The aim of this work is to evaluate the changes in the central vault after using implantable Collamer® lenses (ICL) to correct myopia. This cohort study included 133 eyes; mean spherical equivalent -9.47 ± 3.71 diopters (D) (range: -2.75 to -22.25 D) who underwent ICL V4 implantation. Besides a complete ophthalmologic examination, the central vaulting was measured with Visante OCT and evaluated between different periods of follow-up (1week, 1, 3, and 6months, and yearly postoperatively). Post-operative time ranged from 6 to 73months. Within the first 6months, the mean central vaulting dropped from 510 ± 238μm (range 100 to 940μm) to 439 ± 231μm (range 90 to 910) a significant decrease by 71 ± 58μm (range -170 to 30μm) (p = 0.028) with a trend to a lower reduction after this period. After 36month from ICL implantation, this variation tends to be smaller with the majority of the eyes having a mean decrease smaller than 2μm per month. Initial vault (Spearman Rho = -0.237, p = 0.006) was the factor more significantly associated with decrease in vault; eyes presenting a reduction in vault >100μm had an average initial vault that was 141μm and 184μm higher than eyes with no change or with increase in vault over time, respectively. This study shows a continuous reduction of central vault over time. The reduction is highest during the first 6months and tends to be lower and slow down over time. The decrease of vaulting was more pronounced in eyes with larger initial vaulting.