Tooth defects can affect not only periodontal tissue but also the whole body if not restored in good time. Composite resin materials are commonly used filling materials in dental restorations, but they have low material strength and are likely to cause insufficient secondary caries. Improving the ability of composite resin materials to restore defective teeth has thus become the focus of research interest. Nanocomposite materials are widely used in dentistry because of their good design characteristics, wide indications, strong restorative power, and high economic efficiency. However, whether they cause respiratory tract inflammation or tissue damage due to their large specific surface area still needs further investigation. This study compared the effects of nanocomposite resin materials with those of traditional light-curable composite resin materials on the restoration of dental defects in elderly patients and found that nanomaterials could not only reduce the incidence of tooth sensitivity and tooth pain after restoration but also improve the aesthetic outcomes of the tooth. In addition to the restoration effect, the occurrence of adverse reactions in patients who underwent dental restoration using nanomaterials within 2 years after the procedure was significantly lower than that in patients who underwent dental restoration using traditional materials. These results indicate that the nanocomposite resin material improved the restoration effect in elderly patients without increasing their risk for adverse reactions. Therefore, nanocomposite resin materials should be used as the preferred filling material for dental restoration in elderly patients with dental defects.