the biochar surface area and pore volume can be increased by incorporation of iron oxide from industrial waste.

Complex dielectric-impedance spectroscopic studies of magnetite added chitin biopolymer

We have successfully synthesized magnetic chitin (MCH) by incorporating iron oxide nanoparticles into biodegradable and abundantly naturally available chitin by the coprecipitation method. X-ray diffraction (XRD) characterization revealed formation of cubic inverse spinel structure of Fe3O4 nanoparticles. In addition to this, other characterization studies like energy dispersive X-ray analysis (EDX) and vibrating sample magnetometry (VSM) were also performed to have an insight into the compositional and functional nature of the structure. A detailed spectroscopic study of complex impedance and dielectric constant for a wide frequency range of ~1 Hz to 10 MHz at discrete temperatures ~300–400 K has been performed by us for the first time on MCH in order to understand various relaxation processes. From permittivity, we have estimated the height of the potential barrier to be ~95.8 ± 0.3 meV. Impedance measurements yielded an activation energy of ~35.85 meV. Thermogravimetric analysis (TGA) of the sample showed exceptionally high thermal stability of the sample with percentage of residual mass at 800 ℃ being ~73% in MCH, which is quite high in comparison to the pristine chitin. An S shaped curve obtained through VSM measurement confirmed the superparamagnetic nature of the nanocomposite. The study assumes significance in the present scenario of rising awareness about the environment and demand to explore alternative green materials with numerous biomedical/environmental applications ranging from drug delivery vehicles in COVID-19 treatment to food packaging.

Enhancement of surface area of iron oxide modified by natural moieties towards defluoridation from water and antibacterial properties

A novel adsorbent has been developed by modifying iron oxide (Fe2O3) surface using humic acid (HA) biopolymer and reduced graphene oxide (rGO), resulting in a highly efficient composite rGO/HA-Fe2O3 with magnetic property for removal of fluoride. The surface area of the composite is found to be 455.6 m2/g which has been enhanced around five times after modification with rGO and HA. Batch adsorption experiments were conducted to determine the optimal conditions for fluoride adsorption. The study found that the maximum fluoride adsorption occurred at adsorbent dose of 0.3 g/L, pH 7, contact time of 120 min. Equilibrium adsorption study data best fitted for the freundlich isotherm model, whereas, kinetic studies follow second-order kinetics which demonstrates multilayer adsorption on a heterogeneous surface with chemisorption type interaction. The adsorption process was found to be feasible, spontaneous, endothermic in nature and also the adsorbent was capable of removing around 99% of fluoride at 100 ppm initial fluoride concentration. The composite demonstrated a fluoride removal capacity of 376.46 and 395.32 mg/g at 30 and 50 °C, respectively, at pH 7, and also exhibited antibacterial properties. The composite was successfully regenerated using a 0.1 M alkaline solution with 98% efficiency and can be reused up to four cycles with an efficiency of 83.1%. The antibacterial property of the composite was assessed using solutions of Escherichia coli in water. This study is unique in its use of humic biopolymer in fluoride adsorption studies with graphene oxide, incorporating iron oxide to maintain a neutral pH during the adsorption process. The high surface area of the rGO/HA-Fe2O3 facilitates for removal of fluoride up to a very high-level fluoride concentration broadening its practical applications in various aspects. Moreover, this adsorbent is cost-effective as the precursors are easily and abundantly available in the natural environment.

Targeted treatment of triple-negative-breast cancer through pH-triggered tumour associated macrophages using smart theranostic nanoformulations

Triple-negative breast cancer (TNBC) represents 15–25 % of the new breast cancer cases diagnosed worldwide every year. TNBC is among the most aggressive and worst prognosis breast cancer, mainly because targeted therapies are not available. Herein, we developed a magnetic theranostic hybrid nanovehicle for targeted treatment of TNBC through pH-triggered tumour associated macrophages (TAMs) targeting. The lipid core of the nanovehicle was composed of a Carnaúba wax matrix that simultaneously incorporated iron oxide nanoparticles and doxorubicin (DOX) - a chemotherapeutic drug. These drug-loaded wax nanovehicles were modified with a combination of two functional and complementary molecules: (i) a mannose ligand (macrophage targeting) and (ii) an acid-sensitive sheddable polyethylene glycol (PEG) moiety (specificity). The TAMs targeting strategy relied on the mannose − mannose receptor recognition exclusively after acid-sensitive “shedding” of the PEG in the relatively low tumour microenvironment pH. The pH-induced targeting capability towards TAMs was confirmed in vitro in a J774A.1 macrophage cell line at different pH (7.4 and 6.5). Biocompatibility and efficacy of the final targeted formulations were demonstrated in vitro in the TNBC MDA-MB-231 cell line and in vivo in an M-Wnt tumour-bearing (TNBC) mouse model. A preferential accumulation of the DOX-loaded lipid nanovehicles in the tumours of M-Wnt-tumour bearing mice was observed, which resulted both on an efficient tumour growth inhibition and a significantly reduced off-target toxicity compared to free DOX. Additionally, the developed magnetic hybrid nanovehicles showed outstanding performances as T2-contrast agents in magnetic resonance imaging (r2 ≈ 400–600 mM−1·s−1) and as heat generating sources in magnetic hyperthermia (specific absorption rate, SAR ≈ 178 W·g−1Fe). These targeted magnetic hybrid nanovehicles emerge as a suitable theranostic option that responds to the urgent demand for more precise and personalized treatments, not only because they are able to offer localized imaging and therapeutic potential, but also because they allow to efficiently control the balance between safety and efficacy.