Importance Of Mean Platelet Volume Research Articles

Prognostic importance of Mean Platelet Volume/ Platelet Ratio Before Treatment in Patients with Metastatic Pancreatic Cancer

Objectives: Pancreatic cancer (PC) is one of the cancers with the worst prognosis in the world. Despite protooncogenes such as BRCA and PALB2 , effective, inexpensive, and simple methods for predicting the prognosis of patients with metastatic PC are still lacking. We aim to investigate whether mean platelet volume/ platelet (MPV/PLT) and platelet indices such as MPV and plateletcrit (PCT) have a prognostic significance in patients with metastatic PC.
 Methods: Patients diagnosed with metastatic PC in 3 centers in Turkey between 2016 and 2022 were analyzed retrospectively. We recorded patient’s demographic data such as age, gender, performance status and platelet, MPV and PCT. Overall survival (OS) and progression-free survival (PFS) were also recorded. There were 80 patients in our study.
 Results: Median PFS was found 6.2 months for MPV/PLT ratio 0.045 group retrospectively. The median PFS of the MPV/PLT ratio ≤0.045 groupwas shorter than MPV/PLT ratio >0.045 group, but there wasn’t statistically meaningful difference between the groups (p:0,957). Median OS for the MPV/PLT ratio ≤0.045 groupwas 10.1 months and the MPV/PLT ratio for the >0.045 group was 9 months, but there wasn’t statistically significant difference between the groups (p:0.506).There was nosurvival difference between the groups when comparing both MPV and PCT status.
 Conclusion: MPV/PLT ratio is a cheap, simple and useful marker and can be used in our daily practice to predict the prognosis of patients with advanced PC, if confirmed by prospective studies and larger patient numbers.

A simple scoring system in COVID-19 patients with neurological manifestations

Background: Coronavirus disease 2019 (COVID-19) has affected a rapidly growing patient population worldwide. To effectively manage the disease, physicians need tests or methods that classify patients according to their risks. Our aim is to determine the importance of mean platelet volume (MPV), neutrophil-lymphocyte ratio (NLR), MPVNLR score (MPV×Neutrophil/lymphocyte) in predicting the clinical course and mortality in hospitalized COVID-19 patients with neurological manifestations. Methods: A total of 300 patients were enrolled in the study. MPV, NLR, MPVNLR score, CRP, D-dimer, IL-6, and procalcitonin tests were obtained for each patient. Results: MPV, NLR, MPVNLR score, IL-6, D-dimer, procalcitonin, and CRP in the non-survivor group were higher than the survivor group (p=0.001, p:0.001, p=0.001, p=0.001, p=0.001, p=0.027, and p=0.001, respectively). MPV, NLR, MPVNLR score, IL-6, D-dimer, procalcitonin and CRP were higher in patients with altered mental status (p=0.001, p=0.001, p=0.001, p=0.014, p=0.002, p=0.026, and p=0.001, respectively). Conclusion: High MPV, NLR, and MPVNLR scores may be simple markers to predict mortality and mental deterioration in COVID-19.

The Importance of MPV as a Marker of Subclinical Inflammation in FMF Patients and It’s Correlation with Disease Severity

Objective: Inflammation markers increase during Familial Mediterranean Fever (FMF) attacks and often return to normal within a few days. It is known that a subclinical inflammation continues in FMF patients in the inter-episode period, which increases the risk of developing amyloidosis. In recent years, several works have been conducted showing the relationship between platelet indices and inflammation, such as platelet count (PLT), platelet distribution width (PDW), mean platelet volume (MPV), plateletrite (PCT). In this study, we aimed to investigate the relationship between platelet indices and disease severity in FMF patients without attacks. 
 Method: The records of all FMF patients followed by us were reviewed retrospectively. Patients with a hematological or oncological disease, patients with data deficiency for the study, and patients under 18 years of age were excluded. While the laboratory data were recorded, the condition of patients to be at least 3 months without attack was required. As the control group, the automation records of all healthcare professionals working in the internal medicine clinic of our hospital were examined. Our clinical staff, who did not have chronic diseases and regular drug use, were taken as a healthy control group. 173 patients and 20 control groups who met the conditions mentioned above were included in the study. Platelet indices were compared between patient and control groups. 
 Results: It was determined that the value of MPV, one of the platelet indices, in the patient group was statistically significantly higher than the value in the healthy control group (p = 0.029). MPV was also found to correlate with disease severity (p

The importance of mean platelet volume to lymphocyte ratio in predicting atrial fibrillation after coronary bypass operations

Background/Aim: The rate of postoperative atrial fibrillation (PoAF) after coronary artery bypass graft (CABG) operations ranges between 25-40%. Inflammation plays an important role in the pathogenesis of PoAF, and mean platelet volume and lymphocyte count are important inflammatory parameters. This study aimed to investigate the importance of the mean platelet to lymphocyte ratio (MPVLR) in predicting PoAF after CABG operations. Methods: Three hundred and eighty consecutive patients who underwent on-pump CABG in our clinic between August 2016 and August 2020 were included in this retrospective observational cohort study. Patients with a known history of atrial fibrillation, reoperations, emergency operations, patients who had acute coronary syndrome within the last month, combined surgeries, those with systemic inflammatory disease, chronic autoimmune disease, chronic liver/kidney disease, and hematological diseases, and patients under steroid therapy were excluded from the study. Patients who did not develop postoperative PoAF were included in Group 1, while those who did were included in Group 2. Results: There were 319 patients in Group 1 with a median age of 59 (32-83) years, and 61 patients in Group 2, with a median age of 66 (38-86) years (P<0.001). There was no difference between the groups in terms of gender distribution, hypertension (HT), diabetes mellitus (DM), smoking, body mass index, hyperlipidemia, ejection fraction, and current medical treatments (such as Angiotensin-converting enzyme inhibitor and beta-blocker therapy). The rate of chronic obstructive pulmonary disease (P=0.017), as well as MPV, MPVLR, intensive care unit stay and total hospitalization times were significantly higher (P<0.001 for all) in Group 2, while lymphocyte levels were significantly lower (P=0.006). Based on multivariate analysis, being over 70 years old (OR: 2.432, CI 95%: 1.966-3.723, P<0.001), having an ejection fraction below 35% (OR: 1.325, CI 95%: 1.190-1.1894, P=0.021) and MPVLR (OR: 1.821, 95%CI: 1.645-2.1592, P<0.001) were independent predictors of PoAF. Conclusion: We found that the preoperative MPVLR value, which can be obtained from a simple hemogram test, is an important predictor of PoAF in patients who underwent CABG. MPVLR value can be a marker in determining risky groups preoperatively.

Diagnostic importance of mean platelet volume, platelet distribution width and platelet large cell ratio as screening tool in immune thrombocytopenia.

Objective:To determine diagnostic importance of mean platelet volume (MPV), platelet distribution width (PDW) and platelet large cell ratio (PLCR) in diagnosing cases of immune thrombocytopenia.Methodology:The study was done in Khyber Teaching hospital from January 2017 to May 2018. Cases with low platelet count of all the ages and both the genders were included in the study by non probability purposive sampling technique and were subjected to bone marrow aspiration to rule out other causes of thrombocytopenia and thus confirm the diagnosis of immune thrombocytopenia. The platelet indices were noted and their sensitivity, specificity and accuracy were determined for immune thrombocytopenia. Mean and standard deviation were used for quantitative data. Percentage and frequency were used to measure qualitative data. Data was analysed by SPSS.Results:84 cases with thrombocytopenia of mean age 23.4 ± 12.1 years (range 7–81 years) were included in the study. There were 38 (45.2%) males and 46 (54.8%) females. There were 40 cases of immune thrombocytopenia. The sensitivity and specificity for PDW (59.1% and 43.1%, respectively), MPV (59.1% and 52.9%, respectively), and PLCR (50% and 52.9%, respectively) were found low to be used as screening tool for immune thrombocytopenia.Conclusion:The MPV, PDW and PLCR has low sensitivity and specificity and therefore should not be used as reliable screening tool in giving preliminary diagnosis of the immune thrombocytopenia.

TThe Role of Mean Platelet Volume in the Diagnosis of Testicular Torsion

The aim of this study is to examine the clinical importance of mean platelet volume (MPV) in patients with testicular torsion. In this retrospective study, two study groups were analyzed. Group I consisted of 31 patients diagnosed with testicular torsion following scrotal exploration. Group II was determined as control group. A total of 38 healthy male patients visited the urology clinic for their routine controls were included in the study. MPV values between Groups I and II were compared statistically. The mean age of the 69 patients included in the study was 10.87±8.99 years. MPV values were calculated as 8.33±1.08 and 9.7±1.49 for Group I and II, respectively. MPV values in Group I were statistically lower than that in Group II (p&amp;lt;0.001). The MPV value is significantly reduced in patients with testicular torsion. Therefore, we think that MPV values can be used as a supporting criterion in the diagnosis of testicular torsion.

Clinical significance of mean platelet volume/lymphocyte ratio and mean platelet volume/platelet ratio in the exacerbation of chronic obstructive pulmonary disease

Objectives: Studies showing the role of systemic inflammation in chronic obstructive pulmonary disease (COPD) are increasing. Particularly, importance of mean platelet volume (MPV) and neutrophil/lymphocyte ratio (NLR) for acute exacerbation of COPD has been reported. The use of MPV/lymphocyte ratio (MLR) and MPV/platelet ratio(MPR) in acute exacerbation of COPD patients was investigated in our study, considering that MPV alone may be a more valuable marker of inflammation. Methods: Between March 2017 and March 2018, COPD patients who applied to Abant Izzet Baysal University School of Medicine, Chest Diseases outpatient clinic were examined. Results were retrospectively scanned from patient files after institutional approval. Sixty-four (60.4%) stable COPD and 42 (39.6%) acute exacerbation COPD patients were included in the study. Results: Seventy-one (67%) of patients were male and 35 (33%) were female. NLR was 2.26 (0.93-6.48) in stable patients and 4 (1.18-36) in acute attack patients (p &amp;lt; 0.001); PLR was 137.44 (66.9-436.6) in patients with stable disease and 162.8 (85-1056.6) in patients with attack (p = 0.068). MLR was 5 (2.92-25) in acute attack patients and 4 (1.89-8.67) in stable patients; this difference was statistically significant (p = 0.003). MPV was found to be 7 (5.5-9.1) fL in patients with stable disease and 8 (5-13.4) fL in acute patients. This difference was statistically significant (p &amp;lt; 0.001). MPR was found to be statistically significantly higher in acute patients than in patients with stable disease (p = 0.04). WBC, neutrophil and CRP were found to be statistically significantly higher in acute patients than in stable patients (p &amp;lt; 0.05). There was a statistically significant correlation between WBC and NLR (r = 0.269, p = 0.005) and between CRP and NLR (r = 0.379, p &amp;lt; 0.001). Conclusions: Hemogram parameters from routine laboratory tests in COPD patients are cheap and easily accessible. It is important to detect the presence of subclinical inflammation in the stable phase, as well as to identify patients at risk of exacerbation. Prospective studies are needed to demonstrate correlations with inflammatory markers.

Importance of Mean Platelet Volume in Predicting Cardiac Mechanics Parameters and Carotid-Intima Media Thickness in Children With End-Stage Renal Disease and Comparison With Healthy Children.

Cardiovascular disease (CVD) is the major cause of death in children with ESRD. Echocardiography and Doppler ultrasound are useful devices for diagnosing cardiovascular abnormalities in such patients. However, they are expensive, difficult to perform as a routine, and not available in many centers. Therefore, finding a more accessible and inexpensive method for CVD evaluation biomarkers is needed. The aim of this study was to evaluate the relationship between mean platelet volume (MPV) as a routine hematological parameter with cardiac mechanics characteristics in children with ESRD. Forty-two children under dialysis and 60 age- and sex-matched healthy subjects as control group were enrolled in the study. Carotid-intima media thickness (CIMT) and echocardiographic parameters were measured in both groups. In addition, hematological and biochemical variables were evaluated in blood samples of participants. MPV was significantly higher in patients than in controls. CIMT, left ventricular mass index (LVMI), end diastolic diameter, strain rate, and global longitudinal strain were significantly different between the two groups. MPV was positively correlated with LVMI and inversely with ejection fraction. In receiver operating characteristic (ROC) curve analysis, the area under the ROC curve (AUC) values for MPV in predicting left ventricular hypertrophy (LVH) and abnormal CIMT were 0.65 (P = 0.07) and 0.53 (P = 0.74), respectively. MPV was correlated with some cardiac abnormalities in children with ESRD. However, it could not show appropriate predictive values in diagnosing LVH and subclinical atherosclerosis. Further studies with prospective design could shed more light in this topic.

The Importance of Mean Platelet Volume in Children with Nephrotic Syndrome

The Importance of Mean Platelet Volume in Children with Nephrotic Syndrome

Mean Platelet Volume in Patients with Chronic Venous Insufficiency

Objective: the mean platelet volume (MPV) is a good indicator of platelet activity; it is reported to increase in diseases associated with inflammatory processes and in vascular diseases. This study investigated the importance of mean platelet volume in patients with chronic venous insufficiency (CVI) and whether the MPV was likely to be a predictor of the CVI. Methods: 117 patients who were diagnosed as CVI by colored Doppler Ultrasound (CDU) method and 49 healthy volunteers (forming the control group) were en­rolled to this study, which was planned retrospectively. The patients’ blood count values taken within one month before and after the CDU evaluation were recorded by the hospital information system. The complete blood count, routine biochemical tests and thyroid function tests of the patients diagnosed with CVI were compared to the control group. Results: Significant differences were not detected be­tween the patients and the control group in terms of the levels of creatinine, aspartate aminotransferase, total cholesterol, LDL cholesterol, HDL cholesterol, triglycer­ides, erythrocyte, sedimentation speed, leukocyte, hae­moglobin and thrombocyte (p>0.05). The thyroid stimulat­ing hormone and the MPV levels were significantly lower in the control group (p<0.05). Conclusion: MPV levels as an easy, cheap and practi­cal data extracted from complete blood count, were found higher in patients diagnosed with CVI compared to the control group. This may be originated from endothelium changes as an answer to venous hypertension and dila­tation in CVI. MPV can be used as a follow-up marker in CVI patients.

Mean Platelet Volume in Patients with Chronic Venous Insufficiency

Objective: the mean platelet volume (MPV) is a good indicator of platelet activity; it is reported to increase in diseases associated with inflammatory processes and in vascular diseases. This study investigated the importance of mean platelet volume in patients with chronic venous insufficiency (CVI) and whether the MPV was likely to be a predictor of the CVI. Methods: 117 patients who were diagnosed as CVI by colored Doppler Ultrasound (CDU) method and 49 healthy volunteers (forming the control group) were enrolled to this study, which was planned retrospectively. The patients’ blood count values taken within one month before and after the CDU evaluation were recorded by the hospital information system. The complete blood count, routine biochemical tests and thyroid function tests of the patients diagnosed with CVI were compared to the control group. Results: Significant differences were not detected between the patients and the control group in terms of the levels of creatinine, aspartate aminotransferase, total cholesterol, LDL cholesterol, HDL cholesterol, triglycerides, erythrocyte, sedimentation speed, leukocyte, haemoglobin and thrombocyte (p>0.05). The thyroid stimulating hormone and the MPV levels were significantly lower in the control group (p<0.05). Conclusion: MPV levels as an easy, cheap and practical data extracted from complete blood count, were found higher in patients diagnosed with CVI compared to the control group. This may be originated from endothelium changes as an answer to venous hypertension and dilatation in CVI. MPV can be used as a follow-up marker in CVI patients. J Clin Exp Invest 2016; 7 (1): 73-77

A new diagnostic marker for acute pulmonary embolism in emergency department: mean platelet volume.

To investigate the diagnostic importance of mean platelet volume (MPV) on acute pulmonary embolism (APE) in the emergency Department (ED). Subjects were selected from patients admitted to ED with clinically suspected APE. Demographic, anthropometric and serologic data were collected for each patient. A total of 315 consecutive patients were analyzed, including 150 patients (53.44 ± 15.14 y; 92 men/58 women) in APE group and 165 patients (49.80 ±13.76y; 94 men/71 women) in the control group. MPV in the APE group was significantly higher than in the control group (9.42±1.22 fl vs. 8.04±0.89 fl, p<0.0001). The best cut-off values for MPV when predicting APE in patients with clinically suspected APE presenting at the ED were 8.55 fl (sensitivity 82.2%; specificity 52.3%). MPV is a helpful parameter for the diagnosis of APE in ED, for the first time in the literature.

Clinical importance of mean platelet volume in children with nephrotic syndrome

Aim: The importance of changes about platelet emphasized in most chronically diseases in recent years. Mean platelet volume (MPV) and platelet count can be used as a prognostic biomarker. In this study, clinical importance of the changes of MPV during active and remission phases in children with nephrotic syndrome was investigated. Patients and methods: Fifty-five children with nephrotic syndrome (30 females, 25 males) and 29 healthy children (18 females, 11 males) were included to the study. Patients were divided in two groups (steroid sensitive nephrotic syndrome and focal segmental glomerulosclerosis). Demographic characteristics of the patients, type of nephrotic syndrome were recorded and laboratory parameters in active and remission phases were evaluated. Results: Mean platelet count in the patient group was significantly higher than control group. Mean platelet count of FSGS group was significantly higher than SSNS group. Mean MPV value was significantly lower in active period of nephrotic syndrome when compared with control group. A significant negative relation between mean MPV value and mean platelet count was found. Significant positive correlations between mean platelet count and mean total cholesterol and mean triglyceride levels were demonstrated. Conclusion: MPV in nephrotic syndrome patients can be an easy, cheap and simple method for determine the prognosis of the disease and steroid resistance.

Importance of mean platelet volume in patients with chronic obstructive pulmonary disease

Chronic obstructive pulmonary disease (COPD) is an important public health problem and it is associated with systemic inflammation. Mean platelet volume (MPV) is one of the markers indicating platelet activation, and there are different results in different diseases related to inflammation. As for COPD some studies found it to be high whereas others found low results. In this study, we aimed to study parameters like MPV, platelet distribution volume (PDW), red blood cell (RBC), which are studied in the complete blood count testing routinely of patients with COPD, smoking and nonsmoking subjects without chronic diseases. Data of 121 patients with COPD, 101 nonsmoking subjects and 102 smoking subjects were retrospectively enrolled. Results were statistically analyzed. MPV levels were lower in patients with COPD compared with smokers (P

Correlation of the Coronary Severity Scores and Mean Platelet Volume in Diabetes Mellitus

It is known that mean platelet volume (MPV) increases during acute coronary syndrome. However, there are conflicting data about the importance of MPV in patients with stable coronary artery disease (CAD). This study aimed to assess relationship between MVP and the severity of coronary atherosclerosis in patients with diabetes mellitus (DM), stable CAD and normal left ventricular ejection fractions. Thirty-three DM and 46 nonDM patients with stable CAD diagnosed by selective coronary angiography were included in the study. All angiographic variables pertinent to Gensini score (GS) and Syntax score (SS) calculation were computed by two experienced interventional cardiologists. All patients underwent echocardiographic examination. MPV and other biochemical markers were measured on admission. All patients were evaluated and it was found that both scoring systems are correlated with MPV (GS: r=0.373, p<0.001; SS: r=0.385, p<0.001). DM and nonDM groups were severally evaluated, it was found that the correlation between MPV and GS and SS increased in DM patients (GS: r=0.638, p<0.001; SS: r=0.624, p<0.001); however, no differences were identified in nonDM patients (GS: r=0.124, p=0.410; SS: r=0.124, p=0.411). It is thought that high MPV levels may be an effective marker in determining the severity of CAD in patients with DM. And the high MPV level may be related with CAD pathophysiology in DM patients.

Diagnostic accuracy of mean platelet volume in thromboangiitis obliterans

Thromboangiitis obliterans (TAO) affects small- and medium-sized vessels of the extremities via a non-atherosclerotic inflammatory process in the elderly. Although diagnostic criteria have been determined, only a few studies have been described in the laboratory features. Diagnostic biomarkers are important for reducing disruptions caused by TAO. The diagnostic importance of mean platelet volume (MPV) was investigated in TAO patients. Forty-four patients diagnosed with TAO (study group) and 45 healthy individuals (control group) were included in the study. The age, gender and complete blood parameters obtained via peripheral venous blood samples were compared between the two groups. A receiver operating characteristic (ROC) curve was used for determining the diagnostic accuracy of the MPV variable. All the variables were statistically similar in each group except MPV and platelet counts. MPV was significantly higher and platelet count was significantly lower in the TAO group (P< 0.05). In addition, diagnostic accuracy was measured by the area under the ROC curve (Figure 1), and MPV differs significantly (P< 0.001), with a value of 0.783 (95% CI: 0.711-0.854). This study indicates that MPV is probably an important diagnostic predictor in TAO patients. Detection of blood parameters such as platelet properties is important for meticulous care of these patients.

The importance of mean platelet volume in early mortality of pulmonary embolism

Objective: In this study whether mean platelet volume (MPV) is associated with early period hospital mortality or not in patients with pulmonary embolism (PE) was investigated. Methods: Data of patients that hospitalized in chest diseases clinic with the diagnosis of PE between the years 2009-2012 were screened retrospectively from digital archive system. The demographic data, symptoms, treatment outcomes and MPV values in complete blood count of patients were recorded. Results: The mean age was 57.93 ± 18.52 years (16-91). The number of patients is 143 and 91 women (63.9%), 52 men (36.4%), respectively. MPV values were available for 137 of 143 patients. 129 of patients were discharged, and 8 had died in the early period of hospitalization. The mean MPV value was 7.85 ± 1.40 fL in patients who experienced and 9.08 ± 1.61 fL in died respectively. The difference was statistically significant (p = 0.01). Conclusion: The results of this study suggests that increased MPV value may be used as a marker for early hospital mortality in patients with PE.

Mean Platelet Volume as a Potential Predictor of Renovascular Thrombosis After Renal Transplant

We sought to evaluate the importance of mean platelet volume as a marker to follow-up, the tendency for hemorrhagic diatheses, and/or thrombotic complications in patients before and after renal transplant. Thirty-four patients (aged, 5 to 18 y) were included. Demographics of the patients, cause of chronic renal failure, dialysis modality, duration of dialysis, arterio-venous fistula thrombosis, and posttransplant immunosuppressive regimens were recorded and laboratory variables were evaluated. At the end of the first posttransplant month, mean platelet volume level was decreased significantly when compared with pretransplant levels (8.3 ± 1.5 vs 7.7 ± 0.9; P = .04). A significant increase was observed in platelet levels during posttransplant measures (273.750 ± 97.700 vs 318.740 ± 84.586; P = .02). Prothrombin time and partial thromboplastin time levels did not differ before and after transplant. None of the patients had any thrombotic events and/or renal allograft loss. A negative correlation was observed between mean platelet volume and C-reactive protein (r=-0.53). Mean platelet volume level was not found to be related to the cause of renal failure, pretransplant dialysis modality, or posttransplant immunosuppressive regimens. Platelet numbers increased and mean platelet volume decreased after pediatric renal transplant, but the potential for increased thrombosis was not observed.