The current changing in world dynamics leads to an increased complexity on countries relations. From this perspective, the article's general objective analyses the impact of Latin America and East Asia integration through the Bioceanic Corridor and the Belt and Road Initiative on illicit markets. The specific objectives focus on identifying complicating elements for regional security, stemming from the collaborative and competitive engagements of actors within illegal networks. The adopted methodology is predominantly qualitative, involving bibliographic review, document analysis and case studies based on data from academic and government documents, and reports from international organizations. The addressed topics include drug and weapons trafficking, infrastructure initiatives, regional and global interconnection, and their relations to the criminal phenomena in South America. From the results obtained, the article emphasizes the anticipatory dimension, providing preventive recommendations in international collaboration, standardization of informational capabilities through common data models in road logistics hubs, and the application of security protocols in maritime hubs, with emphasis on the ARESP methodology (Risk Analysis with Emphasis on Port Security), contributing to regional integration on global security, and proposing practical and collaborative measures to anticipate and mitigate potential challenges arising from the interconnection of illicit networks on a global scale.