Incidence Of Insomnia Research Articles

Effects of magnesium and potassium supplementation on insomnia and sleep hormones in patients with diabetes mellitus

ObjectivesDiabetes mellitus is a metabolic condition with hyperglycemia. Literature has shown a correlation between poor sleep quality and duration with an increased incidence of insomnia in diabetic individuals. The goal of this study was to determine the magnesium and potassium supplementation effect among diabetic individuals with insomnia.MethodsA randomized controlled trial (single blind) was conducted on 320 patients with diabetes; after 2 months of follow-up, 290 patients completed the trial. The Insomnia Severity Index (ISI) was used to assess the severity and duration of insomnia, before and after the trial. Tablets containing supplements were prepared: placebo (T1), magnesium (Mg, T2), potassium (K, T3), and a combination of Mg and K (T4). Melatonin and cortisol (sleep hormones) were measured from blood (serum) using an enzyme-linked immunosorbent assay (ELISA), before and after the trial.ResultsThe study included 93 (32.1%) male and 197 (67.9%) female participants. According to the analysis, there was a significant association between the treatment groups and ISI after the trial (post-trial), p = 0.0001. Analysis showed that there was significant association between pre- and post-serum cortisol levels in treatment groups 2, 3, and 4 (T2, T3, and T4) as p-values are 0.001, 0.001, and 0.001 respectively. Similar findings were observed for serum melatonin.ConclusionsThe study revealed that magnesium, potassium, and magnesium and potassium combined had a significant effect on serum cortisol and melatonin levels (sleep hormones). In addition, supplementation significantly decreased the severity of insomnia among patients with diabetes by improving sleep duration.

Incidence Of Insomnia, Anxiety, Depression, Overweight And Drug And Alcohol Use Among Medical Students

Introduction: The existence of a toxicity in medical culture caused by chronified stress in the exercise of the profession by demanding excellence in practice and the adoption of infallible knowledge. As a result, doctors and medical students have shown higher rates of psychological distress, burnout and diagnosed mental illness. Methodology: A questionnaire consisting of 11 questions about sleep quality, depression, anxiety, diet and exercise was carried out among medical students. A total of 83 medical students from 7 different Brazilian educational institutions answered the questionnaire. Objective: To Carry out a descriptive of a quantitative nature and exploratory research through a structured and pre-planned questionnaire with questions regarding the quality of sleep, anxiety, diet, depression, alcohol and drug consumption by medical students, in different periods of training.

Insomnia and sleep apnea in the entire population of US Army soldiers: Associations with deployment and combat exposure 2010-2019, a retrospective cohort investigation

ObjectivesThis retrospective cohort study examined clinically diagnosed insomnia and sleep apnea and analyzed associations with deployment and combat exposure in active-duty soldiers (n=1,228,346) from 2010 to 2019. MethodsRetrospective data were obtained from the Soldier Performance, Health, and Readiness database. ResultsOverseas soldier deployments peaked in 2010, decreasing thereafter as soldiers were withdrawn from Iraq and Afghanistan. From 2010 to 2012 insomnia incidence increased at a rate of 6.7 cases/1000 soldier-years, then decreased after 2012 at 5.3 cases/1000 soldier-years. Sleep apnea increased 2010-2016 at 1.9 cases/1000 soldier-years and generally declined thereafter. Risk of insomnia increased with deployment (hazard ratio=1.51; 95% confidence interval=1.49-1.52) and combat exposure (hazard ratio=1.15; 95% confidence interval=1.13-1.17). Risk of sleep apnea was increased by deployment (hazard ratio=1.89; 95% confidence interval, 1.86-1.92) and combat exposure (hazard ratio=1.09; 95% confidence interval, 1.07-1.11). Most relationships remained after accounting for other factors in multivariable analyses, except that the association between sleep apnea and combat exposure was reduced (hazard ratio=0.94; 95% confidence interval=0.92-0.97). ConclusionsInsomnia risk decreased in the period nearly in parallel with a reduction in the number of deployments; nonetheless deployment and combat exposure increased insomnia risk in the period examined. Risk of sleep apnea increased in the period and was related to deployment but not combat exposure after accounting for demographics and comorbid conditions. Despite reductions in insomnia incidence and a slowing in sleep apnea incidence, sleep disorders remain highly prevalent, warranting continued emphasis on sleep-disorder screening and improving the soldier sleep habits.

Relationship Between Duration of Gadget Use and Insomnia Incidence in Adolescents at Junior High School Betzata ABD Leilem

Many teenagers now spend most of their time playing gadgets. The teenagers can spend all day playing gadgets. The teenagers can spend all day playing gadgets. Using for a long time causes them to take about 60 minutes longer to fall asleep than usual, resulting in them experiencing insomnia. The purpose of this study is to determine the relationship between the duration of gadget use and the incidence of insomnia in adolescents at Betzata ABD Leilem Junior High School. Sampling in this study with the Slovin formula, as many as 62 respondents. Data collection using questionnaires via google forms. The data analysis in this study was univariate and bivariate analysis (Chi square test) measuring the relationship between each variable with a valeα= 0.05. The results of the study were obtained, there was a relationship between the duration of gadget use and the incidence of insomnia with a value = 0.06 (value < 0.05). The conclusion in this study is that there is a relationship between the duration of gadget use and the incidence of insomnia in adolescents at Betzata ABD Leilem Junior High School.

Pengaruh Aromaterapi Ylang-Ylang terhadap Insomnia Ibu Hamil Trimester III di UPTD. Puskesmas Kuta II

Intoduction: Pregnancy is a sensitive phase in women's lives. Pregnant women have insomnia due to hormonal changes caused by adapting to the fetus's growth and development in the womb. To reduce the incidence of insomnia in pregnant women, non-pharmacological therapy is used, specifically ylang-ylang aromatherapy. The purpose of this study is to assess the impact of ylang-ylang aromatherapy on insomnia in third-trimester pregnant women. Metohds: This study used a quasi-experimental research methodology with a Non-Equivalent Control Group design and accidental sampling, with 34 pregnant women separated into two groups: the experimental group and the control group. The level of insomnia was measured using the PSQI questionnaire, then data analysis was carried out using Mann Whitney. Result: The results showed that there was a difference in the level of insomnia of TM III pregnant women in the experimental group after being given the intervention where the p-value was 0.00 < 0.05. Meanwhile, in the control group, the post-test p-value was 1,000 > 0.05, which means that there was no difference in the level of insomnia in the control group. Analysis using Mann Whitney found that there was a significant effect of giving ylang-ylang aromatherapy on insomnia in TM III pregnant women where the p-value was 0.00 < 0.05. Suggestion: From It is hoped that ylang-ylang aromatherapy will be employed as part of comprehensive midwifery care for TM III pregnant women to lower the occurrence of insomnia.

Android-based Voice of Insomnia Implementation for Elderly Sleep Quality: A Literature Review

Elderly people who experience sleep disturbances result in deterioration of disease conditions, fatigue, weakness, increased risk of falls, psychological disorders, and decreased quality of life. Poor sleep patterns trigger insomnia events such as difficulty maintaining sleep. The use of technology has been widely used in overcoming the problem of sleep disorders, one of the implementations used by the Voice of Insomnia application is an android-based application as a relaxation music therapy to overcome sleep disorders or insomnia and is expected to reduce the use of drugs as a stimulus by people with insomnia. The purpose of this literature review is to explore the benefits of implementing the Voice of insomnia application on the quality of elderly sleep. the method used in this literature review is a systematic study by collecting and analyzing relevant literature related to the research topic. Academic journals were searched through online databases such as science direct, Scopus, Google Scholar, Pubmed, Clinicalkey Nursing from 2015 to 2023. The results of literature review from several journals provide information on the benefits of using android-based technology, especially in people with insomnia as an alternative option to improve the quality of elderly sleep. Interventions using android-based technology can improve sleep quality and reduce the incidence of insomnia in the elderly. Voice of Insomnia application as an android application in the form of relaxation music therapy for people with sleep disorders or insomnia. Furthermore, the application of android-based technology can be used as a non-invasive mobile therapy media to help maintain sleep quality.

Investigation of Insomnia Influencing Factors and Their Relationship with TCM Syndrome Elements in 621 Medical Staff Members

Objectives: Our study examined the incidence of insomnia among Chinese medical professionals, delved into associated factors, and examined its connection with Traditional Chinese Medicine (TCM) diagnostic elements. Methods: Between January 2020 and December 2022, our evaluation included 621 medical personnel, utilizing the Pittsburgh Sleep Quality Index (PSQI). Our team gathered data on demographics and occupations to pinpoint potential risks linked to insomnia. Furthermore, the components of TCM syndrome were assessed to understand their correlation with the quality of sleep. Results: Overall, 523 staff were classified as experiencing insomnia (PSQI score ≥ 8). We found statistically significant differences age, professional title, abnormal menstruation, night shift assignment, work intensity, and years of service between insomnia and non-insomnia groups. Logistic regression analysis revealed age over 40, senior professional title, night shift assignment, and high work intensity as risk factors for insomnia, while longer tenure was protective. Insomnia patients predominantly exhibited TCM syndromes such as phlegm-heat internally, heart-fire hyperactivity, and liver-depression fire. Conclusion: Our results reveal a high prevalence of insomnia among medical staff and its association with various demographic and occupational factors. They underscore the relevance of TCM syndrome elements in understanding sleep disorders and suggest personalized interventions targeting specific syndromes. Effective management of insomnia in medical staff is crucial for promoting both individual well-being and patient care quality.

A comparison of sleep, insomnia and health-related quality of life between mothers and fathers of preterm versus full-born infants: a longitudinal study from Norway

BackgroundPoor sleep may negatively affect parents’ health-related quality of life (HRQoL). This longitudinal study aimed to describe and compare sleep, insomnia and HRQoL in mothers and fathers of preterm and full-born infants, and to assess possible associations between sleep, insomnia, and HRQoL from birth up to 12 months in the total sample.MethodsA longitudinal study of parents of preterm (n = 25 couples) and full-born (n = 76 couples) infants was conducted. To assess sleep, parents wore wrist actigraphs and filled out sleep diaries for 2 consecutive weeks before responding to a digital questionnaire regarding insomnia symptoms and HRQoL. Actigraphy and sleep diary data were collected at the infant age of 2 months, while questionnaire data on insomnia and HRQoL were collected at the infant ages of 2, 6, and 12 months. Statistical analyses included linear regression and linear mixed models for repeated measures.ResultsThere were no statistically significant differences in total sleep time (actigraphy and sleep diary) between the parent groups (preterm and full-born) at 2 months postpartum. Sleep efficiency was significantly higher for the full-born group. All mothers reported significantly shorter total sleep time and lower sleep efficiency compared to fathers (all p < 0.01). In the whole sample, insomnia incidence at 2 months postpartum was high (> 43.5%), and for mothers, it remained high at 6 and 12 months (> 50%). No significant HRQoL differences were identified between the parent groups over time. Fathers in both groups reported significantly higher physical HRQoL levels compared to mothers (p = 0.04). There were no significant associations between total sleep time or sleep efficiency and HRQoL at 2 months postpartum. Insomnia symptoms were associated with reduced mental and physical HRQoL at all measurement points.ConclusionsSleep efficiency (actigraphy and sleep diary) was significantly higher for the full-born group compared to the preterm group. Mothers (both groups) experienced significantly shorter total sleep time and lower sleep efficiency compared to fathers. The incidences of insomnia symptoms were high at 2 months postpartum for the whole sample and remained high at follow-up for mothers. Fathers (both groups) reported higher physical HRQoL compared to mothers. Insomnia symptoms had a significantly negative impact on parents’ long-term HRQoL.

Safety and patient-reported outcomes in patients with hormone receptor-positive, HER2-negative advanced breast cancer treated with CDK4/6 inhibitors in China: A cross-sectional study.

1054 Background: It is reported that the adverse event (AE) profile may vary with different CDK4/6 inhibitors. With the prolongation of survival, AEs occurred during the treatment period may affect quality of life (QoL) for patients with advanced disease. Currently, there has been no study focusing on the safety and patient-reported outcomes in Chinese patients treated with different CDK4/6 inhibitors. Methods: This was a large cross-sectional study conducted at 10 sites in China. Randomly selected patients with hormone receptor-positive, HER2-negative advanced breast cancer and their physicians were asked to fill the self-designed questionnaires. Disease characteristics and AEs were collected from the perspectives of both patients and physicians, while the patient questionnaire additionally included feedback on the AE management and the European Organization for Research and Treatment of Cancer (EORTC) Quality-of-Life Questionnaire-breast cancer module (QLQ-BR23). Results: Between Jan 30, 2023 and Sep 15, 2023, a total of 1254 patients (median age, 55 years) were included; 212 (16.9%) patients were treated with palbociclib, 483 (38.5%) with abemaciclib, 550 (43.9%) with dalpiciclib, and 9 (0.7%) with ribociclib. Of them, 197 (15.7%) had switching history or dose adjustment of CDK4/6 inhibitor, with the main reason being AEs (51.8%). From the perspective of physicians, the most common AEs for patients were decreased white blood cell (63.3%), decreased neutrophil count (58.7%), and diarrhea (36.3%). The incidence of increased alanine aminotransaminase (ALT) and increased aspartate aminotransaminase (AST) was 9.3% (grade ≥3, 6.0%) and 8.4% (grade ≥3, 6.7%), respectively. Dalpiciclib showed the lowest incidence of increased ALT (3.5%; grade ≥3, none), increased AST (4.2%; grade ≥3, none), and diarrhea (10.5%) compared with other CDK4/6 inhibitors (P&lt;0.001). From the perspective of patients, dalpiciclib showed the lowest incidence of fatigue, alopecia, hot flashes, insomnia, arthralgia, nausea, vomiting, diarrhea, and anorexia (P&lt;0.05). Regarding QoL, the mean scores of upset by hair loss for different CDK4/6 inhibitors were higher than other symptom subscale scores. Dalpiciclib showed the lowest mean score of upset by hair loss compared with abemaciclib and palbociclib, whether in total (19.74 vs 27.23 vs 21.47, P=0.006) or in patients with &gt;6 months of treatment (12.59 vs 27.78 vs 17.95, P&lt;0.001). Conclusions: AEs are different among various CDK4/6 inhibitors. Dalpiciclib has the lowest risk of diarrhea and hepatotoxicity based on physicians' reports, and shows the best patient-perceived safety. Regarding QoL, CDK4/6 inhibitors can result in upset by hair loss, while patients have the least concern about this issue when using dalpiciclib, especially for those with long treatment duration (&gt;6 months).

Differences in insomnia-related self-reported outcomes among elderly hospitalized patients.

Insomnia is among the most common sleep disorders worldwide. Insomnia in older adults is a social and public health problem. Insomnia affects the physical and mental health of elderly hospitalized patients and can aggravate or induce physical illnesses. Understanding subjective feelings and providing reasonable and standardized care for elderly hospitalized patients with insomnia are urgent issues. To explore the differences in self-reported outcomes associated with insomnia among elderly hospitalized patients. One hundred patients admitted to the geriatric unit of our hospital between June 2021 and December 2021 were included in this study. Self-reported symptoms were assessed using the Athens Insomnia Scale (AIS), Generalized Anxiety Disorder Scale-7 (GAD-7), Geriatric Depression Scale-15 (GDS-15), Memorial University of Newfoundland Scale of Happiness (MUNSH), Barthel Index Evaluation (BI), Morse Fall Scale (MFS), Mini-Mental State Examination, and the Short Form 36 Health Survey Questionnaire (SF-36). Correlation coefficients were used to analyze the correlation between sleep quality and self-reported symptoms. Effects of insomnia was analyzed using Logistic regression analysis. Nineteen patients with AIS ≥ 6 were included in the insomnia group, and the incidence of insomnia was 19% (19/100). The remaining 81 patients were assigned to the non-insomnia group. There were significant differences between the two groups in the GDA-7, GDS-15, MUNSH, BI, MFS, and SF-36 items (P < 0.05). Patients in the insomnia group were more likely to experience anxiety, depression, and other mental illnesses, as well as difficulties with everyday tasks and a greater risk of falling (P < 0.05). Subjective well-being and quality of life were poorer in the insomnia group than in the control group. The AIS scores positively correlated with the GAD-7, GDS-15, and MFS scores in elderly hospitalized patients with insomnia (P < 0.05). Logistic regression analysis showed that GDS-15 ≥ 5 was an independent risk factor for insomnia in elderly hospitalized patients (P < 0.05). The number of self-reported symptoms was higher among elderly hospitalized patients with insomnia. Therefore, we should focus on the main complaints of patients to meet their care needs.

The effect of cumulative night shift duties on insomnia, fatigue, and mental health in intensive care unit

BackgroundNight shift duties are crucial in the ICU to ensure care continuity, where critically ill patients require round-the-clock care. However, cumulative night shift duties may disturb circadian rhythm, insomnia, fatigue, and depression, and require further elucidation. ObjectivesThis study aims to examine the negative consequences of various night shift patterns on insomnia, fatigue, and mental health of ICU Workers. MethodsA cross-sectional study examined how cumulative night shift duty affects insomnia, fatigue, and mental health in critical care providers (CCPs). ResultsA total of 1006 participants completed this study between June 2022 and March 2023, including 54.5 % males. About 35 % were between 20 and 30 years of age, and Respiratory Therapists accounted for approximately 46.5 % of the entire sample. Most of our respondents (476; 47 %) reported working night shifts, with a monthly range of 8–15 nights. The prevalence rates for moderate to severe clinical insomnia, fatigue, and moderate to severe depression were 42 %, 48 %, and 32 %, respectively. CCPs working 8–15 nights had a 2-fold risk of clinical insomnia than those working fewer than eight nights with (AOR) and 95 % (CI) of 2.12 and 1.41–3.20, while those working ≥16 nights per month had a greater incidence of clinical insomnia compared to those working <8 nights per month, AOR (CI): 3.09 (1.90–5.03). Only those working ≥16-night shifts per month had a substantially higher fatigue risk compared to those working < 8-night shifts per month, with an AOR (CI) of 1.92 (1.19–3.08). Working 8–15-night shifts per month increases depression risks by 34 % compared to the <8-night shifts group, AOR (CI): 1.34 (0.87–2.08). Those working ≥16-night shifts per month showed a higher depression risk than those working <8-night shifts, AOR (CI): 2.53 (1.53–4.19). ConclusionA cumulative night shift above eight nights per month is linked with an increased risk of insomnia, fatigue, and depression. The risk of these conditions was significantly directly proportional to the number of night shifts performed per month.

Effect of acupuncture combined with Ningshen mixture on climacteric insomnia: A randomized controlled trial.

In recent years, the incidence of menopause insomnia has gradually increased, seriously affecting women's physical and mental health. Total 82 climacteric insomnia patients received from January 2021 to January 2023 were divided into 2 groups at random. In control group, 41 cases received conventional Western medicine, and in study group, 41 cases received acupuncture combined with Ningshen mixture. Clinical effectiveness of both groups was compared, neurotransmitter levels, TCM syndrome integral and Pittsburgh Sleep Quality Index (PSQI) were assessed in both groups. Meanwhile, the recurrence rate and safety were evaluated in 2 groups. The curative effect in study group was better than that in control group (P < .05). After treatment, the expressions of 5-hydroxytryptamine and β-endorphin (β-EP) in study group were higher than control group (P < .05); TCM syndrome scores and PSQI scores in study group were lower than control group (P < .05). The total recurrence rate in study group was obviously lower than control group at 3 months after treatment (P < .05). There were no serious adverse reactions in both group, and no distinct difference between 2 groups was found (P > .05). Acupuncture united with Ningshen mixture has a significant therapeutic effect and high safety in climacteric insomnia patients. It can effectively improve the neurotransmitter levels, clinical symptoms and sleep quality, and reduce the recurrence rate of climacteric insomnia patients, which has high clinical application value and is worthy of clinical promotion.

Mendelian randomization study supports positive bidirectional causal relationships between genetically predicted insomnia symptom and liability to benign prostatic hyperplasia

BackgroundSleep quality may be related to benign prostatic hyperplasia (BPH), however causal associations have not been established. This study aimed to evaluate causal relationships between six sleep traits ([i] day time napping, [ii] daytime sleepiness, [iii] insomnia, [iv] long sleep duration, [v] short sleep duration, and [vi] sleep duration per hour) and BPH through a bidirectional Mendelian randomization (MR) study.MethodsGenome-wide association summary statistics of sleep traits and BPH were downloaded from public databases. Inverse variance weighting (IVW) was used as the main approach for causal inference. For causal estimates identified by IVW, various sensitivity analyses were performed to assess the reliability of the results: (i) four additional MR methods to complement IVW; (ii) Cochran’s Q test to assess heterogeneity; (iii) MR-Egger intercept test and MR-PRESSO global test to assess horizontal pleiotropy; and (iv) leave-one-out method to assess stability.ResultsForward MR analyses indicated that genetically predicted insomnia symptom significantly increased BPH risk (OR = 1.267, 95% CI: 1.003–1.601, P = 0.048), while reverse MR analyses identified that genetically predicted liability to BPH significantly increased the incidence of insomnia (OR = 1.026, 95% CI: 1.000-1.052, P = 0.048). In a replicate MR analysis based on summary statistics including exclusively male participants, the finding of increased risk of BPH due to genetically predicted insomnia symptom was further validated (OR = 1.488, 95% CI: 1.096–2.022, P = 0.011). No further causal links were identified. In addition, sensitivity tests demonstrated the reliability of the MR results.ConclusionThis study identified that a higher prevalence of genetically predicted insomnia symptoms may significantly increase the risk of BPH, while genetically predicted liability to BPH may in turn increase the incidence of insomnia symptom. Therefore, improving sleep quality and reducing the risk of insomnia could be a crucial approach for the prevention of BPH.

Development of insomnia in patients with stroke: A systematic review and meta-analysis.

Stroke is a serious threat to human life and health, and post-stroke insomnia is one of the common complications severely impairing patients' quality of life and delaying recovery. Early understanding of the relationship between stroke and post-stroke insomnia can provide clinical evidence for preventing and treating post-stroke insomnia. This study was to investigate the prevalence of insomnia in patients with stroke. The Web of Science, PubMed, Embase, and Cochrane Library databases were used to obtain the eligible studies until June 2023. The quality assessment was performed to extract valid data for meta-analysis. The prevalence rates were used a random-efect. I2 statistics were used to assess the heterogeneity of the studies. Twenty-six studies met the inclusion criteria for meta-analysis, with 1,193,659 participants, of which 497,124 were patients with stroke.The meta-analysis indicated that 150,181 patients with stroke developed insomnia during follow-up [46.98%, 95% confidence interval (CI): 36.91-57.18] and 1806 patients with ischemic stroke (IS) or transient ischemic attack (TIA) developed insomnia (47.21%, 95% CI: 34.26-60.36). Notably, 41.51% of patients with the prevalence of nonclassified stroke developed insomnia (95% CI: 28.86-54.75). The incidence of insomnia was significantly higher in patients with acute strokes than in patients with nonacute strokes (59.16% vs 44.07%, P < 0.0001).Similarly, the incidence of insomnia was significantly higher in the patients with stroke at a mean age of ≥65 than patients with stroke at a mean age of <65 years (47.18% vs 40.50%, P < 0.05). Fifteen studies reported the follow-up time. The incidence of insomnia was significantly higher in the follow-up for ≥3 years than follow-up for <3 years (58.06% vs 43.83%, P < 0.05). Twenty-one studies used the Insomnia Assessment Diagnostic Tool, and the rate of insomnia in patients with stroke was 49.31% (95% CI: 38.59-60.06). Five studies used self-reporting, that the rate of insomnia in patients with stroke was 37.58% (95% CI: 13.44-65.63). Stroke may be a predisposing factor for insomnia. Insomnia is more likely to occur in acute-phase stroke, and the prevalence of insomnia increases with patient age and follow-up time. Further, the rate of insomnia is higher in patients with stroke who use the Insomnia Assessment Diagnostic Tool.

Hubungan Aromaterapi Frangipani terhadap Peningkatan Kualitas Tidur pada Remaja

Adolescents are individuals who are in a period of purbetas where there will be many changes such as the way of behavior and lifestyle. Insomnia is a condition that is often experienced by teenagers. Based on the National Sleep Foundation, the prevalence of insomniacs in Indonesia reaches 70%. Aromatherapy frangipani is one therapy that can relax so that the body can fall asleep. Frangipani contains triterpenoid compounds, amyrin, geraniol, citronellol, and linalool which can provide a relaxing effect. This research study aims to determine the relationship between the use of aromatherapy frangipani to improve sleep quality in adolescents. Research in this study uses literature review studies or literature reviews compiled using secondary data in the form of studies of research journals obtained from various scientific journal databases on the internet related to the relationship of aromatherapy use to improve sleep quality. The results, from 4 articles discussing the benefits of aromatherapy on improving sleep quality all showed that there was a significant influence between aromatherapy and the incidence of insomnia or improved sleep quality in adolescents. Bottom Line: Aromatherapy has a significant relationship to improved sleep quality and may reduce insomnia. The quality of adolescent sleep can be disrupted can be caused by various factors such as lifestyle, drugs, smoking, and stress in anxiety disorders.

Efficacy and safety of dasotraline in attention-deficit hyperactivity disorder: A systematic review and meta-analysis.

Pharmacotherapeutic options for attention-deficit hyperactivity disorder (ADHD) are limited due to adverse effects and inadequate efficacy of existing drugs. Clinical trials were conducted on dasotraline in search of a safer and more efficacious alternatives to stimulant agents. This meta-analysis was conducted to evaluate the efficacy and safety of dasotraline in ADHD compared to placebo. The reviewers extracted data from five relevant clinical trials after a literature search on Medline/PubMed, Embase, Scopus, Google Scholar, and Cochrane databases and Clinical Trial Registries. Quality assessment was done using the risk of bias assessment tool, and the random-effects model was used to estimate the effect size. Sub-group analysis, meta-regression, and sensitivity analysis were done as applicable. PRISMA guidelines were followed in the selection, analysis, and reporting of findings. Dasotraline significantly reduced the ADHD total symptom score (SMD: -0.35; 95% CI: -0.55 to -0.15; P < 0.001), hyperactivity/impulsivity subscale score (SMD: -0.27; 95% CI: -0.44 to -0.11; P = 0.001), inattentiveness sub-scale score (SMD: -0.33; 95% CI: -0.53 to -0.14; P < 0.001), and CGI-S (SMD: -0.25; 95% CI: -0.42 to -0.08; P = 0.003). Sub-group analysis showed a significant reduction of ADHD symptoms in both pediatric and adult age groups. Meta-regression showed a significant association between SMD of ADHD symptom score reduction and the duration of dasotraline therapy. The incidence of decreased appetite showed dose dependence but not the incidence of insomnia. Dasotraline 4 mg (in children) and 6 mg (in adults) can improve the clinical outcome in patients with ADHD by improving symptoms and global functioning with acceptable tolerability.PROSPERO Registration number: CRD42022321979.

HUBUNGAN PENGGUNAAN SMARTPHONE DENGAN KEJADIAN INSOMNIA PADA MAHASISWA PROGRAM STUDI SARJANA KEDOKTERAN DAN PROFESI DOKTER FAKULTAS KEDOKTERAN UNIVERSITAS UDAYANA

Background: Smartphones are not only used as a communication tool, smartphone have become inseparable from human life around the world. Smartphone usage is always increases. The Central Statistics Agency of Indonesia noted that in 2018 as many as 62.41% of the Indonesian had used mobile phones and mobile phone users in Indonesia increases 3% per year. Beside the positive effects, smartphones also have many negative effects if used excessively. One of the negative effects of excessive smartphone use is insomnia. Aim: Knowing the relationship between smartphone use and the incidence of insomnia among students of Faculty of Medicine, Udayana University. Methods: The method used in this study was an analytical cross-sectional study. Samples selected using simple random sampling method, there are 79 respondents participated in this study and the questionnaires distributed with google form. The data were processed and tested for analysis using the chi-square method. Results: After going through the process of exclusion and drop out, the final number of samples was 75. From 75 samples, 35 samples (46.7%) use smartphone excessively, and 25 samples (33.3%) have insomnia. The results of the bivariate analysis showed a significant relationship between smartphone use and the incidence of insomnia among students of Faculty of Medicine, Udayana University (p = 0,014). Conclusion: There is a relationship between smartphone use and the incidence of insomnia among students of Faculty of Medicine, Udayana University (p = 0,014). Keywords: Smartphone, Insomnia, Medical Students

Effect of remimazolam on postoperative sleep quality in patients undergoing laparoscopic hysterectomy: A randomized controlled trial

IntroductionRemimazolam is a new sedative-hypnotic drug, which has been demonstrated to be safe and effective for the induction and maintenance of anesthesia, but its effects on the postoperative sleep quality of patients remain unknown. MethodsPatients enrolled in this study were randomly received remimazolam (Group R) or propofol (Group P) for induction and maintenance of anesthesia. The primary outcome was the Athens insomnia scale (AIS) score. The secondary outcomes included smart wristband data on the first night after surgery, the Ramsay sedation scale score at 1 h postoperatively, time from drug withdrawal to laryngeal mask removal, postanesthesia care unit (PACU) discharge time, postoperative nausea and vomiting, intraoperative awareness and reported adverse reactions. ResultsThe AIS score on postoperative day 1 was higher in group R compared with group P, but no significant difference was found between the two groups in 8 items of the AIS on postoperative day 1. Additionally, there was no significant difference in the proportion of patients with suspected insomnia and insomnia between the two groups at POD 1. The monitoring data of smart wristband found that compared with group P, the total sleep duration of the first night after surgery of group R was decreased, and the proportion of deep sleep was reduced. Moreover, the time from drug withdrawal to laryngeal mask removal and PACU discharge time was longer in group R than group P. The Ramsay sedation scale score at 1 h postoperatively was higher in group R than group P. There were no statistically significant differences between groups for postoperative nausea and vomiting. Furthermore, neither group experienced any intraoperative awareness or serious adverse events. ConclusionsTotal intravenous anesthesia using remimazolam decreased postoperative sleep quality in patients undergoing laparoscopic hysterectomy compared to propofol. The effect of remimazolam on postoperative sleep quality may primarily manifest in the severity rather than the incidence of insomnia. Patients needed a more extended recovery period afterward and had higher sedation scores following recovery.

The mediating effect of resilience and COVID-19 anxiety on the relationship between social support and insomnia among healthcare workers: a cross-sectional study.

Insomnia in healthcare workers has become a topic of concern in the health system. The high infectivity and longevity of the COVID-19 pandemic have resulted in great pressure and a high incidence of insomnia among healthcare workers. Insomnia among healthcare workers has a negative impact on high-quality healthcare services in addition to their health. Thus, it's necessary to explore insomnia's underlying mechanisms. The present research's aims were threefold: explored the association between social support, resilience, COVID-19 anxiety, and insomnia among healthcare workers during the pandemic, elucidated the underlying mechanism of insomnia, and offered recommendations for improving the health of these workers. A cross-sectional design was adopted. From May 20 to 30, 2022, 1038 healthcare workers were selected to fill out the Oslo 3-item Social Support Scale, the eight-item Athens Insomnia Scale, the Coronavirus Anxiety Scale, and the Brief Resilience Scale. Descriptive statistics and correlations were analyzed by SPSS 25.0. Mediation analysis was conducted by Mplus 8.3 using 5000 bootstrap samples. Of the participating 1038 healthcare workers, the prevalence of insomnia was 41.62% (432/1038). Significant associations were found involving insomnia, resilience, COVID-19 anxiety, and social support. Insomnia was directly affected by social support. Moreover, three indirect pathways explain how social support affected insomnia: resilience's mediating role, COVID-19 anxiety's mediating role, and the chain-mediation role of resilience and COVID-19 anxiety. The results validated our hypotheses and supported the opinion of Spielman etal. 's three-factor model of insomnia. Social support of healthcare workers has an indirect impact on insomnia in addition to its direct one via independent and chain-mediation effects of resilience and COVID-19 anxiety.

Efficacy of an iron-fortified gummy on iron-deficiency anemia in young women

Objective: We conducted this single-center, double-blinded, randomized and placebo-controlled study to explore the efficacy of an iron-fortified gummy on relieving iron-deficiency anemia in young Chinese women. Participants’ blood hemoglobin level was set as the primary outcome. The secondary objectives were to assess the effects of the iron-fortified gummy on participants’ blood iron levels, skin barrier functions, skin temperature regulating ability, menstruation and leucorrhea status, sleep quality, and overall quality of life.Methods: Seventy female participants aged 18-35 years with moderate iron-deficiency anemia (blood hemoglobin 90-120 g/L) were recruited and randomly assigned to an intervention group or a placebo group. We supplemented the diets of the participants with an iron-fortified gummy or a placebo for eight weeks. Their blood hemoglobin level, iron biomarkers, skin biophysical characteristics, hand temperature, self-reported menstruation and leucorrhea status, life quality and sleep quality were recorded at baseline, mid-way through the study and the end of the study. We compared the differences of the above outcomes between the intervention group and the control group. Results: After eight weeks of daily iron-fortified gummy intake, 80% of the participants showed improvement in blood hemoglobin concentration, with a mean increase of 14.5 g/L (95% confidence interval: 9.4, 19.5 g/L) compared to the control. Their serum iron and ferritin levels had significantly increased. They also had improved facial skin hydration and complexions, reduced transepidermal water loss, and accelerated temperature recovery in their hands. Intake of the iron-fortified gummy effectively reduced the incidence of menstrual headaches and insomnia. Participants reported prolonged sleep time, improved energy level, mobility, mental concentration, ability to engage in daily activities and work, as well as better perception of quality of life and health satisfaction.Conclusion:Daily consumption of the iron-fortified gummy over eight weeks could help build up blood iron levels to generate hemoglobin, relieve iron-deficiency anemia and related symptoms in young Chinese women. Intake of iron through gummy on a daily basis is an effective method to gradually increase the participants’ iron levels, leading to sustainable long-term benefits.Study registration: Chinese Clinical Trial Registry (ChiCTR2200061345).