The rapid and accurate classification of Panax notoginseng leaf diseases is vital for timely disease control and reducing economic losses. Recently, image classification algorithms have shown great promise for plant disease diagnosis, but dataset quantity and quality are crucial. Moreover, classifying P. notoginseng leaf diseases faces severe challenges, including the small features of anthrax and the strong similarity between round spot and melasma diseases. In order to address these problems, we have proposed an ECA-based diffusion model and Inception-SSNet for the classification of the six major P. notoginseng leaf diseases, namely gray mold, powdery mildew, virus infection, anthrax, melasma, and round spot. Specifically, we propose an image generation scheme, in which the lightweight attention mechanism, ECA, is used to capture the dependencies between channels for improving the dataset quantity and quality. To extract disease features more accurately, we developed an Inception-SSNet hybrid model with skip connection, attention feature fusion, and self-calibrated convolutional. These innovative methods enable the model to make better use of local and global information, especially when dealing with diseases with similar features and small targets. The experimental results show that our proposed ECA-based diffusion model FID reaches 42.73, compared with the baseline model, which improved by 74.71%. Further, we tested the classification model using the data set of P. notoginseng leaf disease generation, and the accuracy of 11 mainstream classification models was improved. Our proposed Inception-SSNet classification model achieves an accuracy of 97.04% on the non-generated dataset, which is an improvement of 0.11% compared with the baseline model. On the generated dataset, the accuracy reached 99.44%, which is an improvement of 1.02% compared to the baseline model. This study provides an effective solution for the monitoring of Panax notoginseng diseases.