Impact Of Changes Research Articles

Potential Impact of Climate Change-Induced Alterations on Pyroptotic Cell Death in Animal Cells: A Review.

Climate change-induced alterations in temperature variation, ozone exposure, water salinity and acidification, and hypoxia might influence immunity and thus survival in diverse groups ofanimals from fish to mammals. Pyroptosis is a type of lytic pro-inflammatory programmed cell death, which participates in the innate immune response, and is involved in multiple diseases characterized by inflammation and cell death, mostly studied in human cells. Diverse extrinsic factors can induce pyroptosis, leading to the extracellular release of pro-inflammatory moleculessuch as IL-18. Climate change-related factors, either directly or indirectly, can also promote animal cell death via different regulated mechanisms, impacting organismal fitness. However, pyroptosis has been relatively less studied in this context compared to another cell death process, apoptosis. This review covers previous research pointing to the potential impact of climate change, through various abiotic stressors, on pyroptotic cell death in different animal cells in various contexts. It was proposed that temperature, ozone exposure, watersalinity, wateracidification and hypoxia have the potential to induce pyroptotic cell death in animal cells and promote inflammation, and that these pyroptotic events should be better understood to be able to mitigate the adverse effects of climate change on animal physiology and health. This is of high importance considering the increasing frequency, intensity and duration of climate-based changes in these environmental parameters, and the critical function of pyroptosis in immune responses of animals and in their predisposition to multiple diseasesincluding cancer. Furthermore, the need for further mechanistic studies showing the more direct impact of climate change-induced environmental alterations on pyroptotic cell death in animals at the organismal level was highlighted. A complete picture of the association between climate change and pyroptosis in animals will be also highly valuable in terms of ecological and clinical applications, and it requires an interdisciplinary approach. SIGNIFICANCE: Climate change-induced alterations might influence animal physiology. Pyroptosis is a form of cell death with pro-inflammatory characteristics. Previous research suggests that temperature variation, ozone exposure, water salinity and acidification, and hypoxia might have the potential to contribute to pyroptotic cell death in certain cell types and contexts. Climate change-induced pyroptotic cell death should be better understood to be able to mitigate the adverse effects of climate change on animal health.

Caring for our planet: a world apart or same difference? A global music collaboration

PurposeThe impact and collective threat of climate change is of key concern to all. Music and arts education can play a role by responding to the ongoing climate crisis through the creation of artworks as activism. This paper discusses a collaborative online international music project and its potential contribution to sustainable development education.Design/methodology/approach 10,427 miles and 11 hours apart, music education students undertook the project, working in groups with a mix of students from Aberdeen, Scotland and Melbourne, Australia in each group. Each student collected video footage that captured their experience of climate concerns related to their environment. Students combined and edited the footage then collaboratively composed music to accompany the footage. This research was conceived as a collaborative self-study project undertaken by the authors as music teacher educators.FindingsThe results show a range of musical and extra musical outcomes and challenges. Evidence suggests that a collaborative online international music learning experience may contribute to sustainable development education and regenerative practice more broadly. Students began to develop their practice as educators for school and community contexts embedding learning for sustainability and climate consciousness, thus enabling them to develop as active global citizens.Originality/valueThis paper argues for greater attention to the affordances of digital collaborative music technology tools to facilitate creative projects as well as the need to reimagine musical experience, drawing together strands of music, sustainability education, technology and global citizenship. This paper also argues for the importance of embedding the UN Sustainable Development Goals in teaching and learning in Higher Education.

Impact of COVID-19 on road crashes in Thailand

The main goal of this study is to investigate the impact of COVID-19 on road crashes in Thailand using time series and interrupted time series analysis. To achieve the goal, road crash data from the Department of Highway (DOH), which includes total crashes, single vehicle crashes, fatalities, fatal crashes, speeding crashes, and drunk driving crashes, was obtained to conduct Seasonal Autoregressive Integrated Moving Average (SARIMA) time series models and Interrupted Time Series (ITS) models. SARIMA models were applied to forecast the number of crashes in the absence of COVID-19 then compare them to the observed values to identify the difference. The impact of a policy change aimed at addressing the spread of COVID-19 was assessed using ITS models on a time series accident dataset. The goal was to ascertain if the intervention had a meaningful and causative impact on the outcome. The result showed that the first wave of COVID-19 caused a significant reduction in all road crash indicators instead of skyrocketing to a peak. After releasing the lockdown measures from the first wave of spreading, an increase was found in all of the crash indicators as well. However, the third wave of COVID-19, which lasted longest for nearly 7 months, also caused a decrease in the number of crashes, but not as much as the first wave of the outbreak. Moreover, the result from the interrupted time series also revealed that curfews and the closure of entertainment places are associated with a significant decrease in the number of speeding crashes and drunk driving crashes from 10 p.m. to 4 a.m., respectively. It can be observed that the COVID-19 countermeasures, such as curfews and bans on the sales of alcoholic beverages, led to a drop in the number of speeding and drunk driving crashes.

Assessing the Impact of Climate Changes, Building Characteristics, and HVAC Control on Energy Requirements under a Mediterranean Climate

Assessing the Impact of Climate Changes, Building Characteristics, and HVAC Control on Energy Requirements under a Mediterranean Climate

Change of cervical flexion range of motion influences postoperative sagittal alignment of the cervical spine after laminoplasty

ObjectiveThe relationships between preoperative cervical spine range of motion (ROM) and postoperative cervical sagittal alignment (CSA), and clinical outcomes after laminoplasty (LMP) have been widely studied. However, the impact of ROM changes on postoperative CSA and clinical outcomes after LMP remains unclear. Herein, patients with cervical spondylotic myelopathy (CSM) were retrospectively analyzed to explore the association between postoperative cervical ROM changes and CSA and surgical outcomes.MethodsPatients who underwent cervical LMP at our hospital between January 2019 to June 2022 were retrospectively reviewed. CSA parameters were measured before the surgery and at the final follow-up. Loss of cervical lordosis (LCL) was defined as preoperative cervical lordosis (CL) - postoperative CL. An increase in the cervical sagittal vertical axis (I-cSVA) was defined as postoperative cervical sagittal vertical axis (cSVA) - preoperative cSVA. We defined the changes in cervical flexion range of motion (△Flex ROM, preoperative Flex ROM minus postoperative Flex ROM) > 10° as L- Flex ROM group, and △Flex ROM ≤ 10° as S- Flex ROM group. Japanese Orthopedic Association (JOA) score and visual analog score (VAS) were used to assess the surgical outcomes.ResultsThe study comprised 74 patients and the average follow-up period was 31.83 months. CL, total ROM, and Flex ROM decreased and cSVA increased after cervical LMP. LCL and I-cSVA were positively correlated with △Flex. Multiple linear regression analysis showed that a decrease in the Flex ROM was a risk factor for LCL and I-cSVA after LMP. LCL and I-cSVA were higher in the L-Flex ROM group than in the S-Flex ROM group. Postoperative JOA and the JOA recovery rate were worse in the L-Flex ROM group than in the S-Flex ROM group.ConclusionsCervical total and Flex ROM decreased after cervical LMP. The reduction of Flex ROM was associated with LCL and I-cSVA after surgery. The preservation of cervical Flex ROM helps maintain CSA after LMP. Therefore, more attention should be paid to maintaining cervical ROM to obtain good CSA and surgical effects after cervical LMP.

Финансовые аспекты моделирования устойчивого роста в проектах развития энергетических компаний

The goal of this study is to elaborate the recommendations of managing the energy companies’ financial results for maintaining their sustainable growth. According to determined criteria various models of sustainable growth were chosen and tested. Some of them which showed the best prediction power were taken for the further study. Financial analysis of companies’ reports was done and the evidence about the existence of a pattern in forming their financial results was given. The factor analysis was carried out in order to find the impact of changes in external environment on the net income. The main factors that influence the amount of net profit and the sustainable growth ratio and the quantitative extent of their impact are determined. Final recommendations are the set of financial tools, using ones will increase the effectiveness of business of energy companies.

Prognostic Significance of Preoperative and Postoperative Evaluation of Combined Tumor Markers for Patients With Colon Cancer.

The combined value of the tumor markers carcinoembryonic antigen (CEA) and carbohydrate antigen 19-9 (CA19-9) in patients with colon cancer (CC) is unclear. This study aimed to investigate the role of composite tumor markers in the prognosis of CC. Patients who underwent curative resection of colon adenocarcinoma were enrolled. The tumor marker status before and after the operation was used to divide the patients into groups according to the number of tumor markers with abnormal expression, and recurrence-free survival (RFS) and overall survival (OS) of different groups were compared. The impact of changes in composite tumor markers in the perioperative period on outcomes was further explored. Ultimately, 531 patients were enrolled in the study. As the number of preoperative and postoperative elevated tumor markers increased, both RFS and OS rates became lower (both P<0.05). Further analysis revealed that the number of elevated tumor markers after resection can significantly affect the outcomes (both P<0.05). In patients with abnormal preoperative tumor markers, normalization of markers after surgery was a protective factor for prognosis (both P<0.05), and patients with postoperative elevated levels of both tumor markers had a 5.5-fold and 6-fold increase in the risk of recurrence and death. In addition, patients with elevated markers after surgery had a high risk of recurrence within 5 years after colectomy. Postoperative tumor markers had a better ability to differentiate postoperative outcomes in patients with CC than preoperative tumor markers. Patients whose tumor markers normalized after surgery had a better prognosis.

Revisiting resistant hypertension in kidney disease.

As compared to controlled or uncontrolled hypertension, resistant hypertension in patients with chronic kidney disease (CKD) poses a significantly increased healthcare burden due to greater target end-organ damage including cardiovascular disease and CKD progression. Patients with CKD have two to three times higher risk of developing resistant hypertension. True resistant hypertension needs to be distinguished from apparent treatment resistant hypertension (aTRH); however, it is usually not possible in epidemiological studies. Moreover, impact of contemporary guidelines changes in the target blood pressure (BP) goal to less than 130/80 mmHg remains to be determined. Up to half of patients with CKD meet aTRH criteria using 2017 ACC/AHA target BP less than 130/80 mmHg. Excess sodium retention in extracellular and tissue compartment remains the cornerstone cause of resistance to the treatment in CKD. Maximizing and optimizing the diuretic regimen in addition to dietary sodium restriction plays a critical role in these patients. Management requires a trustworthy provider-patient relationship facilitating identification and intervention for the barriers restricting the uptake of lifestyle modifications and medications. Recently, renal denervation has been approved and many other novel agents are on the horizon for treatment of true resistant hypertension associated with CKD. This review discusses the latest in the pathophysiology, definition, identification and treatment strategies of resistant hypertension in individuals with CKD. Further investigations are required to identify the prevalence, future implication and treatment outcome data for true resistant hypertension associated with CKD.

Population-specific climate sensitive top height curves and their applications to assisted migration

AbstractGrowth and yield (G&amp;Y) of forest plantations can be significantly impacted by maladaptation resulting from climate change, and assisted migration has been proposed to mitigate these impacts by restoring populations to their historic climates. However, genecology models currently used for guiding assisted migration do not account for impacts of climate change on cumulative growth and assume that responses of forest population to climate do not change with age. Using provenance trial data for interior lodgepole pine (Pinus contorta subsp. latifolia Douglas) and white spruce (Picea glauca (Moench) Voss) in western Canada, we integrated Universal Response Functions, representing the relationship of population performance with their provenance and site climates, into top height curves in a G&amp;Y model (Growth and Yield Projection System, GYPSY) to develop population-specific climate sensitive top height curves for both species. These new models can estimate the impact of climate change on top height of local populations and populations from a range of provenances to help guide assisted migration. Our findings reveal that climate change is expected to have varying effects on forest productivity across the landscape, with some areas projected to experience a slight increase in productivity by the 2050s, while the remainder are projected to face a significant decline in productivity for both species. Adoption of assisted migration, however, with the optimal populations selected was projected to maintain and even improve productivity at the provincial scale. The findings of this study provide a novel approach to incorporating assisted migration approaches into forest management to mitigate the negative impacts of climate change.

Distribution and ecology of shallow-water black corals across a depth gradient on Galápagos rocky reefs

AbstractAntipathes galapagensis is a prevalent habitat-forming black coral in subtidal ecosystems of the Galápagos Marine Reserve (GMR). Despite their ecological importance and status as a CITES-regulated order, little is known about their depth distribution, population structure and ecology in the GMR. Surveys were conducted in 2021 and 2022 at 9 sites in the central Galápagos Archipelago to investigate how black coral densities, occupancy, size, habitat utilization, and epizoan overgrowth varied between 2.0 and 20.0 m depth. The shallowest black corals occurred at 3.4 m depth, one of the shallowest occurrences of an Antipathes spp. in the world. Coral density increased with depth, with a maximum density of 5.2 colonies per m2 observed across the depth range surveyed. Occupancy modeling also yielded curves with increasing probabilities of black coral presence with depth at all sites. Colony height increased with depth at 8 out of 9 sites and was positively correlated with coral density at 6 of 9 sites. Overall, 47% of colonies surveyed occupied cryptic habitats and 53% were attached to exposed substrate, but black coral habitat usage patterns varied with depth at 5 of 9 sites. At these sites, colonies on shallower transects (5.0, 10.0 m depth) more frequently displayed cryptic habitat usage while colonies along the deeper transects (15.0, 20.0 m) were more often exposed. In general, coral density, probability of occupancy, height, and exposed habitat utilization increased with depth, while the average degree of overgrowth and number of epibiont taxa were unrelated to depth. Five hypotheses regarding factors potentially limiting the shallow (upper) depth distribution of A. galapagensis—ranging from negative impacts of the physical environment to high predation on exposed substrates—are presented for future testing. These results provide a comprehensive ecological characterization of Galápagos black coral populations that can be used to assess the impact of future environmental change and applied to management decisions for this key marine foundation species in the GMR.

Finding the Words: How Does the Aging Brain Process Language? A Focused Review of Brain Connectivity and Compensatory Pathways.

As people age, there is a natural decline in cognitive functioning and brain structure. However, the relationship between brain function and cognition in older adults is neither straightforward nor uniform. Instead, it is complex, influenced by multiple factors, and can vary considerably from one person to another. Reserve, compensation, and maintenance mechanisms may help explain why some older adults can maintain high levels of performance while others struggle. These mechanisms are often studied concerning memory and executive functions that are particularly sensitive to the effects of aging. However, language abilities can also be affected by age, with changes in production fluency. The impact of brain changes on language abilities needs to be further investigated to understand the dynamics and patterns of aging, especially successful aging. We previously modeled several compensatory profiles of language production and lexical access/retrieval in aging within the Lexical Access and Retrieval in Aging (LARA) model. In the present paper, we propose an extended version of the LARA model, called LARA-Connectivity (LARA-C), incorporating recent evidence on brain connectivity. Finally, we discuss factors that may influence the strategies implemented with aging. The LARA-C model can serve as a framework to understand individual performance and open avenues for possible personalized interventions.

Climate Change and Socio-Economic Impacts: Determinants of Vulnerability for Developing Countries

Climate change is the connected system of solar cycle that creates fluctuations weather arrays across tropics to polls. Anticipated climate changes for the 21st century have been encountered complex challenges for humanity that significantly influence over diverse components such as environmental, ecological, socio-political and socio-economic systems among others. This study incorporates a desk literature review and at the first step researchers shortlisted the keywords regarding climate change, socioeconomic impacts and determinants of vulnerability. Mixed method approach applied for this desk review. Numerous online search engines such as Google, Google Scholar, Scopus, Web of Science and Springer were selected to review the published research studies. The collected data comprises on various forms such as book chapters, books, research articles, reports, working papers, organizational evaluation studies and conferences papers. After strict inclusion and exclusion criteria researchers gathered to 89 studies from 31 publications outlets, which were interrelated to different search engine and covering climate change impacts on developing countries. The findings endorsed the climate change socio-economic impacts are more sever particularly in developing countries of south Asia like Pakistan. The astonishing and spatial heterogeneities are the clear indications for comprehensive integrated interventions, policies and procedure to eliminate or reduce socio-economic climate change impacts of developing countries. Keywords: Climate change, Socio-economic impacts, Determinants of vulnerability, Environmental degradation, climate change and developing countries

Modeling the impact of measured and projected climate and management systems on agricultural fields: Surface runoff, soil moisture, and soil erosion.

As global climate change poses a challenge to crop production, it is imperative to prioritize effective adaptation of agricultural systems based on a scientific understanding of likely impacts. In this study, we applied an integrated watershed modeling framework to examine the impacts of projected climate on runoff, soil moisture, and soil erosion under different management systems in Central Oklahoma. The proposed model uses measured climate data and three downscaled ensembles from the Coupled Model Intercomparison Project Phase 6 (CMIP6) at the water resources and erosion watershed to understand the impact of climate change and various climate conditions under three management systems: (1) continuous winter wheat (Triticum aestivum) under conventional tillage (WW-CT; baseline system), (2) continuous winter wheat under no-till (WW-NT), and (3) cool and warm season forage cover crop mixes under no-till (CC-NT). The study indicates that the occurrence of agricultural drought is projected to increase while erosion rates will remain unchanged under the WW-CT. In contrast, climate simulations imposed on the WW-NT and CC-NT systems significantly reduce runoff and sediment while preserving soil moisture levels. Especially, implementing the CC-NT system can bolster food security and foster sustainable farming practices in Central Oklahoma in the face of a changing climate.

The impact of land use and cover changes on river flows in Wundanyi Catchment of Taita Hills, Kenya (1970–2030)

&lt;p&gt;Taita hills are one of the most important biodiversity hotspots of Kenya but experiencing a high rate of deforestation due conversion of its original forestland to agriculture and settlement during the last century. These landscape dynamics coupled with rainfall fluctuations in these critical ecosystems may significantly affect water resource distribution and food security in Taita Taveta County and its environs. This study aimed to establish the trends of land use/cover change (LUCC) in Wundanyi catchment from 1970 to 2030 and predict their specific and combined effects on surface runoff and stream flow in the same period. The analysis was based on statistical trend analysis and dynamic landscape modeling using both historical and primary data from Wundanyi catchment, and Landsat TM and ETM+ imagery of Taita Hills for 1990, 2000, and 2010. Results show highly variable mean seasonal and annual values of discharge in Wundanyi catchment probably attributed to environmental changes affecting Taita Hills in general and Wundanyi catchment in particular. Compared to 1990, major land use/cover changes in 2010 were featured by the expansion of built-up area (250%), plantation forest (23.7%), broadleaved forest (17.4%), and thicket (15.9%). Was also notable the decrease in woodland (−30.3%), cropland (−21.6%), and shrubland (−0.8%). Dynamic spatial trends by the year 2030 will be evidenced by increased thicket by 0.41% per annum (&lt;em&gt;R&lt;/em&gt;&lt;sup&gt;2&lt;/sup&gt; = 81.6%), and by decreased plantation forests (−0.13%; &lt;em&gt;R&lt;/em&gt;&lt;sup&gt;2&lt;/sup&gt; = 91.3%), woodland (−0.10%; &lt;em&gt;R&lt;/em&gt;&lt;sup&gt;2&lt;/sup&gt; = 77.6%), shrubland (−0.11%; &lt;em&gt;R&lt;/em&gt;&lt;sup&gt;2&lt;/sup&gt; = 85.2%), broadleaved forests (−0.03%; &lt;em&gt;R&lt;/em&gt;&lt;sup&gt;2&lt;/sup&gt; = 56.6%) and cropland (−0.09%; &lt;em&gt;R&lt;/em&gt;&lt;sup&gt;2&lt;/sup&gt; of 84.4). These changes will shape the catchment landscape and influence its hydrology, unless the existing forest and agricultural policy interventions are enforced. Hence, crop diversification, agroforestry, and soil and water conservation structures are recommended to maintain effective control of LUCC on hydrological processes going on in the Wundanyi catchment.&lt;strong&gt;&lt;/strong&gt;&lt;/p&gt;

Evaluation of hydrological responses to climate change in the Gibe Gojeb catchment, southwestern Ethiopia

ABSTRACT The expected influences of climate alteration on hydrological responses in the Gibe Gojeb catchment, southwestern Ethiopia, were evaluated using the Soil and Water Assessment Tool (SWAT) model and regional climate models (RCMs). This study emphasizes the evaluation of the climate change impact on hydrological responses. The RCM data were downloaded from CORDEX-Africa. Power transformation and delta change methods were used for bias correction of precipitation and temperature, respectively. The calibration and validation of the SWAT model showed good agreement, and climate change impact was simulated. Accordingly, precipitation, soil water content, percolation, water yield, and groundwater are projected to decrease by 28.18, 7.5, 9.1, 5.4, and 9.2%, respectively, under RCP4.5 in the future (2021–2050). Besides, surface runoff and potential and actual evapotranspiration are projected to increase by 17.4, 11.32, and 5.06%, respectively. Soil water content, percolation, water yield, and precipitation are projected to decrease by 10.51, 5.63, 2.76, and 21.57%, respectively, under RCP8.5 in the future. Rain-fed crop production and hydropower generation in the catchment would be highly vulnerable to the likely effects of climate change. The attained results help to develop effective adaptation measures to reduce the ongoing impacts of climate change and draft long-term water resource management plans in the Gibe Gojeb catchment.

Impact of air pollution and climate change on mental health outcomes: an umbrella review of global evidence.

The impact of air pollution and climate change on mental health has recently raised strong concerns. However, a comprehensive overview analyzing the existing evidence while addressing relevant biases is lacking. This umbrella review systematically searched the PubMed/Medline, Scopus and PsycINFO databases (up to June 26, 2023) for any systematic review with meta-analysis investigating the association of air pollution or climate change with mental health outcomes. We used the R metaumbrella package to calculate and stratify the credibility of the evidence according to criteria (i.e., convincing, highly suggestive, suggestive, or weak) that address several biases, complemented by sensitivity analyses. We included 32 systematic reviews with meta-analysis that examined 284 individual studies and 237 associations of exposures to air pollution or climate change hazards and mental health outcomes. Most associations (n=195, 82.3%) involved air pollution, while the rest (n=42, 17.7%) regarded climate change hazards (mostly focusing on temperature: n=35, 14.8%). Mental health outcomes in most associations (n=185, 78.1%) involved mental disorders, followed by suicidal behavior (n=29, 12.4%), access to mental health care services (n=9, 3.7%), mental disorders-related symptomatology (n=8, 3.3%), and multiple categories together (n=6, 2.5%). Twelve associations (5.0%) achieved convincing (class I) or highly suggestive (class II) evidence. Regarding exposures to air pollution, there was convincing (class I) evidence for the association between long-term exposure to solvents and a higher incidence of dementia or cognitive impairment (odds ratio, OR=1.139), and highly suggestive (class II) evidence for the association between long-term exposure to some pollutants and higher risk for cognitive disorders (higher incidence of dementia with high vs. low levels of carbon monoxide, CO: OR=1.587; higher incidence of vascular dementia per 1 μg/m3 increase of nitrogen oxides, NOx: hazard ratio, HR=1.004). There was also highly suggestive (class II) evidence for the association between exposure to airborne particulate matter with diameter ≤10μm (PM10) during the second trimester of pregnancy and the incidence of post-partum depression (OR=1.023 per 1 μg/m3 increase); and for the association between short-term exposure to sulfur dioxide (SO2) and schizophrenia relapse (risk ratio, RR=1.005 and 1.004 per 1 μg/m3 increase, respectively 5 and 7 days after exposure). Regarding climate change hazards, there was highly suggestive (class II) evidence for the association between short-term exposure to increased temperature and suicide- or mental disorders-related mortality (RR=1.024), suicidal behavior (RR=1.012), and hospital access (i.e., hospitalization or emergency department visits) due to suicidal behavior or mental disorders (RR=1.011) or mental disorders only (RR=1.009) (RR values per 1°C increase). There was also highly suggestive (class II) evidence for the association between short-term exposure to increased apparent temperature (i.e., the temperature equivalent perceived by humans) and suicidal behavior (RR=1.01 per 1°C increase). Finally, there was highly suggestive (class II) evidence for the association between the temporal proximity of cyclone exposure and severity of symptoms of post-traumatic stress disorder (r=0.275). Although most of the above associations were small in magnitude, they extend to the entire world population, and are therefore likely to have a substantial impact. This umbrella review classifies and quantifies for the first time the global negative impacts that air pollution and climate change can exert on mental health, identifying evidence-based targets that can inform future research and population health actions.

Impact of the COVID-19 Pandemic on Obesity, Metabolic Parameters and Clinical Values in the South Korean Adult Population

This study aimed to evaluate the effects of the COVID-19 pandemic on obesity, metabolic parameters, and clinical values in the South Korean population. Data from the seventh and eighth National Health and Nutrition Examination Surveys were analyzed, comprising 3560 participants in 2018 (pre-COVID-19) and 3309 participants in 2021 (post-COVID-19). The study focused on adults aged 19 years and older who were overweight (BMI ≥ 25 kg/m2). The results showed a significant increase in waist circumference (approximately 2 cm), BMI (approximately 0.11 kg/m2), systolic blood pressure, fasting blood sugar (1.76 mg/dL higher), and glycated hemoglobin (0.14% higher) in the post-COVID-19 group compared to the pre-COVID-19 group. Additionally, the prevalence of hypercholesterolemia increased by 4% after the COVID-19 pandemic. These findings suggest an increased risk of obesity, abdominal obesity, and metabolic disorders, such as blood sugar disorders, in the post-COVID-19 period. Urine analysis revealed abnormal findings, including occult blood, urobilinogen, hematuria, proteinuria, ketone urea, glycosuria, and bacteriuria. The study highlights the negative impact of lifestyle changes, such as reduced physical activity and social gatherings, on physical vital signs and clinical values during the COVID-19 pandemic.

Professional regulation in the digital era: A qualitative case study of three professions in Ontario, Canada.

Technology is transforming service delivery and practice in many regulated professions, altering required skills, scopes of practice, and the organization of professional work. Professional regulators face considerable pressure to facilitate technology-enabled work while adapting to digital changes in their practices and procedures. However, our understanding of how regulators are responding to technology-driven risks and the impact of technology on regulatory policy is limited. To examine the impact of technology and digitalization on regulation, we conducted an exploratory case study of the regulatory bodies for nursing, law, and social work in Ontario, Canada. Data were collected over two phases. First, we collected documents from the regulators' websites and regulatory consortiums. Second, we conducted key informant interviews with two representatives from each regulator. Data were thematically analyzed to explore the impact of technological change on regulatory activities and policies and to compare how regulatory structure and field shape this impact. Five themes were identified in our analysis: balancing efficiency potential with risks of certain technological advances; the potential for improving regulation through data analytics; considering how to regulate a technologically competent workforce; recalibrating pandemic emergency measures involving technology; and contemplating the future of technology on regulatory policy and practice. Regulators face ongoing challenges with providing equity-based approaches to regulating virtual practice, ensuring practitioners are technologically competent, and leveraging regulatory data to inform decision-making. Policymakers and regulators across Canada and internationally should prioritize risk-balanced policies, guidelines, and practice standards to support professional practice in the digital era.

Design and fabrication of 3D-printed gastric floating tablets of captopril: effect of geometry and thermal crosslinking of polymer on floating behavior and drug release

The present study aims to investigate the potential of the 3D printing technique to design gastroretentive floating tablets (GFTs) for modifying the drug release profile of an immediate-release tablet. A 3D-printed floating shell enclosing a captopril tablet was designed having varying number of drug-release windows. The impact of geometrical changes in the design of delivery system and thermal cross-linking of polymers were evaluated to observe the influence on floating ability and drug release. Water uptake, water insolubilization, Differential Scanning Calorimetry (DSC), and Attenuated Total Reflection-Fourier Transform Infrared Spectroscopy (ATR-FTIR) were performed to assess the degree of thermal cross-linking of polyvinyl alcohol (PVA) filament. The 3D-printed GFT9 was considered the optimized gastric floating tablet that exhibited >12 h of total floating time with zero floating lag time and successfully accomplished modified-drug release by exhibiting >80% of drug release in 8 h. The zero-order release model, with an r2 value of 0.9923, best fitted the drug release kinetic data of the GFT9, which followed a super case II drug transport mechanism with an n value of 0.95. The optimized gastric floating device (GFT9) also exhibited the highest MDT values (238.55), representing slow drug release from the system due to thermal crosslinking and the presence of a single drug-releasing window in the device.

Vibration energy harvesting system with cyclically time-varying potential barrier

Nonlinear kinetic energy harvesters are becoming more and more popular as well as advanced and efficient. This paper presents the study of the dynamics of such a system in a wide range of excitation parameters, assuming at the same time the possibility of a cyclical and smooth change of the potential function. We have designed a system that allows to obtain a wide spectrum of potential characteristics, from a single well to a three-well system, and we have analyzed its effectiveness. Next, we checked the influence of parameters characterizing the change of potential using bifurcation diagrams and their comparison with the effective voltage values. We also analyzed the behavior of the system in chaotic and periodic motion zones and presented selected sections of Poincare and Fourier amplitude-frequency spectra of chaotic solutions. The last element of the analysis was the impact of cyclic potential change on coexisting solutions. We have shown that the best effectiveness is achieved when the frequency of the external load is equal to the resonant frequency of the flexible cantilever beam and the change of potential is limited to extreme positions.