Since the introduction of lead-free solder alloys, the impact of voids in solder joints has rapidly gained in importance. Particularly in power electronics, voids in solder joints can reduce their reliability due to less heat dissipation and a significant reduction of the cross-sectional area. While void formation in the printed circuit board (PCB) technology has been the focus of many research projects, the increasing application of molded interconnect devices (MIDs) demands a vivid understanding of void formation and its impact on reliability. This report will show that those processes specific to MID technology do not significantly influence the void formation in SAC305 solder deposits. The processed different roughness levels on Vectra, Vestamid, and FR4 substrate materials show no significant impact on void formation. The surface finish metallization was detected as the most important factor. Especially, the chemical-Sn (iSn) surface finish is inclined to having more voids compared to a nickel–phosphor–gold (NiP-Au) finish. Furthermore, three solder processes were investigated: convection, condensation, and vacuum-condensation soldering. The vacuum-condensation processes significantly reduced the voids in the Sn–3.0Ag–0.5Cu (simplified as SAC305) solder joints of CR0805, MLF20, and switches on all the investigated substrates. An accelerated thermal cycling test of these components according to JESD22-A104D demonstrates no significant effect of the void content of <19% on the solder joints’ reliability. Finally, the result of accelerated thermal cycling shows the possibility to achieve an equivalent lifetime of the solder joints on Vectra in comparison to the FR4 substrate.