Incidence For Retinopathy Of Prematurity Research Articles

Optimised retinopathy of prematurity screening guideline in China based on a 5-year cohort study

PurposesTo develop an optimised retinopathy of prematurity (ROP) screening guideline by adjusting the screening schedule and thresholds of gestational age (GA) and birth weight (BW).MethodsA multicentre retrospective cohort study was...

Incidence and Characteristics of Infants with Retinopathy of Prematurity in Croatia

PURPOSE: To study the incidence of retinopathy of prematurity (ROP) in a neonatal intensive care unit in Croatia and obtain information on risk factors associated with ROP. There have been limited studies on ROP in Croatia where the screening for ROP and its treatment is still insufficient and not introduced in many intensive care units.
 MATERIAL AND METHODS: This retrospective study included 247 premature infants admitted to the neonatal intensive care unit of University Hospital Split, over a 5-year period between January 2012, and December 2016. In this paper the relationship between clinical risk factors and the development of ROP was analyzed.
 RESULTS: The overall incidence for ROP was 23,9 % (59 infants), for Type 1 ROP was 9,3% (23 infants); for Type 2 ROP was 14,6% (36 infants). Median gestational age (GA) and birthweight (BW) were significantly lower among infants with ROP versus those without ROP (29: 23-34 vs. 31: 23-34,p<0,001 and 1,180:630-2,000 vs. 1485:590-2000, p<0,001 respectively). Multivariate analysis showed that only BW (p=0,029) and small for gestational age (SGA) (p=0,045) predicted the development of ROP.
 CONCLUSION: Birth weight and small for gestational age were the most significant risk factors for developing ROP. In comparison with studies from highly developed countries, infants with a much wider range of gestational age and birth weights are developing Type 1 ROP.

Retinopathy of Prematurity Among Very Low-Birth-Weight Infants in China: Incidence and Perinatal Risk Factors.

Retinopathy of prematurity (ROP) is the leading cause of blindness in children worldwide. This study aimed to determine the incidence and perinatal risk factors for ROP in very low-birth-weight (VLBW) Chinese infants. A retrospective study of the medical records of 504 VLBW infants screened for ROP from 2012 to 2015 was performed in West China Second University Hospital. VLBW infants were examined according to the Royal College of Ophthalmologists ROP guideline and retinopathy was graded following the International Classification of ROP. Perinatal risk factors for ROP were assessed using univariate and multivariate analyses. The overall incidence of ROP in our study was 26.0% (131/504). Stage 1 ROP, stage 2 ROP, and stage ≥3 ROP were detected in 17.5%, 5.4%, and 3.2% of the infants screened, respectively. In the univariate analysis, many perinatal risk factors were found to have a significant association with ROP. In the subsequent multivariate analysis, in vitro fertilization (IVF) (odds ratio [OR] = 1.896; 95% confidence interval [CI] 1.031-3.486), gestational age (GA) < 32 weeks (OR = 2.171; 95% CI 1.085-4.346), apnea (OR = 2.001; 95% CI 1.224-3.272), bronchopulmonary dysplasia (BPD) (OR = 5.098; 95% CI 2.307-11.265), sepsis (OR = 2.212; 95% CI 1.070-4.576), patent ductus arteriosus (PDA) (OR = 1.675; 95% CI 1.011-2.774), and blood transfusion (OR = 1.819; 95% CI 1.046-3.163) were independently associated with the development of ROP (all P < 0.05). In VLBW Chinese infants, IVF, GA < 32 weeks, apnea, BPD, sepsis, PDA, and blood transfusion were independent perinatal risk factors for ROP.

Starting enteral nutrition with preterm single donor milk instead of formula affects time to full enteral feeding in very low birthweight infants.

This study compared the impact of using either single donor breastmilk or formula to start enteral feeding in preterm infants, on the time to full enteral feeding, growth and morbidity. The milk was provided by other preterm mothers. This was an observational prospective study, carried out from June 2012 to March 2013 at the Medical University of Vienna, Austria, on the effects of preterm single donor milk on 133 very low birthweight infants with a birthweight <1500 g and a gestational age <32 weeks until they were on full enteral feeding. They were compared to a retrospective group of 150 infants from March 2011 to May 2012 who received preterm formula. The time to full enteral feeding, defined as 140 mL/kg, was significantly shorter in the donor milk group than in the formula group (18 vs. 22 days, p = 0.01). Feeding donor milk was also associated with a lower incidence for retinopathy of prematurity (4% vs. 13%, p < 0.01) and culture-proven sepsis (11% vs. 23%, p < 0.01). Feeding preterm infants breastmilk from a single donor rather using formula was associated with a shorter time to full enteral feeding and lower incidences of retinopathy of prematurity and sepsis.

Incidence and Risk Factors of Retinopathy of Prematurity in Mashhad, Northeast Iran

BackgroundRetinopathy of prematurity (ROP) is a vascular retinal disease that can cause low vision or blindness and affects premature newborns of very low birth weight.ObjectivesThe purpose of this study was to determine the incidence and risk factors for ROP among very premature infants in Mashhad located northeast of Iran.Material and MethodsIn this cross-sectional study performed between 2006 and 2010, predisposing factors and severity of ROP were evaluated in very premature infants (<32 gestational weeks). Consecutive infants were enrolled at birth and screened for ROP at 4 to 6 weeks of age by indirect ophthalmoscopy. Severe ROP was defined as stage 4 or 5. Chi-square, Student’s t-, and Fisher’s test were used for statistical analysis.ResultsThe incidence of ROP was 26.2%. Significant differences between the ROP and control groups were observed, these include; gestational age, sex, birth weight, Apgar score, durationof parenteral nutrition, oxygen therapy, phototherapy, maximum PaO2 and minimum SpO2 (P < 0.05). Severe ROP was seen in 31.4% (11/32) of ROP cases (5.4% of newborns).ConclusionThe incidence of ROP is relatively high in this region. Risk factors for ROP among very premature infants include hypoxia, severe hyperoxia, relatively low blood SPO2, gestational age, birth weight, and Apgar score.

Research Letters

Retinopathy of prematurity (ROP) is an emerging cause of blindness. Few data are available from secondary care centres. Analyses of the incidence and risk factors for ROP from a secondary care center indicate that the incidence (19.7%) is higher than that noted in tertiary care centers. This highlights the need to screen even big preterms (>1500 g or >32 wks) born at these centers for ROP.