This research aims to examine the connection between physical activity, mental health, and quality of life through a systematic review of scholarly literature. The approach used is a Systematic Literature Review (SLR), leveraging the Scopus database, employing a keyword search strategy relevant to the topic, and following PRISMA guidelines. Articles published from 2020 to 2024 that focus on physical activity and mental health within Q1-Q2 percentile indices were screened. Out of the 89 articles identified, 28 met the inclusion criteria and were relevant to the topic. The analysis of these studies reveals that increased physical activity is associated with a reduction in symptoms of depression and anxiety, and an improvement in mental well-being and quality of life. Additionally, the study notes variations in measurement methods, such as the use of accelerometers and different mental health questionnaires. These findings support the development of evidence-based interventions to enhance mental well-being through physical activity, especially among children, adolescents, and the elderly. However, the study identifies challenges related to measurement methods and intervention duration, indicating a need for further research to develop more comprehensive and practical recommendations.