Incidence Of Disc Degeneration Research Articles

Influence of cement-augmented pedicle screws with different volumes of polymethylmethacrylate in osteoporotic lumbar vertebrae over the adjacent segments: a 3D finite element analysis

BackgroundPolymethylmethacrylate (PMMA) is commonly used for cement-augmented pedicle screw instrumentation (CAPSI) to improve the fixation stability and reduce the risk of screw loosening in the osteoporotic thoracolumbar spine. Biomechanical researches have shown that various dose of cement (1-3 ml) can be injected to enhance screw stability. To date, there have been no studies on the relationship between adjacent segment degeneration and the volume of PMMA. This study aimed to explore the influence of CAPSI with different volumes of PMMA in osteoporotic lumbar vertebrae over adjacent segments by using finite element analysis.MethodsSeven different finite element models were reconstructed and simulated under different loading conditions, including (1) an intact model, (2) three single-level CAPSI models with different volumes of PMMA (1, 1.73, and 2.5 ml), and (3) three double-level CAPSI models with different volumes of PMMA (1, 1.73, and 2.5 ml). To improve the accuracy of the finite element analysis, the models of the injectable pedicle screw and bone cement were created by using a three-dimensional scanning machine and the CAPSI patient’s CT data, respectively. The range of motion (ROM), the stress of intervertebral discs, and the stress of facet in the adjacent segment were comparatively analyzed among the different models.ResultsThe ROMs of the different segments were compared with experimental data, with good agreement under the different load conditions (21.3°, 13.55°, 13.99°, and 6.11° in flexion, extension, bending, and rotation at L3-S1 level, respectively). Compared with the intact model, the ROM, disc stresses, and facet stress in adjacent segments were found to be higher in the six operative models. Otherwise, with a larger volume of PMMA injected, the ROM, disc stresses, and facet stress slightly increased at the adjacent segment. However, the differences were insignificant with the biggest difference less than 3.8%.ConclusionsCAPSI could increase the incidence of disk degeneration in the adjacent segment, while within a certain range, different volumes of PMMA provided an approximate impact over the adjacent segment degeneration.

Diagnostic value and clinical significance of magnetic resonance imaging with the FS-PD-TSE sequence in diagnosing lumbar cartilaginous endplate failure.

The aims were to use magnetic resonance imaging (MRI) to compare the efficacy of fat-suppressed proton-density turbo-spin-echo (FS-PD-TSE) images and T1-weighted (T1WIs) and T2-weighted images (T2WIs) in identifying cartilaginous endplate failure (CEF), and to propose a modified Rajasekaran classification based on the FS-PD-TSE sequence. Thirty-one lumbar disc herniation (LDH) cases were enrolled. Totally, 155 discs and 310 endplates were evaluated by MRI with T1W, T2W, and FS-PD-TSE sequences. Disc degeneration (DD), LDH grades, and the total endplate score (TEPS) of CEF were evaluated. Chi-square, Spearman rank correlation analysis, and multiclass logistic regression were used to compared the sensitivity in diagnosing CEF. A modified Rajasekaran classification based on FS-PD-TSE sequence was established to diagnose CEF. The multiclass logistic regression model was used to analyse the relationship between modified Rajasekaran classification and DD and LDH. There were 117 (75.5%) segments with CEF in T1WIs, 115 (74.2%) in T2WIs, and 127 (81.9%) in FS-PD-TSE, respectively. Chi-square test showed FS-PD-TSE images were more sensitive than T1WIs and T2WIs (P < 0.05). Spearman rank correlation analysis revealed a significant correlation between TEPS and LDH and DD in T1WIs, T2WIs, and FS-PD-TSE images (P < 0.05). A multiclass logistic regression model showed that the incidence of DD and LDH significantly increased accordingly with increases in modified Rajasekaran classification (P < 0.05). The FS-PD-TSE sequence has high diagnostic value for lumbar CEF. CEF is a risk factor for LDH. The new classification for lumbar CEF based on the FS-PD-TSE sequence has good predictive ability for LDH and DD. These slides can be retrieved under Electronic Supplementary Material.

Progression, incidence, and risk factors for intervertebral disc degeneration in a longitudinal population-based cohort: the Wakayama Spine Study.

The present study examined the progression, incidence, and risk factors for intervertebral disc degeneration (DD) throughout the lumbar spine using magnetic resonance imaging (MRI) in a large population-based cohort. We followed up 617 subjects for more than 4 years as part of the Wakayama Spine Study. 1) "Progression of DD" in each of the entire, upper (L1/2 to L3/4) and lower (L4/5 and L5/S1) lumbar spine was defined as Pfirrmann grade progression at follow-up in at least one disc in the affected region. 2) "Incidence of DD" in each of these regions was defined if all discs were grade 3 or lower (white disc) at baseline, and at least one disc had progressed to grade 4 or higher (black disc) at follow-up. Logistic regression analyses were used to determine the risk factors for progression and incidence of DD. DD progression and incidence in the entire lumbar spine were 52.0% and 31.6% in men, and 60.4% and 44.7% in women, respectively. Women was associated with DD progression in the upper lumbar spine (odds ratio [OR]=1.68, 95% confidence interval [CI]=1.18-2.42). Aging was associated with the incidence of DD in each region (entire: OR=1.14, CI=1.06-1.14; upper: OR=1.10, CI=1.05-1.15; lower: OR=1.11, CI=1.05-1.19). Diabetes mellitus (DM) was associated with the incidence of DD in the upper lumbar spine (OR=6.83, CI=1.07-133.7). This 4-year longitudinal study is the first to demonstrate DD progression and incidence in the lumbar spine and their risk factors in a large population-based cohort.

Anatomic radiological variations in developmental lumbar spinal stenosis: a prospective, control-matched comparative analysis

Background contextDevelopmental lumbar spinal stenosis is a maldevelopment of the dorsal spinal elements involving short pedicles and a trefoil bony spinal canal that increases the likelihood of neural compression at an earlier age. PurposeTo identify radiographically the anatomic variations caused by the maldevelopment of the infrequently characterized dorsal spinal elements. Study designA prospective, control-matched comparative analysis. MethodsMagnetic resonance imaging (MRI) and anteroposterior (AP) plain radiographs of 66 patients (mean age, 40.7 years) selected and randomized prospectively and compared with images of 45, age- and gender-matched control subjects. Variables assessed included spinal canal cross-sectional area (CSA), thecal sac AP and transverse canal diameters (CSA), and interpedicular distance. All were expressed in ratios with vertebral body diameter (VBD), interlaminar angle, stenosis grade, and MRI evidence of disc degeneration. ResultsIn the stenosis cohort, global pathology and multilevel involvement with L3, L4, and L5 segments were involved more commonly and severely. Severe stenosis, at L1, L2, and S1 occurs infrequently. Multivariate analysis demonstrated a statistically significant reduction in spinal canal CSA-to-vertebral body CSA ratio, AP spinal canal diameter-to-VBD ratio on axial and sagittal magnetic resonance images, and plain radiograph interpedicular distance-to-VBD ratio at all levels. Interlaminar angle and the transverse spinal canal diameter-to-VBD ratio were reduced significantly in the stenosed cohort at all levels, except L1. No statistically significant difference regarding the incidence of disc degeneration on MRI between the two cohorts, as well as thecal sac CSA-to-spinal canal CSA ratios across all levels were observed, except for L3 and S1 (p<.05). ConclusionsThree spinal canal morphologies were identified: (1) “flattened” canal with predominantly reduced spinal canal AP diameter, (2) spinal canal with predominantly reduced interlaminar angle, and (3) global reduction of all canal parameters. Early age at presentation and subtle spondylosis, although typical, should not be considered the identifying, differentiating factors.

Prevalence and Patterns of Degenerative Disk Disease in the Whole Spine: Hierarchical Cluster Analysis of Pan-Spine MRI Images of 785 Subjects

IntroductionThe study presents the results of whole spine analysis of disk degeneration and a comparison of the incidence and patterns of degeneration between controls and patients for the first ti...

Association of Interleukin-1 Receptor Antagonist Gene Polymorphism With Response to Conservative Treatment of Lumbar Herniated Nucleus Pulposus

A case-control study. To evaluate the relationship between gene polymorphism in interleukin 1 receptor antagonist (IL1RN) and response to conservative treatment of lumbar herniated nucleus pulposus (HNP). There had been several studies on IL1RN polymorphism related with incidence of disc degeneration or back pain but, there had been no report on clinical features of lumbar HNP. We analyzed the variable number tandem repeat polymorphism of IL1RN genes in 54 single level subligamentous extruded lumbar HNP patients and compared allele frequency and incidence of heterozygote with 227 healthy adult controls. Within HNP group, we compared 2 groups; surgery group and conservative treatment group according to response to conservative treatment. The prevalence of A1 (odd ratio = 0.45, P = 0.0009) and A3 (odd ratio = 3.86, P = 0.0006) was significantly higher in HNP group than control group. The allele frequency of A1, A2, A3, A4, and A5 were 84.2:84.6, 7.3:15.4, 8.5:0, 0:0, 0:0, respectively, in surgical and conservative treatment group. The allele frequency for A3 was found significantly higher in the surgery group than in the conservative treatment group. These results suggest that a high allele prevalence of A3 contribute to the clinical progression and the response to conservative treatment for lumbar HNP. IL1RN gene polymorphism may affect the clinical course of lumbar HNP.

Pharmacological enhancement of disc diffusion and differentiation of healthy, ageing and degenerated discs

Pharmacological enhancement of disc diffusion and differentiation of healthy, ageing and degenerated discs

Familial predisposition for lumbar degenerative disc disease. A case-control study.

A case-control study using magnetic resonance imaging and plain radiography to evaluate whether a family history of lumbar disc herniation is a risk factor for disc degeneration. To evaluate the significance of a family history of operated lumbar disc herniation in the development of lumbar disc degeneration and lumbar disc herniation. There are only a few epidemiologic studies indicating that a family history of intervertebral disc herniation is a risk factor for juvenile disc herniation. Recently, similarities in degenerative findings of the lumbar spine between identical twins have been reported. In the case group, 24 patients who were the immediate relatives of patients who had undergone surgery for disc herniation and who presented or had a history of low back pain and/or unilateral leg pain were included. Control individuals included 72 age- and gender-matched outpatients who reported low back pain and/or leg pain without a family history of operated disc herniation. The incidence, level, and topographic location of disc herniation/diffuse bulge; the incidence and grade of disc degeneration observed on magnetic resonance images; and degenerative changes suggesting disc degeneration observed on plain radiographs were compared between the relatives of patients with disc herniation (cases) and the controls. The incidence of disc degeneration at L4-L5 and L5-S1 in cases (L4-L5, 18/24; L5-S1, 18/24) and controls (L4-L5, 45/72; L5-S1, 43/72) was similarly high. However, the grade of disc degeneration according to magnetic resonance imaging signal intensity on the T2-weighted sagittal image using Schneiderman's four-grade classification was significantly more severe in cases (L4-L5: Grade 1, 6/24; Grade 2, 4/24; Grade 3, 13/ 24; Grade 4, 1/24; L5-S1: Grade 1, 6/24; Grade 2: 3/24, Grade 3: 12/24, Grade 4: 3/24) than in controls (L4-L5: Grade 1, 27/72; Grade 2, 24/72; Grade 3, 20/72; Grade 4, 1/72; P = 0.034; L5-S1: Grade 1, 29/72; Grade 2, 23/72; Grade 3, 13/72; Grade 4, 7/72; P = 0.023; Mann-Whitney U test). The incidence of disc herniation/diffuse bulge at L4-L5 (16/24) and L5-S1 (11/24) in cases was higher than that in controls (L4-L5, 33/72; P = 0.07; L5-S1, 17/ 72; P = 0.04; chi-square test). The current study provided evidence that a family history of operated lumbar disc herniation has a significant implication in lumbar degenerative disc disease. There may be a genetic factor in the development of lumbar disc herniation as an expression of disc degeneration.

The Use of In Vivo Lumbar Discography to Assess the Clinical Significance of the Position of the Intercrestal Line

An investigation of the clinical relevance of the location of the intercrestal line in relation to the pattern of disc degeneration in the lower lumbar spine is presented. An analysis of the discograms from 89 symptomatic patients has demonstrated a difference in the incidence of disc degeneration in the L4-5 and L5-S1 disc spaces dependent on the position of the intercrestal line. This difference supports the hypothesis that additional protection will be given to those L5-S1 discs with which high intercrestal lines are associated as compared to those associated with intercrestal lines lying lower down the spine. A corollary of this hypothesis is that for any individual there is an increased likelihood that the L4-5 disc space will undergo degeneration from the influence of normal mechanical stresses before the L5-S1 disc space if the intercrestal line lies comparatively high up the spine.