Objectives: To conduct a comparative analysis of the outcomes associated with needle aspiration and surgical incisionand drainage of breast abscess.Study Design: Randomized controlled trial.Place and duration of study: The present investigation was carried out at the Department of Surgery, ServicesInstitute of Medical Sciences, Lahore, spanning a duration of six months from July 2020 to January 2021.Methods: The research comprised a cohort of 60 female patients, aged 18 to 65 years, who presented with unilateralbreast abscess. These patients were separated into two equal groups, each consisting of 30 individuals. The femaleparticipants in Group-NA had ultrasonic-guided needle aspiration, while the female participants in Group-I&Dunderwent incision and drainage of the breast abscess. The main variables assessed in this study were the duration ofthe surgery and the length of hospitalization for both groups.Results: The age range in this research was 25–58 years old, with a mean±SD of 39.93±13.97 years. GroupNA had an abscess of 7.2±1.71 cm, while Group-I&D had an abscess measuring 6.96±1.56 cm. The study’smajor findings indicate that Group-N A needed considerably less time for the surgery (7.2±1.54 Vs 19.96±2.77minutes, p=0.000) than Group-I&D. Similarly, Group-NA’s mean hospital stay length was considerably shorterthan Group-I&D’s (1.63 ± 1.06 Vs. 3.23 ± 1.38 days, p=0.000).Conclusion: The main benefits of needle aspiration over incision and drainage procedures for female patients withbreast abscesses include shorter operation times and shorter hospital stays.Keywords: Breast abscess, Incision & Drainage, Needle aspiration.