At present, the main difficulties in oil and gas exploration are focused on the exploration of the deep region. How to improve the efficiency of imaging on the same accuracy of migration is an urgent problem. The paper puts forward the concept of multi-scale grid for the underground medium based on finite difference time domain (FDTD) of reverse time migration (RTM), which can avoid the oversampling to high speed and hold the sampling density to low-speed layer. The method can shorten the time of RTM with the same accuracy of the traditional RTM imaging. Firstly, devise the multi-scale grid model according to the velocity model; it uses the small-scale grid for the low-speed area and large-scale grid for high-speed area; secondly, calculate the value of each point of the wave field on multi-scale model, especially the points of transition zone; finally, image the underground media according to the RTM imaging condition. The experimental results show that under the condition of the same simulation order, the multi-scale RTM imaging computational efficiency can be promoted by 25.05% average within this paper.