Incidence Of Hepatitis-associated Antigen Research Articles

Incidence of hepatitis-associated antigen among male narcotic addicts in a drug treatment program.

Since September of 1972, the Drug Dependence Treatment Unit has been screening its narcotic addict patients for the hepatitis-associated antigen (HAA). Among a random population of 243 patients, 2% were positive HAA, a relatively high incidence.

Incidence of Hepatitis Associated Antigen In Commercial Control Serum

Incidence of Hepatitis Associated Antigen In Commercial Control Serum Get access Steven C. Maschmeyer, Steven C. Maschmeyer Search for other works by this author on: Oxford Academic PubMed Google Scholar Frank Gittins, Frank Gittins Search for other works by this author on: Oxford Academic PubMed Google Scholar David E. Smith David E. Smith Search for other works by this author on: Oxford Academic PubMed Google Scholar Laboratory Medicine, Volume 4, Issue 6, 1 June 1973, Pages 23–24, https://doi.org/10.1093/labmed/4.6.23 Published: 01 June 1973

Hepatitis-associated antigen and immunoglobulin composition in patients with Down's anomaly.

The relationship between immunoglobulin composition and incidence of Australia antigen in patients with Down’s syndrome was investigated. Simultaneous hemochemical, electrophoretic, and immunochemical analyses of serum proteins, immunoglobulins A, G, and M, and hepatitis-associated antigen were performed on the blood of 26 institutionalized patients with Down’s anomaly and 100 healthy volunteers. A 52 to 101% increase in IgG was detected in all patients with Down’s anomaly irrespective of age or sex. A 65% incidence of hepatitis-associated antigen occurred in the patients with Down’s syndrome, and of those positive for hepatitis-associated antigen, 27% exhibited a decrease in IgA. Patients with Down’s syndrome had lower concentrations of α 1-globulin, α 2-globulin, and β -globulin, and an increased γ -globulin. Generally, total serum protein, albumin:globulin ratios, and IgM titers were within normal limits. The results obtained suggest a chronic response to infectious agents rather than an immunologic malfunction in institutionalized patients with Down’s syndrome.

PROTEIN CALORIE MALNUTRITION AND INFECTION WITH HEPATITIS-ASSOCIATED ANTIGEN

The incidence of hepatitis-associated antigen (HAA) in normal Thai adults is approximately 10%. When Thai children were studied for the age-specific prevalence of serum hepatitis-associated antigen it was found that the adult frequency is reached at about the age of 5 years. Children below this age showed a lower prevalence, with serum hepatitis-associated antigen being significantly more common in boys. In young children with severe protein-calorie malnutrition, however, serum HAA was found in 29% of 48 patients during their eight-week hospitalization, with no sex-difference in the incidence of antigenemia. In three of the four patients who were antigenemic throughout the period of observation the titer of serum hepatitis-associated antigen declined significantly as the patients' nutritional status improved. It is suggested that undernutrition and its associated defects in host defense mechanisms contributes to an increased susceptibility to infection with hepatitis-associated antigen. This may in part help to explain the relatively high prevalence of hepatitis-associated antigen infection as found in tropical countries.

Epidemiologic aspects of viral hepatitis in Greece.

Studies of hepatitis-associated antigen (HAA) in viral hepatitis in Greece have shown a high incidence of positive findings not only in serum hepatitis, but also in cases classified as infectious because of the absence of a history of parenteral inoculation. 1-3 However, in most of these studies, no distinction between adults and children was made, and no cases of epidemic hepatitis were included. 2,3 We believe it of interest, therefore, to present briefly additional findings of ours on the incidence of HAA in three major epidemiological cateogries of viral hepatitis (serum, epidemic, and sporadic) and to compare the findings in adults with those in children. Material and Methods Two hundred twenty-nine patients with viral hepatitis were included; 132 were adults and 97 were children (under 14 years of age). Viral hepatitis was classified in three major epidemiological groups: (1) posttransfusion or syringe (50 cases), (2) sporadic without history of

Hepatitis associated antigen carriers among blood donors in Greece.

The incidence of hepatitis-associated antigen (HAA) among presumably healthy adults in Greece has been unusually high (2.9%) compared with figures reported in other European countries and in the United States. 1,2 In addition to this high incidence, a parallel high frequency of icteric posttransfusion hepatitis (307 cases/10,000 units of transfused blood) has also been discovered in our country. 3 Because of these findings and of the known intimate relationship of HAA with infectivity, 4 we investigated the incidence of the carrier state of HAA among blood donors in Greece, its distribution by several factors, and its relation to icteric posttransfusion hepatitis. Material and Methods Sera from 5,035 blood donors were examined for HAA by the immunodiffusion technique; 1,500 were also examined by counterelectrophoresis. 5 Among the donors, 2,300 were professionals, 1,735 were relatives of patients, and 1,000 were recruits. Liver function tests and serial determinations of HAA were performed in

Hepatitis associated antigen in acute viral hepatitis in Greece.

The significance of hepatitis associated antigen (HAA) was studied by immunodiffusion techniques in 270 sporadic acute viral hepatitis cases in Greece. The antigen was detected in 94 (34.8%) cases. The incidence was higher in the early stages and declined later in the course of the disease. It was further demonstrated that there is no sex or age difference in the incidence of HAA, which is also independent from the severity of the disease as reflected in the SGPT activity. The cases were characterised by available detailed history as infectious hepatitis (IH) or serum hepatitis (SH). The HAA was detected in almost equal proportions in both types. Also, they did not differ in their mean geometrical titre of HAA or in the trend of decline of their incidence in the later stages of the disease.

Hepatitis-Associated Antigen in Blood Donor Populations

Blood-donor serum samples from five medical centers, tested for hepatitis-associated antigen (HAA), showed widely varying incidence (0.06% to 1.47%). The incidence of HAA in the donor population correlated excellently with that of overt posttransfusion hepatitis. The sensitivity of the agar-gel immunodiffusion test was evaluated by study of the serum of 92 blood donors highly implicated in the transmission of hepatitis. Seventeen percent of these implicated donors were found to be HAA-positive, compared to 0.2% of 13,049 normal donors.

The Incidence of Hepatitis‐Associated Antigen and Antibody in Patients with Thalassaemia in Greece

The Incidence of Hepatitis‐Associated Antigen and Antibody in Patients with Thalassaemia in Greece

The Incidence of Hepatitis-Associated Antigen and Antibody in Patients with Thalassaemia in Greece

The Incidence of Hepatitis-Associated Antigen and Antibody in Patients with Thalassaemia in Greece