Due to their compact size, electromagnetic interference immunity, and compatibility with embedding in composite materials, optical fiber sensors have emerged as a versatile and integral solution for structural health monitoring (SHM) in various structures. Among the key contributors to the evolution of this field is the significant progress in optical frequency domain reflectometry (OFDR), a technology that offers unparalleled high resolution and sensitivity in distributed strain sensing, thereby establishing itself as an indispensable tool in the realm of SHM. Through the implementation of OFDR, we devised a distributed fiber optic sensor tailored for the precise measurement of vibration or strain within structures. In previous works, vibration monitoring has been achieved using an OFDR with an array of 20 in-line interferometers, serving as weak reflectors that not only facilitated vibration monitoring but also furnished valuable strain information. In this study takes a step further by introducing an innovative technique wherein in-line interferometers are strategically arranged in a non-uniform fashion along the optical fiber. To validate the practical utility of this technology, extensive simulations and experiments were conducted, utilizing a cantilever beam as a representative structure. The results obtained from these endeavors showcase the tangible potential and reliability of optical fiber sensors in the practical implementation of SHM across various applications. By enhancing the precision and scope of structural monitoring, optical fiber sensors equipped with non-uniform interferometer arrangements pave the way for more effective and comprehensive structural health assessment in diverse settings.