The quality factor (Q) of two inductors for 5–60 GHz applications fabricated in an industrial back-end of line (22FDX® from GlobalFoundries) with thick Cu metal layers on top of several Si substrates of different bulk resistivities is analyzed in this paper. The low frequency RF inductor shows an improvement of up to 44% in Q with a high-resistivity substrate. However, no significant improvement is observed for the high-frequency MMW fabricated inductor. This is identified to be due to lower electric field concentration in the substrate due to the small geometry of this MMW inductor that is realized in the top metal Cu layer. Nevertheless, simulations show that a 30% improvement can be achieved with a low loss substrate when designing a MMW inductor as a stacked coil of all BEOL thick metal layers.