Objectives: This cross-sectional study aimed to assess the knowledge and attitudes of dental interns and dentists in Jeddah, Saudi Arabia, about Cement-Retained Restoration (CRR), Screw Retained Restoration (SRR), and implant restoration. Methods: A total of 530 dentists and students participated in the study. Data were collected using a self-administrated questionnaire modified from previous studies. The collected data were analyzed using SPSS software for t-test, linear regression, and ANOVA. Results: Participants had a mean score of 5.01 (SD = 1.50) for a total of nine implant-retained restoration (IRR)knowledge questions (lowest score = 0, highest score = 9), and general implant knowledge had a mean score of 3.12 (SD = 1.25) for five questions with scores of 0 to 5. The participants’ knowledge about implants significantly differed in relation to gender, place of work, and work status. Also, participant knowledge about IRR showed significant differences in relation to participants' knowledge, age, gender and place of work. The dental interns and dentists were in agreement in considering SRR to be better than CRR for six out of nine factors. Those factors were cost effectiveness, expertise required for provision, retrievability, retention, fracture resistance, and passivity of fit. Conclusion: The overall knowledge of dental interns and dentists regarding implants and IRR was fair and needs to be improved, given the tendency of general dentists to engage in implant dentistry. Both dentists and interns considered CRR to be aesthetically superior, easier to fabricate, and requiring comparatively less expertise in comparison to SRR.