Understanding the economic and social impact of nuclear power on a region is crucial; this is particularly important for Fukushima because the region relies on nuclear power and its sustainable recovery following the nuclear accident at Fukushima Daiichi. However, existing studies do not reveal any consensus on the economic impact of nuclear power plants. Further, long-term time-series data for conducting such an analysis are lacking; so, for this study, a long-term database from 1960 to 2010 was constructed (before the earthquake and nuclear power plant accidents happened in 2011). The data were analyzed to evaluate the effects of the nuclear power plants on employment in various sectors in Fukushima, using the difference-in-differences (DID) and staggered DID methods. Unlike previous studies, this study revealed that nuclear power surprisingly increased agricultural employment (892.62 more jobs) while reducing manufacturing employment (−466.40 fewer jobs) due to crowding-out effects. Furthermore, although employment in the construction sector also increased, the impact was temporary. These findings highlight the complex economic dynamics triggered by the presence of a nuclear power plant, which may have significant implications for long-term recovery strategies in the region. Despite the positive impacts on certain sectors, the negative effects on manufacturing underscore the need for careful consideration in future economic planning and recovery efforts. The study's findings provide valuable insights into the challenges and opportunities faced by regions hosting nuclear power plants, which must be considered for long-term recovery.