Motorcycle crashes account for a significant proportion of traffic-related fatalities on U.S. roadways. Compared with motor vehicles, motorcycles traveling straight ahead are more susceptible to collisions with left-turning vehicles at intersections (note – in a system where traffic travels on the right-hand side of the road). The limited knowledge of the causes and influences of this specific type of crash deters efforts to improve motorcycle safety and is partly influenced by two issues. First, significant variables are unknown; second, motorcycles comprise a small proportion of vehicles in the traffic stream. This study sought to understand the factors that may contribute to the disproportionate crash risk left-turning vehicles pose for motorcyclists while accounting for the imbalance of vehicle proportions. Data containing motorcycle-motor vehicle and motor vehicle-motor vehicle crashes involving left-turning motor vehicles at intersections in South Florida were collected from 2015 to 2017. The study applied logistic regression on a balanced dataset generated using the random oversampling technique. The proposed model improved the predictive accuracy and enabled the identification of factors contributing to motorcycle crashes with left-turning vehicles. A Bayesian network analysis was also applied to the balanced data to analyze the interrelationship of factors associated with motorcycle crashes with left-turning vehicles. Results indicated that the type of intersection and traffic control, time of day, age of drivers, sex of the motorcyclist, roadway type, and weather were significantly associated with motorcyclists’ susceptibility to collisions with left-turning vehicles. Recognizing these attributes could help devise engineering measures and policies for promoting motorcycle safety.