Building thermal mass (BTM) plays an essential role in maintaining a comfortable indoor environment for intermittently heated rooms (IHR). However, how to properly determine the BTM in IHR is unclear for the comprehensive consideration of the opposite effects on the reduction of heating energy consumption (HEC) as well as the improvement of indoor thermal comfort (ITC). This study aims to investigate the comprehensive impact of BTM on the HEC and ITC of IHR in the hot summer and cold winter (HSCW) zone of China using the validated EnergyPlus model. The results indicate that BTM can significantly improve the ITC of IHR, whereas increase HEC. The degree of impact is mainly related to the internal wall heat accumulation coefficient, external wall insulation layer thermal resistance, and outdoor air mean temperature during non-heating periods. Response surface methodology is further employed to quantify the effects of BTM on HEC and ITC of IHR. Based on the predictive models, the range of parameter variations for BTM that simultaneously meet HEC and ITC requirements is obtained. The predictive models can provide a theoretical basis for balancing HEC and ITC in intermittently heated buildings in the HSCW zone of China.