A numerical framework is presented to predict the transport of soft elastic capsules immersed in an incompressible fluid with the aim of simulating inertial microfluidics applications. The flow evolution is modeled by a fully incompressible lattice Boltzmann method whereas a finite element model is considered for describing the dynamics of deformable structures. An immersed boundary technique is adopted to reconstruct the solution in the vicinity of the immersed surface and the time integration of the fluid-structure interaction problem is obtained by following an explicit procedure. The effectiveness of the framework is validated by means of several test cases involving: flows between two parallel plates for Reynolds numbers in the range 1÷100; capsules immersed in a fluid at Stokes regime exhibiting small and large deformations under shear; capsules migrating in a long straight microchannel with square cross-section at low-to-moderate Reynolds number. A very good agreement between the present results and literature data obtained using different numerical methods is found for all test cases. Finally, the method allowed to accurately simulate incompressible flows subjected to large pressure difference between the inlet and the outlet, characteristic of long curved microchannels, obtaining very smooth particle dynamics.
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