AbstractThe impact of latitudinal variations in the Intertropical Convergence Zone (ITCZ) on northern Andean hydroclimate during the Medieval Climate Anomaly (MCA; 950–1,150 CE) and Little Ice Age (LIA; 1,300–1,850 CE) is uncertain. Synthesis of two new lacustrine paleoclimate records from the Eastern Colombian Andes with existing circum‐Andean records shows that effective moisture anomalies were synchronous and in phase across the tropical Andes during the last millennium. During the MCA, when the ITCZ was shifted northward, topographically controlled responses in the northern Andes to vigorous atmospheric convection resulted in low precipitation and high evaporation, while precipitation was also reduced in the southern tropical Andes. During the LIA, precipitation decreased in the northern Andes as the ITCZ migrated southward but was offset by cooling that lowered evaporation, establishing high effective moisture. In the southern tropical Andes, the southward ITCZ position simultaneously strengthened precipitation, increasing effective moisture. MCA‐like responses to continued warming trends could similarly reduce northern Andean precipitation while increasing evaporation, thereby lowering effective moisture and possibly reducing water resource availability.