Incidence Of Erectile Dysfunction In Patients Research Articles

High prevalence of erectile dysfunction in men with hyperthyroidism: a meta-analysis

ObjectiveThe objective of this study was to evaluate the association between hyperthyroidism and the risk of developing erectile dysfunction (ED).MethodsA comprehensive search of multiple databases, including PubMed, Embase, Cochrane, and Web of Science, was conducted to identify relevant studies investigating the relationship between hyperthyroidism and ED in men. The quality of the included studies was assessed using the Newcastle‒Ottawa Quality Rating Scale, and a meta-analysis was performed using Stata 16.0 and RevMan 5.3 software.ResultsA total of four papers encompassing 25,519 study subjects were included in the analysis. Among these, 6,429 individuals had hyperthyroidism, while 19,090 served as controls. The overall prevalence of ED in patients with hyperthyroidism was determined to be 31.1% (95% CI 0.06–0.56). In patients with uncomplicated hyperthyroidism, the incidence of ED was 21.9% (95% CI 0.05–0.38). The combined odds ratio (OR) for the four studies was 1.73 (OR: 1.73; 95% CI [1.46–2.04]; p < .00001).ConclusionOur findings demonstrate a higher incidence of ED in patients with hyperthyroidism. These results provide valuable information for healthcare professionals and can facilitate discussions surrounding appropriate treatment options for ED in patients with hyperthyroidism.

332 Recognizing and Treating Undiagnosed Erectile Dysfunction (ED) in Patients Presenting With Lower Urinary Tract Symptoms (LUTS)

Aim of the study is to ascertain the prevalence of erectile dysfunction (ED) in patients with LUTS due to BPH regularly treated either with α-blockers or combination therapy, which was previously undiagnosed and rate the response of a suitable treatment. 110 patients presenting to our Department with LUTS due to BPH regularly treated with tamsulosine or tamuslosine + finasteride were evaluated for ED; Information provided were demographic factors, duration of treatment, medicine used, ED risk factors and comorbidities, IPSS score and IIEF score. Non- treated ED was present in 63.8% of 110 patients presenting with LUTS. After basic and specific diagnostic evaluation, suitable treatment was applied in 67.2 % or 39 of these patients. In 79.5 % of the patients there was a positive treatment response. A clear correlation was seen between the severity of LUTS and ED, as well as an increase in incidence of ED in patients with risk factors.

Clinical significance and expression of microRNA in diabetic patients with erectile dysfunction.

The aim of the present study was to investigate the expression of microRNA (miR)-93, miR-320 and miR-16 and to assess their diagnostic value in diabetic patients with erectile dysfunction (ED). A total of 120 individuals were divided into three groups, which included the diabetics with ED group (ED group), the diabetics without ED group (NED group) and the healthy volunteers group (control group). Each group included 40 individuals. Serum samples were collected and reverse transcription quantitative polymerase chain reaction detection of the three types of miRNA was performed and the sensitivity of ED was analyzed by receiver operating characteristic curves. A negative correlation was identified between the incidence of ED in patients with diabetes and serum total testosterone levels (r=0.302, P<0.05); however, a positive correlation was observed between the incidence of ED in diabetics and the HbA1c level (r=0.231, P<0.05). Additionally, the relative expression levels of the three types of miRNA were higher in the ED group when compared with the NED and control groups (P<0.05). When compared with the control group, the area under the curve (AUC) values for miR-93, miR-320 and miR-16 were 0.793, 0.818 and 0.810, respectively, in the ED group and 0.576, 0.532 and 0.542 in the NED group, respectively. Furthermore, when compared with the NED group, the AUC value for miR-93, miR-320 and miR-16 was 0.707, 0.810 and 0.833, respectively, in the ED group. Therefore, the expression levels of miR-93, miR-320 and miR-16 may be useful for the early diagnosis of ED in patients with diabetes.

Improvement of Erectile Dysfunction after Surgery for Cervical Disk Herniation

Erectile dysfunction (ED) has been previously reported in patients with cervical spondylotic myelopathy. After treatment, patients usually experience an improvement in sexual function. Herewith, we present a patient with cervical disc herniation at the C3-C4 and C5-C6 level with ED but without myelopathy. The patient underwent anterior microdiscectomy and fusion with cages. ED improved postoperatively. We propose that the presence of ED should be checked in patients with cervical disc herniation. Further studies are needed to clarify the incidence of ED in patients with cervical disc herniation.

Erectile dysfunction after open versus angioplasty aortoiliac procedures: a questionnaire survey.

Erectile dysfunction (ED) is a common complication after aortoiliac surgery. The aims of this study were to determine the incidence of ED in patients with aortoiliac occlusive disease or aneurysm and evaluate the effect of revascularization by means of open surgery or iliac angioplasty/stenting upon erectile function by using the new International Index of Erectile Function (IIEF) questionnaire. All male patients who had previously undergone open aortoiliac reconstruction or iliac angioplasty/stenting and who were alive at the time of this study were first contacted by telephone. Those who agreed to take part in the study were sent anonymous IIEF questionnaires. Patients were asked to recall their sexual function before and 3 months after the procedure. ED was defined as IIEF score of <11. After telephone interview, a total of 116 patients agreed to take part in the study. The response rate was 61%. Two patients, one in each group, had ED preoperatively. The preoperative IIEF scores were no different in surgery and angioplasty/stenting groups (p=0.3). Overall, 46/63 patients reported worsening erectile function postoperatively. In the surgery group (n=37), 32 patients reported deterioration of their sexual function, 3 no change, and 2 improvement, while in the angioplasty/stenting group (n=26), 14 patients had deterioration, 11 no change, and 1 improvement. In both groups, the IIEF score decreased significantly postintervention; however, the deterioration was much more pronounced after open surgery (p<0.001). Of the 61 patients with "normal" erectile function (IIEF > or =11), 10 patients (28%) developed ED following surgery, but none after angioplasty/stenting (p=0.003). As judged by the IIEF, a significant proportion of patients undergoing open and endovascular procedures experience worsening sexual function.

The Choice of Antihypertensive Drugs in Patients with Erectile Dysfunction

SummaryIt is well established that hypertension and the more traditional anti-hypertensive drugs are associated with erectile dysfunction (ED). There is evidence showing that two antihypertensive drugs - doxazosin and losartan - have a positive effect on erectile function. Therefore these drugs may decrease the incidence of ED in patients who need treatment for hypertension. Doxazosinand/or losartan can also be beneficial in patients who develop ED after starting treatment with other antihypertensive drugs. These options could, in turn, ensure better compliance and blood pressure control. A fall in the overall cost of treatment will also be anticipated if there is a reduced need for drugs prescribed for ED in patients with hypertension.