Inbred Research Articles

Transplantable adenocarcinomas from color-rectal tumors induced by infusion of N-methyl-N'-nitro-N-nitrosoguanidine in ACI/N rats.

Two transplantable strains of adenocarcinoma were established from the carcinomas of the colon and rectum induced by infusion of N-methyl-N'-nitro-N-nitrosoguanidine in inbred ACI/N rats, The tumors are solid type, not converted to ascite form yet, either papillary or tubulo-papillary adenocarcinomas, and particularly grow slowly, showing 2 to 4 months of survival in animals transplanted subcutaneously. Besides histological resemblance of the tumors to human adenocarcinoma of the large intestine, marked mucin production in tumor was noted in one of these strains.

Mouse strain difference in the expression of antitumor activity of PS-K.

Effect of PS-K on tumor growth and antibody production was studied in inbred C57BL/6, SL, C3H/He, and AKR mice, and in colony-bred ICR mice. (1) PS-K exhibited antitumor activity on sarcoma-180 in ICR mice, but not in AKR mice. Growth of sarcoma-180 was suppressed to the intermediate extent in other strains. (2) In ICR strain, antibody production against trinitrophenyl was depressed in mice bearing sarcoma-180 and restored by PS-K. In AKR mice, on the other hand, antibody production was not depressed in tumor-bearing state and was not augmented by PS-K. Other strains showed intermediate degrees of suppression of antibody-producing capacity by sarcoma-180 and its restoration by PS-K.CR strain, the growth of Ehrlich tumor as the challenge tumor was enhanced in mice bearing sarcoma-180 as compared to that in controls. After the treatment with PS-K in this strain, however, not only the growth of sarcoma-180 but also of Ehrlich tumor was inhibited completely. On the other hand, the growth of Ehrlich tumor in AKR strain was neither enhanced in mice bearing sarcoma-180 nor inhibited by PS-K.

Intracisternal A particles in transplantable reticulum cell sarcoma of rats.

Electron microscopic examination on three lines of transplantable reticulum cell sarcomas, induced spontaneously in the mesenteric lymph nodes of inbred strain ACI rats, proved the presence of intracisternal A particles in all the three tumor lines. The doughnut-shaped particles measured 50 to 70 nm and were seen to bud from the membranes of rough-surfaced endoplasmic reticulum. Frequency of appearance of these particles varied with the tumor line.

Reproductivity in inbred strains of mice and project for their efficient production (author's transl)

系統マウスの生産を効率よく行なうための基礎データを得る目的で, 当研究所で系統繁殖している8系統のマウスの繁殖性について, 交配分娩間隔, 産子数, 正常分娩率, 分娩時母体重, 0, 12, 20日齢平均子体重, 12日齢増体率, 12, 20日齢育成率, 繁殖不能個体率, 死産子率などを調べ, これらの成績に基づいた生産方法, とくに追いかけ妊娠方式による計画生産についての試案を作成した。分娩間隔においてBALB/cHeのみが約5週間で長かったが, 他の系統は約4週間であった。産子数においては系統内産次間で顕著な変動はみられなかったが, 系統間においては相違が認められた。正常分娩率ではC3HeB/FeJax, CBA, C57BL/6Jax, C3H/HeMs, Aでは90%前後であったが, BALB/cHe, RIII, DBA/2は70%であり, 良いグループと悪いグループに2大別された。20日齢育成率でもRIII, Aが他系とくらべて悪かった。以上の成績を基にして, 週単位の生産を基準とした追いかけ妊娠による計画生産の試案を作成した。分娩間隔の成績から生産群の編成はBALB/cHeを5群, 他の系統は4群を設け, 各系統の分娩率, 産子数, 育成率の平均値を用いて, 毎週100匹の動物を生産するのに必要な生産親ケージ数を算出したところ, C3HeB/FeJax, C3H/HeMs, C57BL/6Jax, CBA, BALB/cHe, A, RIII, DBA/2ではそれぞれ76, 84, 88, 96, 160, 168, 200, 200ケージとなった。本実験の一部は文部省科学研究助成金 (がん特別研究1, No.90183) によるものである。

The induction of pulmonary neoplasms in mice by isonicotinic acid hydrazide.

Mice have a high incidence of spontaneous pulmonary neoplasms. Inbred strains with particularly high spontaneous incidence are also more susceptible to induction of such neoplasms by a variety of o...

Response if an Inbred Strain of Platyfish and the Fathead Minnow to Zinc

(1968). Response if an Inbred Strain of Platyfish and the Fathead Minnow to Zinc. The Progressive Fish-Culturist: Vol. 30, No. 4, pp. 203-207.

CHARACTERISTICS IN INBRED MOUSE POPULATIONS PLATEAUED BY DIRECTIONAL SELECTION

CHARACTERISTICS IN INBRED MOUSE POPULATIONS PLATEAUED BY DIRECTIONAL SELECTION

The genetic control of two types of esterases in inbred strains of the mouse.

The genetic control of two types of esterases in inbred strains of the mouse.

STUDIES ON DOMINANCE AND PLEIOTROPY USING SEGREGATING INBRED LINES OF FOWL

STUDIES ON DOMINANCE AND PLEIOTROPY USING SEGREGATING INBRED LINES OF FOWL

MUTANT EXPRESSION IN INBRED LINES AND CROSSES.

In Versuchen mit der MutanteciD vonDrosophila melanogaster wurden die Komponenten der nichtgenetischen Varianz der Merkmalsauspragung bestimmt durch Einkreuzen vonciD in verschiedene Inzuchtstamme, Die unabhangige Komponente (Vi) fur die beiden Flugel ist mehrere Male grosser als die gemeinsame Komponente (Vc). Nach Kreuzung zwischen den Inzuchtstammen wurde keine Veranderung derVi-Werte und in den Werten der Merkmalsauspragung keine Annaherung an den normalen Phanotypus festgestellt.

QUANTITATIVE GENETICS OF SKELETAL VARIATIONS IN THE MOUSE. II. CROSSES BETWEEN FOUR INBRED STRAINS (C3H, DBA, C57BL, BALB/c)

QUANTITATIVE GENETICS OF SKELETAL VARIATIONS IN THE MOUSE. II. CROSSES BETWEEN FOUR INBRED STRAINS (C3H, DBA, C57BL, BALB/c)

The Distribution of Vitamin B6 in the Tissues of Two Inbred Strains of Mice Fed Complete and Vitamin B6-deficient Rations

The Distribution of Vitamin B6 in the Tissues of Two Inbred Strains of Mice Fed Complete and Vitamin B6-deficient Rations

The B blood group system of chickens. II. The effects of genotype on livability and egg production in seven commercial inbred lines.

The B blood group system of chickens. II. The effects of genotype on livability and egg production in seven commercial inbred lines.

Susceptibility of inbred mice of strain C57BL/10-H-2d to tick-borne encephalitis virus

Мы сравнивали чувствительность к вирусу клещевого знцеϕалита у инбридного штамма мыштй C57B/10-H-2d и у бтлых мыштй штамма аНН. У инбридного штамма наблюдалась практичтски такая же чувствительность, как У высоко чувствительных мышей йНН, применятмых обычно для работ с вирусом клещевого знцеϕалита.

HETEROSIS IN CROSSES OF INBRED LINES OF RATS

HETEROSIS IN CROSSES OF INBRED LINES OF RATS

A CHROMATOGRAPHIC ANALYSIS OF THE FREE AMINO ACIDS IN THE BLOOD PLASMA OF THREE INBRED STRAINS OF THE HOUSE MOUSE, MUS MUSCULUS

A CHROMATOGRAPHIC ANALYSIS OF THE FREE AMINO ACIDS IN THE BLOOD PLASMA OF THREE INBRED STRAINS OF THE HOUSE MOUSE, MUS MUSCULUS

HETEROSIS AND GENETIC VARIANCE IN HYBRIDS BETWEEN INBRED LINES OF DROSOPHILA MELANOGASTER IN RELATION TO THE LEVEL OF HOMOZYGOSITY

HETEROSIS AND GENETIC VARIANCE IN HYBRIDS BETWEEN INBRED LINES OF DROSOPHILA MELANOGASTER IN RELATION TO THE LEVEL OF HOMOZYGOSITY

GENETIC VARIATION IN THE ACUTE LETHAL RESPONSE OF FOUR INBRED MOUSE STRAINS TO WHOLE BODY X-IRRADIATION

GENETIC VARIATION IN THE ACUTE LETHAL RESPONSE OF FOUR INBRED MOUSE STRAINS TO WHOLE BODY X-IRRADIATION

ON THE INHERITANCE OF NATURAL ANTISHEEP AGGLUTININS IN MICE OF INBRED STRAINS

ON THE INHERITANCE OF NATURAL ANTISHEEP AGGLUTININS IN MICE OF INBRED STRAINS

NATURAL MUTATIONS IN INBRED LINES OF MAIZE AND THEIR HETEROTIC EFFECT. II. COMPARISON OF MOTHER LINE VS. MUTANT WHEN OUTCROSSED TO UNRELATED INBREDS

NATURAL MUTATIONS IN INBRED LINES OF MAIZE AND THEIR HETEROTIC EFFECT. II. COMPARISON OF MOTHER LINE VS. MUTANT WHEN OUTCROSSED TO UNRELATED INBREDS