Icing on transmission lines may cause damage to tower components and even lead to structural failure. Aiming at the lack of research on predicting mechanical characteristic parameters of weak components of transmission towers, and the cumbersome steps of building a finite element model (FEM), the study of prediction for mechanical characteristic parameters of weak components of towers based on a finite element simulation and machine learning is proposed. Firstly, a 110 kV transmission tower in a heavily iced area is taken as an example to establish its FEM. The locations of the weak components are analyzed, and the accuracy of FEM is verified. Secondly, meteorological and terrain parameters are considered as input parameters of the prediction model. The axial stresses and nodal displacements of four weak components are selected as output parameters. The FEM of the 110 kV transmission tower is used to obtain input and output datasets. Thirdly, five machine learning algorithms are considered to establish the prediction models for mechanical characteristic parameters of weak components, and the optimal prediction model is obtained. Finally, the accuracy of the prediction method is verified through an actual tower collapse case. The results show that ACO-BPNN is the optimal model that can accurately and quickly predict the mechanical characteristic parameters of the weak components of the transmission tower. This study can provide an early warning for the failure prediction of transmission towers in heavily iced areas, thus providing an important reference for their safe operation and maintenance.