Incidence Of Hypercholesterolemia Research Articles

Incidence of hypercholesterolaemia and hyperglycaemia in schizophrenic patients: Atypical antipsychotic medication and clinical variables

Background: Atypical or second-generation antipsychotic drugs commonly used in the management of schizophrenia include risperidone. Risperidone is linked to the incidence of metabolic syndrome-related adverse effects. Objective: This study aims to investigate the correlation between the administration of risperidone therapy and the incidence of metabolic syndrome in outpatients diagnosed with schizophrenia. This inquiry involves an examination of relevant laboratory parameters, specifically cholesterol, blood glucose, and haemoglobin A1c (HbA1C) levels, alongside an evaluation of pertinent clinical variables that may exert an influence. Methods: This study adopted a cross-sectional approach to receiving risperidone therapy for a minimum of three months at Grhasia Mental Hospital in Yogyakarta, Indonesia. Sampling was executed using an accidental sampling technique, targeting patients who met the predefined inclusion criteria. Results: The study enrolled a total of 97 participants, comprising 58 males and 39 females. Subsequent statistical analyses failed to demonstrate any statistically significant associations between hyperglycemia and various factors, including the risperidone regimen (p = 0.574), risperidone dosage (p = 0.619), and the duration of risperidone therapy (p = 1.000). Conclusion: Risperidone has a long-term risk of causing hyperglycemia in people with schizophrenia; consequently, blood glucose and HbA1C levels must be monitored on a regular basis.

Incidence of non-AIDS defining comorbidities among young adults with perinatally acquired HIV in North America.

The aim of this study is to describe the incidence of diabetes mellitus type 2 (T2DM), hypercholesterolemia, hypertriglyceridemia, hypertension, and chronic kidney disease (CKD) from 2000 to 2019 among North American adults with perinatally acquired HIV (PHIV) aged 18-30 years. Description of outcomes based on electronic health records for a cohort of 375 young adults with PHIV enrolled in routine HIV care at clinics contributing data to the North American AIDS Cohort Collaboration on Research and Design (NA-ACCORD). We estimated overall, sex, and race-stratified cumulative incidences using Turnbull estimation, and incidence rates using quasi-Poisson regression. T2DM was defined as glycosylated hemoglobin more than 6.5% or based on clinical diagnosis and medication use. Hypercholesterolemia was based on medication use or total cholesterol at least 200 mg/dl. Hypertriglyceridemia was based on medication use or fasting triglyceride at least 150 mg/dl or nonfasting at least 200 mg/dl. Hypertension was based on clinical diagnosis. CKD was defined as estimated glomerular filtration rates less than 90 ml/mi|1.73 m 2 for at least 3 months. Cumulative incidence by age 30 and incidence rates from age 18 to 30 (per 100 person-years) were T2DM: 19%, 2.9; hypercholesterolemia: 40%, 4.6; hypertriglyceridemia: 50%, 5.6; hypertension: 22%, 2.0; and CKD: 25%, 3.3. Non-Black women had the highest incidence of hypercholesterolemia and hypertriglyceridemia, Black adults had the highest hypertension incidence, and Black men had the highest CKD incidence. There was a high incidence of five chronic comorbidities among people with PHIV. Earlier screening at younger ages might be considered for this unique population to strengthen prevention strategies and initiate treatment in a timely way.

Relationship between nutritional status and other factors with the incidence of hypercholesterolemia in adults in Cikupa

The prevalence of hypercholesterolemia in Tangerang Regency, the prevalence of hypercholesterolemia based on a total cholesterol concentration of >200 mg/dl is 39,8%. The research aims to determine the description of nutritional status, physical activity, habits of eating fatty foods and fat intake with the incidence of hypercholesterolemia in adults in Cikupa Village. This research is observational with a cross sectional research design. The number of respondents was 61 people using accidental sampling technique. The data taken includes data on body weight, height, nutritional intake, frequency of eating fatty foods, physical activity and total cholesterol levels. The research instrument used a food recall questionnaire, FFQ, and PAL. Bivariate analysis uses the chi-square test. The results of the prevalence of hypercholesterolemia in the adult group in Cikupa were 59,4%. Most of them had normal nutritional status (77,6%), light physical activity (71,6%), often consumed fatty foods (44,8%) and a higher fat intake of (53,7%). There was no significant relationship between nutritional status, physical activity, eating habits of fatty foods, and fat intake with hypercholesterolemia in the adult group in Cikupa Village (p>0,05).

ИЗМЕНЕНИЕ ЛИПИДНОГО ПРОФИЛЯ ПЛАЗМЫ КРОВИ, ПАРАМЕТРОВ ХОЛТЕРОВСКОГО МОНИТОРИРОВАНИЯ И ЭХОКАРДИОГРАФИИ У ПАЦИЕНТОВ С ИШЕМИЧЕСКОЙ БОЛЕЗНЬЮ СЕРДЦА И ГИПОТИРЕОЗОМ

The article presents the results of a study of changes in the lipid spectrum of the blood plasma and certain indicators of Holter monitoring and echocardiography data in patients with coronary heart disease (CHD) and hypothyroidism who were in a cardiology hospital. The incidence of hypothyroidism in cardiac patients was 2.8 %. In patients with ischemic heart disease and hypothyroidism, no reliable correlation has been established between the presence of hypothyroidism and dyslipidemia, but a high incidence of hypercholesterolemia and increased levels of low-density lipoprotein cholesterol was found in patients with ischemic heart disease in combination with hypothyroidism, as in the control group. Extrasystole was determined in all patients with coronary artery disease, regardless of the presence of hypothyroidism. Only 2.7 % of patients with coronary artery disease and hypothyroidism had a decrease in myocardial contractile function according to the assessment of left ventricular ejection fraction (EF). The detection rate of left ventricular hypertrophy (LVH) in patients with coronary artery disease and hypothyroidism was 83.7 %. There was a significantly significant moderate correlation in the group of patients with coronary artery disease, regardless of the presence of hypothyroidism, between the number of premature atrial complexes (PAC) and the number of premature ventricular complexes (PVC). There was no effect of TSH level on EF values and the presence of LVH in patients with coronary artery disease in combination with hypothyroidism and in the absence of the latter.

Cholesterol, Blood Glucose and Hemoglobin Profiles of Urban Adolescents

Background: Prevention of heart and cardiovascular disease must be carried out as early as possible with routine biochemical examinations. Aim of this study is to describe the profile of Cholesterol, Blood Glucose and Hemogobin in urban adolescents.
 Methods: This research method uses a descriptive design with a cross sectional approach. The sample population in this study was 63 nursing students at the Surakarta Health Polytechnic. The study was conducted in August 2023 and the sample was selected randomly. Data were analyzed descriptively.
 Results: The average cholesterol level was 197mg/dl, the average blood sugar level was 91.1 mg/dl and the average hemoglobin was 13.2 g/dl.
 Conclusion: The incidence of hypercholesterolemia was high in respondents. This condition is possible due to insufficient consumption of vegetables and lack of physical activity resulting in high cholesterol levels. These specific findings can help create policies to develop more strategic evidence-based interventions, through grouping risk factors in controlling the risk of non-communicable diseases in adolescents.

Analysis Study of “Food Cholesterol Detect” Application Development in Early Detection of High Cholesterol Food Consumption

The incidence of hypercholesterolemia in Indonesia is increasing daily, caused by a sinful lifestyle, lack of physical activity, and high consumption of foods high in fat. Patients with hypercholesterolemia have a cholesterol intake from food consumed by 46%. Related to these problems, we need a technology that can make it easier for people to manage the consumption of foods high in cholesterol by utilizing the sophistication of Smartphones. So researchers are interested in designing an application, "Food Cholesterol Detect", to detect early consumption of foods high in cholesterol. The system testing scenario is carried out using the system testing method of Black Box Testing. Trials on Users were conducted to assess the website-based Food Cholesterol Detect Application's appearance and the information presented. As for the test results, all of these website systems run well, and the test results on users, namely an average rating of 3-3.5 (good), and users feel helped by this application.

Benefits and risks evaluation of recombinant human growth hormone replacement therapy in children with GHD after craniopharyngioma surgery.

Childhood-onset craniopharyngiomas (CPs) have a high incidence of growth hormone deficiency (GHD) leading to growth failure and metabolic disorders. We aim to evaluate the benefits and risks of recombinant human growth hormone replacement therapy (GHRT) in postoperative children. We retrospectively analyzed auxological and metabolic parameters and adverse events before and after GHRT of 44 children after CP surgery. The median duration of GHRT was 24months (IQR, 12.5-36). Growth velocity (GV) increased significantly after different treatment duration (TD) compared with baseline (p<0.001) and attained the greatest GV of 12.06±4.16cm/year at TD6. The mean height standard deviation score (HtSDS) from-3.20±1.16at baseline improved significantly to-1.51±1.32 at TD36 (p<0.001). There were significant increases in insulin-like growth factor-1 SDS (IGF-1SDS), insulin-like growth factor binding protein 3 SDS (IGFBP-3SDS), bone age (BA), and BA/chronological age (CA) (p<0.05). There was a significant reduction in waist-to-hip ratio (WHR), but there were no significant changes in weight SDS (WtSDS) or BMISDS. Low-density lipoprotein-cholesterol (LDL-C) levels and the incidence of hypercholesterolemia decreased (p<0.05). Three patients (6.8%) had tumor recurrence after 15, 30, and 42months, respectively. A patient had residual tumor enlargement after 3months. There was no adverse influence on glucose metabolism or any severe adverse events. GHRT effectively accelerates GV, increases HtSDS, and improves lipid profiles without unfavorable effects on glucose metabolism. The benefits are clear and the risks of adverse events are low.

Apolipoprotein E*Ɛ2 carriers exhibit high aspirin-treated platelet reactivity and low cardiovascular risk during long-term aspirin treatment.

Apolipoprotein E (APOE) loci, including rs429358 (Ɛ4) and rs7412 (Ɛ2), are involved in cardiovascular (CV) health. However, their effect on the CV-protective effect of aspirin remains unknown. A total of 515 aspirin-treated individuals with existing CV diseases were recruited, and their APOE genotypes, platelet functions and other routine laboratory parameters were assessed when they enrolled. The first major CV events (myocardial infarction, stroke, revascularisation and CV death) and all CV events (major CV events plus unstable angina and transient ischaemic attack) during a mean 5.2-year follow-up period were recorded. After adjusting for age, gender, BMI, lifestyle, lipid profiles and other CV drugs and comorbidities, Ɛ2 carriers were found to exhibit ~80% lower risk of major CV and 60% lower risk of all CV (HR = 0.186, CI: 0.048-0.715, P = 0.014; HR = 0.435, CI: 0.234-0.812, P = 0.009, respectively) than Ɛ2 noncarriers. Furthermore, high incidence of high platelet reactivity assessed by arachidonic acid-induced light transmission aggregometry (23.4 vs. 13.7%, P = 0.038), triglyceride and haemoglobin and low low-density lipoprotein were observed. Ɛ4 carriers had slightly increased cholesterol and hypercholesterolemia incidence relative to Ɛ4 noncarriers. Our results demonstrated that APOE*Ɛ2 carriers can derive additional CV benefit from long-term aspirin treatment. Moreover, it was observed that APOE2 interacts with cyclooxygenase-1 (COX-1) and upregulates its activity. The CV-protective effect of aspirin in Ɛ2 carriers is likely attributed to APOE2 upregulating vascular COX-1-mediated CV protective pathway, together with aspirin partially inhibiting platelet COX-1-mediated platelet aggregation.

Характериcтика лабораторних показникiв за ревматоїдного артриту окремо та у поєднанні з ішемічною хворобою серця

The purpose of the study was to analyze the indicators of the lipid spectrum of blood in patients with rheumatoid arthritis individually and in combination with coronary heart disease. Materials and methods. 91 patients with rheumatoid arthritis were examined, which were divided into 2 subgroups – patients with rheumatoid arthritis without concomitant pathology of the cardiovascular system and patients with rheumatoid arthritis with coronary heart disease. The groups were matched in age and gender. The control group consisted of 31 patients with coronary heart disease. When entering the hospital a detailed clinical and biochemical examination with the determination of the pain scale, the number of painful and swollen joints, the duration of the morning stiffness, functional condition, lipid profile of blood was carried out. Results and discussion. In the study of the lipid spectrum of blood, a probable difference between the number of patients with signs of previously undiagnosed hyperlipidemia among patients with rheumatoid arthritis and rheumatoid arthritis with coronary heart disease was detected. At the same time, they observed dependence on the duration of the disease and the age of patients. The most significant changes were detected in the analysis of levels of total cholesterol, high density lipoprotein and low density lipoprotein, atherogenic coefficient. The indicators of blood triglycerides content had only a trend towards an increase in the subgroup of patients with combined nosology, which was not statistically confirmed. The incidence of hypercholesterolemia was 43.4% in the population of patients with rheumatoid arthritis, and 57.6% in patients with rheumatoid arthritis with coronary heart disease. Low density lipoprotein levels exceeded 3.0 mmol/l in 62.7% of rheumatoid arthritis patients and in 81.2% of patients with rheumatoid arthritis with coronary heart disease. The quantitative content of high density lipoprotein less than 1.0 mmol/l was found in 22.9% of patients with rheumatoid arthritis and in 39.6% of patients with rheumatoid arthritis with coronary heart disease. Conclusion. Among patients with rheumatoid arthritis without concomitant cardiovascular disease, and for the combination of rheumatoid arthritis with coronary heart disease, there is a high percentage of patients with hyperlipidemias. Patients with rheumatoid arthritis with concomitant coronary heart disease have reliably higher rates of total cholesterol and low density lipoprotein in the blood, and a reliably lower high density lipoprotein content. The growth of atherogenic coefficient above 3.5 in young and middle-aged patients for the combination of rheumatoid arthritis and coronary heart disease indicates a higher risk of developing cardiovascular disease and their complications in these age groups

Prevention of High-Fat Diet-Induced Hypercholesterolemia by Lactobacillus reuteri Fn041 Through Promoting Cholesterol and Bile Salt Excretion and Intestinal Mucosal Barrier Functions

Objectives:Lactobacillus reuteri Fn041 (Fn041) is a probiotic isolated from immunoglobulin A coated microbiota in the human breast milk of Gannan in China with a low incidence of hypercholesterolemia. This study aims to explore the role and mechanism of Fn041 in preventing hypercholesterolemia caused by a high-fat diet in mice.MethodsC57BL/6N mice were fed a low-fat diet or a high-fat diet and gavage with Fn041 and Lactobacillus rhamnosus GG (LGG) for 8 weeks.ResultsBoth Fn041 and LGG prevented the occurrence of hypercholesterolemia, liver and testicular fat accumulation. In addition, a high-fat diet causes intestinal dysbiosis and mucosal barrier damage, which is associated with hypercholesterolemia. Fn041 prevented the high-fat diet-induced reduction in alpha diversity of intestinal microbiota and intestinal mucosal barrier damage. Fn041 treatment significantly increased fecal total cholesterol and total bile acids.ConclusionsFn041 prevented hypercholesterolemia by enhancing cholesterol excretion and mucosal barrier function.

Ocular associations in hyperlipidaemia: A rural hospital based study

The incidence of hypercholesterolemia is ever increasing as the co morbid conditions such as diabetes mellitus, hypertension, stressful life is on a rise. Ocular conditions associated with hypercholesterolemia are issues which are minimally discussed. : This prospective cross-sectional study was conducted from January 2019 to June 2019. Complete eye examination was performed including visual acuity examination, refraction, tear film evaluation, slit lamp examination, measurement of intraocular pressure using rebound tonometer, gonioscopy, direct and indirect ophthalmoscopy Total of 81 patients were examined, out of which males were 55, females were 26. Most common ocular finding was Xanthoma and Xanthelasma in 61(70%) patients. Arcus juvenalis was noted in 12 (14.63%), Lipid keratopathy in 23(29.26%). Other comorbidities associated were Hypertensive Retinopathy, diabetic retinopathy, Pre senile cataract, Primary open angle Glaucoma, Branch retinal vein occlusion which has indirect causal relationship. Along with systemic workup, Hypercholesterolemia also warrants a routine detailed ocular examination even if the patient is asymptomatic. This aids in early diagnosis and management of the co-existing ocular morbidities.

Hepatoprotective Effect of Supercritical Carbon Dioxide Extracted Dabai Pulp Oil and Its Defatted Pulp.

All food scientists must utilize plants for their application as functional foods to reduce hypercholesterolemia incidence through diet. Canarium odontophyllum (dabai) is a novel source for new healthy oil and functional foods. In this work, we evaluate the hepatoprotective effects of supercritical carbon dioxide (SC-CO2) extracted dabai pulp oil (DPO) and defatted dabai pulp (DDP) against hypercholesterolemia elicited by a high-cholesterol diet in rats. Our results show that DPO and DDP supplementation exerted beneficial hypocholesterolemic effects against the high-cholesterol diet-fed rat. Nevertheless, supplementation with DDP revealed superior total cholesterol, low-density lipoprotein, and HMG-CoA reductase lowering efficacy (p < 0.05). Supplementation of either DPO or DDP did not significantly affect AST and ALT levels than normal rats (p > 0.05). Therefore, DDP and DPO are considered as having no toxicological significance. The histological section of rats treated with DPO and DDP showed improved steatosis in hepatocytes. HPLC analysis revealed that DPO and DDP contained syringic acid, which plays an important role in the beneficial effect. In conclusion, our results support the hypocholesterolemic and hepatoprotective effects of DPO and DDP in the hypercholesterolemic rats model.

Lipid metabolic dysregulation is involved in Parkinson's disease dementia.

Dementia is very common in the late stage of patient with Parkinson's disease (PD). We aim to explore its underlying pathogenesis and identify candidate biomarkers using untargeted metabolomics analysis. Consecutive PD patients and healthy controls were recruited. Clinical data were assessed and patients were categorized into Parkinson's disease without dementia (PDND) and Parkinson's disease dementia (PDD). Fast plasma samples were obtained and untargeted liquid chromatography-mass spectrometry-based metabolomics analysis was performed. Based on the identified differentially-expressed metabolites from the metabolomics analysis, multivariate linear regression analyses and receiver operating characteristic (ROC) curves were further employed. According to the clinical data, the mean ages of PDND and PDD patients were significantly higher than those of healthy controls. The incidence of hypercholesterolemia was decreased in PDD patients. PDD patients also had lower levels of triglyceride, low-density lipoprotein cholesterol, and apolipoprotein B. There were 24 and 57 differentially expressed metabolites in PDD patients when compared with the healthy controls and PDND patients from the metabolomics analysis. Eleven lipid metabolites were simultaneously decreased between these two groups, and can be further subcategorized into fatty acyls, glycerolipids, glycerophospholipids, sphingolipids, and prenol lipids. The plasma levels of the eleven metabolites were positively correlated with MMSE score and can be candidate biomarkers for PDD patients with areas under the curve ranging from 0.724 to 0.806 based on the ROC curves. Plasma lipoproteins are significantly lower in PDD patients. A panel of eleven lipid metabolites were also decreased and can be candidate biomarkers for the diagnosis of PDD patients. Lipid metabolic dysregulation is involved in the pathogenesis of Parkinson's disease dementia.

Dietary Patterns and the Risk of Dyslipidemia in Korean Adults: A Prospective Cohort Study Based on the Health Examinees (HEXA) Study

BackgroundIdentifying dietary patterns that contribute to dyslipidemia development can inform prevention, nutritional counseling, and other treatment recommendations. ObjectiveThis study aimed to identify major dietary patterns and examine the association between these dietary patterns and dyslipidemia incidence by sex among Koreans. DesignThe Health Examinees (HEXA) study is a community-based prospective cohort study. The baseline and follow-up surveys were conducted in 2004-2013, and 2012-2016, respectively, at 38 health examination centers and training hospitals located in eight regions in Korea. Dietary intake data were collected using a web-based, validated semiquantitative food frequency questionnaire (FFQ) at baseline. Participants/settingAmong 65,642 participants who completed the baseline and follow-up survey, data from 38,170 participants without dyslipidemia and other related chronic diseases at baseline were analyzed. Main outcome measuresIncidence of dyslipidemia and its components (hypercholesterolemia, hyper-low-density lipoprotein [LDL] cholesterolemia, hypo-high-density lipoprotein [HDL] cholesterolemia, and hypertriglyceridemia) after baseline but before the follow-up examination was examined. Statistical analysesFactor analysis was conducted on data from the semiquantitative FFQ to identify major dietary patterns for Korean adults. Cox proportional hazards regression analysis was performed to estimate the relative risk (RR) and 95% confidence interval (CI) according to the quintiles of three dietary pattern scores, after adjusting for potential confounders by sex. ResultsOf the three identified dietary patterns, the higher “prudent” pattern score was associated with a lower incidence of dyslipidemia (RR, 0.90; 95% CI, 0.82-0.99; P = .02) after adjusting for potential confounders in women. Higher “flour-based food and meats” pattern score was associated with a higher incidence of hypercholesterolemia (men: RR, 1.63; 95% CI, 1.21-2.20; P = .003; women: RR, 1.47; 95% CI, 1.30-1.67; P < .001), hyper-LDL cholesterolemia (men: RR, 1.45; 95% CI, 1.03-2.04, P = .06; women: RR, 1.35; 95% CI, 1.16-1.58, P < .001), and dyslipidemia (men: RR, 1.30; 95% CI, 1.09-1.54; P = .009; women: RR, 1.28; 95% CI, 1.16-1.42; P < .001) in both men and women. The “white rice” pattern score was associated with a lower incidence of hypo-HDL cholesterolemia (RR, 0.75; 95% CI, 0.58-0.96; P = .01) and dyslipidemia (RR, 0.90; 95% CI, 0.81-0.99; P = .07) in women. ConclusionsAdherence to the “prudent” and “white rice” patterns was associated with a lower dyslipidemia risk in Korean women, whereas adherence to the “flour-based food and meats” pattern was associated with increased risks of dyslipidemia and its components (hypercholesterolemia and hyper-LDL cholesterolemia) in both Korean men and women.

Research of relationship between thyroid-stimulating hormone level after surgery and hypercholesterolemia in female patients with differentiated thyroid cancer

Objective:To evaluate changes of postoperative thyroid-stimulating hormone（TSH） and total cholesterol（TC） levels in serum, and to analyze the risk of hypercholesterolemia in female patients with differentiated thyroid cancer（DTC） receiving levothyroxine after total thyroidectomy. Method:Female patients with DTC in the first affiliated hospital of hebei north university, who underwent total thyroidectomy, were analyzed retrospectively. All patients were divided into four groups according to follow-up TSH levels:<0.03 mIU/L, 0.03-0.29 mIU/L, 0.30-4.20 mIU/L and>4.20 mIU/L. Changes in TC levels before and after surgery were compared and the occurrence of hypercholesterolemia was analyzed. Result:The lower postoperative TSH level groups had higher preoperative TC levels than the higher TSH level groups. Compared with preoperative level, the TC levels remained unchanged in 0.03-0.29 mIU/L group, but decreased in <0.03 mIU/L group, and markedly increased in greater than 0.3 mIU/Lgroups with TSH levels after surgery. The preoperative-to-follow-up change in TC levels had positive correlation with follow-up TSH level. Compared with those with TSH levels of 0.03-0.29 mIU/L, the risk of TC marginal elevation and hypercholesterolemia in the patients with TSH of 0.30-4.20 mIU/L was found to be 1.16 times and 1.91 times higher, respectively. For patients with TSH levels of >4.2 mIU/L, the risk of TC marginal elevation and hypercholesterolemia was 1.29 times and 3 times, respectively. The increase in TSH was consistent with the increase in the incidence of hypercholesterolemia （P for trend=0.003）. Conclusion:Women with DTC who are using levothyroxine to maintain TSH after surgery should be aware of the risk of hypercholesterolemia due to inadequate replacement.

Pengaruh pemberian jus jamur tiram terhadap kadar kolesterol, trigliserida, dan malondialdehid penderita hiperkolesterolemia

The effect of white oyster mushroom juice (Pleurotus ostreatus) to total cholesterol, triglyceride, and malondialdehyde (MDA) levels in patients with hypercholesterolemiaBackground: The high incidence of hypercholesterolemia due to the wrong diet is a health problem that needs to be addressed immediately. One food ingredient that is being cultivated and believed to have a hypocholesterolemic effect is a white oyster mushroom (Pleurotus ostreatus). These foods contain water-soluble fiber (β glucans) and lovastatin which are useful for improving lipid profiles. Objective: To determine the effect of white oyster mushroom juice (Pleurotus ostreatus) to total cholesterol, triglyceride, and malondialdehyde (MDA) levels in patients with hypercholesterolemia. Methods: This is a quasi-experimental study with a pretest and posttest design. This study was conducted by giving white oyster mushroom juice (Pleurotus ostreatus) for 14 days and then measured its effect on total cholesterol, triglyceride, and MDA levels. The location of the study in Pisangan Tridadi Sleman and the respondent was adults aged 18-55 years who had hypercholesterolemia. Data collection of lipid profiles was taken from venous plasma blood after 12 hours of fasting. While MDA levels were measured by using the thiobarbituric acid (TBA) method. The changes in cholesterol, triglycerides, and MDA levels after administration of white oyster mushroom juice analyzed using paired-t-test and Wilcoxon signed-rank test. Results: The oyster mushroom juice affected decreasing triglyceride levels (2.27 mg/dL; p=0.023). There was no difference in the mean total cholesterol and MDA levels between before and after the intervention. Conclusions: Consumption of white oyster mushroom juice for 14 days significantly reduce triglyceride levels in patients with hypercholesterolemia.

Risk factors, comorbiditiEs and Atherogenic dysLipidaemia in Indian YOUNG patients with dyslipidaemia attending hospital/clinic: REAL YOUNG (dyslipidaemia) study.

Objective:To evaluate the pattern of dyslipidaemia, risk factors, and comorbidities in young Indian adults with dyslipidaemia.Methods:A retrospective, multi-centric real-world study included individuals with dyslipidaemia, aged 18 - 45 years, attending to 623 hospitals/clinics across India. Data were collected retrospectively from medical records to note demographics, risk factors (smoking, alcohol consumption, sedentary lifestyle, family history of dyslipidaemia, diabetes mellitus, and hypertension), and clinical details (height, weight, waist circumference, body mass index (BMI), blood pressure, blood sugar, glycated hemoglobin (HbA1c), triglycerides (TG), total cholesterol (TC), low-density lipoproteins (LDL-C), and high-density lipoprotein (HDL-C)).A descriptive analysis and comparative analysis (Mann-Whitney U test and Chi-square test) were done.Results:Of the total 8135 patients, the majority were men (65.0%). Overall, 87.1% of population had one or multiple comorbidities which included the presence of dyslipidaemia alone (12.9%), dyslipidaemia with diabetes and hypertension (39.1%), dyslipidaemia with diabetes (33.6%), and dyslipidaemia with hypertension (14.4%). Sedentary lifestyle was prevalent observation in >50% of the population. Youngest age (18 - 25) group had higher prevalence of hypertriglyceridemia (63.2%), high LDL-C levels (56.8%), and low HDL-C levels (64.6%), while patients from the age group >25 to ≤35 years had the highest incidence of hypercholesterolemia (66.6%). Atherogenic dyslipidaemia was observed in 41.9%, 25.5%, and 23.2% of patients from age groups of ≥18 to ≤25, >25 to ≤35, and >35 to ≤45 years, respectively. Patients with HbA1c ≥6.5% had significantly higher levels of TG, TC, LDL-C, and lower HDL-C compared to those with HbA1c <6.5%.Conclusion:Hypertriglyceridemia, high LDL-C, low HDL-C, and atherogenic dyslipidaemia were prevalent in the young Indian cohort and sedentary lifestyle, and HbA1c ≥ 6.5% were the predominant risk factors of dyslipidaemia.

SCP2-mediated cholesterol membrane trafficking promotes the growth of pituitary adenomas via Hedgehog signaling activation

BackgroundMetabolic reprogramming is an important characteristic of tumors. In the progression of pituitary adenomas (PA), abnormal glucose metabolism has been confirmed by us before. However, whether cholesterol metabolism is involved in the process of PA remains unclear. This study aimed to investigate whether abnormal cholesterol metabolism could affect the progression of PA.MethodsWe analyzed the expression of sterol carrier protein 2 (SCP2) in 40 surgical PA samples. In vitro experiments and xenograft models were used to assess the effects of SCP2 and cholesterol on proliferation of PA. The incidence of hypercholesterolemia between 140 PA patients and 100 heathy controls were compared.ResultsWe found an upregulation of SCP2 in PA samples, especially in tumors with high proliferation index. Forced expression of SCP2 promoted PA cell lines proliferation in vitro. Furthermore, SCP2 regulated cholesterol trafficking from cytoplasm to membrane in GH3 cells, and extracellularly treating GH3 cells and primary PA cells with methyl-β-cyclodextrin/cholesterol complex to mimic membrane cholesterol concentration enhanced cell proliferation, which suggested a proliferative effect of cholesterol. Mechanistically, cholesterol induced activation of PKA/SUFU/GLI1 signaling via smoothened receptor, which was well-known as Hedgehog signaling, resulting in inhibiting apoptosis and promoting cell cycle. Accordingly, activation of Hedgehog signaling was also confirmed in primary PA cells and surgical PA samples. In vivo, SCP2 overexpression and high cholesterol diet could promote tumor growth. Intriguingly, the incidence of hypercholesterolemia was significantly higher in PA patients than healthy controls.ConclusionsOur data indicated that dysregulated cholesterol metabolism could promote PA growth by activating Hedgehog signaling, supporting a potential tumorigenic role of cholesterol metabolism in PA progression.

Value of serum high density lipoprotein-cholesterol in risk assessment of non-alcoholic fatty liver disease

Objective To investigate the value of high density lipoprotein-cholesterol (HDL-C) in the diagnosis and risk assessment of non-alcoholic fatty liver disease (NAFLD). Methods A cross-sectional study and multistage stratified random sampling method were performed in epidemiological survey. According to inclusion and exclusion criteria, a total of 3 312 individuals were enrolled and divided into NAFLD group (913 cases) and non-NAFLD group (2 399 cases). The serum lipid levels were compared between the two groups. Receiver operating characteristic (ROC) curve was performed to evaluate the value of HDL-C in the diagnosis of NAFLD. The binary logistic regression models were established based on HDL-C level.The differences in liver function indexes were compared among the research objects with different HDL-C levels.T test and Mann-Whitney U test were performed for statistical analysis. Results The serum levels of total cholesterol, triglyceride and low density lipoprotein-cholesterol (LDL-C) of NAFLD group were all higher than those of non-NAFLD group ((5.24±0.92) mmol/L vs.(4.98±0.92) mmol/L, (1.95±1.41) mmol/L vs.(1.13±0.68) mmol/L, (3.31±0.84) mmol/L vs.(3.09±0.84) mmol/L), and the differences were statistically significant (t=-7.29, -22.38 and -6.84, all P<0.01). However the serum HDL-C level of NAFLD group was lower than that of non-NAFLD group((1.30±0.33) mmol/L vs.(1.64±0.40) mmol/L), and the difference was statistically significant (t=24.93, P<0.01). The incidence of hypercholesterolemia, hypertriglyceridemia, hypo-high-density lipoprotein cholesterolemia and hyper-low-density lipoprotein cholesterolemia of NAFLD group was 48.0%(438/913), 44.8%(409/913), 31.0%(283/913) and 82.8%(756/913), respectively, which were significantly higher than that of non-NAFLD group (36.8%, 882/2 399; 13.2%, 317/2 399; 10.5%, 251/2 399; 71.8%, 1 723/2 399), and the differences were statistically significant (χ2=34.65, 385.43, 206.18 and 42.37, all P<0.01). Using the cut-off values of HDL-C≤1.66 mmol/L in female and≤1.33 mmol/L in male, the area under curve (AUC) values for NAFLD diagnosis were 0.720(95% confidence interval (CI) 0.693 to 0.747) and 0.708 (95%CI 0.679 to 0.737), respectively, the sensitivity was 79.1% and 76.6%, and the specificity was 55.0%and 54.6%. The results of binary logistic regression models based on HDL-C level indicated that prevalence of NAFLD in female with low HDL-C was 4.584 times (95%CI 3.530 to 5.940, P<0.01) higher than that in female with high HDL-C; the prevalence of NAFLD in male with low HDL-C was 3.898 times (95%CI 3.020 to 5.030, P<0.01) higher than that of male with high HDL-C. The alanine aminotransferase (ALT), aspartate transaminase (AST), gamma glutamyl transpeptidase (GGT) and alkaline phosphatase (ALP) levels of low HDL-C group were all higher than those of high HDL-C group (20.10 U/L, 14.40 U/L to 29.40 U/L vs. 16.80 U/L, 12.70 U/L to 23.00 U/L; 19.20 U/L, 16.00 U/L to 23.70 U/L vs. 19.00 U/L, 16.00 U/L to 22.17 U/L; 22.00 U/L, 14.00 U/L to 34.00 U/L vs. 15.00 U/L, 11.00 U/L to 23.00 U/L and 71.00 U/L, 59.00 U/L to 85.00 U/L vs. 66.00 U/L, 55.00 U/L to 82.00 U/L), and the differences were statistically significant (Z=-10.53, -2.20, -14.19 and -5.87, all P<0.05). Conclusion The serum HDL-C level is negatively correlated with the risk of NAFLD level, and the NAFLD risk of individuals with low HDL-C level is significantly higher than individuals with high HDL-C level. Key words: Cholesterol, HDL; Non-alcoholic fatty liver disease; Risk factors; Anti-inflammation effects

The Relationship Of Waist Circumference And Hypercholesterolemia Incidence In Patient With Hypertension in Tegal Gundil Public Health Center at Bogor City

Hypertension and hypercholesterolemia are the causes of coronary heart disease (CHD) so that the presence of hypercholesterolemia in patients with hypertension will increase the risk of CHD. Central obesity describes the accumulation of fat in the stomach which can lead to abnormalities in the amount of lipids in the blood, when it occurs in patients with hypertension can lead to progression of the occurrence of high blood cholesterol and the risk of causing atherosclerosis and heart disease. The purpose of this study was to determine the relationship of waist circumference and other factors with the incidence of hypercholesterolemia in patients with hypertension. This research is a quantitative study through secondary data with Cross Sectional design. According to the results of multivariate tests with multiple logistic regression, there was a relationship between waist circumference, gender and age after being controlled by physical activity variables. Gender as a risk factor most associated with the incidence of hypercholesterolemia with a risk 8.5 times higher in women than men, then carried out waist circumference stratification test by sex in hypertensive patients with cases of central obesity found a significant relationship that women with central obesity have a risk of experiencing hypercholesterolemia as much as 5.5 times compared to central obesity in men with a value of p &lt;0.05. There is a waist circumference relationship with the incidence of hypercholesterolemia in women who are central obesity more at risk of developing hypercholesterolemia than central obesity in men.&#x0D; Keywords: Hypercholesterolemia, waist circumference, hypertensive patients