Incidence Of Ameloblastoma Research Articles

A Retrospective Analysis of 129 Ameloblastoma Cases: Clinical and Demographical Trends from a Single Institution.

A retrospective chart review of patients evaluated for ameloblastoma between 2010 and 2020 at a single tertiary care center. Age, race, sex, tumor size, tumor location, and histological subtypes were recorded. A total of 129 cases of ameloblastoma were recorded with a mean patient age of 42 ± 18.6 years (range 9-91 years old), male to female ratio 1.08:1. Ameloblastoma presenting in the mandible outnumbered maxilla in primary (118 to 8, respectively) and recurrent cases (8 to 1, respectively). There was a higher prevalence of ameloblastoma in Black patients (61.3%) with mean age of Black patients occurring at 40.5 years and the mean age of White patients occurring at 47.8 years and mean tumor size trended larger in the Black patients (15.7 cm2) compared to White patients (11.8 cm2). Data suggests a strong influence of racial factors on the incidence of ameloblastoma, with regards to size, Black patients with ameloblastoma trended higher and more data is needed to clearly elucidate any relationship between the tumor size and race, as other factors may influence the size (such as time to discovery).

A multi-centre evaluation of 566 cases of ameloblastoma in Nigeria by the African Oral Pathology Research Consortium

Ameloblastoma is a locally aggressive odontogenic tumour (OT) that arises from odontogenic epithelium without neoplastic involvement of odontogenic ectomesenchyme. It is the commonest OT in developing countries, especially in Africa, and, hence, a clinically significant lesion among Africans. It has been suggested that the biologic behaviour of ameloblastoma in black Africans is different from the other populations. The high incidence of ameloblastoma in Africans warrants further evidence-based research. In this descriptive cross-sectional study, AOPRC employed a multi-centre approach to retrieve archival demographic and clinicopathological data on ameloblastoma from five major tertiary health institutions in South–West and South–South regions of Nigeria. Data were generated using a standardized data extraction format and analysed using Epi-info (version 7.0). From the five centres, a total of 566 cases met our study criteria. We observed that there was a slight male preponderance on ameloblastoma among the cases studies. For all types of ameloblastoma, mandibular lesions were found more frequently than maxillary ones. Most patients presented within 1–5 years of onset of jaw swelling (45.94%). There was a statistically significant higher mean duration for unicystic variants as compared to multi-cystic ameloblastoma (p = 0.0215). Overall, we also observed that the plexiform variants were the most frequently occurring and that the acanthomatous variant was significantly more common in females than males (p = 0.01). The current study serves as primer and justification for the application of emerging novel molecular techniques to understand the pathobiology and basis for clinic-pathological disparity of ameloblastoma among men of African descent.

Prevalence of ameloblastoma: A three-year retrospective study

Context: This study intends to assess the data on the prevalence and types of ameloblastoma reported in the Outpatient Department retrospectively, so that the distribution of ameloblastomas among this geographic area can be reported. Aims: To retrospectively analyze and evaluate the distribution and frequency of ameloblastoma cases based on the gender and histopathological types. Settings and Design: Retrospective study. Materials and Methods: Radiographs and biopsy records of all histologically diagnosed cases of ameloblastoma archived from January 2010 to December 2012 were retrieved from the Outpatient Department. Statistical Analysis: Descriptive statistics were performed to calculate the frequency and percentages of these variables. Age was stratified into various groups at 15-year intervals. The chi-square test for differences between two groups and the analysis of variance (ANOVA) test for differences among three or more groups were used. The level of statistical significance was set at P < 0.05. Results: From the data of ameloblastoma patients, about 30 cases were short-listed and their data was analyzed. It was found that the 15-30 year old age group had the highest percentage of occurrence (about 46.6%) among all cases. Frequently the posterior segment and vertical ramus of the mandible was involved. Radiographically, unilocular appearance was noted in 50% of the cases and unicystic ameloblastoma was the most frequently encountered histological subtype (49.9%). Conclusion: Studies on the incidence of ameloblastoma among the Indian population is rare. By performing a meta-analysis at the level of societies and geographic places, we can identify the demographic distribution of common odontogenic lesions like ameloblastoma among the various populations.

Les tumeurs odontogènes bénignes : analyse épidémiologique de 97 cas dans la population algérienne

Odontogenic tumours are often benign. They are originating from dento-maxillary structures and their embryonic remnants. They represent a wide variety of lesions derived from epithelial cells, mesenchymal, or both. The series reported in literature show a distinct geographic variation. However, there has been no concrete study and detailed epidemiological profile of these tumours in the Algerian population.Our prospective study based on the classification of the World Health Organization (WHO) in 2005, focused on the epidemiological analysis of 97 cases of odontogenic tumours, collected in the department of maxillofacial surgery of the University Hospital of Constantine. This study was designed to determine the relative frequency of such tumours, their distribution by age and sex, and their histological distribution.In our series, women were most affected by the disease (64% of cases) than men (36% of cases). The population was predominantly young with an average age of 29.9 years (range from 12 to 85). The mandible was the site of choice in 74% of cases. Epithelial tumours were diagnosed in 77% of cases; almost half of these cases were ameloblastomas (44% of cases).The distribution of odontogenic tumours is different depending on the population studied. The incidence of ameloblastoma is increased in African and Asian population with a female predominance. On the other hand, the odontoma is the most recognized odontogenic tumour in North America and Europe, and more particularly in men.

A 4-year prospective study on epidemiology and clinicopathological presentation of odontogenic tumours in Tanzania

In this black African population, the incidence of ameloblastoma did not differ from that of European populations.

A 4-year prospective study on epidemiology and clinicopathological presentation of odontogenic tumors in Tanzania

This study, conducted between 1999 and 2003, included all patients with odontogenic tumors referred from all dental clinics and other health facilities in Tanzania to the only 4 referral centers. Demographic data and clinical and histopathologic findings were recorded. Histopathologic specimens were examined by expert pathologists. Ameloblastoma had the highest relative frequency (80.1%) and an incidence rate of 0.68 per million, followed by odontogenic myxoma (7.0%) with an incidence rate of 0.07 per million. Follow-ups of between 6 months and 4 years were carried out. Two patients developed recurrences of ameloblastoma. The incidence of ameloblastoma in this exclusively black African population did not differ from that of European countries. This is contrary to the belief that ameloblastoma has a higher incidence in black Africans as compared to Caucasians.

Maxillary ameloblastomas: a review of the literature and of a 15-year database

Introduction: Cases of maxillary ameloblastomas from 15-year database (1986–2000) collected in the Department of Cranio-Maxillofacial Surgery of the University Hospital of Zurich were evaluated. Patients: Twenty-six patients suffering from ameloblastoma had been collected. Five of them, had a maxillary ameloblastoma, three females and two males. Methods: A clinical retrospective study was performed. In addition a review of the literature was undertaken and the findings have been compared and contrasted. Patients: The overall incidence of ameloblastoma within the mandible (21) was four times higher than in the maxilla (5). In 69 per cent of the cases (18) it occurred in men, in 31 percent (8) in women. The sex ratio differed with the maxillary ameloblastomas: 40 percent male (2) and 60 per cent female (3). Although slow growing and nearly painless, it can reach a considerable size within the mid-face involving such highly specialized structures as the orbit, skull-base and brain. Wide resections with a safety margin of healthy bone to prevent local recurrence were undertaken. Nevertheless, recurrence was frequent due to invasion of the adjacent bone. Conclusion: On the one hand, a recurrence was found after a simple curettage of a ‘dental cyst’. On the other hand, extensive bone destruction, involvement of the nasal cavity, the ethmoidal and sphenoidal sinuses, infiltration of the skull-base and distant metastasis were observed. The current treatment of choice is partial maxillectomy with a 10–15mm safety margin of healthy bone including the alveolar ridge, the hard palate, the mucosa of the maxillary sinus and the lateral nasal wall. For the removal of tumours close to or invading the retromaxillary space the temporal approach gives ample access. Copyright 2002 European Association for Cranio-Maxillofacial Surgery. Published by Elsevier Science Ltd. All rights reserved

Maxillary ameloblastomas: a review of the literature and of a 15-year database.

Cases of maxillary ameloblastomas from 15-year database (1986-2000) collected in the Department of Cranio-Maxillofacial Surgery of the University Hospital of Zurich were evaluated. Twenty-six patients suffering from ameloblastoma had been collected. Five of them, had a maxillary ameloblastoma, three females and two males. A clinical retrospective study was performed. In addition a review of the literature was undertaken and the findings have been compared and contrasted. The overall incidence of ameloblastoma within the mandible (21) was four times higher than in the maxilla (5). In 69 per cent of the cases (18) it occurred in men, in 31 percent (8) in women. The sex ratio differed with the maxillary ameloblastomas: 40 percent male (2) and 60 per cent female (3). Although slow growing and nearly painless, it can reach a considerable size within the mid-face involving such highly specialized structures as the orbit, skull-base and brain. Wide resections with a safety margin of healthy bone to prevent local recurrence were undertaken. Nevertheless, recurrence was frequent due to invasion of the adjacent bone. On the one hand, a recurrence was found after a simple curettage of a 'dental cyst'. On the other hand, extensive bone destruction, involvement of the nasal cavity, the ethmoidal and sphenoidal sinuses, infiltration of the skull-base and distant metastasis were observed. The current treatment of choice is partial maxillectomy with a 10-15 mm safety margin of healthy bone including the alveolar ridge, the hard palate, the mucosa of the maxillary sinus and the lateral nasal wall. For the removal of tumours close to or invading the retromaxillary space the temporal approach gives ample access.