Incidence Of Cerebral Desaturation Events Research Articles

Two-lung ventilation with artificial pneumothorax on cerebral desaturation and early postoperative cognitive outcome: a randomized controlled trial.

The effect of two lung ventilation (TLV) with carbon dioxide artificial pneumothorax on cerebral desaturation and postoperative neurocognitive changes in elderly patients undergoing elective minimally invasive esophagectomy (MIE) is unclear. The first aim of this study was to compare the effect of TLV and one lung ventilation (OLV) on cerebral desaturation. The second aim was to assess changes in early postoperative cognitive outcomes of two ventilation methods. This prospective, randomized, controlled trial enrolled patients 65 and older scheduled for MIE. Patients were randomly assigned (1:1) to TLV group or OLV group. The primary outcome was the incidence of cerebral desaturation events (CDE). Secondary outcomes were the cumulative area under the curve of desaturation for decreases in regional cerebral oxygen saturation (rSO2) values below 20% relative to the baseline value (AUC.20) and the incidence of delayed neurocognitive recovery. Fifty-six patients were recruited between November 2019 and August 2020. TLV group had a lower incidence of CDE than OLV group [3 (10.71%) vs. 13 (48.14%), P = 0.002]. TLV group had a lower AUC.20 [0 (0-35.86) % min vs. 0 (0-0) % min, P = 0.007], and the incidence of delayed neurocognitive recovery [2 (7.4%) vs. 11 (40.7%), P = 0.009] than OLV group. Predictors of delayed neurocognitive recovery on postoperative day 7 were age (OR 1.676, 95% CI 1.122 to 2.505, P = 0.006) and AUC.20 (OR 1.059, 95% CI 1.025 to 1.094, P < 0.001). Compared to OLV, TLV had a lower incidence of CDE and delayed neurocognitive recovery in elderly patients undergoing MIE. The method of TLV combined with carbon dioxide artificial pneumothorax may be an option for these elderly patients. Chinese Clinical Trial Registry (identifier: ChiCTR1900027454).

ANESTHESIA PECULIARITIES IN BEACH CHAIR POSITION (LITERATURE REVIEW)

Beach chair position (BCP) that is applied for shoulder surgery has a number of advantages for surgeons, but it may lead to intraoperative hypotension, bradycardia and postoperative neurologic complications. Objective of the publication is to review up-to-date literature to emphasize complications related to BCP and methods of their monitoring and prophylaxis. Methods. We have analyzed publications from Google Scholar, PubMed, and specialized scientificjournals databases. Results. In orthopedic practice the main types of surgical positions that are used for shoulder surgery are the next: semi-BCP — 30°, BCP — 60°, Semi-upright sitting position — 90°. In spite of its correlations with hemodynamic changes the tilt angle is rarely measured in clinical practice. The etiology of nervous system impairment is thought to be hypotension and subsequent brain hypoperfusion that is induced by BCP under generalanesthesia. Blood pressure at the standard brachial level is significantly higher than at the meatus acoustic level. That is why today the safety level of blood pressure for BCP surgery is not clearly estimated. The majority of clinical investigations have shown that BCP leads to decreasing of regional cerebral blood flow and brain oxygenation. The high incidence of cerebral desaturation events in BCP (more than 50 %) require its accurate monitoring. The most widely used method is NIRS (near-infrared spectroscopy). Other methods including Doppler scanning of brain vessels and jugular saturation has limited clinical using. In majority of trials of cerebral desaturation events has shown to have controversial impact on postoperative cognitive dysfunction. Serum neurospecific proteins examination may be a perspective method of further investigations for neurologic impairment after surgeries in BCP.

The beach chair position for shoulder surgery in intravenous general anesthesia and controlled hypotension: Impact on cerebral oxygenation, cerebral blood flow and neurobehavioral outcome

Study objectivesThe aim of this study was to assess the impact of intravenous general anesthesia and controlled hypotension on cerebral saturation (rScO2), cerebral blood flow measured as middle cerebral artery blood flow velocity (Vmax MCA) and neurobehavioral outcome in patients scheduled for shoulder surgery in beach chair position. DesignProspective, assessor-blinded observational study. SettingUniversity hospital, shoulder surgery operating room. PatientsForty ASA I-II patients scheduled for shoulder surgery in beach chair position and controlled hypotension. InterventionsNeurological and neurobehavioral tests were performed prior and the day after surgery. The baseline data for near-infrared spectroscopy, bispectral index, cerebral blood flow, PaCO2 and invasive blood pressure (radial artery) were taken prior anesthesia and after anesthesia induction, after beach chair positioning and all 20 min after surgery start until discharge of the patient. MeasurementsNeurological and neurobehavioral tests, cerebral saturation (rScO2) using near-infrared spectroscopy, BIS, cerebral blood flow using Doppler of the middle cerebral artery (Vmax MCA), PaCO2 and invasive blood pressure assessed at heart and at the external acoustic meatus level. Main resultsThe incidence of cerebral desaturation events (CDEs) was 25%. The blood pressure drop 5 min after beach chair position measured at the acoustic meatus level in the CDE group was higher compared to patients without CDEs (p = 0.009) as was the rScO2 (p = 0.039) and the Vmax MCA (p = 0.002). There were no neurological deficits but patients with CDEs showed a greater negative impact on neurobehavioral tests 24 h after surgery compared to patients without CDEs (p = 0.001). ConclusionsIn ASA I-II patients intravenous general anesthesia and controlled hypotension in the beach chair position affects cerebral blood flow and cerebral oxygenation with impact on the neurobehavioral outcome.

Does the degree of beach chair position during shoulder arthroscopy affect cerebral oxygenation? A prospective comparative study

Background: The aim of this prospective cohort study was to determine the incidence of cerebral desaturation events (CDE) in patients undergoing shoulder arthroscopy in the beach chair position (BCP) compared to patients undergoing shoulder arthroscopy in the semi-upright sitting position (SSP). Methods: This prospective study included 220 patients, 150 men (68.18%) and 70 women (31.82%). The average age was 46 yr (24-68) years. Patients under 18 yr of age, those with uncontrolled diabetes, a previous cerebral stroke, a myocardial infarction, rheumatoid arthritis, congestive heart failure, severe cervical disc prolapsed, or severe obesity (body mass index &gt;30) were excluded from the study. The patients were divided into two groups (110 patients in each group). Group A patients had shoulder arthroscopy done in the 60-degree beach chair position and Group B had shoulder arthroscopy done in a semi-upright sitting position at 90 degrees. Mean arterial blood pressure and cerebral oxygen saturation were measured at different stages: before induction of anesthesia (T0), after induction (T1 [baseline]), after positioning (T2), after induction of hypotension (T3), and 1 hr after final position (T4). Cerebral desaturation was defined as a reduction in regional cerebral oxygen saturation to less than 80% of baseline value for 15 sec or longer. Each stage was compared with others in the same group and with the other group. Results: In both groups, the mean arterial blood pressure (MAP) values at T2 were significantly lower than at T1. The MAP values at T3 and T4 were significantly lower than those at T1 and T2. There was a significant decrease in regional cerebral oxygen saturation in stage T3 when compared to previous stages in the same group. Without any significant decrease in stage T4 compared to T3 in the same group. We found no significant difference in regional cerebral oxygen saturation when comparing each stage in both groups. Conclusions: No significant difference was noted in regional cerebral oxygen saturation between patients operated on in the beach chair position and those operated on in the semi-upright sitting position. A direct relation was noted between the decrease in mean arterial pressure and decrease in cerebral oxygen saturation.

Cerebral oxygenation in the beach chair position for shoulder surgery in regional anesthesia: impact on cerebral blood flow and neurobehavioral outcome

Study objectiveBeach chair position is considered a potential risk factor for central neurological events particularly if combined with low blood pressure. The aim of this study was to assess the impact of regional anesthesia on cerebral blood flow and neurobehavioral outcome. DesignThis is a prospective, assessor-blinded observational study evaluating patients in the beach chair position undergoing shoulder surgery under regional anesthesia. SettingUniversity hospital operating room. PatientsForty patients with American Society of Anesthesiologists classes I-II physical status scheduled for elective shoulder surgery. InterventionsCerebral saturation and blood flow of the middle cerebral artery were measured prior to anesthesia and continued after beach chair positioning until discharge to the postanesthesia care unit. The anesthesiologist was blinded for these values. Controlled hypotension with systolic blood pressure≤100mm Hg was maintained during surgery. MeasurementsNeurobehavioral tests and values of regional cerebral saturation, bispectral index, the mean maximal blood flow of the middle cerebral artery, and invasive blood pressure were measured prior to regional anesthesia, and measurements were repeated after placement of the patient on the beach chair position and every 20 minutes thereafter until discharge to postanesthesia care unit. The neurobehavioral tests were repeated the day after surgery. Main resultsThe incidence of cerebral desaturation events was 5%. All patients had a significant blood pressure drop 5 minutes after beach chair positioning, measured at the heart as well as the acoustic meatus levels, when compared with baseline values (P<.05). There was no decrease in either the regional cerebral saturation (P=.136) or the maximal blood flow of the middle cerebral artery (P=.212) at the same time points. Some neurocognitive tests showed an impairment 24 hours after surgery (P<.001 for 2 of 3 tests). ConclusionsBeach chair position in patients undergoing regional anesthesia for shoulder surgery had no major impact on cerebral blood flow and cerebral oxygenation. However, some impact on neurobehavioral outcome 24 hours after surgery was observed.

The Effect of Compression Stockings on Cerebral Desaturation Events in Obese Patients Undergoing Shoulder Arthroscopy in the Beach-Chair Position

To determine if the use of thigh-high compression stockings could decrease the incidence of cerebral desaturation events (CDEs) in patients with a body mass index (BMI) of 30 kg/m(2) or greater undergoing shoulder arthroscopy in the beach-chair position (BCP). Between December 2013 and May 2014, 23 patients aged 18 years or older with a BMI of 30 kg/m(2) or greater undergoing shoulder arthroscopy in the BCP were monitored intraoperatively using near-infrared spectroscopy while wearing thigh-high compression stockings. Data obtained on these patients were compared with data from a previous cohort at our institution comprising 24 patients with a BMI of 30 kg/m(2) or greater who underwent elective shoulder arthroscopy in the BCP with the same monitoring but without wearing compression stockings. The incidence of CDEs was identified in each group. The incidence of CDEs in the group with compression stockings was 4% (1 of 23) compared with 18% (7 of 24) in the group without compression stockings (P= .048). There were no statistically significant differences in mean age (53.0 years v 53.3 years, P= .91), mean BMI (34.5 kg/m(2)v 36.2 kg/m(2), P= .21), or various medical comorbidities between the treatment group and control group. There was a significant difference in the operative time between the treatment group (156.6 minutes) and control group (94.1 minutes) (P < .001). The use of thigh-high compression stockings may decrease the incidence of CDEs in obese patients undergoing shoulder arthroscopy in the BCP. Level IV, therapeutic case series.

Effect of ventilation on cerebral oxygenation in patients undergoing surgery in the beach chair position: a randomized controlled trial

Surgery in the beach chair position (BCP) may reduce cerebral blood flow and oxygenation, resulting in neurological injuries. The authors tested the hypothesis that a ventilation strategy designed to achieve end-tidal carbon dioxide (E'(CO₂)) values of 40-42 mm Hg would increase cerebral oxygenation (Sct(O₂)) during BCP shoulder surgery compared with a ventilation strategy designed to achieve E'(CO₂) values of 30-32 mm Hg. Seventy patients undergoing shoulder surgery in the BCP with general anaesthesia were enrolled in this randomized controlled trial. Mechanical ventilation was adjusted to maintain an E'(CO₂) of 30-32 mm Hg in the control group and an E'(CO₂) of 40-42 mm Hg in the study group. Cerebral oxygenation was monitored continuously in the operating theatre using near-infrared spectroscopy. Baseline haemodynamics and Sct(O₂) were obtained before induction of anaesthesia, and these values were then measured and recorded continuously from induction of anaesthesia until tracheal extubation. The number of cerebral desaturation events (CDEs) (defined as a ≥20% reduction in Sct(O₂) from baseline values) was recorded. No significant differences between the groups were observed in haemodynamic variables or phenylephrine interventions during the surgical procedure. Sct(O₂) values were significantly higher in the study 40-42 group throughout the intraoperative period (P<0.01). In addition, the incidence of CDEs was lower in the study 40-42 group (8.8%) compared with the control 30-32 group (55.6%, P<0.0001). Cerebral oxygenation is significantly improved during BCP surgery when ventilation is adjusted to maintain E'(CO₂) at 40-42 mm Hg compared with 30-32 mm Hg. ClinicalTrials.gov NCT01546636.

Incidence of cerebral desaturation events in the ICU following cardiac surgery

We hypothesize that there is a high incidence of cerebral desaturation events (CDE - an absolute decrease in SctO2 to <55% for ≥15 seconds) during the first 6 hours of ICU admission following cardiac surgery. Clinical trials have validated transcranial cerebral oximetry, a non-invasive tool that uses near-infrared spectroscopy to measure cerebral oxygen saturation, as a way to detect cerebral ischemia [1]. Cerebral oximetry is frequently used in the intraoperative setting, but rarely utilized postoperatively [2]. We attempted to identify if CDEs occur in the ICU.

Cerebral Oxygen Desaturation Events Assessed by Near-Infrared Spectroscopy During Shoulder Arthroscopy in the Beach Chair and Lateral Decubitus Positions

Patients undergoing shoulder surgery in the beach chair position (BCP) may be at risk for adverse neurologic events due to cerebral ischemia. In this investigation, we sought to determine the incidence of cerebral desaturation events (CDEs) during shoulder arthroscopy in the BCP or lateral decubitus position (LDP). Data were collected on 124 patients undergoing elective shoulder arthroscopy in the BCP (61 subjects) or LDP (63 subjects). Anesthetic management was standardized in all patients. Regional cerebral tissue oxygen saturation (Scto(2)) was quantified using near-infrared spectroscopy. Baseline heart rate, mean arterial blood pressure, arterial oxygen saturation, and Scto(2) were measured before patient positioning and then every 3 minutes for the duration of the surgical procedure. Scto(2) values below a critical threshold (> or = 20% decrease from baseline or absolute value < or = 55% for >15 seconds) were defined as a CDE and treated using a predetermined protocol. The number of CDEs and types of intervention used to treat low Scto(2) values were recorded. The association between intraoperative CDEs and impaired postoperative recovery was also assessed. Anesthetic management was similar in the BCP and LDP groups, with the exception of more interscalene blocks in the LDP group. Intraoperative hemodynamic variables did not differ between groups. Scto(2) values were lower in the BCP group throughout the intraoperative period (P < 0.0001). The incidence of CDEs was higher in the BCP group (80.3% vs 0% LDP group), as was the median number of CDEs per subject (4, range 0-38 vs 0, range 0-0 LDP group, all P < 0.0001). Among all study patients without interscalene blocks, a higher incidence of nausea (50.0% vs 6.7%, P = 0.0001) and vomiting (27.3% vs 3.3%, P = 0.011) was observed in subjects with intraoperative CDEs compared with subjects without CDEs. Shoulder surgery in the BCP is associated with significant reductions in cerebral oxygenation compared with values obtained in the LDP.