School enterprise cooperation is of great strategic significance to China’s manufacturing industry. The Party Central Committee has repeatedly proposed to strengthen the integration of industry and education and deepen the cooperation between schools and enterprises. In recent years, experts and scholars at home and abroad have been from different perspectives, although they have achieved fruitful results, there are also problems such as insufficient attention to theoretical research, relatively backward research, narrow research scope, and so on. In view of this phenomenon, this paper will study a new school-enterprise cooperation mechanism based on the improved decision tree algorithm. The research of this paper is divided into three parts. First, after analyzing the advantages and disadvantages of the algorithm, the algorithm of the decision tree is improved, which makes the improved algorithm more suitable for the field of school-enterprise cooperation. Then, based on cloud computing and intelligence, this paper establishes a new model of school-enterprise cooperation platform, which solves some problems of data management and information exchange in school-enterprise cooperation. Finally, in order to make the cooperation mechanism of this paper better used in practice, this paper builds an online and offline hybrid training base, hoping to make the cooperation between schools and enterprises closer through the training base. In order to test the effect of the cooperation model, this paper takes school as the experimental model. After investigation and research, it is believed that thanks to the school-enterprise cooperation mechanism in this paper, the cooperative enterprise of school has been greatly improved in the past three years, and the willingness of enterprises to cooperate has become more and more strong. No matter students, teachers, or enterprises are reaping huge benefits under this cooperation mechanism, it is a suit for extensive promotion The school-enterprise cooperation mechanism of Guangyun.