Introduction: Issues related to doctors' pharmacovigilance exist due to their lack of knowledge and the challenges of a rapidly changing society. In addition, issues exist with the subject's existing systems. Proper intervention with a comprehensive system of pharmacovigilance can resolve these problems.Objective: This research is intended to assess the knowledge, perception, and practices of pharmacovigilance among medical officers in a district of Sri Lanka with surveillance systems through interventions.Methodology: A pre-and post-intervention design research study was conducted among 237 doctors in the curative sector in the Hambanthota district. All the doctors in these hospitals were considered the study population, and no sampling method was employed. A self-administered questionnaire was used to collect the data using active and passive surveillance data systems and workshops.Results: The results indicated that most of the doctors were from the 31-40 age category (55.3%), females (53.59%), preliminary and grade 2 medical officers (67.1%, 37.6%) who are working in the base hospitals (64.1%) of the area with a basic medical degree (90.8%). A large proportion of them (67.5%) had training in this area as undergraduates (25%). The overall knowledge of pharmacovigilance was poor (69.7%). The overall perception was positive (53.2%). Overall, practices were poor. Knowledge and perception have improved with the intervention.Conclusion and recommendations: This research revealed poor general knowledge, practices, and a positive perception regarding pharmacovigilance, which improved through an intervention. Substantial consideration should be paid to including those topics in undergraduate and postgraduate curricula. Continuous professional development and in-service training programmes should be arranged for doctors with a comprehensive system of surveillance.
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