The Tabuk province of Saudi Arabia (SA) has an arid zone, few aquifers, high groundwater salinity (seawater intrusion), and accelerated population, industrial, and agricultural development. The development of Tabuk Basin is essential for the addition of new freshwater resources and the enhancement of aquifer recharge potential. The hydrological characteristics of the drainage basin aid in the identification of watersheds, enabling the protection and management of land erosion and ground/surface water resources. This study analyzed hydro-morphometric data from the eighteen sub-basins of the Tabuk Basin using multivariate statistical approaches and coupled remote sensing (RS) and geographic information systems (GIS) for water priority determination. The results show that the four principal components(PC1-4) have a variance of90.4% concerningbifurcation ratio (Rb), ruggedness number (Rn), elongation ratio (Re), drainage density (Dd), basin relief (Bh), circularity ratio (Rc), and relief ratio (Rh). The Al Ula, Thaibah, Hamd, Dama, Al Wajh, Al Ghamra, and Azlam sub-basins showed the highest priority, indicating soil erosion and the necessity for mitigating measures to reduce infrastructure damage. Mostexposed geology (67%) exhibited strong permeability and good infiltration (sedimentary cover and Quaternary sediments). The rest(23%) showed low to medium permeability(igneous, metamorphic, and carbonate rocks). The bestpromisingsitesfor building new wells can reduce surface runoff and soil erosion through aquifer infiltration and abstraction. The aquifer potentiality map was accomplished for Al Ula, Thaibah, Hamd, and Dama drainage basins. The most prospective groundwater investigation regions were identified, coincidingwith the drilled wells that confirmed and validated the results. The estimated zones of high to very high aquifer potentiality were used to add additional wells for investment reduce soil erosion, mitigate alternatives, agriculture,urbanization, etc. The other sub-basins have a medium to low priority, with less soil erosion and aquifer recharge.