Incidence Of Febrile Seizures Research Articles

The protective effect of breastfeeding on febrile seizures: a systematic review with meta-analysis.

Several potential risk factors have been identified in the etiopathogenesis of febrile seizures (FS), including the type and extent of breastfeeding (BF). Given the lack of conclusive data, this study aims to systematically evaluate the evidence on the association between BF and FS. We conducted a systematic review and meta-analysis according to PRISMA guidelines. The search was conducted using descriptors for FS, BF, and formula feeding in MEDLINE, Embase, and Web of Science databases. We included observational studies that compared the incidence of FS between those who had ever breastfed and those who were formula fed. The study protocol was registered on the PROSPERO platform under the number CRD42023474906. A total of 1,893,079 participants from 8 datasets were included. Our main analysis showed no significant association of any type of BF on the incidence of FS compared with formula-fed children (OR: 0.84; CI: 0.67-1.04; I2 = 78%; Cochran's Q = 0.0001), although meta-regression showed that BF was associated with a lower incidence of FS in preterm infants. Our secondary outcome showed a significantly reduced incidence of FS in children who received BF exclusively (OR: 0.80; CI: 0.65-0.99; I2 = 70%; Cochran's Q = 0.02). Conclusion: There was no significant reduction in the incidence of FS in those who were breastfed compared to formula feeding. However, our meta-regression analysis indicated an association between BF and a lower incidence of FS in preterm infants. Additionally, children who exclusively received BF had a significantly reduced incidence of FS. These findings should be further investigated in prospective cohorts. What is Known: • Breastfeeding can modify risk factors for febrile seizures, such as susceptibility to viral and bacterial infections, micronutrient deficiencies, and low birth weight. •However, studies have shown conflicting results regarding the impact of breastfeeding on febrile seizures. What is New: •When comparing any breastfeeding pattern with no breastfeeding, there is no significant difference in the incidence of febrile seizures. •When comparing exclusive breastfeeding with no breastfeeding, there may be a decrease in the occurrence of febrile seizures.

Hypertensive disorders of pregnancy increase the incidence of febrile seizures in offspring.

Intrauterine exposure to hypertensive disorders of pregnancy (HDP) may increase the risk of neuropsychiatric disorders. This investigation examined for associations between maternal HDP and febrile seizures (FS) in offspring by the age of three years. The present cohort study analyzed data from the Japan Environment and Children's Study, a large national birth cohort. We included mother-child pairs recruited between January 2011 and March 2014. Information regarding maternal HDP, the presence of FS in offspring up to 3 years of age, and potential confounding factors were assessed using written questionnaires administered to mothers. A total of 77,699 mother-child dyads were analyzed. The prevalence of FS was 8.4% in children without HDP exposure, 10.6% in those exposed to mild HDP, and 10.4% in those with severe HDP exposure. Among children with full-term birth, logistic regression analysis indicated that exposure to mild or severe HDP was significantly associated with a higher incidence of FS (adjusted odds ratio [95% confidence interval]: 1.27 [1.05-1.53] and 1.27 [0.90-1.78], respectively, P for trend = 0.008), compared with children without HDP exposure. In children with full-term birth, intrauterine exposure to HDP was significantly associated with FS by the age of three years. This study revealed a significant association between intrauterine exposure to hypertensive disorders of pregnancy (HDP) and the subsequent development of febrile seizures (FS) in offspring by three years. This increased incidence of FS by HDP was independent of preterm birth status. This is the first large nationwide birth cohort study showing the impact of intrauterine exposure to HDP on FS in early childhood.

Evaluation of febrile seizures in children infected with SARS-CoV-2 Omicron variant in Yunnan, China: a multi-center, retrospective observational study.

The SARS-CoV-2 Omicron variant was reported to be linked to febrile seizures (FSs), but studies on FSs in children with Omicron infection remain relatively scarce, especially in the Chinese population. This study aimed to investigate the characteristics of children diagnosed with Omicron infection with FSs in Yunnan, China, and evaluate the potential association between FSs and Omicron infection. This study was conducted at four hospitals in Yunnan from December 8, 2022, to January 8, 2023, and consisted of 590 pediatric subjects. According to clinical characteristics, 85, 129 and 376 subjects were divided into the FS-only, Omicron-FS, and Omicron-only groups, respectively. Demographic, clinical and laboratory data were retrospectively collected for analysis. The incidence of FSs in children with Omicron infection was 25.5% (129/505). Older age, stronger male predominance, as well as lower proportions of prior history and family history of seizures were observed in Omicron-FS and Omicron-only groups than in FS-only group, but there were no differences in these four above-mentioned events between these two Omicron-related groups. Compared to FS-only group, Omicron-FS group also had a shorter fever-to-seizure onset duration and more frequent seizures during a single course of fever. Moreover, higher levels of IL-6, TNF-α and ferritin as well as decreased counts of leukocytes and lymphocytes were confirmed in Omicron-FS group than in FS-only and Omicron-only groups. Regarding COVID-19 vaccination status, Omicron-FS group revealed a higher proportion of unvaccinated children and a lower proportion of three-dose vaccination than Omicron-only group. As for clinical outcomes, proportions of mechanical ventilation and intensive care unit admission observed in the two Omicron-related groups were notably higher than those in FS-only group. Meanwhile, Omicron-FS group showed the longest length of hospital stay, followed by Omicron-only group and FS-only group, in order. Finally, all patients but one who died of fulminant myocarditis had been successfully discharged. The incidence of FSs in children with Omicron infection was 25.5% in Yunnan. FSs might be a clinical sign deserving more attention in children with Omicron infection. Furthermore, COVID-19 vaccination is likely to provide effective protection against Omicron-related FSs in children.

Effects of the coronavirus disease outbreak on the development of neurological disorders in children: A comparison of the incidence of febrile seizure and epilepsy using an interrupted time-series approach

BackgroundWith the outbreak of COVID-19, school closures and quarantines following social distancing have brought significant changes to children's lifestyles. Therefore, we aimed to compare the population-adjusted incidence of febrile seizures(FS) and epilepsy before and after the COVID-19 outbreak in Korea and to assess the effects of the COVID-19 outbreak on the incidence by region and age group. MethodsA retrospective cohort study was conducted using nationwide claims data and covid data from January 2019 to December 2020. The incidence of diseases and difference in incidence before (Jan 20 to Dec 30, 2019) and after (Jan 20 to Dec 30, 2020) the COVID-19 outbreak was measured using rate ratio. An Interrupted time series analysis was used to identify the effect of COVID-19 on trends of FS and epilepsy. Subgroup analysis by age, sex, insurance, and risk of coronavirus by area were conducted. ResultsFollowing the onset of the pandemic, the number of newly diagnosed FS cases decreased sharply by 69 % (24,182 to 7238), whereas the incidence of epilepsy, increased to 1.02 times (30,286−29,312), when adjusted in proportion to the population. Notably, a greater decrease in the incidence of FS were found in the regions with high-risk of coronavirus. A result of segmented regression analysis proved the decrease was significant and made immediately after the pandemic started(p < 0.001). In contrast to the incidence of FS, that of epilepsy did not exhibit a significant month-to-month change during the baseline period, immediately after the pandemic started, and during the pandemic. ConclusionsThe COVID-19 outbreak and resulting social distancing measures reduced the incidence of febrile seizure immediately rather than gradually. Unlike in the case of acute febrile seizure, the COVID-19 pandemic had no effect on the incidence of chronic epilepsy.

Hubungan Tingkat Pengetahuan Orang Tua Tentang Kejang Demam Pada Anak Usia 1-5 Tahun Di UPTD Puskesmas Penerokan Kecamatan Bajubang

Febrile seizures are seizures that occur in children aged 6 months to 5 years who experience an increase in body temperature (temperature above 38° C). Batanghari Regency is the district with the highest cases of febrile seizures in children. The health center with the highest incidence of febrile convulsions in children is Penerokan Community Health Center. The aim of the research was to determine the relationship between the level of parental knowledge about febrile seizures and the incidence of febrile seizures in children aged 1-5 years at the UPTD Penerokan Community Health Center. This research is a quantitative study, cross sectional design. Data collection was carried out on 24 July 2023 – 30 July 2023 at the UPTD Penerokan Community Health Center. The sample consisted of 87 respondents. The sampling technique is accidental sampling. The analysis carried out was univariate and bivariate analysis. The statistical test used is the chi square test. The research results showed that more than half of the children experienced febrile convulsions (62.1%), most of the parents' knowledge was lacking (37.9%), there was a relationship between the level of parental knowledge about febrile convulsions and the incidence of febrile convulsions (p value = 0.000). . Nurses try to increase parents' understanding regarding the management of children who experience febrile convulsions by providing flip sheets or posters that parents can display at home, which can be easily read so that when a febrile convulsion occurs, parents are prepared to deal with the problem of febrile convulsions in children.

Characteristics of febrile seizures with SARS-CoV-2 infection in the Omicron era.

While the pandemic of coronavirus disease 2019 (COVID-19) is ongoing, the Omicron variant of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been dominant recently. The Omicron variant causes more seizures in pediatric patients compared with previously circulated variants. This study aimed to investigate the incidence and clinical features of febrile seizure (FS) in pediatric patients with COVID-19 during the Omicron era. The medical records of pediatric patients (≤18 years of age) diagnosed with COVID-19, who presented with FS between February 2020 and June 2022, were reviewed retrospectively to analyze clinical characteristics of FS in seven university-affiliated hospitals of Korea. Of 664 pediatric patients with COVID-19 during the study period, 46 during the pre-Omicron period and 589 during the Omicron period were included in the study analysis; 29 patients during the transition period were excluded. Among the included patients, 81 (12.8%) had concomitant FS, and most (76.5%) experienced simple FS. All FS episodes occurred during the Omicron period and none of them during pre-Omicron period (P=0.016). Sixty-five (80.2%) and 16 (19.8%) patients were categorized as FS (patient age ≤60 months) and late-onset FS (patient age >60 months), respectively. Underlying neurologic disease (P=0.013) and focal onset seizure (P=0.012) were more common in the late-onset FS group than in the FS group; however, overall clinical manifestations and outcomes including seizures consistent with characteristics of complex FS and subsequent epilepsy were similar between the two groups. As the COVID-19 pandemic persists, the incidence of FS has increased with the emergence of the Omicron variant. About one-fifth of the patients experiencing FS due to infection by the Omicron variant of SARS-CoV-2 were aged >60 months; however, clinical characteristics and outcomes were favorable. More information and long-term prognoses in patients with FS due to COVID-19 should be acquired.

The Relationship Between Genetic Factors and the Incidence of Fever Seizures in Children at Bhayangkara Setukpa Hospital Lemdiklat Polri Sukabumi City Year 2022

Febrile seizures can be caused by various factors, genetic factors or a family history of seizures, an immature brain, and infection, so the cause of febrile seizures is called multifactorial. (Veisani Y. 2013). One of the factors, namely genetic factors, has a major influence on the incidence of febrile seizures. Based on previous studies, one-third of all febrile seizure patients have a history of seizures in their families. ObjectiveThis study aims to determine the relationship between genetic factors and the incidence of febrile seizures in children at Bhayangkara Setukpa Hospital, Sukabumi Police Education and Training Center, in 2022

Relationship between Febrile Seizures and the Incidence of Microcytic Hypochromic Anemia in Children at Sanjiwani General Hospital, Gianyar, Indonesia

Background: Febrile seizures are the most common seizures in children. As many as 2% to 5% of children aged less than 5 years have had seizures accompanied by fever, and most occurrences are at the age of 17-23 months. Microcytic hypochromic anemia causes hypoxic conditions and neuronal instability due to iron depletion. This study aimed to explore the relationship between febrile seizures and the incidence of microcytic hypochromic anemia in children at Sanjiwani General Hospital, Gianyar, Indonesia.&#x0D; Methods: This study was an analytic observational study with a cross-sectional approach. A total of 59 subjects participated in this study. Data analysis was carried out with the help of SPSS software in univariate and bivariate to determine the relationship between febrile seizures and microcytic hypochromic anemia.&#x0D; Results: There is a relationship between the incidence of febrile seizures and the incidence of microcytic hypochromic anemia, with p&lt;0.05. This study also showed that the risk of febrile seizures increased 1.7 times higher in individuals with microcytic hypochromic anemia.&#x0D; Conclusion: There is a relationship between the incidence of febrile seizures and the incidence of microcytic hypochromic anemia in pediatric patients at Sanjiwani General Hospital, Gianyar, Indonesia.

Perbedaan Manifestasi Klinis Kejang Demam Pada Anak Anemia dengan Tanpa Anemia di RSPAL dr. Ramelan Surabaya Tahun 2019-2022

Study aims: Febrile seizures are the most common neurological disorder in children. The incidence of febrile seizures is related to the incidence of epilepsy at 2-4% in the future and the probability of recurrence is about 30% and 50% after the first and second febrile seizures, respectively. Several recent studies have suggested that febrile seizures are more common in children with anemia. Anemia patients who experience febrile seizures can cause more severe clinical manifestations. Where 40.5% of the incidence of anemia in Indonesia occurs in children under the age of 5 years. Therefore, this study is conducted to determine the differences of the clinical manifestations of febrile seizures with and without anemia in children at RSPAL Dr. Ramelan Surabaya on 2019-2022.&#x0D; Methods: This study was an observational analytic study with a cross-sectional study approach and qualitative methods from secondary medical record data of infants and children aged 6 months-5 years at RSPAL Dr. Ramelan Surabaya for the period May 2019-May 2022. The number of samples in this study was 82 samples.&#x0D; Results: The characteristics of the sample which experiences the most febrile seizures occurres between the ages of 6-18 months, the gender of male with a temperature &gt;38°C and manifestations in the form of simple febrile seizures. In addition, the results of the fisher exact test with a significance level of 5% shows p = 0.96 which means there is no difference in the clinical manifestations of febrile seizures in anemic and non-anemic children.&#x0D; Conclusion: The conclusion of this study is that based on the classification of febrile seizures, the most common clinical manifestations that occur in children with anemia and without anemia are simple febrile seizures. So that there is no difference in the clinical manifestations of febrile seizures in anemic children and without anemia.

Incidence of Febrile Seizures in Children with COVID-19.

The coronavirus disease 2019 (COVID-19) has become a common cause of febrile seizures (FS), especially after the Omicron surge. This study aimed to determine the incidence of COVID-19-associated FS in children. The number of confirmed COVID-19 cases in patients aged below five years residing in the Jeonbuk province from January 2020 to June 2022 was obtained from official data provided by the Ministry of Public Administration and Security. During the same period, data on FS patients with COVID-19 were obtained from all local hospitals capable of FS treatment and were analyzed retrospectively. The number of children under five years of age in Jeonbuk was 62,772, of which 33,457 (53.2%) were diagnosed with COVID-19 during the study period. Of these, 476 patients (1.4%) required hospitalization, and 64 (0.19%, 44 boys; 68.8%: 20 girls; 31.2%) developed FS. All patients with FS presented with symptoms after the Omicron surge. Before the Omicron variant, 23.4% of the patients (89 of 381) required hospitalization; however, no children with COVID-19 were hospitalized for FS. Twenty-five patients (39.1%) had complex FS while one (1.6%) presented with febrile status epilepticus. Forty-two patients (65.6%) experienced first-time FS with an average of 1.5 convulsive events.

Evaluation of Vitamin D Level in Children With Febrile Seizure Referred to Amirkola Children's Hospital, Babol.

Objective. This study aim to evaluate the level of vitamin D with the incidence of febrile seizure. Method. This case-control study was conducted on 90 febrile children referred to Amirkola Children's Hospital from 19 February to 21 August 2021. Febrile children with and without seizures were considered as case and control groups, respectively. Vitamin D, calcium, phosphorus, and alkaline phosphatase were evaluated. Results. The mean level of vitamin D was not significant between the 2 groups (P = .62), but the mean level of alkaline phosphatase was higher in the case group, statistically (P = .04). 46.75% and 15.6% of case group, 28.9% and 26.7% of control group had deficiency and insufficiency levels of vitamin D, respectively (P = .17). Conclusion. In this study the mean level and deficiency of Vitamin D were not significant between the 2 groups. No correlation was also found between Vitamin D levels and the incidence of Febrile Seizure.

Iron deficiency as risk factor for febrile convulsion and the association of iron deficiency anemia and febrile convulsion

Background: Febrile seizure occurs in 2–5% of neurologically healthy infants and children. The recurrence of febrile seizures is 30% after single episode, 50% after 2 or more episodes, and 50% when febrile seizures occur in infants. Their incidence of febrile seizures in India is 10–17% which is higher than in developed countries (2–7%). Aims and Objectives: The purpose of this study was to evaluate iron deficiency (ID) as a risk factor for febrile convulsion and the association of ID anemia with febrile convulsions. Materials and Methods: This was an observational case–control study conducted in tertiary care center in central India between December 2019 and June 2021. All patients with febrile seizures taken as cases and control from similar age group with febrile illness. Body temperature of children in both the groups was measured and recorded. The blood tests of complete blood count, serum iron, and TIBC were performed. Results: In the present study, mean age was 2.33 years in case and mean age was 2.204 years in control. The mean hemoglobin levels were 8.25±1 g/dL in the febrile seizure case group and 9.86±1.49 g/dL in the control group; and their statistical difference was significant. Serum ferritin values was significantly lower among cases group than the control group. The average of MCV, MCH, and MCHC for the case group was less than that of the control group. The present study also demonstrates an association between ID and febrile seizures. Thus, ID is one of the possible risk factors for febrile seizures. Conclusion: The present study showed that hemoglobin, MCV, serum ferritin, and serum iron levels are significantly lower in children suffering from febrile seizures, suggesting that a low iron status has an important role in children with febrile seizures. Thus, ID is predictor for febrile convulsion.

Monitoring of Adverse Events in Recipients of the 2-Dose Ebola Vaccine Regimen of Ad26.ZEBOV Followed by MVA-BN-Filo in the UMURINZI Ebola Vaccination Campaign.

From 2019 to 2021, Rwandan residents of the border with the Democratic Republic of the Congo were offered the Ad26.ZEBOV (adenovirus type 26 vector vaccine encoding Ebola virus glycoprotein) and MVA-BN-Filo (modified vaccinia virus Ankara vector vaccine, encoding glycoproteins from Ebola, Sudan, Marburg, and nucleoprotein from Tai Forest viruses) Ebola vaccine regimen. Nonpregnant persons aged ≥2 years were eligible. Unsolicited adverse events (UAEs) were reported through phone calls or visits, and serious adverse events (SAEs) were recorded per International Council for Harmonisation of Technical Requirements for Pharmaceuticals for Human Use guidelines. Following Ad26.ZEBOV, UAEs were reported by 0.68% of 216 113 vaccinees and were more common in younger children (aged 2-8 years, 1.2%) compared with older children (aged 9-17 years, 0.4%) and adults (aged ≥18 years, 0.7%). Fever and headache were the most reported symptoms. All 17 SAEs related to vaccine were in children aged 2-8 years (10 postvaccination febrile convulsions ± gastroenteritis and 7 fever and/or gastroenteritis). The incidence of febrile seizures was 8 of 26 062 (0.031%) prior to initiation of routine acetaminophen in December 2020 and 2 of 15 897 (0.013%) thereafter. Nonobstetric SAEs were similar in males and females. All 20 deaths were unrelated to vaccination. Young girls and adult women with UAEs were less likely to receive the second dose than those without UAEs. Seven unrelated SAEs occurred in 203 267 MVA-BN-Filo recipients. Postvaccination febrile convulsions in young children were rare but not previously described after Ad26.ZEBOV and were reduced with routine acetaminophen. The regimen was otherwise safe and well-tolerated.

Snotwatch: an ecological analysis of the relationship between febrile seizures and respiratory virus activity

BackgroundFebrile seizures are the commonest type of seizure in occurring in the first few years of life, mostly affecting children aged six months to five years old. While largely benign, the incidence of each febrile seizure increases the risk of recurrence, afebrile seizures and epilepsy. Viruses are the most frequent cause of febrile illnesses in which a febrile seizure occurs. Febrile seizure presentation patterns appear to follow a seasonal trend.AimsTo identify patterns of febrile seizure incidence across different seasons with specific viral activity, and to establish a framework for analysing virus circulation data with common illnesses within a shared region and population.SettingOur study was a study of febrile seizure presentations in Victoria, Australia and respiratory virus detection.ParticipantsWe obtained independent datasets of emergency department febrile seizure presentations at Monash Health and all respiratory multiplex PCR tests performed at Monash Health from January 2010–December 2019 to observe common trends in virus circulation and febrile seizure incidence.Study designTrends were studied temporally through mixed effects Poisson regression analysis of the monthly incidence of febrile seizures and the rate of positive PCR tests. Peak viral seasons (95th centile incidence) were compared to median viral circulation (50th centile incidence) to calculate peak season risk ratios.ResultsWe found a 1.75–2.06 annual risk ratio of febrile seizure incidence in June–September. Temporal analysis of our data showed this peak in febrile seizures was attributable to circulating viruses in this season, and virus modelling showed correlation with increased rates of positive Influenza A (1.48 peak season risk ratio), Influenza B (1.31 peak season risk ratio), Human metapneumovirus (1.19 peak season risk ratio) and Respiratory Syncytial Virus (1.53 peak season risk ratio) on PCR testing.ConclusionOur ecological study statistically demonstrates the recognised winter peak in febrile seizure incidence and ascribes the seasonal relationship to several viral infections which affect the community, including a novel association with Human metapneumovirus.

Hubungan Tingkat Pengetahuan Ibu dengan Penanganan Kejadian Kejang Demam pada Anak Usia 6 Bulan-5 Tahun di Puskesmas Tanjung Uncang

Background: Febrile seizures occur in 2-5% of children aged 6 months-5 years. Although the incidence of febrile seizures in childhood generally has a good prognosis and can resolve spontaneously, the occurrence of seizures is considered frightening for most mothers. Actions for handling and/or management of febrile seizures are certainly influenced by the behavior of mothers, one of which is based on knowledge. Methods: This research method is descriptive analysis with a cross sectional approach conducted at Tanjung Uncang Public Health Center in December 2021. Sampling technique is accidental sampling with the number of samples as much as 72 mothers. The results of the study were analyzed with chi square. Results: Results of this study in 72 respondents, obtained (90,3%) respondents with less knowledge, (69,5%) respondents with less behavior for the handling of febrile seizure. The results of the chi-square test bivariate analysis found a meaningful relationship between the level of knowledge and the handling of febrile seizure (p=0,000). Conclusion:Based on this research that there is a relationship between the mother's level of knowledge and the handling of febrile seizures in children aged 6 months-5 years at the Tanjung Uncang Health Center in 2021.

Low serum zinc and magnesium–a possible risk factor for first episode Simple febrile seizures in children between 6 months to 5 years of age

Background: Febrile seizure is the most common type of seizure in children. The incidence of febrile seizure is 5-10% in India. There are multiple aetiologies like high grade fever; genetic predisposition, viral infections and trace elements deficiency like iron, zinc, magnesium and calcium are postulated to be risk factors for developing febrile seizures. Recent studies had shown there is a significant association between low serum zinc, low serum magnesium levels and febrile seizures in children.Methods: This was a case control study with 40 children in each group. Children aged 6 months to 5 years with first episode of simple febrile seizures who attends the out-patient department/emergency room (OPD/ER) were included in case group consecutively and 40 children with acute febrile illness without febrile seizures were included in control group. Serum zinc and magnesium levels were estimated for all the children along with other investigations after proper consent from parents. Using statistical package for the social sciences (SPSS) software, independent sample t test was used to analysis the observations between the two groups. Normal lab reference value of serum zinc was 60-120 μg/dl and serum magnesium was 1.7-2.5 mg/dl.Results: The incidence of febrile seizure was high (37.5%) in children between 1-2 years and male (55%) children had increased incidence when compared to female children in case group. The children with febrile seizure had significantly low levels of serum zinc with mean value of 35.08 μg/dl (±8.56) when compared to control group with mean value of 70.23 μg/dl (±13.41) and serum magnesium level in case group was 1.35 mg/dl (±0.29) versus 1.68 mg/dl (±0.42) in control group, which was also statistically significant.Conclusions: The incidence of febrile seizure was high in children between 1-2 years of age with male preponderance. The serum levels of both zinc and magnesium is significantly low in children with febrile seizure pointing a need of further studies in role of supplemental zinc and magnesium in this age group to reduce the incidence of febrile seizures.

Incidence of febrile seizures and associated factors in children in Soweto, South Africa.

Febrile seizures (FSs) are a common cause of paediatric emergencies, but there is limited research on the aetiology and epidemiology of FSs, especially in Africa. To determine the incidence of FS hospitalisations in children aged 6 - 59 months in Soweto, South Africa, and factors associated with FS hospitalisations. In a secondary data analysis using a cohort of children enrolled in a 9-valent pneumococcal conjugate vaccine efficacy trial conducted in Soweto during 1998 - 2005, the incidence of FS hospitalisation was calculated and stratified by age group. Regression analysis was used to investigate factors associated with FS at the time of hospitalisation. Influenza A, influenza B, respiratory syncytial virus (RSV), adenovirus and parainfluenza were investigated for among those with respiratory symptoms using immunofluorescent assays. FSs accounted for 780 (11.0%) of 7 126 hospitalisations during the study period. The overall incidence of FSs was 4.4 (95% confidence interval (CI) 4.10 - 4.97) per 1 000 person-years, with the highest incidence in children aged 12 - 23 months (7.25; 95% CI6.44- 8.14). Among hospitalised children, FS hospitalisation was associated with HIV-negative status (odds ratio (OR) 6.25; 95% CI 4.34 - 8.99), body temperature ≥39ºC (OR 2.03; 95% CI 1.56 - 2.64) and concurrent diagnosis of acute otitis media (OR 2.16; 95% CI 1.74 - 2.67). Influenza A was identified in 44/515 FS hospitalisations (8.5%) compared with 123/3 794 non-FS hospitalisations (3.2%) (OR 2.22; 95% CI1.56 - 3.16). In contrast, RSV detection was less commonly identified in children with FSs (21; 4.1%) than without (419; 11.0%) (OR0.36; 95% CI 0.24 - 0.54). FSs contributed significantly to the burden of paediatric hospitalisations in Soweto, and were strongly associated with influenza A virus infection.

INFECTION THAT UNDERLIES THE OCCURRENCE OF FEBRILE SEIZURES: A CASE REPORT OF A 2-YEAR-OLD BOY WITH COMPLEX FEBRILE SEIZURE

Background: Febrile seizures are seizures associated with fever during childhood that most often occurs in children ages six months-five years, with a peak incidence of 18 months Although febrile seizures generally have a good prognosis, they can signal an underlying serious acute infectious infection. This report aims to present a case of febrile seizures associated with the underlying extracranial infection in Semarang.Method: This report describes the anamnesis, physical examination, and supporting examination in patients with febrile seizures.Case: A 2-year-old boy coming to the ER with complaints of seizures that accompanied by fever, When the child seizures are unconscious, after the seizures the child cries.Discussion: The patient came with seizures accompanied by fever three times before being taken to the hospital, the duration of the seizure ± 10 seconds, with a range of ± 2 hours between the first, and the next seizures, twitching convulsions throughout the body, eyes glared upwards, when the child got the seizure, he was unconscious, and after a seizure, the child cries. Three days before, the child had a fever and a cough with yellowish phlegm. On physical examination, It was found ronchi in both lung fields. From x-ray obtained bronchopneumonia picture. Patients diagnosed with complex febrile seizures and bronchopneumonia.Conclusion: Patients were diagnosed with complex febrile seizures and bronchopneumonia, treated for six days, and sent home because the patient's clinical condition improved. Infection is associated with the incidence of febrile seizures.

ASSOCIATION OF FEBRILE SEIZURES WITH IRON DEFICIENCY ANEMIA: A PROSPECTIVE STUDY.

Introduction: Febrile seizures are common in pediatric age group. These seizures are benign and self limiting and usually do not recur after 5 years of age. In pediatric patients viral illnesses are commonly associated with incidence of febrile seizures. Family history of febrile seizures may be present in many cases. Many studies have concluded that febrile seizures are more common in children having iron deficiency some other studies have even reported that iron deficiency is less frequent in children with febrile seizures. We conducted this study of iron deficiency anemia in children presenting with febrile seizures.&#x0D; Materials and Methods: 50 pediatric patients presenting with febrile seizures were included in this study on the basis of a predefined inclusion and exclusion criteria. Demographic details such as age and gender was noted. Previous history of febrile seizure was asked for and noted. Family and past history was noted. Serum Ferritin levels were determined in all the cases. Hemoglobin levels less than 11 gm/dl was taken as cutoff for the diagnosis of anemia. For statistical analysis SSPS 21.0 software was used and p value less than 0.05 was taken as statistically significant.&#x0D; Results: Out of 50 studied cases 36 (72.00%) were males and 14 (28.00%) were females with a M: F ratio of 1:0.38. The mean age of patients was found to be 18.18 +/- 11.32 months. Majority of the cases (74%) were having first onset of febrile seizures. Second and third episode of febrile seizures was seen in 8 (16%) and 5 (10%) cases respectively. 42 (84%) patients were found to have simple febrile seizures whereas remaining 8 (16%) patients had complex febrile seizures. criteria 36 (72%) patients were found to have iron deficiency anemia defined as serum Ferritin level below 12 microgram/lit.&#x0D; Conclusion: Iron deficiency anemia is associated with an increased risk of febrile seizures in pediatric age group.&#x0D; Keywords: Febrile Seizures, Iron deficiency anemia, Serum Ferritin, Hemoglobin.

Decrease in Incidence of Febrile Seizure Following Social Distancing Measures: A National Cohort Study in South Korea

Decrease in Incidence of Febrile Seizure Following Social Distancing Measures: A National Cohort Study in South Korea