Ideal Location Research Articles

Transplantation of Islet Organoids into Brown Adipose Tissue in a Diabetic Mouse Model.

Pancreatic islet transplantation is a promising cell replacement therapy for patients with type 1 diabetes (T1D), an autoimmune disease that destroys insulin-producing islet β cells. However, the shortage of donor pancreatic islets significantly limits the widespread use of this strategy as a routine therapy. Pluripotent stem cell-derived insulin-producing islet organoids present a promising alternative β cell source for T1D patients. One critical challenge is the lack of vascularization in islet organoids, making it essential to investigate vascularized transplantation sites to support their survival. Brown adipose tissue (BAT) is well vascularized and secretes active cytokines, facilitating islet organoid survival. Thus, BAT represents a promising transplantation site for islet organoids, making it an ideal location to support cell replacement therapies and improve treatment approaches for T1D. Here, we describe the methods for transplanting human-induced pluripotent stem cell (iPSC)-derived islet organoids into the BAT of a mouse model.

Neutrosophic fuzzy decision-making framework for site selection

These days, the area of interest based on canteen location selection in the university campus is a prominent topic. This research work directly affects students' convenience, accessibility and the total campus experience. An ideal canteen site not only provides good food to the students and staff but also takes care of their health by providing a healthy environment. In this paper, we choose various criteria and sub-criteria to calculate the best site for a canteen in the university campus. Location, space and layout, infrastructure and Utilities, safety and compliance and environmental factors as criteria with their corresponding sub-criteria are chosen for this work. Here, the data sets used are provided by decision makers in linguistic words and then converted into crisp numbers. The criteria and sub-criteria weights are considered by a popular multi criteria decision-making (MCDM) method named Criteria Importance Through Intercriteria Correlation, i.e., CRITIC method. Therefore, the ideal location for the canteen in the university campus was determined by applying the complex proportional assessment method (COPRAS), which is basically a ranking method of MCDM. And finally, sensitivity analysis was conducted to make sure the outcomes were flexible and stable.

Extremely low biodiversity Arctic intertidal habitats as sentinels for environmental change

The Arctic is undergoing dramatic changes, including an unprecedented decline in sea ice. Previous studies have shown the severe structuring impact of sea ice scour upon polar intertidal communities. A dramatic example of the influence of Arctic sea ice is the highly depauperate intertidal of Cambridge Bay (Iqaluktuuttiaq) on Victoria Island, Nunavut, Canada. Cambridge Bay intertidal is dominated by a single species of amphipod crustacean, Gammarus setosus, with rare examples of another amphipod, bivalve molluscs, and oligochaetes. Primary producers are limited to a thin algal film, with no macroalgae present shallower than 2 m water depth. This intertidal biodiversity has remained extremely low since it was first surveyed 70 years ago, however, the seasonal sea ice thickness has been in decline for over 50 years. Given the observed dramatic increases in biodiversity and biomass with decreased sea ice cover elsewhere in the Arctic and the presence of the Canadian High Arctic Research Station, we suggest that the intertidal of Cambridge Bay offers an ideal location for a low cost, low effort, and long-term monitoring of biodiversity change and tipping points that may be influenced by sea ice loss in the Arctic as part of a network intertidal monitoring stations.

Origins of Very Low Helium Abundance Streams Detected in the Solar Wind Plasma

The abundance of helium (A He) in the solar wind exhibits variations typically in the range from 2% to 5% with respect to solar cycle activity and solar wind velocity. However, there are instances where the observed A He is exceptionally low (<1%). These low-A He occurrences are detected both near the Sun and at 1 au. The low-A He events are generally observed near the heliospheric current sheet. We analyzed 28 low-A He events observed by the Wind spacecraft and 4 by Parker Solar Probe to understand their origin. In this work, we make use of the ADAPT-WSA model to derive the sources of our events at the base of the solar corona. The modeling suggests that the low-A He events originated from the boundaries of coronal holes, primarily from large quiescent helmet streamers. We argue that the cusp above the core of the streamer can produce such very low helium abundance events. The streamer core serves as an ideal location for gravitational settling to occur as demonstrated by previous models, leading to the release of this plasma through reconnection near the cusp, resulting in low-A He events. Furthermore, observations from Ulysses provide direct evidence that these events originated from coronal streamers.

Designing for Teen Mental Health: An exploration of the co-design of virtual reality in the public library setting

Teen mental health is in a state of crisis in the United States. One in three adolescents is suffering from a mental health issue and suicide is the third leading cause of death for teens ages 15–24. The demand for mental health resources far outweighs the supply suggesting creative and accessible mental health resources are needed. The public library is a community resource available to all community members and is an ideal location for providing mental health supports. Therefore, in this project, we engaged three, diverse groups of teens (n = 30) in the design and development of a virtual reality environment intended to support teen mental health. Teens from two urban (Seattle and Washington, D.C.) and one rural setting (Texas) participated in a 13-session, after school co-design program led by local library staff. Through these design sessions, we learned that (1) Teens are interested and engaged in talking about their mental health and find nature and animals relaxing and helpful. (2) Teens envision virtual reality (VR) as an environment to help them manage or avoid stress and feelings of overwhelm. (3) As designers teens enjoy active interaction and the ability to iterate on their designs. (4) VR designs by teens often included being in nature and with animals. These data suggest that virtual reality may be a successful medium and public libraries an appropriate site in which to engage teens in co-design for mental health. More importantly, such programs may offer an invitation to encourage teens to think about and discuss their own mental health.

An Innovative Collaboration-Based Ozone and Aerosol Observation Network in Northeast Asia

Abstract Situated in close proximity to the Korea Peninsula and the Japan Islands, Shandong Province in China (SDP) has emerged as a focal point for global attention due to its significant surface ozone (O3) and aerosol pollution. Despite this attention, there are notable gaps in knowledge across various interconnected research domains, encompassing climate change, atmospheric circulation, anthropogenic emissions, and the chemistry of O3 and aerosols. The impact of frequent heat waves on regional O3 and aerosol pollution remains unclear, while our comprehension of atmospheric circulation dynamics and the chemistry involved with O3 and aerosols is still hampered by substantial limitations. The unique topography and geographical setting of SDP, with its complex interplay of factors like sea–land breezes, mountain–valley winds, and urban heat islands, make it an ideal location for investigating the dynamics of O3 and aerosol chemistry. Moreover, it is essential to explore the effects of transboundary transport on O3 and aerosol pollution and delve into the underlying mechanisms contributing to their combined pollution effects. To bridge these knowledge gaps, the Innovative Collaboration-Based Ozone and Aerosol Observation Network in Northeast Asia has been established through collaborative efforts involving the Bureaus of Ecology and Environment, Meteorology in SDP, and the Chinese Academy of Sciences. This network encompasses various components, including air quality and weather stations, a network of low-cost air quality sensors, monitoring stations focused on atmospheric photochemical smog and aerosol chemical speciation, and vertical measurement systems targeting O3 and its precursor gases (utilizing light detection and ranging, balloon sounding, and drone-based measurements), as well as measurements conducted via vehicles and ships. Additionally, preliminary findings from this comprehensive observational campaign will be shared.

Application of Walrus Optimizer for Power Quality Improvement in Radial Distribution System

To increase power quality (PQ) in radial distribution systems (RDS) by utilizing active power filters (APFs), this research discusses the application of walrus optimization algorithms (WaOA). The main problem with the PQ is harmonics. The harmonics are added to the RDS by nonlinear loads (NLs). In this instance, together with NL at two end nodes, nonlinear distributed generation (NLDG) is additionally considered. APFs are used to decrease the harmonics to specified limits. In this instance, APFs are positioned correctly to reduce harmonics and improve PQ. WaOA is utilized to maximize the APF's size at the ideal bus location. The WaOA is inspired by natural processes and contains features that are well-balanced for both exploration and exploitation. Within limitations on inequality, optimization seeks to minimize APF's current. On the IEEE-69 bus RDS, a simulation is run to assess the WaOA's performance. Four distinct cases are examined here: a) NL+NLDG only (no APF); b) APF at bus 27; c) APF at bus 67, and d) APFs are located at busses 27 and 67. These examples are taken into consideration to examine the impact of APF sizing and location on PQ in RDS. Using the artificial bee colony (ABC) optimization method, a comparison analysis is performed. The simulation results confirm that the WaOA algorithm solves the optimization problem with stability and efficacy.

An approach for adaptive filtering with reinforcement learning for multi-sensor fusion in condition monitoring of gearboxes

Condition monitoring of gearboxes is integral to maintaining floor safety, system stability, and inventory management. Capturing vibration response using sensors and subsequent response analysis is the standard procedure for gearbox fault detection. However, the sensors are susceptible to non-constant reliability due to the convolution of vibration responses from multiple sources, background noise interference, and transfer-path effect. The problem is multi-fold when ideal sensor attachment locations are unavailable due to spatial constraints of industrial floors. The response component reflective of the fault information must be enhanced for adequate fault severity estimations. The present study addresses this hurdle by proposing a multi-sensor framework with available sensor attachment locations for gearbox condition monitoring. Adaptive filtering is done in the framework with parameters optimised to enhance fault information. A proximal policy optimisation agent is trained with a reinforcement learning environment for parameter refinement. Further, fault severity estimation is achieved by a weighted fusion of spectral features reflective of the side-band excitation effect caused by gear fault. The proposed method is applied to datasets acquired from an in-house seeded fault test bed. The proposed method underscores superior performance compared to conventional single-sensor-based fault severity analysis and alternate fusion approaches.

Development and application of an optimization model to evaluate future charging demand for long-haul electric vehicles in Ontario, Canada

Establishing a charging network is critical to support vehicle electrification. Determining the ideal locations of charging stations can be challenging due to conflicting stakeholder constraints. This study aims to identify the optimal number of on-route charging locations that can support the projected maximum charging demand of long-haul electric vehicles (LHEVs) in the Canadian province of Ontario in the year 2040. A flow-based path-segment coverage model is proposed, which considers the time when each charging event at each candidate location is likely to occur. The impact of charging LHEVs on the grid is also evaluated. Based on projected 2040 LHEV adoption, results suggest that almost 90 % of the trips will be completed without the need to recharge. However, at least 82 fast charging station locations must be established throughout Ontario to support the remaining LHEV trips within the province. Moreover, almost 75 % of these trips are dependent primarily on 18 of these locations. In general, more than 46 GW of electricity per day is expected to be used when LHEVs have been adopted on a much larger scale in Ontario. Specifically, the Greater Toronto Area (GTA) is likely to experience approximately 4.86 GW of additional energy from LHEV charging activities during peak hours.

The effect of the oxygen dangling on the thermoelectric properties of organic Thienoisoindigo single-molecule junction.

Theoretical investigation for thermoelectric characteristics of organic Thienoisoindigo single-molecule is carried out using the first-principles calculations based on the density functional theory. It reveals that modifying the position or removing oxygen atoms significantly alters the thermoelectric properties. Transmission coefficient calculations show that the lowest unoccupied molecular orbital (LUMO) dominates across all molecular configurations. Repositioning oxygen atoms increases the bandgap from 1.14 to 1.53 eV, while the complete removal of oxygen further increases to 1.8 eV. This change leads to the disruption of constructive quantum interference, which is replaced by destructive one. The electrical conductance is similarly affected by changes in oxygen atom positioning, with values shifting from 1.06 to 1.63. Molecules without oxygen atoms exhibit lower conductance compared to those with dangling oxygen, resulting in reduced semiconductor-like behavior and enhanced insulating properties. The Seebeck coefficient remains stable at 2.99 V/K when oxygen atoms are repositioned. However, the removal of one oxygen atom changes the coefficient to a positive value (290.14 V/K), causing the molecule to transition from n-type to p-type behavior. The complete absence of oxygen atoms returns the Seebeck coefficient to a negative value ( 256.08 V/K), switching the molecule back to n-type conduction. This investigation was achieved by applying the SIESTA software through density functional theory (DFT) computations. To account for exchange and correlation effects, we use a double-zeta polarized (DZP) basis set in conjunction with the generalized gradient approximation (GGA-PBE) to determine the ideal ground-state atomic locations. By combining the Hamiltonian of each system with the quantum transport code GOLLUM, we can calculate the transmission coefficient, projected density of states, electrical conductance, and Seebeck coefficient to examine the thermoelectric characteristics of the molecular junction.

Growth and globalization of the Central African wildlife economy: Insights from a 23-year study of wild meat markets on Bioko Island, Equatorial Guinea

The commercial trade in wild meat is booming in Central Africa. Addressing this issue is a global priority because the trade poses a major threat to biodiversity and human health. We investigated the impact of socioeconomic factors, public health emergencies, and conservation efforts on the wild meat trade using daily surveys of wild meat markets on Bioko Island, Equatorial Guinea (EG), from 1997 through 2021. Bioko is an ideal location for examining how external factors impact the wild meat market trade. Although small, the island has large areas of intact forest that host populations of commercially valuable wildlife; low-cost protein substitutes are available; and Malabo, the island’s only large metropolitan area and wild meat trading hub, hosts a wealthy class of urbanites. We found significant associations between global market trends and the wild meat trade, especially China’s foreign investment and oil production in the US and EG. Economic crises like EG’s 2009 economic downturn that followed a global crash in oil prices and reduced production, redirected demand towards cheaper mainland wildlife carcasses amid reduced consumer demand. Public health emergencies had the most comprehensive impact on the wild meat trade. The 2014 Ebola outbreak and the COVID-19 pandemic both induced shifts in market demand, and the COVID-19 pandemic disrupted trade routes, affecting both urban and rural markets. Internally, we observed market decentralization over the last decade and changes in wildlife supply chains during public health emergencies. Conservation policies, including anti-poaching measures and educational outreach, temporarily influenced wildlife market trends, sometimes leading to trading surges in endangered primate carcasses. Our study highlights the importance of monitoring global market trends, public health campaigns, and adapting conservation strategies to disrupt wildlife supply chains and curb consumer demand for wild meat.

A Novel Rainfall Classification for Mapping Rainwater Harvesting: A Case Study in Kalar, Iraq

Increasing water demand driven by population growth and climate change strains water resources, especially in arid regions. The effectiveness of rainwater harvesting (RWH) as a viable solution is contingent upon the meticulous selection of appropriate sites. Contemporary efforts have increasingly utilized Geographic Information Systems (GIS) and remote sensing technologies to optimize the identification of ideal locations for implementing RWH infrastructure. However, inconsistencies in rainfall classification methodologies can compromise the accuracy of the resulted suitability maps. Consequently, a standardized approach to grading rainfall depth for mapping RWH sites becomes imperative. This study presents an innovative rainfall classification method tailored for both micro and macro catchment areas, offering a reliable and adaptable approach to rainfall analysis. By refining classification criteria, this method aims to improve the consistency and precision of RWH mapping, addressing a gap in existing methodologies and providing a more standardized approach. Through the application of FAHP and Fuzzy overlay techniques in ArcGIS 10.4, the study compares traditional rainfall classification with the proposed new classification method to assess RWH suitability in Kalar. The comparison highlights that the new rainfall classification-based map yielded higher accuracy and realism compared to traditional methods.

Multi-objective location-distribution optimization in blood supply chain: an application in Turkiye

PurposeBlood donors are crucial in maintaining the blood supply chain. This study aims to improve the location and distribution of blood donation centers by focusing on two main objectives: minimizing costs and maximizing quality. Minimizing costs includes setting up and transporting blood efficiently while maximizing quality to ensure that blood products are delivered to hospitals promptly and in the right quantities.MethodsA multi-objective mathematical model is proposed to address the placement of both fixed and mobile blood donation centers. The first objective focuses on minimizing the costs of setting up centers and transporting blood. The second objective aims to maximize quality by ensuring timely deliveries and meeting hospitals’ blood demand. The model utilizes real-world traffic and blood donation data from urban settings to simulate its effectiveness and applicability in practice. The model uses the ε\\documentclass[12pt]{minimal} \\usepackage{amsmath} \\usepackage{wasysym} \\usepackage{amsfonts} \\usepackage{amssymb} \\usepackage{amsbsy} \\usepackage{mathrsfs} \\usepackage{upgreek} \\setlength{\\oddsidemargin}{-69pt} \\begin{document}$$\\varepsilon$$\\end{document} constraint method to optimize both objectives simultaneously.ResultsThe model was tested in various scenarios, optimizing cost and quality separately. The algorithm determined the ideal locations for blood donation centers to meet demand by exploring different options. It also accounted for factors that reduce quality, such as delayed deliveries and product returns, and showed that these issues could be minimized.ConclusionThis study highlights the need to balance cost and quality when determining the locations of blood donation centers. Using the ε\\documentclass[12pt]{minimal} \\usepackage{amsmath} \\usepackage{wasysym} \\usepackage{amsfonts} \\usepackage{amssymb} \\usepackage{amsbsy} \\usepackage{mathrsfs} \\usepackage{upgreek} \\setlength{\\oddsidemargin}{-69pt} \\begin{document}$$\\varepsilon$$\\end{document} constraint method, the model successfully optimized both objectives, offering valuable insights for improving the efficiency and effectiveness of blood donation operations.

A safe, novel and ingenious method for autogenous bone graft storage in spine surgery with constrained resources - operative site as the bone bank.

The aim of our study is to establish whether the bone graft harvested and stored in the surgical wound by our novel technique is safe, reproducible and preserves the viability of the graft. In doing so, it promises successful bony fusion in spine and orthopaedic surgeries. A prospective clinical case series was conducted for autogenous bone graft storage in complex spine surgeries requiring staged procedures, in resource constrained settings. The bone graft harvested was morselized, wrapped in moist sterile gauze and stored in the paraspinal gutter within the operative site. Thereafter, the surgical wound was easily closed without tension. During the second stage surgery, the stored bone was retrieved and mixed with more autologous/allogenic bone (if necessary) and appropriately laid at fusion sites. Bacterial samples were sent before implantation. 16 complex spinal deformity patients who underwent surgery in a resource constrained hospital over a period of 5 years were included. Duration between both stages was within 2 weeks. All patients showed successful fusion, with mean follow-up of 2.6 years. There were no cases of deep or systemic infection in our series. Surgeons found harvesting, storing and retrieval of graft to be straightforward. The operative site provides an ideal, safe and reproducible location for bone graft storage for staged surgeries conducted in resource constrained situations. The osteogenic potential of the autogenous bone graft is retained. This technique can be extrapolated to other orthopaedic surgeries conducted under resource limited environments like in surgical camps or combat medical facilities.

Helping the Most Vulnerable Stay Cool in Extreme Heat

Choosing the ideal location for air-conditioned cooling centers in cities facing dangerously high temperatures takes good population data and community engagement.

Optimized demand-based charging networks for long-haul trucking in Europe

Abstract Battery electric trucks (BETs) are the most promising option for fast and large-scale CO2 emission reduction in road freight transport. Yet, the limited range and longer charging times compared to diesel trucks make long-haul BET applications challenging, so a comprehensive fast charging network for BETs is required. However, little is known about optimal truck charging locations for long-haul trucking in Europe. Here we derive optimized truck charging networks consisting of publicly accessible locations across the continent. Based on European truck traffic flow estimates for 2030 and actual truck stop locations we construct a long-term charging network that minimizes the total number of required locations. Our approach introduces an origin-destination (OD) pair sampling method and includes local capacity constraints to compute an optimized stepwise network expansion along the highest demand routes in Europe. For an electrification target of 15% BET share in long-haul and without depot charging, our results suggest that about 91% of electric long-haul truck traffic across Europe can be enabled already with a network of 1,000 locations, while 500 locations would suffice for about 50%. We furthermore show how the coverage of OD flows scales with the number of locations and the size of the stations. Ideal locations to cover many truck trips are at highway intersections and along major European road freight corridors (TEN-T core network).

Genomic surveillance of Canadian airport wastewater samples allows early detection of emerging SARS-CoV-2 lineages

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic has shown wastewater (WW) surveillance to be an effective means of tracking the emergence of viral lineages which arrive by many routes of transmission including via transportation hubs. In the Canadian province of Ontario, numerous municipal wastewater treatment plants (WWTPs) participate in WW surveillance of infectious disease targets such as SARS-CoV-2 by qPCR and whole genome sequencing (WGS). The Greater Toronto Airports Authority (GTAA), operator of Toronto Pearson International Airport (Toronto Pearson), has been participating in WW surveillance since January 2022. As a major international airport in Canada and the largest national hub, this airport is an ideal location for tracking globally emerging SARS-CoV-2 variants of concern (VOCs). In this study, WW collected from Toronto Pearson’s two terminals and pooled aircraft sewage was processed for WGS using a tiled-amplicon approach targeting the SARS-CoV-2 virus genome. Data generated was analyzed to monitor trends of SARS-CoV-2 lineage frequencies. Initial detections of emerging lineages were compared between Toronto Pearson WW samples, municipal WW samples collected from the surrounding regions, and Ontario clinical data as published by Public Health Ontario. Results enabled the early detection of VOCs and individual mutations emerging in Ontario. On average, the emergence of novel lineages at the airport preceded clinical detections by 1–4 weeks, and up to 16 weeks in one case. This project illustrates the efficacy of WW surveillance at transitory transportation hubs and sets an example that could be applied to other viruses as part of a pandemic preparedness strategy and to provide monitoring on a mass scale.

Knowledge, Attitudes, and Perspectives of Women Who Have Migrated from Sub-Saharan Africa to France Toward HIV Pre-Exposure Prophylaxis in a Family Planning Center.

Women who have migrated from sub-Saharan Africa (SSA) are underrepresented among HIV pre-exposure prophylaxis (PrEP) users in France (∼2%), yet they account for around 20% of new HIV infections annually. We conducted focus groups to explore the knowledge, attitudes, and perspectives of these women toward PrEP in a French family planning center (FPC). Focus groups occurred from November 2023 to February 2024 within the Lariboisière Hospital FPC in Paris. The social ecological model informed the discussion guide, which explored women's PrEP experiences and determinants for uptake on various levels. Five focus groups were conducted (N = 19). The median age of participants was 29 [interquartile range (IQR) 28-37]. Eight African countries were represented. The average time in France since migration was 3 (IQR 1-6) years. The majority of women had never heard of PrEP but expressed strong interest in learning more about it. Women underscored the difficulty of negotiating HIV prevention tools with their partners, risks from transactional sex, and barriers to PrEP use such as adherence challenges to daily pills and misconceptions about HIV transmission. There was strong interest in long-acting injectable PrEP. Women reported high trust in FPC providers and viewed the FPC as an ideal location to access PrEP. Conspiracy theories, cultural beliefs, and anticipated stigma were also identified as barriers to PrEP uptake. Most women advocated for disseminating PrEP information to their peers using diverse community outreach strategies. Despite a strong interest, increasing PrEP uptake in women from SSA will remain challenging without multi-faceted and adapted implementation strategies.

Application of Electromagnetic Method in the Detection of Buried Karst Groundwater in the North-South Archaic Uplift, Ningxia, China

Abstract The North-South Archaic Uplift Karst Area, situated in the Ningxia Hui Autonomous Region, exemplifies the presence of underground karst formations in northern China. This work utilizes the regional hydrogeological survey to carry out geophysical investigations. The objective is to examine the resistivity qualities of layers and formations in order to investigate the attributes of subterranean karst water. The results indicate the existence of karst groundwater within the carbonate fault zone, covered by Quaternary loess with a high resistance and Neogene mudstone with a low resistance. The resistivity of the fault zone is relatively lower compared to the surrounding carbonate rock. The core principle of this rule can be concisely stated as “detect regions of high resistance within regions of low resistance, and detect regions of low resistance within regions of high resistance.” The electrical characteristics of the subterranean karst formation greatly aid in identifying ideal locations for investigating karst groundwater.

Geomorphological study of the gullies in Penticton crater, Mars: Classification and origin

Penticton crater, a southern hemisphere mid-latitude crater on Mars is covered with features that are typical examples of the martian gullies that resemble the terrestrial gullies on Earth. We studied the gullies present in Penticton crater, classified them and interpreted their formation mechanism using a remote sensing approach. A wide variety of gullies including the classic gullies, channel gullies, alcove-apron features, linear gullies and a distinct light toned gully were detected in the crater. With its diverse classes of gullies and absence of a preferential orientation trend between pole-facing and equator-facing slopes, Penticton crater serves as an ideal location for observing present-day gully activity and studying the mechanism of modern gully formation. The geomorphological study points out prominent glacial features like lobate debris apron (LDA), lineated valley fill (LVF), and concentric crater fill (CCF) in the region. Extensive morphologic evidence suggests previous existence of latitude dependent mantle (LDM) on the pole-facing crater walls. The morphometric analysis using parameters like length, orientation, alcove and apron width of the gullies for all the four martian seasons suggest that the gullies are currently not active. The age estimated using crater size frequency distribution indicated that the study area is 5.5 ± 0.7 Ma, which falls in the range of the high obliquity period of Mars. We propose a rare scenario where there are multiple gully forming mechanisms acting on the same crater. Our results implies that the gullies on the pole-facing slopes are formed on LDM due to destabilization triggered by the sublimation during the recent shift in martian obliquity. However, morphometric parameters including the apex slopes gives the impression that the gullies on the steeper equator-facing slope were most likely formed by the sliding of dry granular sand.