In this work, we introduce a new definition for the fractional differential operator that generalizes several well-known fractional differential operators. In fact, we introduce the notion of the p-proportional ω-weighted κ-Hilfer derivative includes an exponential function, Da,λσ,ρ,p,κ,ω, and then we consider a non-instantaneous impulse differential inclusion containing Da,λσ,ρ,p,κ,ω with order σ∈(1,2) and of kind ρ∈[0,1] in Banach spaces. We deduce the relevant relationship between any solution to the studied problem and the integral equation that corresponds to it, and then, by using an appropriate fixed-point theorem for multi-valued functions, we give two results for the existence of these solutions. In the first result, we show the compactness of the solution set. Next, we introduce the concept of the (p,ω,κ)-generalized Ulam-Hyeres stability of solutions, and, using the properties of the multi-valued weakly Picard operator, we present a result regarding the (p,ω,κ)-generalized Ulam-Rassias stability of the objective problem. Since many fractional differential operators are particular cases of the operator Da,λσ,ρ,p,κ,ω, our work generalizes a number of recent findings. In addition, there are no past works on this kind of fractional differential inclusion, so this work is original and enjoyable. In the last section, we present examples to support our findings.