Impact Of Vascular Factors Research Articles

Research status and global trends of late-life depression from 2004 to 2023: bibliometric analysis.

Global research hotspots and future research trends in the neurobiological mechanisms of late-life depression (LLD) as well as its diagnosis and treatment are not yet clear. This study profiled the current state of global research on LLD and predicted future research trends in the field. Literature with the subject term LLD was retrieved from the Web of Science Core Collection, and CiteSpace software was used to perform econometric and co-occurrence analyses. The results were visualized using CiteSpace, VOSviewer, and other software packages. In total, 10,570 publications were included in the analysis. Publications on LLD have shown an increasing trend since 2004. The United States and the University of California had the highest number of publications, followed consecutively by China and England, making these countries and institutions the most influential in the field. Reynolds, Charles F. was the author with the most publications. The International Journal of Geriatric Psychiatry was the journal with the most articles and citations. According to the co-occurrence analysis and keyword/citation burst analysis, cognitive impairment, brain network dysfunction, vascular disease, and treatment of LLD were research hotspots. Late-life depression has attracted increasing attention from researchers, with the number of publications increasing annually. However, many questions remain unaddressed in this field, such as the relationship between LLD and cognitive impairment and dementia, or the impact of vascular factors and brain network dysfunction on LLD. Additionally, the treatment of patients with LLD is currently a clinical challenge. The results of this study will help researchers find suitable research partners and journals, as well as predict future hotspots.

Impact of vascular factors and tau deposition on functional brain network connectivity in participants of the Framingham Heart Study

AbstractBackgroundThe goal of this study was to determine whether vascular factors, expressed as the Framingham Stroke Risk Profile (FSRP), and/or tau deposition impact functional brain connectivity within and between functional brain networks i.e. default mode, frontoparietal, dorsal attention, and ventral attention networks. Regional blood flow measured by fMRI has been used to infer functional brain connectivity. Regions with synchronized blood flow are thought to be functionally connected while areas that have desynchronized blood flow are thought to be less functionally connected. Factors such as age have been linked to a reduction in functional connectivity.Method224 participants (mean age 54±8, 56% men) from the third generation of the Framingham Heart Study were imaged at Boston University from September 2015 to August 2018. Each participant had a high resolution MPRAGE T1 and a seven‐minute resting state fMRI scan. The T1 scans were processed using Freesurfer v6.0 and the resting state fMRI scans with FSL. Functional networks were constructed using the Yeo 7 network atlas (Yeo, 2011). Correlations within and between the functional brain networks were generated and z corrected. The relationship between FSRP, regional amyloid using the Pittsburgh B ligand, tau deposition using Flortaucipir, and functional connectivity were assessed using linear regression models adjusted for age, sex and interval between FSRP (or amyloid and tau) measurements and fMRI.ResultVascular risk factors and tau deposition had opposite impacts on functional connectivity. Increases in the FSRP were linked to increased functional connectivity between the default mode and visual networks, as well as the frontoparietal. Conversely, tau deposition in the inferior temporal, precuneus, and entorhinal cortices was linked to a reduction in functional connectivity within the frontoparietal network, between the default mode and somatomotor, and dorsal attention and somatomotor networks.ConclusionVascular risk factors appear to relate to an enhancement of functional connectivity while regional tau deposition appears to have an adverse impact on both within and between network connectivity. It is plausible that these changes in functional connectivity represent a compensatory response in the brain to alterations in vascular function and the presence of neuropathology in order to maintain cognitive abilities.

Hypertension in Primary Open Angle Glaucoma

The impact of vascular factors in POAG is well known and controversial. Some reports have shown high blood pressure in POAG, some low systolic blood pressure and some described no difference in blood pressure between POAG and controls. However decreased ocular perfusion pressure was found in most of the studies. Our study aims to assess the role of hypertension in POAG . It was cross-sectional case-control hospital based study carried out from 1st June 2012 to 1st June 2013. There were 40 cases and 100 controls included in the study. The role of hypertension were compared with those hypertensive patients with glaucoma (cases) and hypertensive patients without glaucoma (controls). Age above 50 years (odds ratio: 4.827 with 95% CI 1.862-12.517), male genders (odds ratio: 3.10 with 95% CI 1.356-7.146) and low diastolic perfusion pressure (odds ratio: 3.857 with 95% CI 1.362-11.224) showed strongly positive association with POAG. High systolic blood pressure (odds ratio: 1.476 95% CI 0.627-3.476), high diastolic blood pressure (odds ratio: 1.348 95% CI 0.587-3.096) and low systolic perfusion pressure (odds ratio: 1.8661 with 95% CI 0.649- 5.335) were weakly associated with glaucoma in our study. Age above 50 years, male gender and low diastolic perfusion pressure were strong risk factor for the development of POAG.

Age- and genotype-related neurophysiologic reactivity to oxidative stress in healthy adults

The epsilon4 allele of the apolipoprotein E gene (ApoE), as well as aging increase the risk of Alzheimer's and vascular diseases. Electroencephalogram (EEG) reactivity to hyperventilation (HV) depends on hypocapnia-induced cerebral vasoconstriction, which may be impaired in subjects with subclinical cerebrovascular disease. Quantitative EEG at rest and under 3-minute HV was examined in 125 healthy subjects divided into younger (age range 28–50) and older (age range 51–82) cohorts and stratified by ApoE genotype. The younger ApoE-epsilon4 carriers had excessive EEG reactivity to HV characterized by the manifestation of high-voltage delta, theta activity and sharp waves, and larger HV-induced changes in EEG relative powers than in the younger ApoE-epsilon4 noncarriers. EEG reactivity to HV decreased with aging, and in the ApoE-epsilon4 carriers the decrease was more pronounced than in the ApoE-epsilon4 noncarriers. The older ApoE-epsilon4 carriers had smaller HV-induced changes in EEG relative powers than the older ApoE-epsilon4 noncarriers. A marked decline of EEG reactivity to HV in the older ApoE-epsilon4 carriers suggests the possible impact of vascular factors on the pathogenesis of ApoE-induced Alzheimer disease.