Impact Of Prostatitis Research Articles

An inducible model of abacterial prostatitis induces antigen specific inflammatory and proliferative changes in the murine prostate

Prostatitis is a poorly understood disease and increasing evidence suggests inflammation is involved in other prostatic diseases including prostate cancer. The ability of pre-activated CD8 T cells to induce prostatitis was examined by adoptive transfer of prostate antigen specific CD8 T cells into POET-3 mice or POET-3/Luc/Pten(-/+) mice. Characterization of the inflammatory response was determined by examining leukocyte infiltration by histological analysis, flow cytometry and by evaluating cytokine and chemokine levels in prostate tissue. The impact of inflammation on the prostate was evaluated by monitoring epithelial cell proliferation over time. Initiation of inflammation by ovalbumin specific CD8⁺ T cells (OT-I cells) resulted in development of acute prostatitis in the anterior, dorsolateral and ventral prostate of POET-3 and POET-3/Luc/Pten(-/+) mice. Acute prostatitis was characterized by recruitment of adoptively transferred OT-I cells and importantly, autologous CD4⁺ and CD8⁺ T cells, myeloid-derived suppressor cells (MDSC) and regulatory T cells (Treg). In concert with leukocyte infiltration elevated levels of pro-inflammatory cytokines and chemokines were observed. Inflammation also resulted in marked epithelial cell proliferation that was sustained up to 80 days post adoptive transfer of OT-I cells. The POET-3 model represents a novel mouse model to study both acute and chronic prostate inflammation in an antigen-specific system. Further, the POET-3 mouse model can be crossed with other genetic models of disease such as the C57/Luc/Pten(-/-) model of prostate cancer, allowing the impact of prostatitis on other prostatic diseases to be evaluated.

Prostatitis and male factor infertility: A review of the literature

Prostatitis is the most common urologic diagnosis in men under the age of 50 years. Given the prostate’s intimate association with male reproductive function, prostatitis has long been suspected of playing a role in male subfertility. Strong evidence for a direct impact of prostatitis on male fertility is lacking. This article presents a brief overview of the disease entities known collectively as prostatitis and a review of the current literature on the association between prostatitis and seminal fluid variables, sperm morphology and function, seminal reactive oxygen species, antisperm antibodies, and their impact on male fertility.