Cultural and language barriers are a major cause of disparities in health care access and health outcomes for immigrant and refugee children and adolescents. To practice culturally effective health care and promote health equity, health care providers need to be aware of their own cultural backgrounds and biases, and sensitive to differences between their own backgrounds and their patients’ backgrounds. For newcomer children, adolescents and families, health care providers need to understand immigration history, possible immigration trauma, identity development, acculturation, family conflicts, sociocultural dimensions of health beliefs, experiences with bias or racism, and adolescent risk behaviours and protective factors. All of these issues are influenced by culture, and can profoundly affect health status as well as health care-seeking behaviours and relationships with health care providers. What follows are sample questions that can be gathered in the health and psychosocial history of newcomer children and adolescents. These sample questions are not meant to be exhaustive, nor are they meant to be used as a ‘checklist’ to be asked in a certain order, similar to a structured interview. Rather, these questions illustrate approaches that providers can use to begin exploring issues that significantly affect the health of newcomer children and adolescents (1–6). These questions can be asked of the child and/or parent as appropriate. The issues can be explored directly with the older child or adolescent in a developmentally appropriate manner, including as part of the confidential adolescent psychosocial interview. Cultural competence and culturally effective health care is an important investment in promoting health equity and health, reducing disparities for newcomer children and youth. Please visit the Canadian Paediatric Society’s Caring for Kids New to Canada website (www.kidsnewtocanada.ca) for more information and resources on serving this population.