Incidence Of Preeclampsia In Pregnancies Research Articles

Relationship between Detection of Preeclampsia High-Risk by Pregnant Women and Health Workers with the Success of the Preeclampsia Eradication Program at the Nogosari Health Center

The background of Preeclampsia Eradication Program is a program that seeks to accelerate the reduction in the incidence of preeclampsia in pregnancy, delivery and postpartum as well as comprehensive management of preeclampsia events, so that it is expected to reduce the number of maternal mortality rates (MMR). In Boyolali, Indonesia, the number of MMR in 2020 was 17 cases, where one of the causes of death was preeclampsia. Efforts are being made by the government to reduce MMR and infant mortality due to preeclampsia in pregnancy with the preeclampsia eradication program which began in 2018. The purpose of the study was to determine the relationship between detection of preeclampsia high-risk by pregnant women and health workers with increasing the success of the Eradication Program at the Nogosari Health Center. Research design Quantitative research that uses correlation analysis by using the approach retrospective. The results of data analysis using chi-square obtained results of detection of preeclampsia high-risk by pregnant women obtained the value of p-value 0.00 while for FIGO screening by health workers obtained a value of p-values 0.00. The results of the study showed that the variable detection of preeclampsia by pregnant women, FIGO screening by health workers had a significant relationship with the success of the preeclampsia eradication program with p value = 0.000, p = 0.000. where most of the respondents had poor knowledge as many as 40 respondents (66.7%), while for FIGO screening by health workers the score was obtained p-value 0.00 < 0.05 where most of the respondents, namely 41 respondents (68.3%) received incomplete FIGO screening.

THE CORELATION BETWEEN MOTHER'S WEIGHT INCREASE WITH PRE-ECLAMPSION IN PREGNANCY AT SITI KHOLIZAH CLINIC

Pre-eclampsia/eclampsia is one of the main causes of maternal death in Indonesia. The cause of pre-eclampsia in pregnant women is not known with certainty, although there have been several theories that try to explain the cause of pre-eclampsia is placental ischemia. The purpose of this study was to see the relationship between maternal weight gain and the incidence of preeclampsia in pregnancy. This type of research is an observational retrospective analytic study. Analytical observational research. The research location was at the Siti Kholizah Clinic, Medan Marelan District. The statistical test used the Chi Square test with a statistical significance p value of 0.05. After conducting research on statistical data tests, it was found that the increase in body weight during pregnancy has a relationship with the incidence of preeclampsia in pregnancy. There is a significant relationship between weight gain during pregnancy and the incidence of preeclampsia in pregnancy, with a p value of 0.003

Role and expression of miRNAs (miRNA 548e_5p, miRNA 873_5p, miRNA 378b) in fetal development and incidence of Preeclampsia in pregnancy

Role and expression of miRNAs (miRNA 548e_5p, miRNA 873_5p, miRNA 378b) in fetal development and incidence of Preeclampsia in pregnancy

HUBUNGAN OBESITAS DENGAN KEJADIAN PREEKLAMSIA PADA IBU HAMIL

<p><strong><em>Background </em></strong><em>: WHO noted that every year more than 300,000 women die from complications of pregnancy and childbirth. The main causes of maternal death are bleeding, gestational hypertension (preeclampsia and eclampsia) and sepsis. In Indonesia bleeding, hypertension in pregnancy and infection are still the most common causes of maternal death. The purpose of this study was to determine the relationship between obesity and the incidence of preeclampsia in pregnant women. </em></p><p><strong><em>Methods</em></strong><em> : This research is an analytical survey research design with a cross sectional approach. The population in this study were all pregnant women who visited the Manna City Health Center in July-November 2021 totaling 153 people. The sample of this study was 110 respondents who were taken at random systematically by dividing the desired number of samples using the </em><em>Simple Random </em><em>sampling</em><em> method. Data were processed by univariate and bivariate analysis</em></p><p><strong><em>Results</em></strong><em> : from 110 respondents, there were 100 people (90.9%) who were obese and 10 people (9.1%) who were not obese and 97 people who did not have preeclampsia 97 people (88.2 %) and 13 people (11.8%) who had preeclampsia. From the statistical test results of the chi-square test, it is known that the calculated X2 value = 87.3 > X2 table = 5.991 with a value of = 0.000 (<0.05) meaning that there is a significant relationship between obesity and the incidence of preeclampsia in pregnancy at the Manna City Health Center.</em></p><strong><em>Conclusion</em></strong><em> : It is recommended for pregnant women to maintain a regular diet and exercise and regularly check their pregnancy to health workers.</em>

Incidence of pre-eclampsia and other perinatal complications among pregnant women with congenital heart disease: systematic review and meta-analysis.

It has been proposed recently that pre-eclampsia (PE) may originate from maternal cardiac maladaptation rather than primary placental insult. As congenital heart disease (CHD) is associated with reduced adaptation to the hemodynamic needs of pregnancy, it is hypothesized that women with CHD have an increased risk of PE. The aim of this systematic review was to investigate the risk of PE in pregnant women with CHD. A systematic search was performed to identify relevant studies published in English, Spanish, French, Italian, Chinese or German, with no time restrictions, using databases such as PubMed, Web of Science and SCOPUS. Randomized controlled trials and observational studies (prospective or retrospective cohorts) of pregnant women with a history of CHD were sought. The main outcome was the incidence of PE (including eclampsia and HELLP syndrome). For quality assessment of the included studies, two reviewers assessed independently the risk of bias. For the meta-analysis, the incidence of PE in pregnancies (those beyond 20 weeks' gestation) was calculated using single-proportion analysis by random-effects modeling (weighted by inverse variance). Heterogeneity between studies was assessed using the χ2 (Cochran's Q), tau2 and I2 statistics. Subgroup analysis was performed, and meta-regression was used to assess the influence of several covariates on the pooled results. A total of 33 studies were included in the meta-analysis, including 40 449 women with CHD and a total of 40 701 pregnancies. The weighted incidence of PE was 3.1% (95% CI, 2.2-4.0%), with true-effect heterogeneity of 93% according to I2 , and no publication bias found. No difference was found in the weighted incidence of PE between studies including cyanotic CHD vs those excluding (or not reporting) cyanotic CHD (2.5% (95% CI, 1.6-3.4%) vs 4.1% (95% CI, 2.4-5.7%); P = 0.0923). Meta-regression analysis showed that the only cofactor that significantly influenced the incidence of PE in each study was the reported incidence of aortic stenosis; studies with a higher incidence of aortic stenosis had a higher incidence of PE (estimate: 0.0005; P = 0.038). We failed to demonstrate an incidence of PE above the expected baseline risk in women with CHD. This observation contradicts the theory of the cardiac origin of PE. © 2020 International Society of Ultrasound in Obstetrics and Gynecology.

Body Mass Index (BMI) and Special History on the Event of Gestasional Preeclampsia Study in Jombang District Health Center

Background: The most common cause of maternal death in Indonesia is direct obstetric causes, namely28% bleeding, 24% preeclampsia-eclampsia, 11% infection, while indirect causes are obstetric trauma 5%and others 11%. Preeclampsia is hypertension that arises after 20 weeks of pregnancy accompanied byproteinuria. Preeclampsia ranks second cause of maternal death after bleeding.Purpose: The study aims to analyze body mass index (BMI) and spesific history of the preeclampsiagestasional events.Method: The research was conducted with Cross Sectional research type. The study was conducted inthe working area of Jombang Regency in February dd July 2019. The population in this study were allpregnant women with preeclampsia who conducted examinations in independent practice midwives inFebruary, March 2019 totaling 168 pregnant women. Total sampling technique. The research instrumentused a questionnaire with the value of Cronbach’s Alpha 0.862.Results:The results of the analysis showed that the independent variables associated with the incidence ofpreeclampsia were Body Mass Index with p-value 0.003; Exp (B); 11,234, variable history of hypertensionin pregnancy with p-value 0,000; Exp (B); 11,387, and diabetes variable with p-value 0,003; Exp (B); 11,334.Body mass index in the obesity category, history of hypertension and diabetes are the biggest contributingfactors to the incidence of preeclampsia in pregnancy.Conclusion: The study concluded that history of hypertension and diabetes are the biggest contributingfactors to the incidence of preeclampsia in pregnancy.

Risk factors associated with pre-eclampsia in pregnancies conceived by ART.

What are the factors associated with the increased incidence of pre-eclampsia in pregnancies conceived through IVF using autologous oocytes? A nested case-control study from the combined cohort of three multicentre randomized trials comparing fresh to frozen embryo transfer, including women who achieved clinical pregnancy after the first embryo transfer. Multivariable logistic regression was used to assess the effect of baseline characteristics, ovarian response parameters, type of fertilization, type of embryo transfer, and number of gestational sacs on the risk of pre-eclampsia. There were 2965 clinical pregnancies and 90 women were diagnosed with pre-eclampsia. Twin gestations (odds ratio [OR] 2.34, 95% confidence interval [CI] 1.50-3.66), mean arterial pressure (OR 1.04, 95% CI 1.01-1.07), frozen embryo transfer (OR 2.06, 95% CI 1.27-3.35), body mass index (BMI) (OR 1.10, 95% CI 1.02-1.18), progesterone level on the day of human chorionic gonadotrophin trigger (OR 1.53, 95% CI 1.07-2.20), and the total dose of gonadotrophin (OR 0.999, 95% CI 0.999-1.000, P = 0.037) were associated with the risk of pre-eclampsia. When the analysis was confined to women who underwent frozen embryo transfer, twin gestations (OR 2.44, 95% CI 1.43-4.18), BMI (OR 1.13, 95% CI 1.03-1.23) and the total dose of gonadotrophin (OR 0.999, 95% CI 0.999-1.000, P = 0.014) were still related to the risk of pre-eclampsia. The embryo stage at transfer was not included in the final models. Frozen embryo transfer was an independent risk factor of pre-eclampsia in assisted reproductive technology. The high ovarian response may also increase the risk of pre-eclampsia. The embryo stage at transfer was not related to the risk of pre-eclampsia.

Is the use of donor sperm associated with a higher incidence of preeclampsia in women who achieve pregnancy after intrauterine insemination?

To evaluate the incidence of preeclampsia after intrauterine insemination (IUI) with either donor's or partner's sperm in women with primary infertility. Retrospective cohort study. Tertiary referral center. Between January 1999 and December 2006, 823 women who achieved pregnancy after IUI and delivered at > or =24 weeks of gestation were reviewed. Only women with primary infertility and no known medical disorders were included. On the basis of the available outcome data, the final analysis was performed in 713 pregnancies (438 pregnancies using donor's sperm and 275 pregnancies using partner's sperm). None. The incidence of preeclampsia. The incidence of preeclampsia in pregnancies resulting from donor sperm was higher than in the partner insemination group: 10.9% (48/438) versus 7.2% (20/275), respectively (difference, 3.7; 95% confidence interval -0.8 to +7.8). Logistic regression was performed controlling for the following parameters: type of sperm, number of previous cycles, and number of babies. In the final model, the variables that significantly predicted the risk of preeclampsia were the type of sperm used for insemination and the number of previous IUI cycles performed. The fewer cycles that were performed, the higher the incidence of preeclampsia that was observed. IUI with donor sperm appears to increase the incidence of preeclampsia when pregnancy is achieved. A protective effect of multiple cycles appears also to be present in this respect.

Is donor sperm associated with a higher incidence of pre-eclampsia as compared to insemination with partner's sperm?

OBJECTIVE: To evaluate the incidence of pre-eclampsia after intrauterine insemination (IUI) with either donor or partner's sperm in women with primary infertility. DESIGN: Retrospective cohort study. MATERIALS AND METHODS: Between January 2005 and December 2006, 191 women who achieved pregnancy after IUI and delivered at ≥24 weeks were reviewed. Only women with primary infertility and no known medical disorders were included. IUI with donor sperm was performed in 110 women, while in the remaining 81, partner's sperm was used. Medical record information recorded included baseline maternal data (age at conception, etiology of infertility, body mass index-BMI, infertility duration, numbers of previous cycles performed) and outcome data (number of fetuses, pregnancy complications and gestational age at delivery). Pre-eclampsia was defined as the occurrence of blood pressure ≥140/90mm Hg on at least two occasions and at least 4-6 h apart, accompanied by proteinuria ≥300 mg/24h after 20 weeks of gestation. The data were analyzed using the Chi-square and Fisher's exact tests where appropriate. A p value < 0.05 was considered to be statistically significant. RESULTS: In the donor group, indications for IUI included azoospermia (14.5%), severe oligoasthenozoospermia (4.5%), lesbian couple (59.1%) and single mother (21.8%). The indications for IUI with partner's sperm included idiopathic infertility (29.6%), moderate oligoasthenozoospermia (50.6%) and dysovulation (19.8%). No significant differences were present between the donor and the partner insemination group regarding maternal age (31.30 ±4.33 vs 30.67 ± 3.75, respectively), BMI (25.89 ± 4.49 vs 25.44 ±4.15, respectively), duration of infertility (1.99 ± 1.46 vs 2.09 ± 1.44, respectively) and number of cycles previously performed (2.92 ± 2.26 vs 2.25 ± 1.35, respectively). Although the incidence of pre-eclampsia in pregnancies resulting from donor sperm IUI (12.7%,14/110) was more than double compared to that resulting from IUI with partner's sperm (6.2%,5/81), difference was not statistically significant (p=0.13). CONCLUSIONS: Although the current data suggest that an increased incidence of pre-eclampsia is present when donor as compared to partner's sperm is used for IUI, the difference did not reach statistical significance. The study is ongoing with the aim to triple the number of patients included, covering the period between 1999 until 2006, and thus provide adequate power to draw definite conclusions.

Increased incidence of preeclampsia in pregnancies complicated by fetal malformation.

There seems to be a correlation between preeclampsia and congenital abnormalities, but whether it is positive or negative is a matter of controversy. Since it has been demonstrated that reduced perfusion of the trophoblast, which is an early feature of preeclampsia, can also represent a cause of fetal malformation, a positive correlation between the two conditions should be found. In the search for such a correlation we retrospectively examined 8,894 cases collected until 1994 by the IMER group (Indagine Malformazioni Emilia-Romagna). In the presence of malformation a higher incidence of preeclampsia was found (4.60 versus 3.47) with an odds ratio of 1.34 (95% CI = 1.08-1.67). Furthermore multivariate analysis showed that malformations of the male genital apparatus and those named 'multiple congenital abnormalities' can be considered as risk factors for preeclampsia. Since it is known that the development of male genitalia occurs under the influence of androgens, it can be hypothesized that hypoxia could act by favoring low end organ responsiveness. In our opinion the positive correlation with fetal malformations should be interpreted as clinical evidence of the early onset of the physiopathologic mechanism of preeclampsia.

Pre-eclampsia and trisomy 13.

To assess the reported association between field trisomy 13 and maternal pre-eclampsia. A retrospective case-control study. Twenty-five women who gave birth to trisomy 13 infants in southwest England between 1971 and 1989; 38 women who gave birth to trisomy 18 infants in the same region over the same time and 50 women with normal karyotype infants matched for age, parity, and date of delivery with the trisomy 13 group. The medical records of all the women in the three groups were analysed for evidence of pre-eclampsia. Four different thresholds of pre-eclampsia were used. The incidence of pre-eclampsia was compared between the three study groups and analysed separately for primigravid and multigravid women. The incidence of pre-eclampsia in pregnancies complicated by trisomy 13 was significantly higher than the incidence in the trisomy 18 and the normal karyotype control groups. This association was more pronounced in primigravid pregnancies. This, the largest survey of trisomy 13 and pre-eclampsia to date, suggests an association between the two conditions. It also supports the argument for a fetal factor in the pathogenesis of pre-eclampsia. We speculate on how genes encoded on chromosome 13 may be responsible.