Imprinting Technology Research Articles

Magnetic Molecularly Imprinted Polymer Combined with Solid-Phase Extraction for Purification of Schisandra chinensis Lignans

Molecularly imprinted polymers (MIPs) can specifically recognize template molecules in solution with imprinted cavities. Due to their capacity for scalable production, they can be used to isolate target products from natural products for industrial production in the fields of pharmaceuticals and food. In this study, magnetic single-template molecularly imprinted polymers (St-MIPs) instead of magnetic multi-template molecularly imprinted polymers (Mt-MIPs) were prepared by surface imprinting using Schizandrol A as a template molecule and deep eutectic solvent (DES) as a functional monomer, combined with solid-phase extraction (SPE) for the adsorption and separation of Schizandrol A, Schisantherin A, Schizandrin A, and Schizandrin B from Schisandra chinensis (Turcz.) Baill. (S. chinensis) fruits extracts. The synthesized MIPs were characterized by FT-IR, TEM, SEM, TG, XRD and VSM, and their adsorption properties were also evaluated. MIPs can specifically recognize the template molecules with high reusability. The purity of the total S. chinensis lignans after SPE was 74.05%, among which that of Schizandrol A, Schisantherin A, Schizandrin A, and Schizandrin B was 33.38%, 8.69%, 16.33% and 15.67%, respectively. Moreover, the one-step synthesis of carrier was easy to operate. And St-MIPs reduced the production cost compared with Mt-MIPs. This study provides a new idea for natural product separation by molecular imprinting technology (MIT).

Dual-Template Molecularly Imprinted Polymers for Dispersive Solid-Phase Extraction Combined with High Performance Liquid Chromatography for the Determination of Sulfonamide Antibiotics in Environmental Water Samples.

In this study, we designed a molecularly imprinted polymers-dispersive solid-phase extraction-high-performance liquid chromatography (MIPs-DSPE-HPLC) method, as a simple and efficient platform for the sensitive detection of two sulfonamide antibiotics (SAs) of sulfamethoxine (SMM) and sulfamethoxazole (SMZ) in environmental water samples. Using SMM and SMZ as templates, methacrylic acid as the functional monomer, ethylene glycol dimethacrylate as the crosslinking agent, and azodiisobutyronitrile as the catalyst, the dual-template molecularly imprinted polymers (dt-MIPs) were successfully synthesized via surface imprinting technology and multi-template imprinting strategy. The adsorption properties of the prepared MIPs were characterized, and the adsorption capacities of MIPs towards SMZ and SMM were 27.35 mg/g and 30.92 mg/g, respectively. The detection limits of the method in three environmental water samples were in the range of 0.23-1.74 μg/L, and the recoveries were between 82.7 and 110.3%, with relative standard deviations less than 5.93%. The construction process of this MIPs-DSPE-HPLC method is straightforward, exhibits high sensitivity and selectivity, and thus provides a versatile method for the quantification of SAs in complex matrices.

Flexible Au@Ag/PDMS SERS imprinted membrane combined with molecular imprinting technology for selective detection of MC-LR

In this study, a core–shell structured bimetallic nano-cube, Au@Ag NCs, was prepared by seed-mediated growth procedure. The array structure of Au@Ag NCs was achieved at the interface through the autonomous assembly technique at the three-phase boundary. Employing polydimethylsiloxane (PDMS) as a flexible carrier, the array structure was effortlessly transferred to the PDMS membrane, bypassing the need for rigid substrates through a simple “pasting” method. This yielded a highly flexible and transparent SERS substrate with an array structure (Au@Ag NCs/PDMS membrane, AAP). In order to promote the selective detection property to the practical samples, molecularly imprinted polymers (MIPs) were coated on the surface of membrane to prepare the imprinted membrane (Au@Ag NCs/PDMS-MIMs, AAP-MIMs). It was demonstrated from the results that the AAP-MIMs exhibited high SERS sensitivity, stability, and uniformity. Furthermore, the flexible substrate possessed commendable mechanical strength, and facilitated the detection of analytes on irregular surfaces. In summary, this substrate held promising potential for practical on-site detection and analysis of specific target substances.

Design and controlled synthesis of molecularly imprinted fluorescence sensor supported by multifunctional magnetic covalent organic framework: Efficient detection of clofibric acid in the environment

While some studies have explored magnetic covalent organic frameworks (MCOFs) for fluorescence sensing, substantial research gaps remain, especially in integrating molecular imprinting technology (MIT). In this study, superparamagnetic Fe3O4 cores were modified, and a monomer-mediated in situ growth strategy was used to synthesize uniform, multifunctional MCOFs nanoparticles. Subsequently, molecularly imprinted polymers (MIPs) were synthesized via a sol-gel method and deposited on MCOFs, forming MCOFs-supported molecularly imprinted fluorescent sensors (MCOFs@MIPs) for trace analysis of clofibric acid (CLF). This was the first application of molecularly imprinted fluorescence sensing technology for detecting CLF. MCOFs@MIPs combined the superparamagnetism of Fe3O4, the stability and signal amplification of COFs, and the selectivity of MIPs for CLF. Studies demonstrated that MCOFs@MIPs had a maximum fluorescence response in isopropanol, with an optimal dosage of 0.39 mg/mL, an imprinting factor (IF) of 2.73, a detection limit of 94 nM, and a range of 0 ∼ 300 µM. Characterizations revealed that the fluorescence quenching of MCOFs@MIPs was based on a photoinduced electron transfer (PET) mechanism, with MCOFs@MIPs as donors and CLF as acceptors. MCOFs@MIPs were used to detect CLF in actual samples from food, water, agricultural products, cosmetics, and human metabolites. The detection results were consistent with those from high-performance liquid chromatography (HPLC). Additionally, the recoveries of MCOFs@MIPs for actual samples ranged from 94.4 % to 100.7 %, demonstrating exceptional reliability, reusability, and accuracy.

Cyclodextrin-assisted high selectivity of imprinted adsorbents loaded on polyoxometalate@UiO-66 for H2S removal at ambient temperature

The efficient removal of H2S is necessary for clean production and energy safety. However, industrial gases are usually accompanied by CO2 significantly affecting desulfurization effects. Hence, novel imprinted adsorbents (PMo12@UiO-66@H2S-MIP-CDs) were synthesized through surface imprinting technology using cyclodextrins (CDs) as molecular scaffolds and UiO-66 modified by phosphomolybdic acid (PMo12@UiO-66) as a support. Wherein, PMo12@UiO-66@H2S-MIP-β-CD was determined as the optimal adsorbent since β-CD with low solubility is prone to keep its inherent cavity to promote dispersion of imprinted polymers and enrich internal pore channels. H2S capacity of PMo12@UiO-66@H2S-MIP-β-CD (31.67 mg/g) was about 2.4 and 1.7 times that of PMo12@UiO-66 and PMo12@UiO-66@H2S-MIPs, respectively, revealing the remarkable contribution of β-CD as a molecular scaffold to improve desulfurization. The results showed that PMo12@UiO-66@H2S-MIP-β-CD can maintain stable desulfurization efficiency regardless of the presence of CO2 or moisture, and O2 can strengthen the redox reaction between H2S and PMo12 accompanied by the increased reduction degree of Mo6+ in PMo12. After five adsorption-regeneration cycles, PMo12@UiO-66@H2S-MIP-β-CD still exhibited ideal removal efficiency. The excellent desulfurization performance is mainly ascribed to the selective adsorption role of H2S-MIP-β-CD and oxidative removal ability of PMo12. This work provides a valuable reference for the directional design of high-capacity functional adsorbents for room-temperature desulfurization.

Electro-spinning a calcium alginate based molecular imprinted nanofiber membrane for selectively adsorbing cytochrome c

Cytochrome c (Cyt c) is a typical water-soluble heme metalloprotein with a wide variety of physiological properties. High-efficient separation of Cyt c from bio-matrix is very important to Cyt c practical use but always difficult. By coupling the electro-spinning technology and the molecular imprinting technology, a molecularly imprinted nanofiber membrane (MINM) was prepared by using calcium alginate as skeleton. The characterization indicated a well cross-linked calcium alginate nanofiber membrane was formed with good structure stability and high mechanical strength. The obtained MINM showed high capacity of 3312 mg/g on adsorbing Cyt c at the initial concentration of 2 mg/mL. The adsorption selectivity against bovine serum albumin, bovine hemoglobin and ovalbumin was as high as 36.49, 66.01 and 59.70, respectively. A good separation efficacy toward Cyt c was also observed in pig heart extracts. The obtained MINM had homogenous surface and identical adsorption sites, the adsorption of Cyt c on the membrane was monolayer, chemisorption and diffusion controlled, the molecules diffusion in the interior of the membrane was not the only rate-limiting step. The results indicated a good reusability and a promising practical application value of the obtained MINM on Cyt c separation, which further emphasized the value of the synthesis procedure employed in this study.

Biomimetic Contact Behavior Inspired Tactile Sensing Array with Programmable Microdomes Pattern by Scalable and Consistent Fabrication.

Flexible sensor arrays have attracted extensive attention in human-computer interaction. However, realizing high-performance sensor units with programmable properties, and expanding them to multi-pixel flexible arrays to maintain high sensing consistency is still struggling. Inspired by the contact behavior of octopus antenna, this paper proposes a programmable multistage dome structure-based flexible sensing array with robust sensing stability and high array consistency. The biomimetic multistage dome structure is pressurized to gradually contact the electrode to achieve high sensitivity and a large pressure range. By adjusting the arrangement of the multistage dome structure, the pressure range and sensitivity can be customized. More importantly, this biomimetic structure can be expanded to a multi-pixel sensor array at the wafer level with high consistency through scalable and high-precision imprinting technologies. In the imprinting process, the conductive layer is conformally embedded into the multistage dome structure to improve the stability (maintain stability over 22000 cycles). In addition, the braced isolation structure is designed to effectively improve the anti-crosstalk performance of the sensor array (crosstalk coefficient: 26.62dB). Benefitting from the programmable structural design and high-precision manufacturing process, the sensor array can be customized and is demonstrated to detect human musculation in medical rehabilitation applications.

Sensitive Coatings Based on Molecular-Imprinted Polymers for Triazine Pesticides' Detection.

Triazine pesticide (atrazine and its derivatives) detection sensors have been developed to thoroughly check for the presence of these chemicals and ultimately prevent their exposure to humans. Sensitive coatings were designed by utilizing molecular imprinting technology, which aims to create artificial receptors for the detection of chlorotriazine pesticides with gravimetric transducers. Initially, imprinted polymers were developed, using acrylate and methacrylate monomers containing hydrophilic and hydrophobic side chains, specifically for atrazine, which shares a basic heterocyclic triazine structure with its structural analogs. By adjusting the ratio of the acid to the cross-linker and introducing acrylate ester as a copolymer, optimal non-covalent interactions were achieved with the hydrophobic core of triazine molecules and their amino groups. A maximum sensor response of 546 Hz (frequency shift/layer height equal to 87.36) was observed for a sensitive coating composed of 46% methacrylic acid and 54% ethylene glycol dimethacrylate, with a demonstrated layer height of 250 nm (6.25 kHz). The molecularly imprinted copolymer demonstrated fully reversible sensor responses, not only for atrazine but also for its metabolites, like des-ethyl atrazine, and structural analogs, such as propazine and terbuthylazine. The efficiency of modified molecularly imprinted polymers for targeted analytes was tested by combining them with a universally applicable quartz crystal microbalance transducer. The stable selectivity pattern of the developed sensor provides an excellent basis for a pattern recognition procedure.

Approach for concurrent detection and removal of diclofenac in wastewater: Integration of MOF with Poly(deep eutectic solvent) imprinting method

Diclofenac in medical wastewater poses a significant threat to the environment and human health. A simple and efficient enrichment strategy has been established for the selective identification and removal for diclofenac in environmental water samples applying MOF based polymeric deep eutectic solvent (Poly(DES)@MOF). Poly(DES)@MOF was synthesized using a surface imprinting method. The components included MOF-199 as the support material, diclofenac as the template, and a deep eutectic solvent (DES) composed of choline chloride and methacrylate (1:2) as the functional monomer. Density functional theory calculated the Gibbs free energy change during the reaction process, confirming that DES improved the binding performance and selectivity of polymer. Related experiments have shown that Poly (DES) @ MOF has high adsorption capacity, reaching equilibrium within 2 h. In real sample experiments, the maximum adsorption capacity of diclofenac in lake water by the extraction device was 19.39 mg·g−1, with an average recovery rate between 99.4 % and 105.8 %. After 5 repeated uses, the performance did not show significant degradation. After evaluating the principles of green analytical chemistry using agree software, the total score was 0.68, reflecting the high greenness of this study. This study combined molecular imprinting technology and computer theory simulation of MOF based and DES mediated polymerization processes to construct an extraction device that was easy to operate and could extract diclofenac from environmental water samples with high selectivity and adsorption capacity. It showed great potential in the field of environmental monitoring and provided a new approach for the detection of other pollutants in the environment.

Molecular Imprinting‐involving Highly Selective Tetracycline Detection Platform Based on Mn2V2O7 with Excellent Oxidase‐mimicking Activity

AbstractNanozymes‐involving colorimetry may represent an effective solution to tetracycline detection due to its affordability and simplicity. To improve the performance in selectivity, molecular imprinting technology has emerged as a promising approach to simulating the interaction between antibodies and receptors. Herein, Mn2V2O7, a form of nanozyme with oxidase‐mimicking activity, was synthesized. With tetracycline as the template, the cavities with unique dimensions were constructed through the self‐polymerization of dopamine (DA) on Mn2V2O7. In Mn2V2O7@MIP, polydopamine (PDA) acts as molecularly imprinted polymer (MIP) and its cavities are compatible with tetracycline in dimension. It also exhibits oxidase‐mimicking activity. With the introduction of tetracycline, the cavity of PDA is blocked, which leads to obvious color fading, which enables precise tetracycline detection with colorimetry. The range of linear detection is from 10 to 100 μM, and the lower limit of detection is 0.82 μM. It is anticipated that the combination between nanozymes‐involving colorimetry and molecular imprinting technology would contribute to the accurate detection of organic pollutants in the aquatic environment.

Solid-Phase microextraction on Self-Driven microfluidic chip using capillary micropump and microvalves for saliva electrochemical analysis

The real-time detection of biomarkers in saliva is of great significance for early non-invasive diagnostic of related diseases. In this work, molecular imprinting technology was used to prepare a lactic acid monolithic column, which could realize specific adsorption and elution of lactic acid, achieving solid phase microextraction (SPME) of lactic acid in samples, and purify the analytes. Lactic acid monolithic column was then embedded into the microfluidic channel, and passive microfluidic structures such as stop valve, retention valve, trigger valve and capillary pump were utilized to construct the SPME self-driven microfluidic chip. A series of complex operations such as lactic acid adsorption, rinse and elution on the monolithic column could be realized automatically without external power. Since the purification of the analytes was achieved by the monolithic column, the low-cost nano copper oxide modified electrode was used to achieve the specific electrochemical analysis of lactic acid. The screen-printed electrode was designed and fabricated, and the integrated electrochemical detection circuit was used to realize the portable analysis of Na+, K+ and lactic acid simultaneously. The microfluidic chip, screen-printed electrode and miniaturized detection circuit are integrated into a Point-of-care testing (POCT) device, which realizes the automatically real-time detection of saliva. By adjusting the template molecule in monolithic column polymerization, the application of this physiological fluid POCT device can be extended, and may provide some implications for the development of portable non-invasive health monitoring devices.

Molecular Imprinting Technology for Advanced Delivery of Essential Oils.

Essential oils (EOs) hold therapeutic potential, but their conventional delivery systems have some limitations. This review focuses on the critical review and discussion of research related to EO delivery systems. The review also explores how molecular imprinting technologies (MIT) can advance EO delivery. MIT offer several techniques, namely covalent, non-covalent, and semi-covalent imprinting, creating targeted cavities that selectively bind and release EOs. These approaches promise significant advantages including increased selectivity, controlled release, and protection from environmental degradation. However, some challenges related to the stability and biocompatibility of MIPs remain unsolved. Integrating nanotechnology through methods like nanoparticle imprinting and some lithographic techniques seems promising to overcome these limitations. Some recently established models and systems used for EO-related research are paving the way for a more efficient and targeted EO delivery approach to harnessing the therapeutic power of EOs. Therefore, some recent and future research seems promising, and eventually it will increase the effectiveness of MIP-based EO delivery systems.

A novel imprinted porous liquid for lithium extraction

AbstractPorous liquids (PLs) are a novel material that combines the advantages of porous solids and liquid fluidity. In this study, we propose an imprinted porous liquid (IPL) with imprinted polymers as the porous framework and a mixture of TOP + FeCl3 as sterically hindered solvents. Quantum chemical computations and characterization results demonstrate the presence of unoccupied pore structure in IPLs. The prepared IPLs exhibit excellent selective adsorption and extraction performance for lithium extraction, achieving a Li/Mg separation factor of 1540 and a single‐stage Li+ extraction efficiency of 86%. The Li+ extraction efficiency remains above 84% even after eight cycles. Analytical characterization along with quantum chemical computations elucidates the mechanism underlying the coupling between extraction and adsorption in IPLs, enabling efficient lithium extraction. By combining imprinting technology with PLs, IPLs expand upon existing frameworks for PLs materials while providing new insights for designing functional solvents.

AGREEMIP: The Analytical Greenness Assessment Tool for Molecularly Imprinted Polymers Synthesis.

Molecular imprinting technology is well established in areas where a high selectivity is required, such as catalysis, sensing, and separations/sample preparation. However, according to the Principles of Green Chemistry, it is evident that the various steps required to obtain molecularly imprinted polymers (MIPs) are far from ideal. In this regard, greener alternatives to the synthesis of MIPs have been proposed in recent years. However, although it is intuitively possible to design new green MIPs, it would be desirable to have a quantitative measure of the environmental impact of the changes introduced for their synthesis. In this regard, this work proposes, for the first time, a metric tool and software (termed AGREEMIP) to assess and compare the greenness of MIP synthesis procedures. AGREEMIP is based on 12 assessment criteria that correspond to the greenness of different reaction mixture constituents, energy requirements, and the details of MIP synthesis procedures. The input data of the 12 criteria are transformed into individual scores on a 0-1 scale that in turn produce an overall score through the calculation of the weighted average. The assessment can be performed using user-friendly open-source software, freely downloadable from mostwiedzy.pl/agreemip. The assessment result is an easily interpretable pictogram and visually appealing, showing the performance in each of the criteria, the criteria weights, and overall performance in terms of greenness. The application of AGREEMIP is presented with selected case studies that show good discrimination power in the greenness assessment of MIP synthesis pathways.

Advances in the selection of functional monomers for molecularly imprinted polymers: A review.

Molecularly imprinted polymers, a type of special polymer materials, are widely used in biosensing and other fields due to their ability to specifically recognize target molecules, often called "artificial receptors.". Nowadays, researchers are constantly exploring new design and synthesis methods for molecularly imprinted materials to improve the selectivity and sensitivity of molecularly imprinted materials. Among them, the selection of functional monomers has attracted great attention. This review comprehensively analyzes and discusses the selection methods of functional monomers. The most commonly used functional monomers among different types of templates are screened based on the structural properties of the template molecules, including the selection of functional monomers among ion-imprinted polymers, protein-imprinted polymers, and bacterial imprinted polymers. The rich binding sites and functional group types of multifunctional monomers are also highlighted to advance the development of molecular imprinting technology. The article further explores the current challenges and prospects in the selection of functional monomers and emphasizes multiplex experiments and computer simulations as important directions for future research. This review provides comprehensive information and constructive guidelines for researchers in selecting functional monomers in areas such as analytical chemistry and biosensors.

Computer simulation‐guided template selection for a molecularly imprinted polymer for selective trifluralin adsorption

AbstractTo meet selective adsorption toward trifluralin, a novel molecularly imprinted polymer (MIP) was fabricated by the dummy template molecular imprinting technology. First, computational simulation was performed to select a suitable dummy template, 3,5‐dinitro‐4‐methylbenzoic acid (T1), based on the maximum basis set superposition error (BSSE)‐corrected binding interaction energy (ΔE) of the monomer N‐vinylpyrrolidone (NVP)‐T1 complex and its structural overlap with trifluralin. Then, the MIP was prepared via the bulk polymerization. The adsorption experiments showed the MIP exhibited a trifluralin adsorption capacity of 5.1 mg g−1, an imprinting factor (IF) of 2.2, and short adsorption equilibrium time of 5 min. The adsorption of trifluralin conformed to the Freundlich adsorption (R2 = 0.985) and pseudo‐second‐order model (R2 = 0.999). In addition, the MIP exhibited selectivity to trifluralin over other adsorbents, including structural analogs (pendimethalin and oryzalin), pesticide (carbendazim), and nitrocompounds (nitrofurantoin, furazolidone, and furaltadone), with the selectivity factor (β) in the range of 1.2–3.0, respectively. In trifluralin/oryzalin mixture, the IF toward oryzalin was still as high as 1.9. The removal rate of the MIP to trifluralin in environmental water samples ranged from 90.08% to 99.04%. This study provides theoretical and experimental insights for the preparation of MIP using dummy templates.

Dual Template Molecularly Imprinted Polymers Targeting Blockade of CD47 for Enhanced Macrophage Phagocytosis and Synergistic Antimetabolic Therapy.

Glycinamide ribonucleotide formyltransferase (GARFT) is an important enzyme in the folate metabolism pathway, and chemical drugs targeting GARFT have been used in tumor treatments over the past few decades. The development of novel antimetabolism drugs that target GARFT with improved performance and superior activity remains an attractive strategy. Herein, we proposed a targeted double-template molecularly imprinted polymer (MIP) for enhancing macrophage phagocytosis and synergistic antimetabolic therapy. The double-template MIP was prepared by imprinting the exposed peptide segment of the extracellular domain of CD47 and the active center of GARFT. Owing to the imprinted cavities on the surface of MIP, it can actively target cancer cells and mask the "do not eat me" signal upon binding to CD47 thereby blocking the CD47-SIRPα pathway and ultimately enhancing phagocytosis by macrophages. In addition, MIP can specifically bind to the active center of GARFT upon entry into the cells, thereby inhibiting its catalytic activity and ultimately interfering with the normal expression of DNA. A series of cell experiments demonstrated that MIP can effectively target CD47 overexpressed 4T1 cancer cells and inhibit the growth of 4T1 cells. The enhanced phagocytosis ability of macrophages-RAW264.7 cells was also clearly observed by confocal imaging experiments. In vivo experiments also showed that the MIP exhibited a satisfactory tumor inhibition effect. Therefore, this study provides a new idea for the application of molecular imprinting technology to antimetabolic therapy in conjunction with macrophage-mediated immunotherapy.

Fundamentals, Synthetic Strategies and Applications of Non-Covalently Imprinted Polymers.

Molecular imprinting has emerged as an important and practical technology to create economical and stable synthetic mimics of antibodies and enzymes. It has already found a variety of important applications, such as affinity separation, chemical/biological sensing, disease diagnostics, proteomics, bioimaging, controlled drug release, and catalysis. In the past decade, significant breakthroughs have been made in non-covalently imprinted polymers, from their synthesis through to their applications. In terms of synthesis, quite a few versatile and facile imprinting approaches for preparing MIPs have been invented, which have effectively solved some key issues in molecular imprinting. Additionally, important applications in several areas, such as sensors, proteomics and bioimaging, have been well demonstrated. In this review, we critically and comprehensively survey key recent advances made in the preparation of non-covalently imprinted polymers and their important applications. We focus on the state-of-art of this technology from three different perspectives: fundamentals, synthetic strategies, and applications. We first provide a fundamental basis for molecular imprinting technologies that have been developed, which is extremely helpful for establishing a sound understanding of the challenges in molecular imprinting. Then, we discuss in particular the major breakthroughs within the last ten years (2014-2024), with emphasis on new imprinting approaches, what strengths the breakthroughs can provide, and which new applications the properties of the prepared non-covalently imprinted polymers are fit for.

Computational simulation-assisted template selection of magnetic MOFs molecularly imprinted materials applying the adsorption and detection of multiple fluoroquinolones

This study utilized computational simulation and surface molecular imprinting technology to develop a magnetic metal-organic framework molecularly imprinted polymer (Fe3O4@ZIF-8@SMIP) capable of selectively recognizing and detecting multiple fluoroquinolones (FQs). The Fe3O4@ZIF-8@SMIP material was synthesized using the “common” template-ofloxacin, identified by computational simulation, demonstrating notable adsorption capacity (88.61–212.93 mg g−1) and rapid mass-transfer features (equilibration time: 2–3 min) for all tested FQs, consistent with Langmuir adsorption model. Subsequently, this material was employed as a magnetic solid-phase-extraction adsorbent for adsorption and detection of multiple FQs by combining with high performance liquid chromatography. The developed method exhibited good linearity for various FQs within the concentration range of 0.1–500 μg L−1, with low limit of detection (0.0605–0.1529 μg L−1) and limit of quantitation (0.2017–0.5097 μg L−1). Satisfactory recoveries (88.38–103.44%) were obtained when applied to spiked food samples, demonstrating the substantial potential of this Fe3O4@ZIF-8@SMIP material for rapid enrichment and identification for multiple FQs residues.

Simultaneous removal of CTRX and Cr(Ⅵ) by CQDs-doped bifunctional molecular imprinted BiOCl/Bi3NbO7 photocatalyst: The enhanced selective performance and charge separation abilities

As a commonly used additive in breeding industry, the complex pollutants and metabolites formed by antibiotics and heavy metals in aquaculture wastewater have the characteristics of strong persistence, refractory degradation and easy accumulation, and exist in the environment and human body for a long time, which caused seriously ecological, environmental and health problems. Their effective removal studies are very essential. In this paper, a CQDs-doped bifunctional molecular imprinted BiOCl/Bi3NbO7 heterojunction photocatalyst (CQDs-MIP-BNO) was fabricated and the micromorphology along with photoelectric characteristics were explored by SEM, XRD, FTIR, XPS, UV-Vis and PL analysis. The photocatalytic performance experiments implied that 10 % doping of CQDs showed the highest selectivity and photocatalytic activity for the 94 % removal rate of Ceftriaxone Sodium (CTRX) and 80 % of Cr (VI) within 45 min. On this basis, a photocatalytic reactor loaded with the as-synthesized bifunctional catalyst through a sponge mesh covered with CS/PVA film was set up and the actual operation potential was further explored. The results showed that the enhanced removal performance of this bifunctional photocatalyst for CTRX and Cr(VI) made it feasible to efficiently remove one or more low-concentration, high-toxicity antibiotics and heavy-metal pollutants from the water column to validate the utility of combining molecular imprinting and photocatalytic technologies for the treatment of aquaculture wastewater.