This literature review explores the significant transformations in the educational landscape prompted by technological advancements and changing learner profiles in the digital era. The review examines the evolution of learner profiles, highlighting the shift towards multisensory learning, digital fluency, and a preference for interactive, personalized learning experiences. It delves into integrating innovative technologies such as virtual reality (VR), augmented reality (AR), and blockchain in education and discusses their implications for teaching and learning. The review also considers the impact of neuroscience on educational practices, emphasizing the importance of understanding brain functioning and neuroplasticity in developing effective teaching strategies. The unprecedented shift to online and blended learning models, accelerated by the COVID-19 pandemic, is analyzed for its long-term effects on educational delivery and pedagogy. Additionally, the review addresses the growing emphasis on interdisciplinary learning, sustainability, mental health, and well-being within educational curricula. The implications of these transformative trends for educators, policymakers, and learners are discussed, highlighting the need for adaptive and responsive approaches to education in the face of rapid technological and societal changes. The review concludes with reflections on the future trajectory of education, anticipating continued technical integration, evolving pedagogical theories, and an increased focus on preparing learners for global challenges and lifelong learning.